122

122 Publications Verification

Purity: 99.69%

Synonyms: Polybrene; 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide

Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer .

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3

Protamine sulfate

3 Cited Publications

Cat. No.: HY-107911

CAS No.: 9009-65-8

Purity: 99.99%

Target:

Thrombin

Research Areas:

Metabolic Disease

Protamine sulfate, polycationic peptide and a antiheparin agent, could neutralize the anticoagulant action of heparin and enhances lipid-mediated gene transfer .

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3

NLS (PKKKRKV)

3 Cited Publications

Cat. No.: HY-P1876

CAS No.: 95088-49-6

Target:

DNA/RNA Synthesis

Research Areas:

Cancer

NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the SV40 large T antigen, which mediates the binding of karyophilic proteins to importin α. NLS (PKKKRKV) serves as a method to enhance nuclear entry in the field of gene transfer research .

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3

NLS (PKKKRKV) (hydrochloride)

3 Cited Publications

Cat. No.: HY-P1876B

Target:

DNA/RNA Synthesis

Research Areas:

Cancer

NLS (PKKKRKV) hydrochloride is the hydrochloride form of NLS (PKKKRKV) (HY-P1876). NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research .

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NADH

Cat. No.: HY-113355

CAS No.: 58-68-4

Category:

Human Gut Microbiota Metabolites Natural Products Microorganisms Endogenous metabolite

Target:

Endogenous Metabolite Apoptosis

NADH is an orally active dehydrogenase coenzyme that acts as a crucial electron carrier in cellular respiration and participates in ATP production. NADH promotes metabolism, supports brain function, and counteracts oxidative stress by transferring electrons to the electron transport chain. As a signaling molecule, NADH regulates multiple biological processes, including anti-apoptosis, synaptic plasticity, gene expression, and calcium homeostasis. Redox imbalance of NADH/NAD⁺ is one of the key pathological mechanisms of various diseases, such as diabetic nephropathy, neurodegenerative diseases, and ischemia-reperfusion injury.

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2'-Deoxy-2'-fluoro-5-iodouridine

Cat. No.: HY-W342664

CAS No.: 55612-21-0

Synonyms: FIRU

Target:

Nucleoside Antimetabolite/Analog HSV

Research Areas:

Cancer

2'-Deoxy-2'-fluoro-5-iodouridine (FIRU) is a nucleoside analog. When labeled with ¹²³I, 2'-Deoxy-2'-fluoro-5-iodouridine accumulates highly selectively in tumors expressing the HSV1-tk gene. Radiolabeled 2'-Deoxy-2'-fluoro-5-iodouridine enables imaging of adenovirus-mediated HSV1-tk suicide gene transfer .

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Transfectam

Cat. No.: HY-143210

CAS No.: 124050-77-7

Purity: ≥98.0%

Target:

Liposome

Research Areas:

Metabolic Disease

Transfectam is a cationic lipid able to interact with DNA to form complexes that mediate efficient gene transfer into various eukaryotic cells .

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GL67 pentahydrochloride

Cat. No.: HY-149037A

Purity: 98.60%

Synonyms: N4-Spermine cholesteryl carbamate pentahydrochloride

Target:

Liposome Drug Intermediate

Research Areas:

Others

GL67 pentahydrochloride (N4-Spermine cholesteryl carbamate pentahydrochloride) is a cationic lipid that serves as a non-viral siRNA delivery vector and a non-viral gene transfer vector. GL67 pentahydrochloride enhances the encapsulation efficiency of siRNA in liposomal formulations and promotes the cellular uptake of siRNA across cancer cell membranes. GL67 pentahydrochloride mediates the transduction of plasmid DNA into cells. GL67 pentahydrochloride can be used in drug delivery-related research .

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DEAE-dextran, MW 500000 hydrochloride

Cat. No.: HY-159067

CAS No.: 9064-91-9

Synonyms: DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides); Diethylaminoethyl-dextran, MW 500000 hydrochloride

DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes .

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Chloroxynil

Cat. No.: HY-W059747

CAS No.: 1891-95-8

Target:

Environmental Pollutants

Research Areas:

Others

Chloroxynil is a Vir gene of Agrobacterium tumefaciens activator. Chloroxynil enhances T-DNA transfer efficiency by activating the expression of Agrobacterium Vir genes. Chloroxynil is promising for research of Agrobacterium-mediated transformation efficiency in legumes and rice .

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GL67

Cat. No.: HY-149037

CAS No.: 179075-30-0

Synonyms: N4-Spermine cholesteryl carbamate

Target:

Liposome Drug Intermediate

Research Areas:

Others

GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid that serves as a non-viral siRNA delivery vector and a non-viral gene transfer vector. GL67 enhances the encapsulation efficiency of siRNA in liposomal formulations and promotes the cellular uptake of siRNA across cancer cell membranes. GL67 mediates the transduction of plasmid DNA into cells. GL67 can be used in drug delivery-related research .

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