62 Results for "

cytosol

" in MedChemExpress (MCE) Product Catalog:
Products (62)

62 Results for "cytosol" in MCE Product Catalog:

352
352 Publications Verification
Cat. No.: HY-18749
CAS No.: 305834-79-1
Target:  

Akt

SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt .
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37
37 Cited Publications
Cat. No.: HY-15695
CAS No.: 58-60-6
Purity:  99.86%
Synonyms: NSC 3056
Puromycin aminonucleoside (NSC 3056) is the aminonucleoside portion of the antibiotic puromycin, and used in nephrosis animal models . Puromycin aminonucleoside induces apoptosis . Puromycin aminonucleoside is a reversible inhibitor of dipeptidyl peptidase II and cytosol alanyl aminopeptidase . Puromycin aminonucleoside induces secretion of cell migrasome .
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4
4 Cited Publications
Cat. No.: HY-139109
CAS No.: 115970-66-6
Purity:  99.87%
Synonyms: ADS 780WS
IR-783 (ADS 780WS) is a heptamethine cyanine dye. IR-783 induces Mitochondrial membrane potential loss, ATP depletion, mitochondrial permeability transition pore opening, Cytochrome c release and Apoptosis in breast cancer cells. IR-783 promotes the translocation of Drp1 from the cytosol to mitochondria. IR-783 increases the expression of mitochondrial fission proteins such as MFF and Fission-1. IR-783 possesses imaging, cancer-targeting and anticancer properties. IR-783 exerts anticancer effects against breast cancer. IR-783 can be used in breast cancer-related research .
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3
3 Cited Publications
Cat. No.: HY-N5072
CAS No.: 17817-31-1
Synonyms: 4',6,7-Trihydroxyisoflavone
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity . Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .
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2
2 Cited Publications
Cat. No.: HY-13676
CAS No.: 595-33-5
Purity:  99.69%
Research Areas:  

Endocrinology Cancer

Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway .
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1
1 Cited Publications
Cat. No.: HY-49116
CAS No.: 500285-30-3
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Infection Inflammation/Immunology

CP26 is a small molecule inhibitor of protein dislocation from the ER lumen to the cytosol. CP26 targets the Hrd1 complex, inhibits ERAD, and induces ER stress .
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Cat. No.: HY-E70069
CAS No.: 37278-88-9
Target:  

Glycosidase

Research Areas:  

Others

Endo-β-N-acetylglucosaminidase (Endo S2) is a key enzyme involved in the processing of free oligosaccharides in the cytosol. Endo-β-N-acetylglucosaminidase catalyzes hydrolysis of N-linked oligosaccharides .
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Cat. No.: HY-P1928
CAS No.: 330936-69-1
Target:  

Bcl-2 Family

Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging .
Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG .
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Cat. No.: HY-P2740
CAS No.: 9031-72-5
Synonyms: EC 1.1.1.1
Research Areas:  

Metabolic Disease

Alcohol dehydrogenase, Saccharomyces cerevisiae is a dimeric protein in the cytosol of cells. Alcohol dehydrogenase, the key enzyme for alcohol consumption in the body, is the highest expressed in the liver and participates in the detoxification mechanism of environmental alcohol .
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Cat. No.: HY-117078
CAS No.: 25001-57-4
Purity:  99.63%
Target:  

Apoptosis

Research Areas:  

Cancer

justicidin A is a nature product that could be isolated form Justicia procumbens. justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis. justicidin A can be used in research of cancer .
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Cat. No.: HY-13676R
CAS No.: 595-33-5
Megestrol acetate (Standard) is the analytical standard of Megestrol acetate. This product is intended for research and analytical applications. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway .
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Cat. No.: HY-P3432
CAS No.: 2035480-78-3
DfTat is a disulfide-linked dimeric cell-penetrating peptide derived from HIV-TAT, and can be used as a delivery enhancer. DfTat is composed of natural amino acids and is rapidly degraded intracellularly. DfTat is taken up via macropinocytosis, accumulates in late endosomes, binds to late endosomal BMP lipids, and co-delivers cell-impermeable drugs into the cytosol of live cells via endocytosis after co-incubation. DfTat can be used in research related to cytosolic drug delivery .
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Cat. No.: HY-P2500
Target:  

