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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
turn-on
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "turn-on" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-D0155
CAS No.: 288574-78-7
1
Synonyms: Nampt degrader-2
PROTAC NAMPT Degrader-30 is a PROTAC degrader targeting nicotinamide phosphoribosyltransferase (NAMPT), with a DC50 of 8.4 nM in A2780 cells. PROTAC NAMPT Degrader-30 binds to the VHL E3 ligase and forms a ternary complex with NAMPT, which induces ubiquitination and subsequent proteasomal degradation of NAMPT, thereby inhibiting the enzymatic activity of NAMPT. PROTAC NAMPT Degrader-30 reduces intracellular NAD + levels and suppresses tumor cell proliferation. PROTAC NAMPT Degrader-30 exhibits a fluorescence turn-on response to the NAMPT protein, enabling real-time visualization of the NAMPT degradation process in living cells. PROTAC NAMPT Degrader-30 is applicable for research on ovarian cancer .
Cat. No.: HY-D2264
CAS No.: 1632296-13-9
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Caffeine Orange (Compound 1) is a fluorescent probe for caffeine detection. Caffeine Orange is a BODIPY backbone-based probe that exhibits a turn-on fluorescence response upon binding to caffeine. The detection mechanism of Caffeine Orange relies on its binding with caffeine in aqueous media, which triggers an increase in fluorescence intensity; under irradiation with a 532 nm light source, the presence of caffeine produces orange fluorescence, with an excitation wavelength of 530 nm and an emission wavelength centered at approximately 620 nm .
Cat. No.: HY-D1262
CAS No.: 1808174-52-8
Synonyms: Thiol-green 2
Cat. No.: HY-W753658
CAS No.: 1335151-56-8
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Coppersensor-3 is a Cu (I)-selective fluorescent probe, λabs 540 nm, λem 548 nm. Coppersensor-3 detects basal levels of labile Cu (I) in living cells and produces fluorescence turn-on by inhibiting photoinduced electron transfer. Coppersensor-3 is useful for studies related to copper homeostasis and copper transport .
Cat. No.: HY-W005148
CAS No.: 5959-52-4
Cat. No.: HY-D1256
CAS No.: 2966537-39-1
Synonyms: SSP4
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Sulfane sulfur probe 4 (SSP4) is a fluorescent indicator with high selectivity and sensitivity toward sulfane sulfur (including small-molecule sulfane sulfur and protein-bound sulfane sulfur), and its fluorescence is inhibited by Cu 2+. Sulfane sulfur probe 4 produces a fluorescence turn-on response upon reaction with sulfane sulfur. Sulfane sulfur probe 4 can detect persulfidated proteins including papain, BSA, GAPDH, and human protein disulfide isomerase. Sulfane sulfur probe 4 enables bioimaging of exogenous and endogenous sulfane sulfur in cells .
Cat. No.: HY-176513
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Cy-OH-LP is a turn-on fluorescent and photoacoustic probe that can detect lipid-associated hydroxyl radicals. Cy-OH-LP can be oxidized to Cy7 in the presence of hydroxyl radicals, which displays weak fluorescent and photoacoustic signals in water-soluble environments and strong fluorescent and photoacoustic signals in lipid-rich environments due to its lipid solubility. Cy-OH-LP can be used for in vivo photoacoustic imaging of hydroxyl radicals .
Cat. No.: HY-150175
CAS No.: 1786411-17-3
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HKSOX-1 is a fluorescent probe for the detection and imaging of superoxide anion radicals (O2 •−) with selectivity. HKSOX-1 reacts with superoxide anion radicals, cleaving the aryl triflate group to generate a free phenol and produce turn-on fluorescence. Derivative variants of HKSOX-1 include HKSOX-1r and HKSOX-1m. HKSOX-1 is applicable to studies related to endogenous superoxide detection .
Cat. No.: HY-D1395
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RH-EDA is a rhodamine-based turn-on fluorescent probe for detecting hydroxyl radicals in living systems.
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LysoFP-NO2 is a turn-on fluorescent probe for carbon monoxide (CO) that localizes to the lysosome. In the presence of lysosomal CO, lysoFP-NO2 is transformed into lysoFP-NH2, which is highly fluorescent. LysoFP-NO2 is selective for CO over various reactive nitrogen, oxygen, and sulfur species. It displays excitation/emission maxima of 440/528 nm, respectively, and is not cytotoxic to HepG2 cells for up to five hours when used at a concentration of 30 μM.
Cat. No.: HY-D1065
CAS No.: 1392488-04-8
Cat. No.: HY-112526
CAS No.: 1004324-99-5
Cat. No.: HY-172333
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HCy-Lyso is a lysosome-targeting turn-on fluorescent probe based on hydrocyanine. HCy-Lyso integrates a hydrocyanine moiety for selective recognition of hydroxyl radicals (•OH) and a morpholine group for lysosome targeting. Upon reacting with •OH, HCy-Lyso undergoes an extension of its π-conjugation system, producing a strong fluorescence signal at 598 nm when excited at 510 nm .
Cat. No.: HY-143285
Cat. No.: HY-D1066
Cat. No.: HY-D1259
CAS No.: 2414276-32-5
Synonyms: VDP-green (NEP)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
