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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
455 Results for "
targeted nanoparticles
" in MedChemExpress (MCE) Product Catalog:
Products (455)
455 Results for "targeted nanoparticles" in MCE Product Catalog:
3
3 Cited Publications
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery .
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AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity .
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AS 1411 (AGRO-100) sodium is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 sodium inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 sodium reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. S 1411 sodium works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. S 1411 sodium-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity
2
2 Cited Publications
Cat. No.: HY-P1848
CAS No.: 395069-86-0
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1
1 Cited Publications
CL4H6 is a pH-sensitive cationic lipid. CL4H6 is the main component of lipid nanoparticles (LNPs), which can be used to target and deliver siRNA, and induces a potent gene-silencing response .
1
1 Cited Publications
Cat. No.: HY-Y0395
CAS No.: 25487-66-5
1
1 Cited Publications
Cat. No.: HY-W583869
CAS No.: 6418-95-7
Synonyms: 1-Stearoyl-2-Oleoyl-sn-glycero-3-PE; 18:0-18:1 PE; PE(18:0/18:1)
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1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine is a phospholipids that contains stearic acid and oleic acid at the sn-1 and sn-2 positions, respectively. It has been used in the generation of lipid nanoparticles (LNPs) for in vitro delivery of mRNA or nuclear-targeted plasmid DNA.
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1
1 Cited Publications
Cat. No.: HY-140739A
CAS No.: 185844-12-6
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DSPE-PEG2000-Maleimide free acid is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide free acid utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide free acid covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide free acid can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration .
1
18:0 mPEG2000 PE (DSPE-mPEG2000) ammonium is a kind of amphiphilic polymer material. 18:0 mPEG2000 PE ammonium combines hydrophobic lipids (18:0 stearic acid chain) with hydrophilic polyethylene glycol (2 kDa) chains to form amphiphilic molecules, which are used to construct stable liposomes/nanoparticles, thereby enhancing drug delivery, prolonging circulation time, and achieving targeted effects through its functional terminal groups (usually biotin or carboxyl groups). 18:0 mPEG2000 PE ammonium can be used for the research of nanoprobes and drug delivery .
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .
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1 Cited Publications
Cat. No.: HY-112624I
CAS No.: 9004-54-0
Synonyms: Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)
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1 Cited Publications
Cat. No.: HY-148775B
Purity: ≥95.0%
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PLGA-PEG-MAL (20KDA-5.0KDA, LA:GA RATIO 40:60) is a biodegradable amphipathic polymeric nanocarrier of poly (lactic-co-glycolic acid)-block-poly (ethylene glycol) (PLGA-PEG-Mal) that allows covalent modification of functional molecules. PLGA-PEG-MAL (20KDA-5.0KDA, LA:GA RATIO 40:60) modified with Angiopep-2 can cross the blood-brain barrier and exhibits targeting selectivity for glioblastoma cells. PLGA-PEG-MAL (20KDA-5.0KDA, LA:GA RATIO 40:60) can capture tumor-derived protein antigens, and exerts immunomodulatory effects when conjugated with anti-OX40 antibody; when used in combination with A2-CL/Dbait nanoparticles and radiotherapy, it prolongs survival time and reduces tumor volume in glioblastoma mouse models. PLGA-PEG-MAL (20KDA-5.0KDA, LA:GA RATIO 40:60) can be used for studies related to bacterial wound infections and glioblastoma .
Synonyms: mPEG5000-SC; mPEG5000-Succinimidyl ester
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m-PEG5000-NHS ester (mPEG5000-SC; mPEG5000-Succinimidyl ester) is a pegylation reagent that targets the primary amino groups of branched polyethyleneimine on gold nanoparticles. m-PEG1000-NHS ester covalently links its PEG moiety to target amino groups via amine-mediated coupling chemistry. m-PEG1000-NHS ester helps improve the biocompatibility of modified gold nanoparticles used as CT contrast agents and prolongs their blood circulation time.
Cat. No.: HY-W011696
CAS No.: 112-90-3
Synonyms: cis-1-Amino-9-octadecene, 80-90%
Cat. No.: HY-174264
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DMG-PEG2000-NHS is a polyethylene glycol lipid with a molecular weight of 2000, which can be used to construct novel drug delivery systems that confer mucoadhesive and cell-targeting capabilities to lipid nanoparticles .
Cat. No.: HY-P5287
CAS No.: 393781-65-2
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cRGDfK-thioacetyl ester is a selective αvβ3 integrin-binding peptide that mediates cellular uptake through integrins overexpressed on tumor cells. cRGDfK-thioacetyl ester is conjugated to maleimide-functionalized PLGA nanoparticles, which enhances nanoparticle uptake and improves accumulation and retention. cRGDfK-thioacetyl ester can be used in research related to tumor-targeted nanodelivery and cancer-targeted imaging .
Cat. No.: HY-P3436
CAS No.: 771479-86-8
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Cat. No.: HY-W440986
CAS No.: 321595-13-5
Synonyms: DSPS sodium
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Distearoylphosphatidylserine (DSPS) sodium is an anionic phospholipid. Distearoylphosphatidylserine sodium possesses both a hydrophilic head group and a hydrophobic tail, enabling it to self-assemble in aqueous phases to form stable lipid bilayer structures. Distearoylphosphatidylserine sodium promotes uptake by phagocytes and participates in the endosomal escape of lipid nanoparticles (LNPs) within cells. Distearoylphosphatidylserine sodium can be used in research on the construction of lipid nanoparticles for targeted delivery of siRNA (for immune or anti-inflammatory therapy), as well as the preparation of ultrasound contrast microbubbles for molecular imaging .
Synonyms: mPEG10000-SC; mPEG10000-Succinimidyl ester
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
