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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
extracellular vesicles
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "extracellular vesicles" in MCE Product Catalog:
3
3 Cited Publications
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TC-I 15 (TC-I-15) is a type of allosteric collagen-binding integrin α2β1 inhibitor, and it also inhibits α1β1 and α11β1. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition. TC-I 15 prevents the formation of a pre-metastatic microenvironment by inhibiting the uptake of cancer-associated fibroblast (CAF) extracellular vesicles (EVs) by lung fibroblasts, which reduces the metastasis of salivary gland adenocystic carcinoma (SACC) to the lungs in mouse models, .
Cat. No.: HY-D1736
CAS No.: 158757-82-5
Cat. No.: HY-W440896
DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .
Cat. No.: HY-164390
CAS No.: 64364-50-7
Synonyms: Neu5Acα2-6Galβ1-4GlcNAc
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6′SLN is a cancer-related extracellular vesicle (EVs) surface glycan that serves as a key form of protein glycosylation in EVs. 6′SLN is also a sialic acid derivative that can interact with hemagglutinins (HAs) from human and avian influenza virus strains, making it useful for research into anti-influenza drugs .
Cat. No.: HY-128736C
Purity: 89.70%
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Cat. No.: HY-128736
CAS No.: 23295-92-3
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Cat. No.: HY-D1765
CAS No.: 1415018-97-1
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FM 1-43FX is a fluorescent styryl membrane dye that stains lipids green. FM 1-43FX labels extracellular vesicle lipid membranes, exosomes/microvesicles, and various sensory neurons through an endocytosis/vesicle recycling-dependent mechanism, and can label NFH-, calbindin-, and TH-positive mechanoreceptor subtypes. FM 1-43FX acts as a membrane-permeable MET channel blocker, partially inhibiting PIEZO1 and PIEZO2 currents in a voltage-dependent manner, and is used to assess cochlear/zebrafish MET function and detect fungal EV lipid transfer. FM 1-43FX can be used for research on progressive hearing loss .
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SpeB cysteine protease is a potent modifier of immunologically important host and bacterial proteins. SpeB cysteine protease degrades streptolysin O (SLO) in extracellular vesicles .
Cat. No.: HY-L168
715 compounds
Extracellular vesicles (EVs) are small membrane binding structures that are released from cells into the surrounding environment and play a crucial role in mediating and regulating intercellular communication related to physiological and pathological processes. EVs are lipid membrane vesicles composed of proteins, lipids, and nucleic acids. EVs can be divided into several types based on their source, such as extracellular vesicles, microcapsules, and apoptotic vesicles. The size range of exosomes is 30-150nm, which are endocrine in multi vesicular endosomes (MVEs); microvesicles (50-1000nm) are secreted directly through extracellular interactions, thereby releasing plasma membrane vesicles. In contrast, apoptotic bodies are usually larger, ranging in size from 1 to 5 μ m. This is generated during programmed cell death. EV plays a crucial role in transmitting information between cells and influencing the behavior and function of receptor cells.
MCE designs a unique collection of 715 small molecules related to extracellular vesicles (EVs). It is a good tool to be used for research on metabolize, cancer and other diseases.
Cat. No.: HY-169819
CAS No.: 882291-37-4
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Calcium influx inducer compound 634 is a calcium influx inducer. Calcium influx inducer compound 634 (10 µM) enhances the release of extracellular vesicles (EVs) from mouse bone marrow-derived dendritic cells (mBMDCs). Calcium influx inducer compound 634 (10 µM) also increases the levels of CD86 and CD80 on the surface of mBMDCs, an effect that can be blocked by the calcium release-activated calcium channel inhibitor YM-58483 (HY-100831) .
Cat. No.: HY-D1867
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Sulfo-Cy3-PEG2-TCO disodium is a cell-impermeable TCO fluorophore. Sulfo-Cy3-PEG2-TCO disodium mediates bioorthogonal fluorescent labeling of cell-surface and extracellular HTz-GlcNAc-modified glycoconjugates, enabling visualization and tracking of cell-surface glycan turnover and extracellular vesicle secretion .
Cat. No.: HY-149025
CAS No.: 2881068-33-1
Synonyms: P18
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DPTIP-proagent 18 (P18) is a orally active and brain-penetrable proagent of DPTIP (HY-131002). DPTIP-proagent 18 is a potent nSMase2 inhibitor. DPTIP-proagent 18 significantly inhibits IL-1β-induced EV (extracellular vesicle) release by inhibition of nSMase2 (neutral sphingomyelinase-2) activity. DPTIP-proagent 18 can be used for brain injury research .
Cat. No.: HY-P11232
CAS No.: 1969250-99-4
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Cat. No.: HY-W127487
CAS No.: 479050-96-9
Cat. No.: HY-K3122
MCE Dry Plant-Derived Extracellular Vesicle Isolation and Purification Kit is specifically optimized for dried plant samples. It facilitates the efficient release of vesicles from plant tissues and employs an optimized extraction and purification system to remove non-vesicular components such as polysaccharides and phenolic compounds, thereby enabling the efficient extraction and purification of plant-derived vesicles. The isolated plant-derived vesicles can be used for downstream applications including transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blotting, qPCR, cell-based studies, and animal experiments.
Cat. No.: HY-K3123
MCE Succulent Plant -Derived Extracellular Vesicle Isolation and Purification Kit is specifically optimized for succulent plant samples. It facilitates the efficient release of vesicles from plant tissues and employs an optimized extraction and purification system to remove non-vesicular components such as polysaccharides and phenolic compounds, thereby enabling the efficient extraction and purification of plant-derived vesicles. The isolated plant-derived vesicles can be used for downstream applications including transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blotting, qPCR, cell-based studies, and animal experiments.
Cat. No.: HY-D3582
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AF633 C5 Maleimide is a fluorescent dye used for surface protein labeling of extracellular vesicles and peptide labeling. AF633 C5 Maleimide covalently binds to protein thiol residues under neutral pH conditions (6.5-7.5), enabling visualization and quantitative analysis of extracellular vesicle uptake by target cells. AF633 C5 Maleimide undergoes maleimide-cysteine conjugation with cysteine residues on peptides in acetonitrile-water buffer solution, supporting detection of peptide-functionalized gold nanorods via confocal laser scanning microscopy, as well as tracking their cellular uptake and localization .
Cat. No.: HY-K3124
MCE Macrofungal-Derived Extracellular Vesicle Isolation and Purification Kit is specifically optimized for fungal fruiting body samples. The optimized extraction system facilitates the release of EVs from fungal tissues, while the purification system effectively removes polysaccharides, proteins, phenolic compounds, terpenoids, and other non-vesicular components, enabling efficient isolation and purification of fungal EVs. The isolated macrofungal-derived vesicles can be used for downstream applications including transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blotting, qPCR, cell-based studies, and animal experiments.
Cat. No.: HY-P11552
CAS No.: 929906-72-9
Synonyms: (DSS)6
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Cat. No.: HY-P5423D
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
