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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
base substitution
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "base substitution" in MCE Product Catalog:
Synonyms: TPP; Tetraphenylporphine; meso-Tetraphenylporphyrin
Tetraphenylporphyrin (TPP) is a symmetrically substituted porphyrin-based heterocyclic compound and used as a structural block for supramolecular synthesis. Tetraphenylporphyrin derivatives can be used for cancer research .
Cat. No.: HY-W093017
CAS No.: 626-61-9
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4-Chloropyridine is a NNMT (Nicotinamide N-methyltransferase) substrate and suicide inhibition-based protein labeling scaffold precursor.4-Chloropyridine undergoes NNMT-catalyzed pyridine nitrogen methylation to increase C4 electrophilicity, enabling aromatic nucleophilic substitution by NNMT cysteine C159 for covalent NNMT modification and inactivation.4-Chloropyridine can be used for the research of various cancers .
Cat. No.: HY-W098021
CAS No.: 24650-42-8
Synonyms: Photoinitiator-651
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2,2-Dimethoxy-2-phenylacetophenone is a hydrophobic benzoin ether-based free radical photoinitiator. 2,2-Dimethoxy-2-phenylacetophenone undergoes α-cleavage upon UV irradiation to generate benzoyl and substituted benzyl free radicals, thereby initiating photopolymerization reactions. 2,2-Dimethoxy-2-phenylacetophenone serves as a hydrophobic free radical photoinitiator for the photopolymerization of acrylamide and trimethylolpropane triacrylate in specific systems .
Cat. No.: HY-W018667
CAS No.: 703-80-0
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3-Acetylindole is a substituted indole derivative that can serve as an intermediate or raw material for research related to organic synthesis. 3-Acetylindole can be used as a synthetic precursor to construct indole-based heterocyclic derivatives .
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2,2-Dihydroxy-1-phenylethan-1-one (Phenylglyoxal hydrate) is a phenylglyoxal-based, antioxidant drug synthesis intermediate. 2,2-Dihydroxy-1-phenylethan-1-one serves as a starting material for the synthesis of aromatic amines or aliphatic amines. It can be used to synthesize polysubstituted pyrrolo[3,2-c]pyridin-4-one derivatives, and also acts as a key structural unit in the microwave-assisted cascade synthesis of substituted 2-methyl-7-aryl-6H-thiazoloindole compounds .
Cat. No.: HY-W023757
CAS No.: 1594-57-6
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N-Hydroxyisonicotinamidine is an amidoxime-based collector. N-Hydroxyisonicotinamidine can be used in the synthesis of substituted α-1,2,4-oxadiazolo esters .
Cat. No.: HY-59343
CAS No.: 61296-22-8
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2-Amino-5-bromothiazole hydrobromide is an aminothiazole and brominated thiazole derivative. 2-Amino-5-bromothiazole hydrobromide induces base-pair substitutions in bacterial test organisms. 2-Amino-5-bromothiazole hydrobromide exhibits mutagenic activity in Klebsiella pneumoniae and Salmonella typhimurium. 2-Amino-5-bromothiazole hydrobromide acts as a Hg 2+-binding moiety in rhodamine-based fluorescent chemical sensors .
Cat. No.: HY-W583317
CAS No.: 2375242-78-5
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sSPhos Pd G2 is a water-soluble palladium catalyst. sSPhos Pd G2 mediates Suzuki-Miyaura cross-coupling reactions for protein biotinylation and on-DNA reactions, thereby enabling robust gel-based ABPP using iodocysteine-reactive probes rather than bromo- or chloro-substituted probes .
Cat. No.: HY-151637
CAS No.: 1009362-00-8
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Fmoc-N-propargyl-MPBA is a propargyl-substituted MPBA linker derived from 4-hydroxy-3-methoxybenzaldehyde. Fmoc-N-propargyl-MPBA can be elongated using standard Fmoc-based solid phase chemistry and linked to supports by standard coupling procedures . Fmoc-N-propargyl-MPBA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-W095635
CAS No.: 17787-40-5
Cat. No.: HY-144128
CAS No.: 1429012-38-3
hGGPPS-IN-1 (Compound 18b) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-1 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo .
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2-Chloro-5-nitrobenzaldehyde is a substituted benzaldehyde and precursor in the synthesis of Schiff base ligands. 2-Chloro-5-nitrobenzaldehyde can be used for the research of breast cancer .
Cat. No.: HY-144129
CAS No.: 2241547-82-8
hGGPPS-IN-2 (Compound 16g) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-2 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-2 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo .
Cat. No.: HY-144130
CAS No.: 2763223-96-5
hGGPPS-IN-3 (Compound 13h) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-3 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-3 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo .
Cat. No.: HY-124987
CAS No.: 2225834-49-9
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MRS4458 is a P2Y14 receptor antagonist with anti-inflammatory activity. MRS4458 mediates inflammatory activity by activating the motility of neutrophils. The design of MRS4458 is based on the interaction with the P2Y14 receptor and optimized by molecular dynamic simulation. MRS4458 performs well in terms of shape and complementarity with the receptor. The prediction that the 5-phenyl group of MRS4458 is substituted with thiophene is generally consistent with empirical results. The biological activity of MRS4458 was verified by fluorescence assay, showing its potent antagonistic effect .
Cat. No.: HY-W584515
CAS No.: 2093386-36-6
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Thalidomide-NH-(CH2)3-NH-Boc is a Boc-modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)3-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)3-NH-Boc is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules targeting 11β-substituted estradiol.
Cat. No.: HY-111297
CAS No.: 868843-84-9
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BMVC4 is a G-quadruplex (G4) stabilizer of the human telomeric sequence d[AG3(T2AG3)3]. Screening by circular dichroism (CD) spectroscopy revealed that BMVC4 is more suitable as the core molecule of G4 stabilizers than BMVC. The results showed that BMVC4-12C and BMVC4-8C3O are better candidates for G4 stabilizers and are worthy of further study. A simple and rapid screening method based on Cu2+-induced G4 unfolding can be used to find better G4 stabilizers for potential anticancer applications. CD results showed that the trivalent cations of 9-substituted BMVC derivatives are more suitable as G4 stabilizers than the divalent cations of BMVC. In addition, by monitoring the disappearance of the 291 nm CD band of human telomeres after Cu2+ addition, it was found that the core molecule of G4 stabilizer BMVC4 has better stability.
Cat. No.: HY-185069E
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Unylinker-NH Resin (Substitution:150±25 mmol/g) is a macroporous polystyrene resin functionalized with Unylinker active groups with uniform particle size and uniform active groups. It is used for synthesis of oligonucleotides with 30-80 base sequences distribution.
Cat. No.: HY-186371
CAS No.: 2495748-86-0
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Coumarin-based kinetic stabilizer-2 is a 3-substituted coumarin-carbamate-distal substructure derivative and a kinetic stabilizer of amyloidogenic immunoglobulin light chain (FL LC) dimers. Coumarin-based kinetic stabilizer-2 stabilizes the native conformation of immunoglobulin light chains, reduces protein misfolding and proteolytic hydrolysis, with an EC50 value of 77.1 nM for the human target and an EC50 value of 27.9 nM for the WIL-FL T46L/F49Y variant. Coumarin-based kinetic stabilizer-2 can be used in research related to immunoglobulin light chain amyloidosis .
Cat. No.: HY-103656R
CAS No.: 917-23-7
Synonyms: TPP (Standard); Tetraphenylporphine (Standard); meso-Tetraphenylporphyrin (Standard)
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Tetraphenylporphyrin (Standard) is the analytical standard of Tetraphenylporphyrin (HY-103656). This product is intended for research and analytical applications. Tetraphenylporphyrin (TPP) is a symmetrically substituted porphyrin-based heterocyclic compound and used as a structural block for supramolecular synthesis. Tetraphenylporphyrin derivatives can be used for cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
