8

AG14361

8 Publications Verification

Cat. No.: HY-12032

CAS No.: 328543-09-5

Purity: 99.44%

Target:

PARP

Research Areas:

Cancer

AG14361 is a potent PARP-1 inhibitor, with a K_i of < 5 nM, and in permeabilized SW620 and intact SW620 cells, the IC₅₀s are 29 nM and 14 nM, respectively.

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2

Verrucarin J

2 Cited Publications

Cat. No.: HY-N10113

CAS No.: 4643-58-7

Synonyms: Muconomycin B

Category:

Infection Natural Products Microorganisms Marine algae Marine natural products Disease Research Fields

Target:

Apoptosis Arenavirus Fungal Antibiotic Reactive Oxygen Species (ROS)

Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC₅₀ of 1.2 ng/mL .

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1

RO5454948

1 Cited Publications

Cat. No.: HY-12838

CAS No.: 1386979-55-0

Purity: 99.53%

Synonyms: Mirk-IN-1; Dyrk1B/A-IN-1

Target:

DYRK

Research Areas:

Cancer

RO5454948 (Compound 9) is the inhibitor for Dyrk1B and Dyrk1A with IC₅₀ of 68 nM and 22 nM. RO5454948 exhibits cytotoxicity in cancer cell SW620 with EC₅₀ of 1.9 μM .

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PROTAC K-Ras Degrader-4

Cat. No.: HY-159788

CAS No.: 2938169-99-2

Target:

PROTACs Ras

Research Areas:

Cancer

PROTAC K-Ras Degrader-4 (Compound 4) is a PROTAC degrader for KRAS that degrades KRAS ^G12D in GP5d and degrades KRAS ^G12V in cell SW620 with DC₅₀s of 1 nM and 13 nM. PROTAC K-Ras Degrader-4 inhibits MAPK signaling pathway .

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PROTAC K-Ras Degrader-3

Cat. No.: HY-168054

CAS No.: 3043670-68-1

Target:

PROTACs Ras

Research Areas:

Cancer

PROTAC K-Ras Degrader-3 (compound 40) is a PROTAC degrader of K-Ras with a DC₅₀ of ≤ 1 nM against SW620 KRAS G12D, and a GI₅₀ of ≤ 10 nM against SW620 3D cell growth. PROTAC K-Ras Degrader-3 can be utilized in cancer research, such as non-small-cell lung cancer (NSCLC) .

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Transketolase-IN-4

Cat. No.: HY-153090

CAS No.: 419547-73-2

Purity: 99.59%

Target:

Transketolase

Research Areas:

Infection Cancer

Transketolase-IN-4 is a potent inhibitor of transketolase with an IC₅₀ value of 3.9 μM. Transketolase-IN-4 inhibits the proliferation of tumor cells including SW620, LS174T and MIA PaCa-2. Transketolase-IN-4 can be used for tumor research .

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ASR-490

Cat. No.: HY-144899

CAS No.: 2690312-67-3

Purity: 99.05%

Target:

Notch

Research Areas:

Cancer

ASR-490 reduces the viability of HCT116 and SW620 cells by downregulating Notch1 signaling. ASR-490 overcomes Notch1 overexpression and inhibits the growth of HCT/Notch1 transfectants. ASR-490 inhibits the tumor growth in control (pCMV/HCT116) and Notch1/HCT116 in xenotransplanted mice .

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KRAS inhibitor-27

Cat. No.: HY-164350

CAS No.: 3033690-83-1

Target:

Ras ERK p38 MAPK

Research Areas:

Cancer

KRAS inhibitor-27 (Compound 15h) is the inhibitor for KRAS. KRAS inhibitor-27 inhibits KRAS G12D/G12V mutated cells AsPC-1, SW620 and KRAS wildtype cell HT-29 with IC₅₀ of 378, 0.6 and 3230 nM, respectively. KRAS inhibitor-27 inhibits ERK phosphorylation (IC₅₀ in cell AsPC-1 and SW620 is 0.6 nM and 1 nM), reduces the expression of DUSP4, thereby inhibiting MAPK signaling pathway .

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WS-898

Cat. No.: HY-139848

CAS No.: 2891562-77-7

Purity: 98.14%

Target:

P-glycoprotein

Research Areas:

Cancer

WS-898 is a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively).

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YS-370

Cat. No.: HY-132866

CAS No.: 2470908-79-1

Purity: 98.07%

Target:

P-glycoprotein

Research Areas:

Cancer

YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity .

