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10 Results for "

SLFN12

" in MedChemExpress (MCE) Product Catalog:

Products (10)

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DNMDP

4 Cited Publications

Cat. No.: HY-W028690

CAS No.: 328104-79-6

Target:

Phosphodiesterase (PDE)

Research Areas:

Cancer

DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity .

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BAY 2666605

4 Cited Publications

Cat. No.: HY-145924

CAS No.: 2275774-60-0

Purity: 99.74%

Target:

Phosphodiesterase (PDE)

Research Areas:

Cancer

BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC₅₀s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer (WO2019025562A1; example 135) .

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OPB-171775

Cat. No.: HY-162730

CAS No.: 2131210-15-4

Target:

Molecular Glues Phosphodiesterase (PDE)

Research Areas:

Cancer

OPB-171775 is an orally active molecular glue. OPB-171775 forms ternary complex with phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12). OPB-171775 causes SLFN12 RNase-mediated cell death, activates SLFN12 RNase-associated GCN2 signaling pathway. OPB-171775 exhibits significant efficacy against gastrointestinal stromal tumor .

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SLFN12 Human Pre-designed siRNA Set A

Cat. No.: HY-RS13364

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

SLFN12 Human Pre-designed siRNA Set A contains three designed siRNAs for SLFN12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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