14

PAP-1

14 Publications Verification

Cat. No.: HY-10015

CAS No.: 870653-45-5

Purity: 99.83%

Synonyms: 5-(4-Phenoxybutoxy)psoralen

Target:

Potassium Channel

Research Areas:

Inflammation/Immunology

PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC₅₀=2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC₅₀=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects .

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TROX-1

Cat. No.: HY-120751

CAS No.: 1309601-26-0

Target:

Calcium Channel

Research Areas:

Neurological Disease

TROX-1 is a selective, orally active and brain-penetrant N-type calcium channel (Cav2.2) inhibitor with an IC₅₀ value of 0.11 μM. TROX-1 exerts state-dependent and use-dependent inhibition, preferentially targets open/inactivated channels, blocks depolarization-associated calcium influx, and fully blocks calcium influx in rat dorsal root ganglion neurons. TROX-1 reverses inflammatory-induced hyperalgesia, nerve injury-induced allodynia. TROX-1 can be used for the research of pain .

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Articaine hydrochloride

Cat. No.: HY-B0516

CAS No.: 23964-57-0

Synonyms: Hoe-045

Target:

Sodium Channel NF-κB NOD-like Receptor (NLR)

Research Areas:

Neurological Disease Inflammation/Immunology

Articaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC₅₀ of 15.8 μM for open-state Na ⁺ channels, and IC₅₀ of 40.6 μM and 378 μM for inactivated and resting-state Na ⁺ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na ⁺ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury) .

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LTGO-33

Cat. No.: HY-157802

CAS No.: 2834106-06-6

Purity: 99.35%

Target:

Sodium Channel

Research Areas:

Neurological Disease

LTGO-33 is a potent and selective voltage-gated sodium channel NaV1.8 inhibitor. LTGO-33 inhibits NaV1.8 in the nM potency range and exhibits over 600-fold selectivity against human NaV1.1-NaV1.7 and NaV1.9. LTGO-33 exhibits state-independent inhibition with similar potencies on channels in the closed and inactivated conformations. LTGO-33 inhibits native TTX-R NaV1.8 currents in non-human primate and human DRG neurons, where it reduces action potential firing. LTGO-33 can be used for pain disorders research .

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Oxazosulfyl

Cat. No.: HY-136330

CAS No.: 1616678-32-0

Purity: 99.88%

Target:

Insecticide Parasite Sodium Channel

Research Areas:

Infection

Oxazosulfyl is a sulfyl insecticide with potent and cross-spectrum insecticidal activity. Oxazosulfyl inhibits sodium currents by binding to and stabilizing the slow-inactivated state of voltage-gated sodium channels, leading to insect paralysis. Oxazosulfyl's ability to block sodium channels is correlated with its insecticidal activity .

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Nav1.2-IN-2

Cat. No.: HY-178963

CAS No.: 7469-49-0

Target:

Sodium Channel Calcium Channel

Research Areas:

Neurological Disease

Nav1.2-IN-2 is a Nav1.2 inhibitor with a human IC₅₀ of 0.18 μM. Nav1.2-IN-2 preferentially binds to the inactivated state of Nav1.2, reduces window current, suppresses neuronal depolarization and action potential generation. Nav1.2-IN-2 suppresses Veratridine (HY-N6691)-induced Ca ²⁺ influx. Nav1.2-IN-2 can be used for the research of epilepsy .

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Nav1.7-IN-19

Cat. No.: HY-178494

CAS No.: 3097995-73-5

Target:

Sodium Channel Potassium Channel

Research Areas:

Neurological Disease

Nav1.7-IN-19 is a potent, selective and orally active Nav1.7 inhibitor with an IC₅₀ of 0.49 μM. Nav1.7-IN-19 shows high selectivity for Nav1.7, with selectivities of 312-fold and 662-fold against Nav1.1 and Nav1.5 in the inactivated state. Nav1.7-IN-19 exhibits weak inhibition on hERG potassium channels. Nav1.7-IN-19 exhibits analgesic effect and can be used for the research of neurological disease .

