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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
monocytic leukemia
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "monocytic leukemia" in MCE Product Catalog:
10
10 Publications Verification
Cat. No.: HY-19619
CAS No.: 200933-14-8
Target:
Research Areas:
m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis .
1
1 Cited Publications
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Research Areas:
PROTAC RIPK degrader-2 is a non-peptidic PROTAC degrader targeting RIPK2, with a DC50 of 1.5 nM. PROTAC RIPK degrader-2 recruits VHL or cereblon E3 ubiquitin ligases, induces ubiquitination and proteasomal degradation of RIPK2, acts via substoichiometric catalysis, and inhibits downstream pro-inflammatory signaling pathways. PROTAC RIPK degrader-2 inhibits the NOD2/RIPK2 pathway and suppresses MDP (HY-127090)-stimulated TNFα release in human whole blood. PROTAC RIPK degrader-2 can be used in studies related to acute monocytic leukemia and glucose metabolism .
1
1 Cited Publications
Cat. No.: HY-P86929
Synonyms: KAT6A; MOZ; MYST3; RUNXBP2; ZNF220; Histone acetyltransferase KAT6A; MOZ; YBF2/SAS3; SAS2 and TIP60 protein 3; monocytic leukemia zinc finger protein; Runt-related transcription factor-binding protein 2; Zinc finger protein 220
Cat. No.: HY-168654
CAS No.: 3090685-34-7
WEE1 degrader 1 (Compound 10) is a CRBN-dependent molecular glue degrader of WEE1 and casein kinase 1α (CK1α) with sub-2 nM DC50 values for both targets. WEE1 degrader 1 can be used for the research of acute lymphoblastic leukemia, acute monocytic leukemia, acute promyelocytic leukemia, colorectal adenocarcinoma, diffuse large b cell lymphoma .
Synonyms: DINP
Research Areas:
Diisononyl phthalate (DINP) is an orally active polyvinyl chloride plasticizer and indirect food additive. Diisononyl phthalate activates the ACE/AT1R axis and inhibits the production of NO. Diisononyl phthalate reduces the expression of eNOS. Diisononyl phthalate induces increased blood pressure in mice. Diisononyl phthalate induces monocytic leukemia in rats. Diisononyl phthalate can be used in hypertension-related research .
Cat. No.: HY-N8390
CAS No.: 168293-15-0
Category:
Triterpenes Plant Terpenoids Poria cocos Extract Polyporaceae Extract Disease Research Fields Cancer
Target:
Cat. No.: HY-175186
Target:
Research Areas:
LO-3-62 is a SMARCA2/4 degrader. LO-3-62 incorporates a truncated fumaramide linker and conjugates it to a SMARCA2/4 inhibitor. LO-3-62 binds covalently to the CUL4 DCAF16 E3 ubiquitin ligase, inducing proteasome-dependent degradation of SMARCA2/4. LO-3-62 can be used in studies of monocytic leukemia .
Cat. No.: HY-168863
CAS No.: 3104468-66-5
Research Areas:
FF2049 is a selective HDAC1-3 PROTAC degrader (with a DC50 of 257 nM against HDAC1). FF2049 recruits the E3 ligase FEM1B to mediate ubiquitination and proteasomal degradation of HDAC1-3. FF2049 induces cell cycle arrest and Apoptosis in cells. FF2049 can be used in research related to multiple myeloma, acute monocytic leukemia, triple-negative breast cancer and glioblastoma .
Cat. No.: HY-19619R
CAS No.: 200933-14-8
Target:
Research Areas:
m-3M3FBS (Standard) is the analytical standard of m-3M3FBS. This product is intended for research and analytical applications. m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis .
Cat. No.: HY-190204
CAS No.: 2930694-65-6
Research Areas:
GSPT1 degrader-21 (compound 12) is a cereblon (CRBN)-recruiting GSPT1 molecular glue degrader. GSPT1 degrader-21 promotes the ubiquitination and proteasomal degradation of GSPT1 and/or IKZF1. GSPT1 degrader-21 has a GSPT1 HiBiT DC50 of < 1 nM. GSPT1 degrader-21 can be used for research on hematological tumors such as B-cell acute lymphoblastic leukemia and monocytic leukemia .
Cat. No.: HY-184882
CAS No.: 2771021-30-6
Target:
Research Areas:
NLRP3-IN-95 is an NLRP3 inflammasome inhibitor with an IC50 of 27 nM. NLRP3-IN-95 inhibits IL-1β secretion in PMA-differentiated THP-1 cells. NLRP3-IN-95 can be used in studies related to acute monocytic leukemia and inflammatory diseases .
Cat. No.: HY-P704206
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KAT6B; K(Lysine) Acetyltransferase 6B; Prev. MYST4; MOZ-Related Factor; MOZ2; ZC2HC6B; Querkopf; MYST-4; Morf; Histone Acetyltransferase MYST4; Qkf; Histone Acetyltransferase MORF; MYST Histone Acetyltransferase (monocytic leukemia) 4; Histone Acetyltrans
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-W409652
CAS No.: 2101206-26-0
CLK1/4-IN-2 is a selective CLK1/4 inhibitor, with an IC50 of 7 nM against CLK1 and an IC50 of 2.3 nM against CLK4. CLK1/4-IN-2 induces protein depletion in cancer cells and exhibits anticancer activity. CLK1/4-IN-2 can be used in research related to breast cancer, monocytic leukemia, bladder cancer, mammary adenocarcinoma and hepatocellular carcinoma .
Cat. No.: HY-W714933
CAS No.: 78362-05-7
Synonyms: (4,8)-(+)-Gallocatechin-(+)-catechin
Research Areas:
Prodelphinidin B3 is a proanthocyanidin compound that exhibits significant anti-tumor activity. Prodelphinidin B3 induces cell cycle arrest at the G1/G0 phase in PC-3 cells, activates caspase-3, and promotes apoptosis. Prodelphinidin B3 can induce the differentiation of leukemia cells and synergistically enhance retinoic acid (HY-14649)-induced granulocytic differentiation and sodium butyrate (HY-B0350A)-induced monocytic differentiation in HL-60 cells. Prodelphinidin B3 also possesses antioxidant activity. Prodelphinidin B3 is used in research on prostate cancer and leukemia .
Cat. No.: HY-180150
Research Areas:
PROTAC BRD4 Degrader-42 (Compound P6) is a PROTAC-based BRD4 degrader with a DC50 of 1.11 μM. PROTAC BRD4 Degrader-42 promotes the ubiquitination and degradation of BRD4. PROTAC BRD4 Degrader-42 downregulates c-Myc expression and induces Apoptosis by upregulating BAD and BAX protein expression. PROTAC BRD4 Degrader-42 also exhibits anticancer activity against myeloid monocytic leukemia .
Cat. No.: HY-W724097
CAS No.: 84746-00-9
Target:
Research Areas:
1-Oleoyl-2-acetylglycerol is a membrane-permeable diacylglycerol analog and PKC activator. 1-Oleoyl-2-acetylglycerol activates TRPC3 channels. 1-Oleoyl-2-acetylglycerol attenuates D609 (HY-70072)-induced Apoptosis. 1-Oleoyl-2-acetylglycerol effectively stimulates insulin secretion . 1-Oleoyl-2-acetylglycerol can be used in research on monocytic leukemia .
Cat. No.: HY-P703234
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KAT6A; Histone Acetyltransferase KAT6A; Prev. MYST3; Zinc Finger Protein 220; Prev. RUNXBP2; ZC2HC6A; Prev. ZNF220; MYST-3; MOZ; Runt-Related Transcription Factor-Binding Protein 2; monocytic leukemia Zinc Finger Protein; Histone Acetyltransferase MYST3;
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
