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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
TIR domain
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "TIR domain" in MCE Product Catalog:
35
35 Publications Verification
Target:
Research Areas:
TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway . TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI) .
16
16 Cited Publications
Cat. No.: HY-19744
CAS No.: 2437475-16-4
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T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively .
12
12 Cited Publications
Cat. No.: HY-P2565
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Research Areas:
3
3 Cited Publications
Cat. No.: HY-W011400
CAS No.: 566914-00-9
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Research Areas:
TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses .
Cat. No.: HY-P10719
CAS No.: 1421052-89-2
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Cat. No.: HY-163035
CAS No.: 1206480-93-4
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EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B) .
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Ethoxybenzene is a SARM1 NAD + hydrolase inhibitor (human SARM1 IC50 = 0.385 μM). Ethoxybenzene co-crystallizes with the SARM1 TIR domain and exhibits an edge-to-face aromatic interaction with Trp638. Ethoxybenzene can be used in research on SARM1-related axonal degeneration .
Cat. No.: HY-P10719A
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Cat. No.: HY-178136
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Research Areas:
MyD88-IN-3 is an orally active, selective MyD88 Inhibitor. MyD88-IN-3 specifically targets the TIR domain of MyD88 (KD = 28.5 μM), thereby preventing MyD88 self-polymerization and interaction with TLRs, which suppresses the activation of MAPK and NF-κB pathways. MyD88-IN-3 demonstrates significant anti-inflammatory efficacy and effectively mitigates Acute Lung Injury (ALI) symptoms in CLP (cecal ligation and puncture) and Lipopolysaccharides (HY-D1056) (LPS)-induced ALI models. MyD88-IN-3 can be used for the study of ALI .
Cat. No.: HY-179474
CAS No.: 2257427-45-3
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TSI-13-57 is a pan-TLR inhibitor (IC50: 2.7 μM, 6.03 μM, 7.37 μM, 6.38 μM for TLR9, TLR7, TLR2, TLR4, respectively). TSI-13-57 inhibits homodimerization of the TIR domains of MyD88. TSI-13-57 reduces systemic inflammatory responses in LPS-induced mice .
Cat. No.: HY-W004721
CAS No.: 2439-04-5
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5-Hydroxyisoquinoline is a SARM1 inhibitor, IC50 = 2.6 μM, with axon-protective activity . 5-Hydroxyisoquinoline binds to and inhibits the NADase catalytic activity of the SARM1 protein TIR domain, reducing SARM1-mediated NAD + depletion and cADPR production . 5-Hydroxyisoquinoline can be used in research on SARM1-related diseases; it can also serve as an intermediate for research related to organic synthesis .
Cat. No.: HY-P10718
CAS No.: 1229954-79-3
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Cat. No.: HY-P74547
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SIGIRR; Single Ig IL-1R-Related Molecule; Single Ig And TIR domain Containing; Single Ig IL-1-Related Receptor; Toll/Interleukin-1 Receptor 8; IL-1R8; TIR8; Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) domain; Single Immunoglobulin domain-C
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P76064
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: SIGIRR; Single Ig IL-1R-Related Molecule; Single Ig And TIR domain Containing; Single Ig IL-1-Related Receptor; Toll/Interleukin-1 Receptor 8; IL-1R8; TIR8; Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) domain; Single Immunoglobulin domain-C
Species:
Human
Source:
HEK293
Cat. No.: HY-P76065
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SIGIRR; Single Ig IL-1R-Related Molecule; Single Ig And TIR domain Containing; Single Ig IL-1-Related Receptor; Toll/Interleukin-1 Receptor 8; IL-1R8; TIR8; Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) domain; Single Immunoglobulin domain-C
Species:
Human
Source:
HEK293
Cat. No.: HY-P702882
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SARM1; Sterile Alpha And Armadillo Repeat Protein; Sterile Alpha And TIR Motif Containing 1; SAM domain-Containing Protein 2; SAMD2; TIR-1 Homolog; SARM; NADase SARM1; Sterile Alpha And TIR Motif-Containing Protein 1; MyD88-5; NADP(+) Hydrolase SARM1; HSA
Species:
Human
Source:
HEK293
Cat. No.: HY-P705957
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SARM1; Sterile Alpha And Armadillo Repeat Protein; Sterile Alpha And TIR Motif Containing 1; SAM domain-Containing Protein 2; SAMD2; TIR-1 Homolog; SARM; NADase SARM1; Sterile Alpha And TIR Motif-Containing Protein 1; MyD88-5; NADP(+) Hydrolase SARM1; HSA
Species:
Human
Source:
HEK293
Cat. No.: HY-139397R
CAS No.: 1357471-57-8
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Research Areas:
TJ-M2010-5 (Standard) is the analytical standard of TJ-M2010-5 (HY-139397). This product is intended for research and analytical applications. TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway . TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI) .
Cat. No.: HY-182940
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Research Areas:
SARM1-IN-10 is an orally active SARM1 inhibitor with a pIC50 of 7.1 and a pKd of 8.3. As a base-exchange inhibitor, SARM1-IN-10 forms a NAD + adduct at the active site of the TIR domain of SARM1, blocks enzymatic function, and induces a unique rotameric state of W662 at the catalytic site of SARM1. SARM1-IN-10 acts as a paradoxical neurodegeneration inducer at low doses and an inhibitor at high doses, and it can exacerbate or protect against SARM1-mediated neurodegeneration depending on concentration. SARM1-IN-10 can be used in studies of peripheral neurodegeneration .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
