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Phospholipid Sensing Drives Viral Replication Complex Assembly

Multiprotein Complexes and Disease Cellular Stress Intercellular Communication & Diseases Proteostasis

Phospholipid sensing in viral replication complex assembly describes the capacity of viral replication proteins to exploit the abundance, identity, and metabolism of host membrane lipids so that new viral replicase complexes form only in a membrane environment that supports RNA synthesis. Work on tombusviruses established a direct sensing model: the p33 replication protein interacts with the Opi1p FFAT-domain phospholipid sensor and the Scs2p VAP protein, relieving repression of phospholipid-biosynthesis genes and increasing cellular phospholipids; deleting OPI1 stimulates Tomato bushy stunt virus (TBSV) RNA accumulation, whereas blocking phospholipid biosynthesis reduces replicase activity and disrupts replication-protein localization. Earlier studies had already placed p33, p92 polymerase, and viral RNA at peroxisomal membranes and showed that their interaction domains are essential for productive assembly. p33 recruits viral RNA and p92 into multimolecular complexes at these membranes, linking lipid availability to membrane targeting and replicase assembly.

The recurrence of this strategy across plant and animal RNA viruses has made membrane lipid remodeling a sustained research focus. More recent work has broadened this framework into a general view of positive-strand RNA virus replication organelles as lipid- and protein-rich membrane compartments whose biogenesis is actively coordinated with host endomembrane resources. Mechanistically, viral replication proteins convert membrane lipid composition into assembly cues through protein-lipid and protein-protein interactions. In TBSV, p33 binds host lipid sensors, while eEF1A binds both p33 and viral RNA and is present in purified replicase complexes, providing a host-factor layer that couples template recruitment and replicase stability to complex formation[1][2][3][4][5].

In hepatitis C virus (HCV), NS5A stimulates PI4KIIIα-dependent phosphatidylinositol 4-phosphate (PI4P) production; PI4KIIIα silencing causes aberrant aggregation of NS5A, NS5B, and NS3, showing that PI4P production influences replication-complex organization. NS5A also binds PI (4,5) P2 through its N-terminal amphipathic helix, and this interaction stabilizes NS5A association with TBC1D20 and is required for HCV RNA replication. A second HCV pathway uses choline kinase-α to bridge NS5A and PI4KIIIα, increasing kinase activity and driving the ternary complex toward ER-derived PI4P-enriched membranes. In rhinovirus, replication requires a PI4P-cholesterol counter-current involving PI4K3β, OSBP1, Sac1, and PITPβ at ER-Golgi membrane-contact sites, whereas Aichi virus proteins recruit ACBD3 and PI4KB to stimulate PI4P synthesis and functional replication-complex formation[2][6][7][8][9][10][11].

These mechanisms make phospholipid sensing a practical entry point for antiviral discovery and a tractable system for basic studies of membrane-contact sites, lipid transfer, organelle remodeling, and viral polymerase assembly. PI4K-centered pathways are especially attractive because several unrelated viruses depend on host-controlled phosphoinositide pools: HCV requires PI4KA-driven PI4P, rhinovirus uses PI4P-cholesterol exchange, and Aichi virus requires ACBD3-PI4KB complexes. The HCV replication organelle also uses VAP proteins, OSBP, and Nir2 to sustain phosphoinositide flow, illustrating how lipid synthesis and lipid transfer cooperate during continued replication. Yet the literature also defines major gaps.

Tombusvirus work shows that viruses can reorganize endomembrane traffic and use alternative membrane environments, indicating that lipid requirements may be adaptable rather than fixed. Future work therefore needs to resolve which lipid species act as direct molecular ligands, which merely create permissive membrane biophysics, how lipid-sensing thresholds change over infection, and which host lipid nodes can be inhibited without unacceptable disruption of normal membrane physiology. Comparative mapping of virus-specific lipid dependencies should clarify where broad-spectrum host-directed antivirals are feasible and where selective disruption of viral protein-lipid interfaces, such as NS5A-phosphoinositide binding, offers a narrower therapeutic strategy[5][7][8][10][11][12].

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Cat. No. Product Name Information Application Publication
HY-L009 Kinase Inhibitor Library
Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders. Kinase inhibitor library designed by MCE contains 4,033 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

Signaling Pathway Targeting Libraries

139
HY-D1048 DiR
DiR is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins.
Fluorescent Dye  
Cancer  
133
HY-L027 Antiviral Compound Library
Viruses are much simpler organisms than bacteria, and they are made from protein substances and nucleic acid. Despite the fact that the exact mechanism of infection is extremely specific to each type of virus, the general scheme of infection can be represented in the following manner: A virus is absorbed at the surface of a host cell and then permeates through the membrane, where it releases nucleic acid from its protein protection. Then the viral nucleic acid begins to replicate, and transcription of the viral genome takes place either in the cytoplasm, or in the nucleus of the host cell. As a result of these events, a large amount of viral nucleic acid and protein are made to make new generations of virions. Therefore, one mechanism of action of antiviral drugs is to interfere with the ability of a virus to get into a target cell. A second mechanism of action is to target the processes that synthesize virus components after a virus invades a cell, such as nucleotide or nucleoside analogs. MCE designs a unique collection of 1,241 anti-virus compounds that target several viruses, including SARS-CoV, HBV, HCV, HIV, HSV and Influenza Virus. It’s an effective tool for anti-virus drug discovery.

Disease Focused Libraries

119
HY-L004 Cell Cycle/DNA Damage Compound Library
DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair. MCE owns a unique collection of 3,557 cell cycle/DNA damage-related compounds which can be used in the research of the same.

Signaling Pathway Targeting Libraries

107
HY-L012 Metabolism/Protease Compound Library
Metabolism is the set of life-sustaining chemical reactions in organisms. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. Acting as catalysts, enzymes are crucial to metabolism - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction. Proteases are used throughout an organism for various metabolic processes. Proteases control a great variety of physiological processes that are critical for life, including the immune response, cell cycle, cell death, wound healing, food digestion, and protein and organelle recycling. Imbalances in metabolic activities have been found to be critical in a number of pathologies, such as cardiovascular diseases, inflammation, cancer, and neurodegenerative diseases. MCE designs a unique collection of 7,420 Metabolism/Protease-related small molecules that act as a useful tool for drug discovery of metabolism-related diseases.

