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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
mitochondria detection
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "mitochondria detection" in MCE Product Catalog:
21
10
6
6 Cited Publications
Cat. No.: HY-D1711
CAS No.: 172971-76-5
Synonyms: IR-808
Cat. No.: HY-DY1073
CAS No.: 1392820-50-6
Solvent and concentration: DMSO: 2 mM
Cat. No.: HY-169838
CAS No.: 74763-44-3
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WYneC can specifically bind to sulfinylated proteins in living cells and then react with fluorescent probes containing azide groups for detection. In the field of redox biology, WYneC can also be used to determine the occupancy of S-sulfinylation sites or as a carrier to deliver substances to mitochondria .
Cat. No.: HY-P11729
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Cat. No.: HY-D3269
CAS No.: 2088127-60-8
Cat. No.: HY-D3132
CAS No.: 1616505-01-1
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Spring Red is a fluorescent probe for mitochondrial pH detection (Ex/Em = 530/680 nm) that can be taken up by live cells and mitochondria. The detection mechanism of Spring Red depends on pH changes and mitochondrial membrane potential. Fluorescence intensity increases with elevated pH, and a significant pH-dependent fluorescent response is observed in the pH range of 5.0‑8.0. Spring Red is suitable for long-term live-cell imaging and in vivo imaging, and can be used to monitor dynamic mitochondrial pH changes .
Cat. No.: HY-D3402
CAS No.: 3121511-18-7
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LHA675 is a fluorescent probe for early detection of ferroptosis. LHA675 mimics polyunsaturated lipids via a 4-phenyl-3-methylbut-2-enyl group to specifically detect highly oxidative radicals associated with ferroptosis, and releases a fluorophore after the reaction. LHA675 has excitation and emission wavelengths of 647 nm and 663-738 nm, respectively. LHA675 enables wash-free labeling of ferroptosis in living cells; the generated fluorophore localizes to mitochondria and emits deep red fluorescence. LHA675 can be used in studies related to the early detection of ferroptosis .
Cat. No.: HY-D3148
CAS No.: 1804107-88-7
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TPE-Ph-In is a mitochondria-targeted voltage-sensitive probe that can be used for mitochondrial membrane potential detection, mitochondrial imaging of animal and plant cells and tissues, mouse sperm activity indication, and detection of mitochondrial membrane potential changes associated with early apoptosis. TPE-Ph-In is non-fluorescent in solution, but emits strong fluorescence when aggregated via restriction of intramolecular rotation/movement, and its fluorescence intensity is directly correlated with local probe concentration or mitochondrial membrane potential level. TPE-Ph-In can penetrate cell membranes, target mitochondria through charge-dependent accumulation, has low cytotoxicity and high photostability, and enables super-resolution imaging of plant mitochondrial fission, fusion and cristae structures. The excitation wavelengths of TPE-Ph-In include 450 nm, 488 nm, and 489 nm, while its emission wavelengths include 551-661 nm, 660 nm, and 694 nm. TPE-Ph-In can be used for studies on mitochondrial dysfunction associated with early apoptosis .
Cat. No.: HY-D3409
CAS No.: 1854026-50-8
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Si-DMA is a far-red fluorescent singlet oxygen probe (Ex/Em = 640/690 nm). After reacting with singlet oxygen, Si-DMA forms an endoperoxide with a 17-fold fluorescence enhancement. Si-DMA localizes selectively to mitochondria with negligible auto-oxidation. Si-DMA can be used for high spatiotemporal resolution visualization and detection of mitochondrial singlet oxygen in living cells .
Cat. No.: HY-D3602
CAS No.: 2558211-88-2
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Mito-CS1 is a fluorescent probe for imaging and reversible detection of the exchangeable mitochondrial Cu + pool in living cells. Mito-CS1 combines a Cu +-responsive fluorescent platform with a mitochondria-targeted triphenylphosphonium group, which localizes the probe to mitochondria via a proton gradient. Mito-CS1 contains a thioether-rich receptor for the selective recognition and binding of Cu +, triggering a fluorescence turn-on response by inhibiting photoinduced electron transfer. The apo-form of Mito-CS1 has excitation/emission wavelengths of 555/569 nm, while those of Mito-CS1 after binding to Cu + are 550/558 nm .
Cat. No.: HY-D3383
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AM4-64 is a fixable cationic styryl fluorescent dye for nerve terminals, which can be used for vesicle cycle evaluation, endocytic pathway tracing and endocytosis detection. AM4-64 inserts into the plasma membrane, is internalized via activity- or energy-dependent endocytosis, and accumulates in vesicles, endosomal compartments, vacuolar membranes, mitochondria and endolysosomal structures. The fluorescence of AM4-64 is enhanced in the membrane-bound state. AM4-64 is applicable to relevant studies on neurons, plant and fungal cells and tissues (Ex/Em = 510/750 nm) .
