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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
righting reflex
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "righting reflex" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: (-)-Scopolamine methyl bromide; Hyoscine methyl bromide
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Methscopolamine bromide ((-)-Scopolamine methyl bromide; Hyoscine methyl bromide) is a peripherally acting muscarinic receptor (mAChR) antagonist that cannot cross the blood-brain barrier. Methscopolamine bromide blocks the muscarinic negative feedback regulation of acetylcholine release from striatal cholinergic terminals, thereby increasing acetylcholine release in the striatum of freely moving rats. Methscopolamine bromide does not induce motor excitation in freely moving rats, nor does it alter the duration of ethanol-induced loss of righting reflex in mice. Methscopolamine bromide fails to antagonize the arecoline-mediated reduction in the duration of ethanol-induced loss of righting reflex in mice .
Cat. No.: HY-W017500
CAS No.: 17833-53-3
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N-Methyl-DL-aspartic acid acts as an agonist for N-methyl-D-aspartic acid receptors and D-isomer-specific aspartate receptors. N-Methyl-DL-aspartic acid activates hypothalamic neurons that regulate gonadotropin-releasing hormone secretion, and stimulates prepubertal male rhesus monkeys to produce sustained intermittent gonadotropin-releasing hormone secretion and pulsatile luteinizing hormone secretion. N-Methyl-DL-aspartic acid activates excitatory effects mediated by N-methyl-D-aspartic acid receptors. N-Methyl-DL-aspartic acid exhibits convulsant effects, inducing clonic convulsions with loss of righting reflex, generalized tonic-clonic seizures or persistent clonic seizures. N-Methyl-DL-aspartic acid causes precocious puberty. N-Methyl-DL-aspartic acid can be used in studies related to convulsions and seizures .
Cat. No.: HY-N15001
CAS No.: 59556-18-2
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Coenzyme Q2 is a benzoquinone electron carrier in the mitochondrial electron transport chain and a p53-dependent apoptosis inducer. Coenzyme Q2 induces p53 phosphorylation at Ser15, promoting p53 accumulation and functional activation. Coenzyme Q2 induces ROS generation, caspase-3 activation, DNA fragmentation, phosphatidylserine externalization, mitochondrial permeability transition pore opening, and oxidative phosphorylation uncoupling. Coenzyme Q2 inhibits Complex I, Complex III, and Complex IV activities, disrupting electron transport and membrane potential generation. Coenzyme Q2 induces excessive mitochondrial proton leak in forebrain mitochondria. Coenzyme Q2 causes loss of righting reflex in mice, accompanied by slow-wave delta EEG activity and reversible loss of wakefulness. Coenzyme Q2 inhibits lipid peroxidation and scavenges superoxide radicals. Coenzyme Q2 is used in research on leukemia, myocardial ischemia-reperfusion injury, and mitochondrial encephalomyopathy .
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Alkaloids Other Diseases Menispermaceae Extract Phenols Polyphenols Plants Cissampelos pareira Disease Research Fields Isoquinoline Alkaloids
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Ambenoxan is a central nervous system-acting skeletal muscle relaxant that is effective in mice, rats, rabbits, dogs, and monkeys without loss of the righting reflex. It has no peripheral neuromuscular blocking effects and significantly reduces or eliminates decerebrate rigidity in rabbits, but does not antagonize the effects of strychnine, leptazol, or tremorine. Like other central nervous system depressants, ambenoxan prolongs sleep duration with hexobarbitone, but it has no local anesthetic effects. In anesthetized cats, the agent lowers blood pressure and reduces the pressor response to epinephrine, but has no effect on norepinephrine.
Cat. No.: HY-121670A
CAS No.: 1617-99-8
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Ambenoxan hydrochloride is a central nervous system-acting skeletal muscle relaxant that is effective in mice, rats, rabbits, dogs, and monkeys without loss of the righting reflex. It has no peripheral neuromuscular blocking effects and significantly reduces or eliminates decerebrate rigidity in rabbits, but does not antagonize the effects of strychnine, leptazol, or tremorine. Like other central nervous system depressants, ambenoxan prolongs sleep duration with hexobarbitone, but it has no local anesthetic effects. In anesthetized cats, the agent lowers blood pressure and reduces the pressor response to epinephrine, but has no effect on norepinephrine.
Cat. No.: HY-112074A
CAS No.: 51274-83-0
Synonyms: HOE 440 hydrochloride
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Tiamenidine hydrochloride (HOE 440 hydrochloride) is an orally active α-2 adrenoceptor agonist. Tiamenidine hydrochloride stimulates peripheral α-adrenergic receptors, causing a transient increase in blood pressure, and activates central adrenergic receptors, inhibiting sympathetic nerve activity. Tiamenidine hydrochloride lowers blood pressure in hypertensive rats and inhibits plasma renin activity. Tiamenidine hydrochloride reduces ethanol preference and intake in ethanol-preferring rats. Tiamenidine hydrochloride attenuates Xylazine-induced loss of righting reflex. Tiamenidine hydrochloride can be used in research on hypertension .
Cat. No.: HY-112074
CAS No.: 31428-61-2
Synonyms: HOE 440
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Tiamenidine (HOE 440) is an orally active α-2 adrenoceptor agonist. Tiamenidine stimulates peripheral α-adrenergic receptors, causing a transient increase in blood pressure, and activates central adrenergic receptors, inhibiting sympathetic nerve activity. Tiamenidine lowers blood pressure in hypertensive rats and inhibits plasma renin activity. Tiamenidine reduces ethanol preference and intake in ethanol-preferring rats. Tiamenidine attenuates Xylazine-induced loss of righting reflex. Tiamenidine can be used in research on hypertension .
Cat. No.: HY-123525
CAS No.: 550310-04-8
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COR628 is a positive allosteric modulator of GABA(B) receptors with the activity of enhancing GABA-induced GTPγS stimulation. COR628 showed significant activity in in vitro studies but did not exhibit endogenous agonist activity. COR628 has shown efficacy in experiments in mice by enhancing the sedation/hypnosis induced by baclofen, shortening the onset time and extending the duration of loss of righting reflex when combined with non-sedating doses of baclofen . The cytotoxic effect of COR628 is comparable to or higher than that of GS39783 or BHF177 in concentration .
Cat. No.: HY-117979
CAS No.: 14107-37-0
Synonyms: Alfadolone
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Alphadolone (Alfadolone) is a GABAA positive allosteric modulator with antinociceptive activity. Alphadolone produces GABAA-mediated antinociception and analgesia, and can induce anesthesia, loss of righting reflex, and deep sedation. Alphadolone blocks calcium channels and downstream cascades of calcium influx, and inhibits histamine release from mast cells. Alphadolone enhances the antinociceptive effects of opioids. Alphadolone promotes Candida albicans yeast/hyphal growth, increases lipid and oxygen uptake, alters sterol composition, and enhances tolerance to polyene antifungals . Alphadolone can be used in pain-related research .
Cat. No.: HY-162620
CAS No.: 2971825-58-6
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α2A-AR agonist 1 (Compound B9) is a selective agonist for α2-adrenergic receptor (α2A-AR) with EC50 of 0.23 nM. α2A-AR agonist 1 exhibits a hypnotic effect, with ED50 of 0.138 mg/kg in the loss of righting reflex (LORR) experiment. α2A-AR agonist 1 exhibits metabolic stability in mouse liver microsomes .
Cat. No.: HY-N6609B
CAS No.: 75413-87-5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