Signaling Pathway Targeting Libraries

104
HY-L044 Nucleotide Compound Library
Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications. MCE offers a unique collection of 592 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

Structure Classified Libraries

104
HY-L091 Lipid Metabolism Compound Library
Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes, and based on this can be broadly classified into five categories: fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids and sphingolipids. Lipids play a crucial role in different metabolic pathways and cellular functions. Lipid metabolism is an important physiological process that is related to nutrient adjustment, hormone regulation, and homeostasis. Lipid metabolism dysregulation is associated with many diseases such as obesity, liver disease, aging and inflammation. MCE offers a unique collection of 1,036 compounds related to lipid metabolism, which target relevant targets in the process of lipid metabolism, such as ATGL, MAGL, FAAH, acetyl-Coa Carboxylase, FASN, etc. MCE lipid metabolism compound library is a useful tool for research lipid metabolism and drug discovery of diseases related to lipid metabolism.

Signaling Pathway Targeting Libraries

99
HY-L940 Antiviral Lead-like compound library
Owing to the widespread transmission and frequent mutation of viral diseases, as well as the continuous emergence of new viruses and drug-resistant strains, antiviral drug development is facing increasingly stringent requirements. Antiviral compound libraries serve as important tools for drug screening, mechanism research and development, enabling the discovery and investigation of various antiviral drugs. These compounds act through diverse antiviral mechanisms, targeting key steps in viral replication, assembly and invasion. They exert antiviral effects by inhibiting viral nucleic acid synthesis, blocking viral protein processing, and preventing viral binding to host cells. This library covers various types of antiviral compounds, including nucleosides, non-nucleosides, protease inhibitors and integrase inhibitors. It supports research on influenza virus, herpes virus, hepatitis virus, emerging respiratory viruses and other pathogens, and enables high-throughput screening of novel antiviral candidates to rapidly identify potential active compounds against diverse viruses. It also facilitates mechanistic studies to elucidate drug-target interactions and viral resistance mechanisms, and supports the screening of effective compounds against mutant strains for research on viral variation and drug resistance. This antiviral library consists of 6,804 compounds with lead-like physicochemical properties. The core sources of the compounds include analogs of known antiviral molecues with a similarity score ≥ 0.6. MCE has collected more than 1450 antiviral molecules. As a small-molecule collection with both activity potential and structural modifiability, it provides strong support for antiviral drug research and development.

Focused and target libraries

99
HY-L029 Autophagy Compound Library
Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. MCE provides a unique collection of 2,100 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Signaling Pathway Targeting Libraries

98
HY-L034 Anti-Aging Compound Library
Aging is a complex biological process characterized by functional decline of tissues and organs, structural degeneration, and reduced adaptability and resistance, all of which contribute to an increase in morbidity and mortality caused by multiple chronic diseases, such as Alzheimer's disease, cancer, and diabetes. Many theories, which fall into two main categories: programmed and error theories, have been proposed to explain the process of aging, but neither of them appears to be fully satisfactory. The programmed theories imply that aging relies on specific gene regulation, and the error theories emphasize the internal and environmental damages accumulated to living organisms. The damage theories proposed the nine hallmarks that were generally considered to contribute to the aging process: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. MCE Anti-Aging Compound Library contains 7,843 compounds, mainly targeting Sirtuin, mTOR, IGF-1R, AMPK, p53, Telomerase, Mitophagy, Mitochondrial Metabolism, COX, Cytochrome P450, Oxidase, etc. This library is a useful tool for anti-aging research.

Disease Focused Libraries

98
HY-L043 Lipid Compound Library
Lipids are a diverse and ubiquitous group of compounds which have many key biological functions, such as acting as structural components of cell membranes, serving as energy storage sources and participating in signaling pathways. Several studies suggest that bioactive lipids have effects on the treatment of some mental illnesses and metabolic syndrome. For example, DHA and EPA are important for monoaminergic neurotransmission, brain development and synaptic functioning, and are also correlated with a reduced risk of cancer and cardiovascular disease in clinical and animal studies. MCE supplies a unique collection of 2,071 lipid and lipid derivative related compounds including triglycerides, phospholipids, sphingolipids, steroids and their structural analogues or derivatives. MCE lipid compound library can be used for research in bioactive lipids, and high throughput screening (HTS) and high content screening (HCS).

Structure Classified Libraries

98
HY-L059 Pyroptosis Compound Library
Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc. MCE designs a unique collection of 2,069 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

Signaling Pathway Targeting Libraries

98
HY-L060 Cytoskeleton Compound Library
The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases. MCE designs a unique collection of 2,345 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Signaling Pathway Targeting Libraries

98
HY-L113 Antiviral Traditional Chinese Medicine Active Compound Library
Increasing research have shown that Traditional Chinese Medicine (TCM) possess antiviral activities against various viral strains, such as herpes simplex virus, influenza virus, hepatitis B and C viruses, and SARS-CoV. To date, dozens of Chinese herbs and hundreds of natural TCM ingredients have been reported to exhibit good antiviral activities. Active components from TCM are one of the important sources for antiviral drugs discovery. MCE designs a unique collection of 239 active compounds of antiviral Chinese Herbal Medicines. MCE Antiviral Traditional Chinese Medicine Active Compound Library is a useful tool for discovery antiviral drugs from TCM.

Disease Focused Libraries Traditional Chinese Medicine Libraries

98
HY-L126 Nuclear Receptor Compound Library
Nuclear receptors (NR) are proteins found in cells that sense androgen and thyroid hormones and certain other molecules. They are ligand-activated transcription factors that participate in many aspects of human physiology and pathology, and regulate the expression of various important genes. Nuclear receptors have become one of the main targets in the development of new drug strategies, providing a unique type of receptors for studying a variety of human diseases, such as breast cancers, skin disorders and diabetes. 13% of U.S. Food and Drug Administration (FDA) approved drugs target nuclear receptors. MCE supplies a unique collection of 1,097 nuclear receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on nuclear receptor. MCE Nuclear Receptor Library is a useful tool for drugs research related to cancer, skin disease and diabetes.

