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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
ATP leakage
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "ATP leakage" in MCE Product Catalog:
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Telavancin hydrochloride (TD-6424 hydrochloride) is a bactericidal agent that exhibits inhibitory activity against Staphylococcus aureus. Telavancin hydrochloride inhibits bacterial cell wall synthesis by binding to the lipid-linked N-acetylglucosamine-N-muramyl pentapeptide (with a D-Ala-D-Ala terminus), a peptidoglycan precursor, and blocks the transglycosylation and transpeptidation steps. Telavancin hydrochloride disrupts bacterial membrane barrier function, induces dissipation of bacterial membrane potential, and causes leakage of cytoplasmic ATP and potassium ions, with its activity restricted exclusively to bacterial membranes. Telavancin hydrochloride can be used in research on bacterial infections, central venous catheter-related bloodstream infections, and Gram-positive bacterial pneumonia .
Cat. No.: HY-W099729
CAS No.: 70445-33-9
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Ethylhexylglycerin is an antibacterial agent. Ethylhexylglycerin can induce allergic contact dermatitis. Ethylhexylglycerin inhibits the growth of various bacteria, disrupts the integrity of bacterial cell membranes, and causes proton leakage, reduced ATP levels, morphological abnormalities, and DNA aggregation. Ethylhexylglycerin serves as a skin conditioning agent, deodorant active ingredient, and preservative synergist. Ethylhexylglycerin is applicable to research related to contact dermatitis and bacterial infections .
Cat. No.: HY-N125722
CAS No.: 33538-71-5
Synonyms: Aabomycin A1
Cat. No.: HY-N6663
CAS No.: 13466-78-9
Cat. No.: HY-P10696
CAS No.: 2154327-48-5
C16G2 is a specifically targeted antimicrobial peptide (STAMP) that targets the cariogenic oral pathogen (Streptococcus mutans). C16G2 links a CSP-derived targeting domain to the bactericidal domain G2 via glycine, thereby selectively binding to and disrupting the cell membrane of S. mutans, leading to the leakage of intracellular contents such as ATP and loss of membrane potential, ultimately causing cell death. C16G2 can be used for research on dental caries .
Cat. No.: HY-139467
CAS No.: 1072100-81-2
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PF-04577806 is a potent, selective and ATP competitive PKC inhibitor. PF-04577806 shows potent inhibitory activity towards PKCα, PKCβI, PKCβII, PKCγ, and PKCθ with IC50s of 2.4 nM, 8.1 nM, 6.9 nM, 45.9 nM, and 29.5 nM, respectively. PF-04577806 can reverse retinal vascular leakage in diabetic rats .
Cat. No.: HY-P10696A
C16G2 TFA is a specifically targeted antimicrobial peptide (STAMP) that targets the cariogenic oral pathogen (Streptococcus mutans). C16G2 TFA links a CSP-derived targeting domain to the bactericidal domain G2 via glycine, thereby selectively binding to and disrupting the cell membrane of S. mutans, leading to the leakage of intracellular contents such as ATP and loss of membrane potential, ultimately causing cell death. C16G2 TFA can be used for research on dental caries .
Cat. No.: HY-W856819
CAS No.: 469-22-7
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Eseroline is a potent μ-opioid receptor agonist, which is the hydrolytic metabolite of Physostigmine (HY-N6608). Eseroline is a selective and competitive acetylcholinesterase (AChE) inhibitor, with its Ki values for AChE and BuChE being 0.1 μM and 200 μM respectively. Eseroline has nicotinic acetylcholine receptor allosteric enhancing ligand (nAChR-APL) activity, meaning it does not activate the receptor but significantly enhances the signal transduction of Ach triggered by the receptor. Eseroline is neurotoxic, causing cell membrane damage (LDH leakage) and energy metabolism collapse (ATP depletion). Eseroline can be used for the study of Alzheimer's disease .
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9,10-Dichlorostearic acid is a chlorinated stearic acid with antimutagenic properties. 9,10-Dichlorostearic acid can cause membrane damage by inducing leakage of adenosine triphosphate (ATP) from mammalian tumour cells in vitro .
Cat. No.: HY-N6663R
CAS No.: 13466-78-9
Cat. No.: HY-179593
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GM47-1, a naphthalene scaffold derivative, is a potent mycolic acid transporter MmpL3 inhibitor exhibiting potent bactericidal activity against Mycobacterium abscessus (Mabs) with an MIC50 of 2.1 µM. GM47-1 targets MmpL3, disrupts cell wall integrity, and induces ATP leakage and uncouples respiration. GM47-1 can be used for Mycobacterium abscessus pulmonary disease (Mabs-PD) research .
Cat. No.: HY-187605
CAS No.: 113476-61-2
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Cat. No.: HY-189732
CAS No.: 2883235-38-7
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Anti-MRSA agent 46 is a Methicillin-resistant Staphylococcus aureus (MRSA) membrane-disrupting agent. Anti-MRSA agent 46 disrupts bacterial membrane integrity and morphology, dissipates membrane potential, increases membrane permeability, and perturbs glycerophospholipid metabolism. Anti-MRSA agent 46 induces intracellular DNA and protein leakage, reduces intracellular ATP levels, and induces reactive oxygen species (ROS) production. Anti-MRSA agent 46 disrupts MRSA biofilms, reduces bacterial burden, exhibits a low propensity for resistance, and retains antibacterial activity after plasma exposure, and improves survival in a mouse sepsis infection model. Anti-MRSA agent 46 can be used for research related to MRSA infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
