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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
cADPR
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "cADPR" in MCE Product Catalog:
7
7 Publications Verification
Synonyms: CZ-48
Target:
Research Areas:
Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production .
3
3 Cited Publications
Cat. No.: HY-Z0816
CAS No.: 87375-91-5
Target:
Research Areas:
Dehydronitrosonisoldipine, a derivative of Nisoldipine (HY-17402), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders .
2
2
1
1 Cited Publications
Target:
Research Areas:
RBN013209 is an orally active small molecule inhibitor of CD38 with an IC50 of 0.01 to 0.1 μM for human CD38. RBN013209 prevents the conversion of extracellular NAD + to ADPR or cADPR in tumor cells and PBMCs. RBN013209 can be used in the study of tumor. In addition, RBN013209 enables CAR-T cells to maintain the naive state and central memory state, and decreases the expression of cell activation markers and exhaustion-related inhibitory receptors .
Cat. No.: HY-117804
CAS No.: 151898-26-9
Synonyms: 8-Bromo-Cyclic ADP-Ribose
Target:
Research Areas:
8-Br-cADPR (8-Bromo-Cyclic ADP-Ribose) is a membrane-permeable competitive antagonist of Cyclic ADP-ribose (cADPR) (HY-N7395) and an antagonist of TRPM2 ion channels. 8-Br-cADPR blocks cADPR-dependent RyR, SR calcium mobilization, and cADPR-mediated signaling; reduces Paclitaxel (HY-B0015)-induced axonal calcium flux, and protects against Paclitaxel-induced axonal degeneration/peripheral neuropathy. 8-Br-cADPR blocks isoproterenol-induced pulmonary artery dilation, angiotensin II-induced arterial calcium signaling/contraction, and hypoxic pulmonary vasoconstriction. 8-Br-cADPR can be used in research related to neurological diseases and cancer .
Cat. No.: HY-P990037
CAS No.: 2430792-01-9
Synonyms: GEN3014
Target:
Research Areas:
Cat. No.: HY-134269A
Synonyms: 7-deaza-8-bromo-cADPR disodium; 7-deaza-8-bromo-cyclic ADP ribose disodium
Target:
Research Areas:
8-Br-7-CH-cADPR disodium (7-Deaza-8-bromo-cADPR) is a potent cADPR antagonist. 8-Br-7-CH-cADPR disodium shows partial inhibition of calcium elevation caused by sTIR dimerization. 8-Br-7-CH-cADPR disodium significantly decreases Paclitaxel (HY-B0015)-induced axon degeneration .
Cat. No.: HY-175081
Synonyms: 8-Bromo-Cyclic ADP-Ribose sodium salt
Target:
Research Areas:
8-Br-cADPR sodium salt (8-Bromo-Cyclic ADP-Ribose sodium salt) is a membrane-permeable competitive antagonist of Cyclic ADP-ribose (cADPR) (HY-N7395) and an antagonist of TRPM2 ion channels. 8-Br-cADPR sodium salt blocks cADPR-dependent RyR, SR calcium mobilization, and cADPR-mediated signaling; reduces Paclitaxel (HY-B0015)-induced axonal calcium flux, and protects against Paclitaxel-induced axonal degeneration/peripheral neuropathy. 8-Br-cADPR sodium salt blocks isoproterenol-induced pulmonary artery dilation, angiotensin II-induced arterial calcium signaling/contraction, and hypoxic pulmonary vasoconstriction. 8-Br-cADPR sodium salt can be used in research related to neurological diseases and cancer .
Cat. No.: HY-W004721
CAS No.: 2439-04-5
Research Areas:
5-Hydroxyisoquinoline is a SARM1 inhibitor, IC50 = 2.6 μM, with axon-protective activity . 5-Hydroxyisoquinoline binds to and inhibits the NADase catalytic activity of the SARM1 protein TIR domain, reducing SARM1-mediated NAD + depletion and cADPR production . 5-Hydroxyisoquinoline can be used in research on SARM1-related diseases; it can also serve as an intermediate for research related to organic synthesis .