Signaling Pathway Targeting Libraries

98
HY-L149 Membrane Protein-targeted Compound Library
A membrane protein is a protein molecule that is attached to or associated with the membrane of a cell or an organelle. Membrane proteins can be classified into two groups based on how the protein is associated with the membrane: integral membrane proteins and peripheral membrane proteins. In humans, about 30% genome encodes membrane proteins. Membrane proteins perform a variety of functions vital to the survival of organisms, for example, signal transduction, molecules or ion transportation, enzymatic catalysis, and intercellular communication. Membrane proteins also play important roles in drug discovery. As reported, more than 60% of current drug targets are membrane proteins. MCE supplies a unique collection of 8,052 compounds targeting a variety of membrane proteins. MCE Membrane Protein-targeted Compound Library can be used for membrane protein-focused screening and drug discovery.

Signaling Pathway Targeting Libraries

98
HY-L009M Kinase Inhibitor Library Mini
Kinases is a class of enzymes that adds chemicals called phosphates to other molecules, such as sugars or proteins. Protein phosphorylation serves as a critical regulatory mechanism for numerous cellular processes including cell division, metabolism, and signal transduction, with approximately 50% of cellular functions in humans being regulated by kinase activity. In drug discovery, kinases represent a major category of therapeutic targets, and kinase inhibitors constitute an important class of pharmaceuticals that block the activity of specific disease-associated enzymes, particularly in cancer and inflammatory disorders. Small molecule kinase inhibitors represent one of the fastest-growing drug categories, having received U.S. Food and Drug Administration (FDA) approval for both oncological and non-oncological indications. As of September 2023, over 70 FDA-approved small molecule kinase inhibitors are commercially available. The MCE Kinase Inhibitor Library Mini contains 271 kinase inhibitors primarily targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.), and carbohydrate kinases. This collection includes 1-3 highly specific representative compounds per target, optimized for screening of kinase-related drug targets in pharmaceutical research.

Signaling Pathway Targeting Libraries

97
HY-L045 Oxygen Sensing Compound Library
Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival. HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O2 concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation. MCE offers a unique collection of 4,368 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Signaling Pathway Targeting Libraries

97
HY-L073 Anti-Hepatitis C Virus Compound Library
Hepatitis C virus (HCV) is a hepatotropic enveloped positive- strand RNA virus (family Flaviviridae) that infects the parenchymal cells of the liver. HCV infection is a significant public health burden. Globally, an estimated 71 million people have chronic hepatitis C virus infection. A significant number of those who are chronically infected will develop cirrhosis or liver cancer. To date, there is no vaccine against HCV, and combination pegylated alpha interferon (pIFN-) and ribavirin, the main standard-of-care treatment for HCV, is effective in only a subset of patients and is associated with a wide spectrum of toxic side effects and complications. More recently, new therapeutic approaches that target essential components of the HCV life cycle have been developed, including direct-acting antiviral (DAA) that specifically block a viral enzyme or functional protein and host-targeted agents (HTA) that block interactions between host proteins and viral components that are essential to the viral life cycle. However, the genetic diversity of HCV viruses and the stage of liver disease (i.e., cirrhosis) are revealing themselves as obstacles for effective, pan-genotypic treatments. There still exists a need for the discovery and development of new HCV inhibitors. In particular, since the future of HCV therapy will likely consist of a cocktail approach using multiple inhibitors that target different steps of infection, new antivirals targeting all steps of the viral infection cycle. MCE offers a unique collection of 401 compounds with identified and potential anti-HCV activity. MCE Anti- Hepatitis C Virus Compound Library is a useful tool for discovery new anti-HCV drugs and other anti-infection research.

Disease Focused Libraries

97
HY-L087 Anti-Obesity Compound Library
Obesity is widely recognized as the largest and fastest growing public health problem and is associated with numerous chronic disorders including osteoarthritis, obstructive sleep apnea, gallstones, fatty liver disease, reproductive and gastrointestinal cancers, dyslipidemia, hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke, etc. Although obesity has long been associated with serious health issues, it has only recently been regarded as a disease in the sense of being a specific target for medical therapy. Obesity may be viewed as the dysregulation of two physiological functions, appetite regulation and energy metabolism, which combine to create disordered energy balance. Consequently, developing obesity treatments that target novel pathways is a growing focus for both biopharmaceutical industries. MCE Anti-Obesity Compound Library owns a unique collection of 3,784 compounds, which mainly target signaling pathway of controlling appetite, fatty acid metabolism and energy expenditure, etc. This library is a useful tool for discovery anti-obesity drugs.

Disease Focused Libraries

97
HY-L214 Liposome Library
Liposomes are spherical or multilayered spherical vesicles formed by the self-assembly of diacyl chain phospholipids (lipid bilayers) in aqueous solutions, which can be made from natural or synthetic phospholipids and exhibit good biocompatibility and low toxicity. They can serve as delivery carriers for various bioactive substances (such as drugs, proteins, nucleic acids, etc.) and are widely used in biomedical and chemical research. The main advantages of liposomes include 1) Protective effect: Their bilayer structure can protect encapsulated molecules from enzymatic degradation, oxidation, and other influences, extending stability and activity; 2) Active targeting: Surface modifications enable active targeting, enhancing the concentration of drugs or molecules in specific tissues or cells; 3) Customizability: The composition and structure of liposomes can be adjusted according to needs, such as altering phospholipid types or adding targeting ligands. These properties make liposomes highly valuable in developing novel drug delivery systems, serving as nucleic acid carriers for gene transfection, studying cellular uptake mechanisms and drug release kinetics, as well as developing functional food additives to improve the bioavailability of nutritional components. MCE contains 130 liposome compounds, which is a good tool for drug delivery-related studies.
97
HY-L264 DNA Damage Repair Inhibitor Library
DNA damage response (DDR) is a fundamental mechanism for maintaining genomic stability. When DNA damage occurs, such as single- or double-strand breaks or replication fork stalling, cells rely on key proteins including ATM, ATR, PARP, and DNA-PK to sense the damage and transmit signals, thereby regulating DNA repair, cell-cycle arrest, and cell death. Inhibition of specific DNA repair or checkpoint pathways can prevent tumor cells from effectively repairing accumulated DNA damage, ultimately leading to tumor cell death. MCE DNA Damage Repair Inhibitor Library contains 1,561 compounds, focusing on key nodes involved in DNA damage response and DNA repair. The library covers multiple DNA repair and cell-cycle checkpoint pathways, providing a systematic compound screening tool for research on precision oncology, synthetic lethality, drug resistance mechanisms, and chemo- or radiosensitization.
97
HY-D0083 DiI
DiI is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins.
Fluorescent Dye  
66
HY-D3305 DiD 4-chlorobenzenesulfonate
DiD is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins (Ex/Em = 633/665 nm) .
Fluorescent Dye  
50
HY-W559684 DiD
DiD is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins (Ex/Em = 633/665 nm) .
Fluorescent Dye  
50
HY-D1028 DiD perchlorate
DiD is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins (Ex/Em = 633/665 nm).
Fluorescent Dye  
50
HY-D0969 DiO
DiO is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins.
Fluorescent Dye  
33
HY-P80450 GPX4 Antibody (YA399)
GPX4 Antibody (YA399) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPX4.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

