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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
disulfide groups
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "disulfide groups" in MCE Product Catalog:
6
6 Publications Verification
PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues . PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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5 Cited Publications
Synonyms: SPDP Crosslinker; Py-ds-Prp-OSu
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SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) .
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3 Cited Publications
Cat. No.: HY-15917A
CAS No.: 16096-97-2
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1 Cited Publications
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KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC50 of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family . KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers .
Synonyms: Maytansinoid DM3
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DM3 (Maytansinoid DM3), a Maytansine (HY-13674) analog bearing disulfide or thiol groups, and is a tubulin inhibitor. DM3 a cytotoxic moiety of antibody-drug conjugates (ADCs) .
Cat. No.: HY-W106411
CAS No.: 71865-37-7
Synonyms: Dithio-bis-maleimidoethane
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DTME (Dithio-bis-maleimidoethane) is a molecular crosslinker. The molecular structure of DTME contains two maleimide groups connected by an ethane disulfide bond, and this structure enables it to react specifically with molecules containing thiol groups (such as cysteine residues) to form stable covalent bonds. DTME is commonly used to investigate and characterize protein structure (especially oligomerization) or protein interactions .
Cat. No.: HY-W014316
CAS No.: 30007-47-7
5-Bromo-5-nitro-1,3-dioxane is a broad-spectrum antimicrobial agent active against Gram-positive bacteria, Gram-negative bacteria and fungi. 5-Bromo-5-nitro-1,3-dioxane oxidizes free thiol groups to their corresponding disulfides. 5-Bromo-5-nitro-1,3-dioxane induces intracellular substance leakage in Escherichia coli and Staphylococcus aureus. 5-Bromo-5-nitro-1,3-dioxane modulates the oxygen consumption of Escherichia coli and Staphylococcus aureus .
Cat. No.: HY-P4087
CAS No.: 1417221-06-7
Synonyms: Sodium (2-Sulfonatoethyl)methanethiosulfonate
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MTSES sodium (Sodium (2-Sulfonatoethyl)methanethiosulfonate) is a negatively charged, membrane-impermeable methanethiosulfonate (MTS). MTS is a compound that reacts with sulfhydryl groups to form mixed disulfide bonds and is often used to study cysteine ??residues on proteins.
Cat. No.: HY-P4087B
Cat. No.: HY-W800651
CAS No.: 2098496-90-1
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Biotin-SS-Amine hydrochloride is a cleavable biotinylation reagent. The amine group can react with carboxylic acids, activated NHS esters and other carbonyl groups. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP.
Cat. No.: HY-W190951
CAS No.: 2401831-98-7
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3-((2-(2,2,2-Trifluoroacetamido)ethyl)disulfanyl)propanoic acid is a cleavable linker containing a carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The disulfide bond can be cleaved via reduction reactions.
Cat. No.: HY-W014316R
CAS No.: 30007-47-7
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5-Bromo-5-nitro-1,3-dioxane (Standard) is the analytical standard of 5-Bromo-5-nitro-1,3-dioxane (HY-W014316). This product is intended for research and analytical applications. 5-Bromo-5-nitro-1,3-dioxane is a broad-spectrum antimicrobial agent active against Gram-positive bacteria, Gram-negative bacteria and fungi. 5-Bromo-5-nitro-1,3-dioxane oxidizes free thiol groups to their corresponding disulfides. 5-Bromo-5-nitro-1,3-dioxane induces intracellular substance leakage in Escherichia coli and Staphylococcus aureus. 5-Bromo-5-nitro-1,3-dioxane modulates the oxygen consumption of Escherichia coli and Staphylococcus aureus .
Cat. No.: HY-W591325
CAS No.: 663598-55-8
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4-((5-Nitropyridin-2-yl)disulfanyl)pentanoic acid is a synthetic building block with terminal nitro and carboxylic acid groups with a disulfide bond in the center.
Cat. No.: HY-133543A
CAS No.: 153569-12-1
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SPDP-sulfo sodium is a water-soluble heterobifunctional crosslinker containing a cleavable disulfide bond . SPDP-sulfo sodium forms a stable amide bond with primary amines through the Sulfo-NHS ester at one end, and reacts with sulfhydryl groups via the 2-pyridyldithiol group at the other end, thereby constructing a disulfide crosslink that can be specifically cleaved in the intracellular reducing microenvironment. SPDP-sulfo sodium can be widely used in the research and construction of ADCs and immunotoxins, receptor-mediated nano-targeted carrier delivery systems, and enzyme-antibody/antigen labels .
Cat. No.: HY-W591360
CAS No.: 1240737-77-2
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Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.
Cat. No.: HY-W015811
CAS No.: 621-27-2
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3-N-Propylphenol is a small phenolic derivative containing a hydroxyl aryl group that competitively inhibits the binding of the peptide to pancreatic-specific protein disulfide isomerase (PDIp). 3-Propylphenol can be used for research on pancreatic-related diseases .
Cat. No.: HY-100216R
CAS No.: 68181-17-9
Synonyms: SPDP Crosslinker (Standard); Py-ds-Prp-OSu (Standard)
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SPDP (Standard) is the analytical standard of SPDP (HY-100216). This product is intended for research and analytical applications. SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