Fluorescent Dye

Research Areas:  

Others

(Arg)9, FAM-labeled, a cell-penetrating peptide (CPP), is a nona-arginine (ARG) with FAM label. CPPs have emerged as powerful tools for delivering bioactive cargoes into the cytosol of intact cells .
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Cat. No.: HY-118438
CAS No.: 23982-76-5
Purity:  99.48%
Research Areas:  

Inflammation/Immunology

10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations .
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Cat. No.: HY-P10153
CAS No.: 1360823-60-4
Target:  

Inhibitory Antibodies

Research Areas:  

Others

gH625 is a cell-penetrating viral peptide which is a part of glycoprotein H of Herpes simplex virus type I. gH625 is able to cross the cell membrane and to transport many conjugated cargoes into the cytosol. gH625 is permeable to the blood-brain barrier (BBB) and can enter the rat brain in vivo without toxic effects. gH625 can be used for siRNA delivery research .
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Cat. No.: HY-125857B
CAS No.: 9007-43-6
Cytochrome C (Saccharomyces cerevisiae) is a type C cytochrome located in the intermembrane space of the mitochondria. As an electron carrier, Cytochrome C (Saccharomyces cerevisiae) transfers electrons between complex III (cytochrome c reductase) and complex IV (cytochrome c oxidase, CIV) of the respiratory chain. Cytochrome C (Saccharomyces cerevisiae) can play a crucial role in triggering apoptosis by being released from the mitochondria into the cytosol .
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Cat. No.: HY-126789
CAS No.: 117367-86-9
Purity:  98.40%
Research Areas:  

Metabolic Disease

DM-Nitrophen is a photolabile caged calcium compound that acts as a calcium releaser. DM-Nitrophen binds Ca 2+ with high affinity and Mg 2+ with considerable affinity before photolysis. DM-Nitrophen releases Ca 2+ into the cytosol upon ultraviolet light irradiation. DM-Nitrophen induces calcium concentration pulses, triggers cytosolic calcium transients, promotes calcium-dependent exocytosis. DM-Nitrophen can be used for the research of calcium-dependent cellular processes .
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Cat. No.: HY-146127
CAS No.: 3069455-54-2
Target:  

MEK

Research Areas:  

Cancer

Grb2 SH2 domain inhibitor 1 is an inhibitor of the Grb2 SH2 domain with an IC50 of 0.40 μM. Grb2 SH2 domain inhibitor 1 is also a cell-permeable cyclic peptide that can enter the cytosol of mammalian cells. Grb2 SH2 domain inhibitor 1 downregulates the expression level of p-MEK. Grb2 SH2 domain inhibitor 1 can be used in the research of breast cancer .
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Cat. No.: HY-P4118
CAS No.: 952754-66-4
Synonyms: Penetrating analog
EB1 peptide (Penetrating analog) is an endosomolytic agent and siRNA delivery agent. EB1 peptide forms an amphipathic alpha helix upon protonation in early-late endosomes, drives endosomal membrane permeabilization, and enables endocytosed siRNA escape into the cytosol. EB1 peptide facilitates biologically active siRNA cellular uptake and targeted gene silencing. EB1 peptide forms complexes with siRNA. EB1 peptide can be used for drug delivery research .
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Cat. No.: HY-E70069GL
CAS No.: 37278-88-9
Endo S2, Streptococcus pyogenes (GMP Like) is Endo S2, Streptococcus pyogenes (HY-E70069) produced by using GMP like guidelines. Endo-β-N-acetylglucosaminidase (Endo S2) is a key enzyme involved in the processing of free oligosaccharides in the cytosol. Endo-β-N-acetylglucosaminidase catalyzes hydrolysis of N-linked oligosaccharides .
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