25
HY-N0158 Oxymatrine
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection.
TGF-beta/Smad   Apoptosis  
Colorectal Cancer   Prostate Cancer   Viral Infection   Digestive System Inflammation   Lung Fibrosis  
23
HY-P0025 NIM811
NIM811 ((Melle-4)cyclosporin; SDZ NIM811) is an orally bioavailable mitochondrial permeability transition and cyclophilin dual inhibitor, which exhibits potent in vitro activity against hepatitis C virus (HCV) .
Cyclophilin   Mitochondrial Metabolism   HCV  
Infection   Inflammation or Immune System Disease  
19
HY-12559 Alisporivir
Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
Cyclophilin   HCV  
17
HY-100198 PI4KIIIbeta-IN-10
PI4KIIIbeta-IN-10 is a potent PI4KIIIβ inhibitor with an IC50 of 3.6 nM.
PI4K   PI3K  
Infection  
16
HY-N1067 Xanthohumol
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).
COX   Acyltransferase   Apoptosis   HSV   CMV   Influenza Virus  
Colorectal Cancer   Prostate Cancer   Pancreatic Cancer   Depression   Digestive System Inflammation   Arthritis   HSV Infection   Obesity  
16
HY-N0058 4,5-Dicaffeoylquinic acid
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects.
HBV   Endogenous Metabolite   Apoptosis   Glycosidase  
Digestive System Disease   Prostate Cancer   Digestive System Inflammation   Hepatitis C Virus Infection   Type 2 Diabetes  
12
HY-103489 PI-273
PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.
PI4K   Apoptosis  
Breast Cancer   Pancreatic Cancer   Digestive System Inflammation   Obesity   Lung Fibrosis  
10
HY-B2235 Lecithin
Lecithin is regarded as a safe, conventional phospholipid source. Phospholipids are reported to alter the fatty acid composition and microstructure of the membranes in animal cells.
Endogenous Metabolite  
Lipid Metabolism  
10
HY-N0638 Dendrobine
Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC50s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively. Dendrobine activates the JNK/p38/Nrf2 signaling pathway. Dendrobine exhibits antiviral, antitumor, anti-inflammatory, and neuroprotective properties.
Influenza Virus   JNK   p38 MAPK   Apoptosis   CDK   Keap1-Nrf2   SOD   Reactive Oxygen Species (ROS)  
Digestive System Disease   Lung Cancer   Breast Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer   Viral Infection   Neurodegenerative Disease   Pain   Digestive System Inflammation   Glucose Metabolism   Obesity   Lung Fibrosis  
7
HY-19798 PI4KIIIbeta-IN-9
PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.
PI4K   PI3K  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Pain   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
6
HY-101213 OSW-1
OSW-1, isolated from Ornithogalum caudatum, is a specific antagonist of ooxysterol binding protein (OSBP) and OSBP-related protein 4 (ORP4) with GI50s in the nanomolar range in human cancer lines.
Oxysterol-binding Protein-related Protein (ORP)  
6
HY-U00426 BF738735
BF738735 is a phosphatidylinositol 4-kinase III beta (PI4KIIIβ) inhibitor with an IC50 of 5.7 nM.
PI4K   Reverse Transcriptase  
Pancreatic Cancer   Viral Infection   Obesity   Lung Fibrosis  
6
HY-12046 PIK-93
PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM, and also inhibits PI3Kγ and PI3Kα with IC50 of 16 nM and 39 nM, respectively.
PI4K   PI3K   Virus Protease  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Pain   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
6
HY-P80692 GPX4 Antibody
GPX4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to GPX4.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

5
HY-108313 T-00127_HEV1
T-00127_HEV1 is a phosphatidylinositol 4-kinase III beta (PI4KB) inhibitor with an IC50 of 60 nM.
PI4K  
Infection   Pancreatic Cancer   Obesity   Lung Fibrosis  
4
HY-15005S Sofosbuvir-13C,d3
Sofosbuvir-13C,d3 is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
Isotope-Labeled Compounds   HCV  
Infection  
2
HY-N0249 Saikosaponin C
Saikosaponin C is an orally active MMP-2 inducer. Saikosaponin C induces the survival, growth, migration and capillary tube formation of endothelial cells. Saikosaponin C inhibits the early stage of hepatitis C virus infection. Saikosaponin C can be used in research related to ischemic tissue diseases, chronic kidney diseases and hepatitis C virus infection.
MMP  
Hepatitis C Virus Infection   Chronic Kidney Disease  
2
HY-125118 GSK-A1
GSK-A1 is a selective type III phosphatidylinositol 4-kinase PI4KA (PI4KIIIα) inhibitor with a pIC50 of 8.5-9.8. GSK-A1 inhibits PtdIns(4,5)P2 resynthesis with an IC50 of about 3 nM. GSK-A1 potently decreases the levels of PtdIns(4)P with a negligible effect on PtdIns(4,5)P2. GSK-A1 has the potential for anti-hepatitis C virus (HCV) research.
PI4K   HCV  
Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Viral Infection   Hepatitis C Virus Infection   Obesity   Lung Fibrosis  
2
HY-P80975 RPA32/RPA2 Antibody (YA679)
RPA32/RPA2 Antibody (YA679) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to RPA32/RPA2.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