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AZA197

Cat. No.: HY-116269

CAS No.: 1249398-09-1

Purity: 98.28%

Target:

Ras Apoptosis PAK ERK

Research Areas:

Cancer

AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts. AZA197 can be used for the study of colon cancer .

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CDK9/EZH2-IN-1

Cat. No.: HY-176165

CAS No.: 3081246-18-3

Target:

CDK Histone Methyltransferase

Research Areas:

Cancer

CDK9/EZH2-IN-1 (Compound D16) is a CDK9/EZH2 dual-target inhibitor (IC₅₀: 83.9/108.6 nM). CDK9/EZH2-IN-1 induces apoptosis and DNA double-strand breaks (DSBs). CDK9/EZH2-IN-1 inhibits the proliferation activity of MKN45, MDA-MB-453 and SW620 cancer cells (IC₅₀ values are 136.3, 171.3 and 315.7 nM, respectively) .

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PROTAC K-Ras Degrader-2

Cat. No.: HY-164365

CAS No.: 3043670-74-9

Target:

PROTACs Ras

Research Areas:

Cancer

PROTAC K-Ras degrader-2 (compound 48) is a KRAS G12V PROTAC degrader with an IC₅₀ of 20-200 nM for KRAS G12V/RAF1. PROTAC K-Ras degrader-2 degrades SW620 KRAS G12V with a DC₅₀ of 1-10 nM. PROTAC K-Ras degrader-2 inhibits cell growth of SW620 3D cell with an IC₅₀ of ≤10 nM. PROTAC K-Ras degrader-2 can be used for the study of colorectal cancer (CRC) .

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Mps1-IN-7

Cat. No.: HY-12862

CAS No.: 1578244-34-4

Purity: 98.55%

Target:

Mps1

Research Areas:

Cancer

Mps1-IN-7 is a potent MPS1 inhibitor (IC₅₀ of 0.020 μM) over JNK1 and JNK2 (JNK1 IC₅₀= 0.11 μM, JNK2 IC₅₀=0.22 μM). Mps1-IN-7 inhibit SW620, CAL51, Miapaca-2, RMG1 cell growth with GI₅₀ values of 0.065, 0.068, 0.25, and 0.110 μM,respectively .

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PROTAC SOS1 degrader-4

Cat. No.: HY-153674

Target:

PROTACs SOS1

Research Areas:

Cancer

PROTAC SOS1 degrader-4 (Compound 10) is a PROTAC degrader that targets the SOS1 protein for degradation by recruiting cereblon. It degrades SOS1 in NCI-H358, A-427, SW-620, and DLD-1 cells and inhibits the proliferation of various KRAS-mutant tumor cells, making it a useful tool for cancer research .

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KRAS-IN-41

Cat. No.: HY-173329

CAS No.: 3056974-50-3

Target:

Ras

Research Areas:

Cancer

KRAS-IN-41 is an inhibitor of KRAS with IC₅₀ values of <0.01 μM for KRAS G12D and KRAS G12V. KRAS-IN-41 inhibits RAS mutant cell lines, GP2D (KRAS-G12D) and SW620 (KRAS-G12V). KRAS-IN-41 can be used in cancer research .

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CDK8-IN-16

Cat. No.: HY-171174

CAS No.: 1860885-61-5

Target:

CDK STAT Wnt

Research Areas:

Cancer

CDK8-IN-16 (Compound 51) is an orally active dual inhibitor for CDK8 and CDK19 wih IC₅₀ of 5.1 nM and 5.6 nM. CDK8-IN-16 inhibits the phospho-STAT1 ^SER727 with an IC₅₀ of 17.9 nM in SW620 cell, inhibits WNT signaling pathway with an IC₅₀ of 7.2 nM in 7dF3 cell. CDK8-IN-16 exhibits good pharmacokinetic characteristics in rat models with an oral bioavailability of 57% .

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PROTAC SOS1 degrader-10

Cat. No.: HY-161654

CAS No.: 3043923-74-3

Target:

PROTACs SOS1 Ras PERK

Research Areas:

Cancer

PROTAC SOS1 degrader-10 is a SOS1 PROTAC degrader dependent on CRBN and the proteasome. PROTAC SOS1 degrader-10 degrades SOS1 in KRAS-mutant cancer cells SW620, A549 and DLD-1, with DC₅₀ values of 2.23, 1.85 and 7.53 nM, respectively. PROTAC SOS1 degrader-10 inhibits ERK phosphorylation. PROTAC SOS1 degrader-10 suppresses the proliferation of KRAS-mutant cancer cells via antiproliferative activity. PROTAC SOS1 degrader-10 can be used in studies related to KRAS-mutant cancers .

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