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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
68 Results for "
cell chemotaxis
" in MedChemExpress (MCE) Product Catalog:
Products (68)
68 Results for "cell chemotaxis" in MCE Product Catalog:
5
5 Cited Publications
Synonyms: GSK-1605786; CCX282-B; Traficet-EN
Research Areas:
Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca 2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 μM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively .
5
5 Cited Publications
Synonyms: GSK-1605786 sodium; CCX282-B sodium; Traficet-EN sodium
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Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon sodium inhibits CCR9-mediated Ca 2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 μM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively .
2
2 Cited Publications
Cat. No.: HY-P4744
CAS No.: 597562-32-8
2
Category:
Plant Coumarins Cimicifuga racemosa (L.) Nutt. Extract Phenylpropanoids Disease Research Fields Inflammation/Immunology Ranunculaceae Extract
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2
2 Cited Publications
Target:
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ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca 2+ concentrations .
2
2 Cited Publications
Cat. No.: HY-P4744A
2
2 Cited Publications
Cat. No.: HY-P4911A
Target:
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SDF-1α (human) TFA is an endogenous CXC chemokine and the primary natural ligand of CXCR4 . SDF-1α (human) TFA activates Gαi, MAP kinase, β-arrestin, and JAK/STAT signaling pathways, promoting chemotaxis of CXCR4-positive cells. SDF-1α (human) TFA induces receptor internalization and promotes cancer cell migration and invasion. SDF-1α (human) TFA promotes dental pulp cell migration and is required for osteogenesis, angiogenesis, and neurogenesis of dental pulp cells. SDF-1α (human) TFA is used in research on CXCR4-mediated diseases, such as cancer and cardiovascular diseases .
1
1 Cited Publications
SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes .
1
1 Cited Publications
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FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca 2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation .
Cat. No.: HY-W127575
CAS No.: 747-90-0
Synonyms: delta-3,5-Cholestadiene
Research Areas:
Cholesta-3,5-diene is an inflammatory modulator that targets immune cells such as neutrophils and accelerates wound healing by promoting neutrophil chemotaxis and fibroblast migration. Cholesta-3,5-diene enhances immune cell recruitment and extracellular matrix deposition by activating chemokine receptor-mediated signaling pathways such as PI3K/Akt. Cholesta-3,5-diene can be applied topically to wound repair and has potential therapeutic value in chronic ulcers or skin lesions .
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Aurothiomalate sodium acts as an inhibitor of PKCI and TrxR1. Aurothiomalate sodium disrupts the PKCI-Par6-Rac1 signaling pathway, and also inhibits TrxR1 activity, TNFα-induced NF-κB activation, and the expression of pro-inflammatory genes. Aurothiomalate sodium blocks Kras-mediated BASC expansion and lung tumor growth, inhibits anchorage-independent growth and tumorigenicity of lung cancer cells, and suppresses neutrophil chemotaxis, phagocytosis, and leukocyte extravasation. Aurothiomalate sodium can be used in research related to rheumatoid arthritis and non-small cell lung cancer .
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DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a DOCK2 inhibitor (IC50 = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases .
Cat. No.: HY-P991567
Synonyms: VX5/5261
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ChemR23-IN-1 is a ChemR23 inhibitor that inhibits chemerin-triggered chemotaxis of CAL-1 cells. ChemR23-IN-1 can be used in research on systemic lupus erythematosus .
Synonyms: VUF6002
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JNJ10191584 (VUF6002) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM. JNJ10191584 shows 540-fold selectivity to H4 receptor over H3 receptor with a Ki value of 14.1 μM. JNJ10191584 inhibits chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively .
Cat. No.: HY-P2040
CAS No.: 118399-22-7
Cat. No.: HY-P99443
CAS No.: 395639-53-9
Synonyms: HuDreg-55
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Cat. No.: HY-P4998
CAS No.: 92899-39-3
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Chemotactic Domain of Elastin is an elastin-derived chemotactic hexapeptide that interacts with Galectin-3, integrin αvβ3, and elastin-binding protein (EBP) and promotes cell chemotaxis and migration. Chemotactic Domain of Elastin promotes melanoma cell migration by regulating invasion-related molecules such as CXCR-4/CXCL-12, MMP-2/MMP-3, cell adhesion molecules, and VEGF-C. Chemotactic Domain of Elastin is used for research on elastin-derived peptide signaling and tumor cell migration and invasion .
Synonyms: SIM010603
Tafetinib (SIM010603) is an oral multi-targets receptor tyrosine kinases inhibitor. Tafetinib inhibitsstem cell factor receptor (Kit),vascular endothelial growth factor receptor-2 (VEGFR-2),platelet-derived growth factor receptor-β (PDGFR-β),glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), andFms-like tyrosine kinase-3 (FLT3)withIC50values between 5.0 and 68.1 nmol/l. Tafetinib inhibits the phosphorylation ofPDGFR-βandVEGFR-2. Tafetinib inhibits endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