2
HY-113308AS Taurolithocholic acid-d4 sodium
Taurolithocholic acid-d4 (sodium) is the deuterium labeled Taurolithocholic acid (sodium salt). Taurolithocholic acid sodium is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.
Isotope-Labeled Compounds   Calcium Channel   Ferroptosis   PI3K   Reactive Oxygen Species (ROS)   Akt   HBV  
Metabolic or Endocrine Disease  
1
HY-135867D NHC-diphosphate
NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV).
CHIKV   Endogenous Metabolite   Enterovirus   HCV   Topoisomerase   SARS-CoV  
Infection  
1
HY-N0620 Mulberroside C
Mulberroside C is one of the main bioactive components in white mulberry (Morus alba L.). Mulberroside C exhibits antiplatelet, antiviral and neutrophil-regulating activities, and binds to EV-A71 VP1 with a Kd value of 1.289 nM. Mulberroside C reduces the phosphorylation level of ERK, promotes the phosphorylation of IP3RI at the Ser1756 site, and decreases calcium influx and calcium mobilization. Mulberroside C inhibits the expression of P-selectin (P-selectin). Mulberroside C upregulates the cyclic nucleotide signaling pathway in human platelets. Mulberroside C binds to IL-23R, upregulates the expression of G-CSF, GM-CSF and RASGRP1, and activates the RAS/ERK signaling pathway. Mulberroside C promotes neutrophil maturation, accelerates the recovery of leukopenia, and enhances the antibacterial activity of neutrophils. Mulberroside C inhibits the replication of hepatitis C virus in replicon cells. Mulberroside C prevents the uncoating and genome release of EV-A71, and inhibits the synthesis of viral proteins and RNA. Mulberroside C can be used in studies related to thrombosis-mediated cardiovascular diseases, chemotherapy- and radiotherapy-induced leukopenia, hepatitis C virus infection, and hand, foot and mouth disease.
HCV   Enterovirus   PERK   Calcium Channel   P-selectin   HCN Channel   Ras   ERK   DNA/RNA Synthesis  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Hepatitis C Virus Infection   Staphylococcus Aureus Infection  
1
HY-N3300 Mellein
Mellein ((R)-Mellein) is an isocoumarin compound with antibacterial activity. Mellein inhibits the activity of HCV Protease, disrupts the cell wall of Xanthomonas sp., and acts as an insect trail pheromone. Mellein is applicable to research related to fungal infections, bacterial infections, and hepatitis C virus infections.

Source: Aspergillus melleus

Antibiotic   Bacterial   Fungal   HCV Protease  
Viral Infection   Bacterial Infection   Fungal Infection  
1
HY-15005S1 Sofosbuvir-d6
Sofosbuvir-d6 is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
Isotope-Labeled Compounds   HCV  
Infection  
1
HY-121584 Lycoperodine-1
Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca2+ sensing receptors (CaSR).
CaSR  
Metabolic or Endocrine Disease  
1
HY-W073074 Mesoporphyrin IX dihydrochloride
Mesoporphyrin IX (dihydrochloride) is a photosensitizer that can be used to modify liposomes. Mesoporphyrin IX (dihydrochloride) can insert into lipid vesicles and disrupt the viral membrane structure in vesicular stomatitis virus (VSV), inducing cross-linking of VSV glycoproteins, thereby inhibiting viral activity.
VSV  
Infection  
1
HY-N0093 Ancitabine hydrochloride
Ancitabine (Cyclocytidine) hydrochloride is a cytarabine derivative that inhibits viral replication. Ancitabine hydrochloride blocks vaccinia virus DNA replication, the progression of viral protein synthesis from early to late stages, and one-step growth of vaccinia virus. Ancitabine hydrochloride is applicable to research related to vaccinia virus infection, leukemia, human cytomegalovirus infection and colorectal cancer.
Autophagy   CMV   DNA/RNA Synthesis   Orthopoxvirus  
Colorectal Cancer   Viral Infection  
1
HY-N3242 Moronic acid
Moronic Acid is a triterpenoid compound, which is an orally available anti-HIV agent with anti-inflammatory activity. Moronic Acid can inhibit viral replication, with an EC50 value of <1 μg/mL. Moronic Acid can be isolated from Brazilian propolis.
HIV   Reactive Oxygen Species (ROS)   NOD-like Receptor (NLR)  
Infection   Inflammation or Immune System Disease  
1
HY-DY1013 DiR (solution)
DiR (solution) is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins.
Solvent and concentration: DMSO: 5 mM
Fluorescent Dye  
1
HY-N3519 Platycodin D3
Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC50 value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases.
HCV   Branched Chain Amino Acid Transaminase (BCAT)   Interleukin Related   NF-κB   ERK   p38 MAPK   JNK  
Hepatitis C Virus Infection   Asthma  
1
HY-106012 PI4K-IN-1
PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC50 values of 4.0/<3.7/5.0/<4.1, respectively.
PI4K   PI3K  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Pain   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
1
HY-W329357 15:0 Lyso PC
15:0 Lyso PC is a lysophosphatidylcholine (Lyso PC), a product of phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine (PC) and is involved in cell membrane remodeling and inflammatory signaling. 15:0 Lyso PC demonstrates significant lipid metabolism disturbances in the serum with ischemic heart disease (IHD) and ischemic cardiomyopathy (ICM). 15:0 Lyso PC can be used as a lipid biomarker for cardiovascular disease.
Endogenous Metabolite  
Cardiovascular Disease  
1
HY-P3008 Submandibular mucin
Submandibular mucin is a high molecular weight glycoprotein that is used as a substrate for the viral enzyme neuraminidase.
Biochemical Assay Reagents  
1
HY-P704066 MYC Protein, Human (C-His)
MYC Protein, Human (C-His) is the recombinant human-derived MYC protein, expressed by E. coli, with C-6*His tag.

Species: Human; Source: E. coli

1
HY-P74354 Capsid protein, Hepatitis B Virus (His)
Capsid proteins play a key role in the assembly of icosahedral capsids, forming T=4 and T=3 particles. Transported along microtubules to the nucleus, its phosphorylation exposes a nuclear localization signal that promotes binding to nuclear pore complexes via α and β import. Capsid protein, Hepatitis B Virus (His) is the recombinant Virus-derived Capsid protein, expressed by E. coli , with C-His labeled tag.