Cat. No.: HY-D3119
CAS No.: 2246946-49-4
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MitoAIE1 is a Fluorescent probe for mitochondrial viscosity detection. MitoAIE1 contains a pyridinium structural unit, which endows it with mitochondria-targeting specificity. The detection mechanism of this probe is based on aggregation-induced emission (AIE): in low-viscosity media such as PBS buffer, intramolecular rotation leads to non-radiative energy dissipation, resulting in only weak fluorescence; however, in high-viscosity environments such as the mitochondrial matrix or the vicinity of the inner mitochondrial membrane, such intramolecular motion is restricted, thereby significantly enhancing its fluorescent signal; in addition, this probe is not interfered by changes in microenvironment polarity and pH. Its emission wavelength is 625 nm, with absorption peaks at 325 nm and 450 nm; when transferred from low-viscosity PBS to high-viscosity 99% glycerol, its fluorescence intensity at 625 nm can be increased by 38-fold. It can be used to monitor changes in mitochondrial viscosity during processes such as Stauroporine (HY-15141)-induced apoptosis and starvation-induced mitophagy in live cells, and has good biocompatibility .
Cat. No.: HY-D3401
CAS No.: 3121511-17-6
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LHA585 is a fluorescent probe targeting the lipid hydrogen abstraction process for the early detection of ferroptosis (Ferroptosis). Its detection mechanism relies on the reactivity of its own 4-phenyl-3-methylbut-2-enyl moiety with biologically relevant oxidative radicals, including peroxyl radicals (ROO·), alkoxyl radicals (RO·), hydroxyl radicals (HO·), and peroxynitrite anions (ONOO−); upon hydrogen abstraction from this structure, radical rearrangement and radical cleavage occur, releasing a xanthene radical which converts into a highly fluorescent rhodamine dye in biological environments, thereby achieving a fluorescence turn-on ratio of up to 360-fold. LHA585 is non-fluorescent in its native state, possesses excellent membrane permeability due to its non-polar property, and the rhodamine dye generated after oxidation diffuses into mitochondria. The excitation wavelength of LHA585 is 561 nm, and its emission wavelength ranges from 570 to 620 nm .
Cat. No.: HY-D3100
CAS No.: 2412201-40-0
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NRTP is a fluorescent probe used for mitochondrial polarity detection and photothermal sensitization. NRTP targets mitochondria via a positively charged triphenylphosphonium moiety, which is attracted by the negative mitochondrial membrane potential; meanwhile, its polarity-sensitive Nile red fluorophore enables it to perceive changes in environmental polarity. NRTP reduces cell viability when used as a photothermal sensitizer. The excitation wavelength is 561 nm, and emission light is collected in two channels: 570-620 nm (red channel) and 665-735 nm (deep red channel). NRTP can reveal the downregulation of mitochondrial polarity during light-induced cell death, as well as polarity changes triggered by exposure to cholesterol .
Cat. No.: HY-D3123
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Ac-MtFluNox is a mitochondria-targeted Fluorescent probe that can be used for the selective detection of labile Fe (II). Ac-MtFluNox can enter living cells, where intracellular esterases cleave its acetyl protecting group to generate activated MtFluNox. Ac-MtFluNox functions through an Fe (II)-mediated deoxygenation mechanism of its amine N-oxide group, which eliminates the fluorescence quenching effect and oxidizes Fe (II) to Fe (III) to deplete the catalytically active Fe (II) pool. A FITC filter set (excitation 465-500 nm, emission 516-556 nm) is used for live-cell imaging. Ac-MtFluNox can be applied to studies related to myocardial ferroptosis .
Cat. No.: HY-D3030
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Concanavalin A-FITC is a FITC (HY-66019)-labeled Concanavalin A (HY-P2149). Concanavalin A-FITC is a fluorescent probe and dye used to detect cell surface sugar-binding sites, oligosaccharide changes and track cell localization. Concanavalin A-FITC binds to α-D-glucose, α-D-mannose and mannose residues on cell surface glycoproteins, glycolipids and glycoconjugates, with fluorescence signals provided by FITC. Concanavalin A-FITC accumulates in perinuclear endoplasmic reticulum-related regions via endocytosis and localizes to mitochondria. The excitation/emission wavelength of Concanavalin A-FITC is Ex/Em = 488/>510 nm, and its emitted green fluorescence can be collected with a 530/30 nm filter during flow cytometry detection .
Cat. No.: HY-D3086
CAS No.: 1668565-72-7
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Mito-polarity is a mitochondria-targeted polarity probe. Mito-polarity can be used to detect mitochondrial polarity. The detection mechanism of Mito-polarity is based on an intramolecular charge transfer (ICT) system designed with a donor-π-bridge-acceptor (D-π-A) structure. Among them, the 467 nm green emission generated by the Coumarin (HY-N0709) structure is extremely sensitive to polarity changes, while the 642 nm red emission produced by the extended π-conjugation and ICT effect between the Coumarin and benzothiazine structures shows only a weak response, thus forming a ratiometric fluorescence response that is linearly correlated with solvent polarity. When Mito-polarity is excited at 405 nm in methanol, its excitation/emission wavelengths are Ex/Em = 405/467 nm and Ex/Em = 405/642 nm, with maximum absorption wavelengths of 426 nm and 561 nm .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
