Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
Rho-associated
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "Rho-associated" in MCE Product Catalog:
6
6
6 Publications Verification
Cat. No.: HY-18990
CAS No.: 817194-38-0
Research Areas:
GSK180736A is potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
1
Target:
Research Areas:
Netarsudil (AR-13324) is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil is mainly used in the study of ocular hypertension and primary open-angle glaucoma .
1
1 Cited Publications
Synonyms: AR-13324 hydrochloride
Target:
Research Areas:
Netarsudil (AR-13324) hydrochloride is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil hydrochloride reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil hydrochloride is mainly used in the study of ocular hypertension and primary open-angle glaucoma .
1
1 Cited Publications
Synonyms: AR-13324 dimesylate
Target:
Research Areas:
Netarsudil (AR-13324) dimesylate is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil dimesylate reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil dimesylate is mainly used in the study of ocular hypertension and primary open-angle glaucoma .
1
Synonyms: RXC007
Zelasudil (RXC007) is an orally active, highly selective small molecule Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor with anti-fibrotic efficacy. Zelasudil elicits positive immunomodulatory effects in metastatic pancreatic tumors with increase of CD8+ and CD4+ T cell infiltrate into the tumor cortex and reduction in immunosuppressive FOXP3+ regulatory T cells at the tumor border. Zelasudil is promising for research of pancreatic ductal adenocarcinoma .
Cat. No.: HY-126432
CAS No.: 1973494-17-5
Synonyms: BA-1049
Target:
Research Areas:
NRL-1049 dihydrochloride (BA-1049) is a selective and orally active rho-associated protein kinase 2 (ROCK2) inhibitor with an IC50 of 0.59 μM. NRL-1049 dihydrochloride shows selectivity for ROCK2 is 44 times that of ROCK1 (IC50 = 26 μM). NRL-1049 dihydrochloride can preserve the blood-brain barrier after acute injury .
Cat. No.: HY-103045A
CAS No.: 1941168-71-3
Research Areas:
CMPD101 hydrochloride is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC50s of 18 nM and 5.4 nM, respectively. CMPD101 hydrochloride also inhibits Rho-associated kinase 2 (ROCK-2) and PKCα (IC50s =1.4 μM and 8.1 μM, respectively) .
Cat. No.: HY-118046
CAS No.: 1123163-20-1
Research Areas:
GSK2163632A is a selective G protein-coupled receptor kinase (GRK) inhibitor that can be used as a probe for studying heart failure and Parkinson's disease. GSK2163632A potently inhibits GRK1 and GRK5, and also inhibits Rho-associated coiled-coil kinase (ROCK) and insulin-like growth factor receptor IGF-1R. GSK2163632A binds to GRK2 in a manner similar to Paroxetine (HY-122272).
Cat. No.: HY-P701769
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ROCK1; Rho-associated, Coiled-Coil-Containing Protein Kinase 1; Rho associated Coiled-Coil Containing Protein Kinase 1; Renal Carcinoma Antigen NY-REN-35; P160ROCK; ROCK-I; Rho-associated Protein Kinase 1; Rho-associated Protein Kinase; P160 ROCK-1; ROCK1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701770
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ROCK1; Rho-associated, Coiled-Coil-Containing Protein Kinase 1; Rho associated Coiled-Coil Containing Protein Kinase 1; Renal Carcinoma Antigen NY-REN-35; P160ROCK; ROCK-I; Rho-associated Protein Kinase 1; Rho-associated Protein Kinase; P160 ROCK-1; ROCK1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705673
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ROCK1; Rho-associated, Coiled-Coil-Containing Protein Kinase 1; Rho associated Coiled-Coil Containing Protein Kinase 1; Renal Carcinoma Antigen NY-REN-35; P160ROCK; ROCK-I; Rho-associated Protein Kinase 1; Rho-associated Protein Kinase; P160 ROCK-1; ROCK1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P86538
Synonyms: ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK
Cat. No.: HY-P702931
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ROCK2; ROCK-II; Rho associated Coiled-Coil Containing Protein Kinase 2; Non-Specific Serine/Threonine Protein Kinase; Rho-associated, Coiled-Coil-Containing Protein Kinase II; Rho-associated Protein Kinase; Rho-associated Protein Kinase 2; Rho Kinase 2; P
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705689
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ROCK2; ROCK-II; Rho associated Coiled-Coil Containing Protein Kinase 2; Non-Specific Serine/Threonine Protein Kinase; Rho-associated, Coiled-Coil-Containing Protein Kinase II; Rho-associated Protein Kinase; Rho-associated Protein Kinase 2; Rho Kinase 2; P
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706094
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ROCK1; Rho-associated, Coiled-Coil-Containing Protein Kinase 1; Rho associated Coiled-Coil Containing Protein Kinase 1; Renal Carcinoma Antigen NY-REN-35; P160ROCK; ROCK-I; Rho-associated Protein Kinase 1; Rho-associated Protein Kinase; P160 ROCK-1; ROCK1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-187858
CAS No.: 2292312-76-4
Bazipsudil is a potent, selective Rho-associated protein kinase (ROCK) inhibitor.
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