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GX-936

Cat. No.: HY-123414

CAS No.: 1235406-09-3

Synonyms: PF-05196233

Target:

Sodium Channel

Research Areas:

Neurological Disease

GX-936 (PF-05196233) is a selective Nav1.7 inhibitor. GX-936 binds to the activated VSD4, forms a bidentate salt bridge with the R4 of the S4 helix, traps VSD4 in the activated state, and prevents the channel from recovering from the inactivated state. GX-936 can be used in studies related to pain .

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PAP-1 (Standard)

Cat. No.: HY-10015R

CAS No.: 870653-45-5

Synonyms: 5-(4-Phenoxybutoxy)psoralen (Standard)

Target:

Reference Standards Potassium Channel

Research Areas:

Inflammation/Immunology

PAP-1 (Standard) is the analytical standard of PAP-1. This product is intended for research and analytical applications. PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects .

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QLS-81

Cat. No.: HY-171778

CAS No.: 2835455-57-5

Target:

Sodium Channel

Research Areas:

Neurological Disease Inflammation/Immunology

QLS-81 is a Nav1.7 channel inhibitor (IC₅₀: 1.5 μM). QLS-81 has significant analgesic activity and can relieve neuropathic and inflammatory pain. QLS-81 exerts frequency-dependent inhibitory effects by inhibiting the inactivated state of Nav1.7 channels. QLS-81 can be used in the study of chronic pain .

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Articaine

Cat. No.: HY-B0516A

CAS No.: 23964-58-1

Synonyms: Hoe-045 free base

Target:

Sodium Channel NF-κB NOD-like Receptor (NLR)

Research Areas:

Neurological Disease Inflammation/Immunology

Articaine (Hoe-045) is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC₅₀ of 15.8 μM for open-state Na ⁺ channels, and IC₅₀ of 40.6 μM and 378 μM for inactivated and resting-state Na ⁺ channels, respectively. Articaine exerts local anesthetic activity by inhibiting Na ⁺ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury) .

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(R)-Duloxetine

Cat. No.: HY-B0161C

CAS No.: 116539-60-7

Synonyms: (R)-LY248686

Target:

Sodium Channel

Research Areas:

Neurological Disease

(R)-Duloxetine ((R)-LY248686) is a neuronal voltage-gated sodium channel blocker with analgesic activity. (R)-Duloxetine blocks Na ⁺ currents with higher affinity for the inactivated state than for the resting state. (R)-Duloxetine alleviates postoperative mechanical allodynia and hyperalgesia. (R)-Duloxetine exerts its effects through a local peripheral mechanism of action. (R)-Duloxetine can be used for research on postoperative (post-incisional) pain .

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(R)-Duloxetine hydrochloride

Cat. No.: HY-B0161D

CAS No.: 910138-96-4

Synonyms: LY248686 hydrochloride

Target:

Sodium Channel

Research Areas:

Neurological Disease

(R)-Duloxetine hydrochloride ((R)-LY248686 hydrochloride) is a neuronal voltage-gated sodium channel blocker with analgesic activity. (R)-Duloxetine hydrochloride blocks Na ⁺ currents with higher affinity for the inactivated state than for the resting state. (R)-Duloxetine hydrochloride alleviates postoperative mechanical allodynia and hyperalgesia. (R)-Duloxetine hydrochloride exerts its effects through a local peripheral mechanism of action. (R)-Duloxetine hydrochloride can be used for research on postoperative (post-incisional) pain .

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(R)-Duloxetine (Standard)

Cat. No.: HY-B0161CR

CAS No.: 116539-60-7

Synonyms: (R)-LY248686 (Standard)

Target:

Reference Standards Sodium Channel

Research Areas:

Neurological Disease

(R)-Duloxetine (Standard) ((R)-LY248686 (Standard)) is the analytical standard of (R)-Duloxetine (HY-B0161C). This product is intended for research and analytical applications. (R)-Duloxetine ((R)-LY248686) is a neuronal voltage-gated sodium channel blocker with analgesic activity. (R)-Duloxetine blocks Na ⁺ currents with higher affinity for the inactivated state than for the resting state. (R)-Duloxetine alleviates postoperative mechanical allodynia and hyperalgesia. (R)-Duloxetine exerts its effects through a local peripheral mechanism of action. (R)-Duloxetine can be used for research on postoperative (post-incisional) pain .

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