Species: Virus; Source: E. coli

Viral Proteins

1
HY-P73911 ICAM-1/CD54 Protein, Human (HEK293)
The ICAM-1/CD54 protein plays a crucial role in cell interactions, acting as a ligand for the leukocyte adhesion protein LFA-1. It promotes leukocyte transendothelial migration by promoting the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. ICAM-1/CD54 Protein, Human (HEK293) is the recombinant human-derived ICAM-1/CD54 protein, expressed by HEK293 , with tag free.

Species: Human; Source: HEK293

CD Antigens Receptor Proteins Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs) ICAM-1/CD54 Immunoglobulin-like Cell Adhesion Molecules

1
HY-P703942 GPX4 Protein, Human (U73C, HEK293, Flag)
GPX4 Protein, Human (U73C, HEK293, Flag) is the recombinant human-derived GPX4 protein, expressed by HEK293, with N-Flag tag.

Species: Human; Source: HEK293

1
HY-P80502 ICAM1/CD54 Antibody (YA725)
ICAM1/CD54 Antibody (YA725) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to ICAM1/CD54.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

1
HY-109025AS2 Baloxavir-d1
Baloxavir-d1 is the deuterium labeled Baloxavir (HY-109025A). Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity.
Isotope-Labeled Compounds   Influenza Virus  
Cancer   Infection  
/
HY-18719S Endoxifen-d5 (Z-isomer)
Endoxifen-d5 (Z-isomer) is the deuterated-labeled Endoxifen (Z-isomer methanesulfonate) (HY-18719H). Endoxifen-d5 Z-isomer is an orally active selective PKCβ1 inhibitor with an IC50 of 360 nM against human PKCβ1. It also acts as an estrogen receptor modulator and antiestrogen. Endoxifen-d5 Z-isomer binds to and blocks ERα, ERβ and PKCβ1, inhibits estrogen and PI3K/AKT/mTORC1 signaling pathways, suppresses the expression of genes associated with cell cycle, cell proliferation and extracellular matrix remodeling, and induces apoptosis, reactive oxygen species (ROS) production and hypoxic features. Endoxifen-d5 Z-isomer inhibits tumor growth in breast tumor and glioblastoma models, reduces bone turnover and blood lipid levels, and does not require metabolism via CYP2D6. It can be used in research related to ER+ breast cancer, invasive breast cancer, glioblastoma multiforme, type I bipolar disorder, desmoid tumor, gynecological malignancies, melanoma and hormone receptor-positive solid tumors
PKC   Estrogen Receptor/ERR   PI3K   Akt   mTOR   Apoptosis   Reactive Oxygen Species (ROS)  
Breast Cancer   Melanoma   Glioblastoma  
/
HY-103586S2 GS-441524-d
GS-441524-d is the deuterium labeled GS-441524 (HY-103586). GS-441524 is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 reduces viral RNA levels in cats. GS-441524 can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19).
Isotope-Labeled Compounds   DNA/RNA Synthesis   SARS-CoV  
Infection  
/
HY-P2502 Hepatitis Virus C NS3 Protease Inhibitor 2
Hepatitis Virus C NS3 Protease Inhibitor 2 is a product-based peptide inhibitor of hepatitis C virus (HCV) NS3 protease, with a Ki of 41 nM.
HCV Protease   HCV  
Infection  
/
HY-B1589S (±)-Carbinoxamine-d6
(±)-Carbinoxamine-d6 is the deuterium labeled (±)-Carbinoxamine (HY-B1589). (±)-Carbinoxamine is a blood-brain barrier-permeable histamine H1 receptor antagonist. (±)-Carbinoxamine blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. (±)-Carbinoxamine inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. (±)-Carbinoxamine can be used in research on allergic rhinitis, influenza, etc.
Isotope-Labeled Compounds   Influenza Virus   Histamine Receptor  
Infection   Inflammation or Immune System Disease  
/
HY-15602AS Ledipasvir-d6 hydrochloride
Ledipasvir-d6 hydrochloride is deuterated labeled Ledipasvir acetone (HY-15602A). Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
HCV   Isotope-Labeled Compounds  
Infection  
/
HY-W654247 Lamivudine-13C,d2
Lamivudine-13C,d2 is the deuterium labeled and 13C-labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS.
HBV  
Cancer   Infection  
/
HY-W754608 EIDD 1931-13C,15N2
EIDD 1931-13C,15N2 (β-D-N4-Hydroxycytidine-13C,15N2) is the 13C- and 15N-labeled EIDD 19312 (HY-125033). EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent?anti-virus agent. EIDD-1931 effectively inhibits the replication activity of?venezuelan equine encephalitis?virus (VEEV),?Chikungunya?virus (CHIKV) and?hepatitis?C virus (HCV)
Isotope-Labeled Compounds   Enterovirus   SARS-CoV   Topoisomerase   CHIKV   HCV  
Infection  
/
HY-W703632 2-(4-Isobutylphenyl)propan-3,3,3-d3-1-ol
2-(4-Isobutylphenyl)propan-3,3,3-d3-1-ol is the deuterium labeled Ibuprofen alcohol (HY-131261). Ibuprofen alcohol, a nonsteroidal antiinflammatory agent (NSAID), exhibits very little activity for acid-sensing ion channels (ASICs).
Isotope-Labeled Compounds   Drug Metabolite  
Inflammation or Immune System Disease  
/
HY-P4038 Hepatitis C Virus S5A/5B
Hepatitis C Virus S5A/5B is a synthetic peptide substrate. Hepatitis C Virus S5A/5B mimics the NS5A/5B junction of the nonstructural protein (NS), served as the substrate for the study of HCV NS3 protease activity.
HCV Protease  
Infection  
/
HY-W778649 Sarmentine-d8