Cat. No.: HY-134269
CAS No.: 189876-06-0
Synonyms: 7-Deaza-8-bromo-cADPR; 7-Deaza-8-bromo-cyclic ADP ribose
Target:
Research Areas:
8-Br-7-CH-cADPR (7-Deaza-8-bromo-cADPR) is a potent cADPR antagonist. 8-Br-7-CH-cADPR shows partial inhibition of calcium elevation caused by sTIR dimerization. 8-Br-7-CH-cADPR significantly decreases Paclitaxel (HY-B0015)-induced axon degeneration .
Cat. No.: HY-147150
CAS No.: 150424-94-5
Target:
Research Areas:
8-Azido-cADPR, with its photoactive azido group, is a potent photoaffinity probe. 8-Azido-cADPR can be used for the identification and characterization of cADPR-binding proteins . 8-Azido-cADPR is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-134280
CAS No.: 477782-33-5
Synonyms: Nicotinamide 8-Br-hypoxanthine dinucleotide
Target:
Research Areas:
8-Br-NHD+ (Nicotinamide 8-Br-hypoxanthine dinucleotide) is a derivative of NAD+ (nicotinamide adenine dinucleotide) that acts as a potential substrate, competitive inhibitor or modulator of enzymes that interact with β-NAD+. 8-Br-NHD+ can be used to synthesize a cyclic ADP nucleotide (cADPR) analog .
Cat. No.: HY-N7395B
Synonyms: cADPR diammonium
Research Areas:
Cyclic ADP-ribose diammonium (cADPR diammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD + by an ADP-ribosyl cyclase. Cyclic ADP-ribose diammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .
Cat. No.: HY-P7791
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BST1; NAD(+) Nucleosidase; Bone Marrow Stromal Cell Antigen 1; ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase; ADP-Ribosyl Cyclase 2; Bone Marrow Stromal Antigen 1; cADPR2; Cyclic ADP-Ribose Hydrolase; CD157; cADPR Hydrolase 2; BST-1; cADPR Hydrolase 2;
Species:
Human
Source:
HEK293
Cat. No.: HY-P7793
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BST1; NAD(+) Nucleosidase; Bone Marrow Stromal Cell Antigen 1; ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase; ADP-Ribosyl Cyclase 2; Bone Marrow Stromal Antigen 1; cADPR2; Cyclic ADP-Ribose Hydrolase; CD157; cADPR Hydrolase 2; BST-1; cADPR Hydrolase 2;
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P76205
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BST1; NAD(+) Nucleosidase; Bone Marrow Stromal Cell Antigen 1; ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase; ADP-Ribosyl Cyclase 2; Bone Marrow Stromal Antigen 1; cADPR2; Cyclic ADP-Ribose Hydrolase; CD157; cADPR Hydrolase 2; BST-1; cADPR Hydrolase 2;
Species:
Rat
Source:
HEK293
Cat. No.: HY-P7792
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BST1; NAD(+) Nucleosidase; Bone Marrow Stromal Cell Antigen 1; ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase; ADP-Ribosyl Cyclase 2; Bone Marrow Stromal Antigen 1; cADPR2; Cyclic ADP-Ribose Hydrolase; CD157; cADPR Hydrolase 2; BST-1; cADPR Hydrolase 2;
Species:
Human
Source:
HEK293
Cat. No.: HY-P76204
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BST1; NAD(+) Nucleosidase; Bone Marrow Stromal Cell Antigen 1; ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase; ADP-Ribosyl Cyclase 2; Bone Marrow Stromal Antigen 1; cADPR2; Cyclic ADP-Ribose Hydrolase; CD157; cADPR Hydrolase 2; BST-1; cADPR Hydrolase 2;
Species:
Rat
Source:
HEK293
Cat. No.: HY-P703809
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BST1; NAD(+) Nucleosidase; Bone Marrow Stromal Cell Antigen 1; ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase; ADP-Ribosyl Cyclase 2; Bone Marrow Stromal Antigen 1; cADPR2; Cyclic ADP-Ribose Hydrolase; CD157; cADPR Hydrolase 2; BST-1; cADPR Hydrolase 2;
Species:
Cynomolgus
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