Sarmentine-d8 is the deuterium labeled Sarmentine. Sarmentine is a broad-spectrum contact herbicide and PSII inhibitor, with an IC50 of 3.0 μM and a Ki of 1.5 μM against spinach, an IC50 of 1.72 μM against wild-type Amaranthus retroflexus, and an IC50 of 0.97 μM against triazine-resistant Amaranthus retroflexus. Sarmentine competitively binds to the QB binding site of plastoquinone on PSII, thereby blocking photosynthetic electron transport. Sarmentine inhibits enoyl-ACP reductase in Arabidopsis thaliana by targeting the early fatty acid synthesis process, with an IC50 of 18.3 μM. Sarmentine induces light-independent loss of plasma membrane integrity and electrolyte leakage. Sarmentine also exhibits antiplasmodial, antimycobacterial, antituberculous, and antiplatelet aggregation activities.
Isotope-Labeled Compounds   Herbicide   Photosystem II  
/
HY-D1259 NEP
NEP (VDP-green (NEP)) is a turn-on fluorescent probe based on the intramolecular charge transfer (ICT) mechanism for sensing vicinal dithiol-containing proteins (VDPs). NEP exhibits high selectivity toward VDPs in live cells and in vivo and displays a strong green fluorescence signal (λex/λem=430/535 nm). NEP has the potential for parkinsonism.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-167911S Cidofovir-13C,15N2 disodium
Cidofovir-13C,15N2 disodium (GS 0504-13C,15N2 disodium) is the 13C- and 15N-labeled Cidofovir disodium (HY-167911). Cidofovir sodium is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir sodium inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir sodium induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir sodium also has anti-orthopoxvirus and anti-variola activities.
Isotope-Labeled Compounds   CMV   Endogenous Metabolite   DNA/RNA Synthesis   Apoptosis   Orthopoxvirus  
Cancer   Infection  
/
HY-172166B TRITC-lysine-dextran (MW 70kDa)
TRITC-lysine-dextran (MW 70kDa) is a fluorescent label prepared by the conjugation of TRITC (HY-D0791), lysine and dextran. TRITC-lysine-dextran (MW 70kDa) serves multiple functions as an axonal tracer, non-viral nanocarrier and fixable fluorescent clonal marker. TRITC-lysine-dextran (MW 70kDa) undergoes anterograde and retrograde transport within axons of sensory neurons, and acts as a non-viral delivery system to precisely deliver biomolecules to neurons. TRITC-lysine-dextran (MW 70kDa) remains stably retained during histological preparation, thereby supporting continuous observation in live or fixed samples.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-137697 ddCTP
ddCTP is a type of chain-terminating deoxynucleotide. ddCTP can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication.
Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis   HIV Protease   HIV   Drug Metabolite  
Viral Infection  
/
HY-P4031 HCV Peptide (131-140)
HCV Peptide (131-140) is a peptide. HCV Peptide (131-140) can be used for the research of hepatitis C virus (HCV) .
HCV  
Infection   Inflammation or Immune System Disease  
/
HY-P10105 TCL1(10-24)
TCL1(10-24) is a encompassing the betaA strand of human TCL1. TCL1(10-24) is a Akt inhibitor. TCL1(10-24) interacts with the Akt PH domain prevented phosphoinositide binding and hence inhibits membrane translocation and activation of Akt. TCL1(10-24) inhibits cellular proliferation and anti-apoptosis. TCL1(10-24) has tumor growth in vivo.
Akt   Apoptosis  
/
HY-P11668 Gosicalcetide
Gosicalcetide is a calcium sensing receptor (CaSR) agonist.
CaSR  
Neurological, Eye or Ear Disease  
/
HY-D2990 KSA01
KSA01 is a two-dimensional fluorescent probe. KSA01 can detect SA-β-gal activity and sense lysosomal pH. KSA01 can accurately distinguish cellular aging from other pathological states with high expression of β-gal.
Fluorescent Dye  
/
HY-P10653 C5A
C5A is a microbicidal peptide, anti-hepatitis C virus (HCV), and anti-HIV agent. C5A disrupts the membrane integrity of the HIV virion as well as the integrity of the conical capsid core that surrounds the viral genome. C5A inhibits in vitro infectivity of a broad range of primary HIV isolates in various primary target cells. C5A protects mice against vaginal and rectal HIV challenges.
HCV   HIV  
Infection  
/
HY-P5807 Cn2 toxin
Cn2 toxin is aβ- toxoins. Cn2 toxin can bind to the voltage sensing domain of voltage gated sodium channels (Nav) .
Sodium Channel  
Neurological, Eye or Ear Disease  
/
HY-113209S2 8-Isoprostaglandin F2α-13C5
8-Isoprostaglandin F2α-13C5 is 13C labeled 8-Isoprostaglandin F2α (HY-113209). 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.
Endogenous Metabolite   Isotope-Labeled Compounds  
/
HY-W676876 Oxynitidine
Oxynitidine is an HBV inhibitor (ID50=30.8 µg/mL), which can effectively inhibit the DNA replication activity of HBV. Oxynitidine can be used in the study of viral infections.
HBV  
Infection  
/
HY-W008351S L-Ribose-13C
L-Ribose-13C is the 13C-labeled L-Ribose (HY-W008351). L-Ribose is the enantiomer of D-ribose (HY-113375). L-Ribose replaces D-ribose to synthesize L-ribonucleic acid in cells, leading to erroneous gene transcription. L-Ribose serves as a starting material for L-nucleoside analogs, glycoconjugates and oligonucleotides. L-Ribose can be used in research related to hepatitis B virus infection, hepatitis C virus infection, hepatitis D virus infection, Epstein-Barr virus infection and cytomegalovirus infection.
Isotope-Labeled Compounds   Drug Intermediate   Drug Isomer  
Cytomegalovirus Infection   Hepatitis B Virus Infection   Hepatitis C Virus Infection  
/
HY-P99526 Vapaliximab
Vapaliximab (2D10) is a monoclonal antibody against human VAP-1.

Species: Human

VAP-1  
Inflammation or Immune System Disease  
/
HY-N15914 14:0 PE-DTPA pentaammonium
14:0 PE-DTPA pentaammonium, a phospholipid, is a chelator.
Biochemical Assay Reagents  
/
HY-P991445 REGN3051
REGN3051 is a human IgG1 monoclonal antibody (mAb) targeting MERS CoV. REGN3051 reduces viral titers in the lungs of mice expressing human DPP4. REGN3051 decreases lung disease severity and viral replication in marmosets inoculated with MERS-CoV. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Virus

SARS-CoV  
Infection  
/
HY-P4030 Herpes virus inhibitor 2
Herpes virus inhibitor 2 is a herpes virus inhibitor and disrupts herpes virus ribonucleotide reductase quaternary structure. Herpes virus inhibitor 2 inhibits viral replication.
HIV Protease  
Infection  
/
HY-N0158R Oxymatrine (Standard)
Oxymatrine (Standard) is the analytical standard of Oxymatrine. This product is intended for research and analytical applications. Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection.
Reference Standards   TGF-beta/Smad   Apoptosis  
Cancer   Infection   Inflammation or Immune System Disease  
/
HY-146947S D-Myo-phosphatidylinositol 4-phosphate diC16-d5
D-Myo-phosphatidylinositol 4-phosphate diC16-d5 is deuterium labeled D-Myo-phosphatidylinositol 4-phosphate diC16.
Isotope-Labeled Compounds  
/
HY-139201C Poly-D-lysine hydrobromide (MW 1000-5000)
Poly-D-lysine hydrobromide (MW 1000-5000) (PDLHB (MW 1000-5000)) is a synthetic cationic polypeptide polymer commonly used as a cell adhesion promoter and surface coating molecule. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide.
CaSR  
/
HY-P11425 Dabcyl-GLRTQSFS-EDANS
Dabcyl-GLRTQSFS-EDANS is a fluorogenic peptide substrate. Dabcyl-GLRTQSFS-EDANS can be used to measure the enzymatic activities of Hepatitis A Virus 3C proteinase.
Fluorescent Dye  
Hepatitis Virus Infection  
/
HY-113400S3 Cytidine diphosphate-d13 dilithium
Cytidine diphosphate-d13 dilithium is deuterium labeled Cytidine diphosphate (HY-113400). Cytidine diphosphate is a nucleoside diphosphate that acts as a carrier for phosphorylcholine, diacylglycerol, and other molecules during phospholipid synthesis.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-B1589AS Carbinoxamine-d6 maleate
Carbinoxamine-d6 (maleate) is the deuterium labeled Carbinoxamine maleate salt. Carbinoxamine maleate salt is a blood-brain barrier-permeable histamine H1 receptor antagonist. Carbinoxamine maleate salt blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. Carbinoxamine maleate salt inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. Carbinoxamine maleate salt can be used in research on allergic rhinitis, influenza, etc.
Isotope-Labeled Compounds   Influenza Virus   Histamine Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-W008351R L-Ribose (Standard)
L-Ribose (Standard) is the analytical standard of L-Ribose (HY-W008351). This product is intended for research and analytical applications. L-Ribose is the enantiomer of D-ribose (HY-113375). L-Ribose replaces D-ribose to synthesize L-ribonucleic acid in cells, leading to erroneous gene transcription. L-Ribose serves as a starting material for L-nucleoside analogs, glycoconjugates and oligonucleotides. L-Ribose can be used in research related to hepatitis B virus infection, hepatitis C virus infection, hepatitis D virus infection, Epstein-Barr virus infection and cytomegalovirus infection.
Reference Standards   Drug Intermediate   Drug Isomer  
Cytomegalovirus Infection   Hepatitis B Virus Infection   Hepatitis C Virus Infection  
/
HY-N15876 18:1-6:0 DNP-C11 BODIPY 505/515 TG
18:1-6:0 DNP-C11 BODIPY 505/515 TG is a fluorescently-labeled triglyceride that can be used to study the effects of phosphoinositides (Ex/Em = 495/503 nm).
Fluorescent Dye  
Metabolic or Endocrine Disease  
/
HY-DY1010 DiO (solution)
DiO (solution) is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins.
Solvent and concentration: DMSO: 5 mM
Fluorescent Dye  
/
HY-115736 Xanthosine-5'-triphosphate
Xanthosine-5'-triphosphate (5'-XTP) is a purine nucleotide that stimulates Adenylate Cyclase to induce Cyclic AMP (cAMP) (HY-B1511) biosynthesis, binds to the AL1 allosteric site of the D137N-SAMHD1 mutant to activate dNTP triphosphohydrolase activity, and stimulates P2Y/P2U purinergic receptor-coupled phosphoinositide-specific phospholipase C with Michaelis-Menten kinetics. Xanthosine-5'-triphosphate can be used for HIV-1 research.
Adenylate Cyclase  
HIV Infection  
/
HY-154644A Soy lecithin-90
Soy lecithin-90 is a mixture containing 90% phospholipids. Soy lecithin-90 can be used as an emulsifier.
Biochemical Assay Reagents  
/
HY-N19639 Tyromycin A
Tyromycin A is an inhibitor targeting Leu-AP, Cys-AP and CP-A, with an IC50 value of 25-41 μg/mL against porcine Leu-AP and an IC50 value of 60 μg/mL against bovine CP-A. Tyromycin A inhibits the hydrolytic activity of target peptidases and exhibits selective activity against Gram-positive bacteria. Tyromycin A moderately inhibits the infectivity of HCV in human hepatocytes, with an IC50 of 6.6 μM, and its inhibitory activity depends on the two maleic anhydride domains. Tyromycin A can be used in studies related to Gram-positive bacterial infections and hepatitis C virus infections.

Source: from the Kenyan WoodInhabiting Basidiomycete, Skeletocutis sp.

Carboxypeptidase   Aminopeptidase   HCV  
Hepatitis Virus Infection   Bacterial Infection  
/
HY-W555382S Pseudane IX-d4
Pseudane IX-d4 (2-Nonylquinolin-4(1H)-one-d4) is deuterium labeled Pseudane IX. Pseudane IX, a compound isolated from the leaves of Ruta angustifolia, has strong anti-HCV activity with an IC50 value of 1.4 μg/mL. Pseudane IX reduces HCV RNA replication and viral protein synthesis levels.
Isotope-Labeled Compounds   HCV  
Infection  
/
HY-166992 1,2-Dioleoyl-sn-glycero-3-PA ammonium
1,2-Dioleoyl-sn-glycero-3-PA (ammonium) is a phospholipid. Phospholipids have good biocompatibility and significant amphiphilic characteristics, making them the main and suitable dosage form or excipient in drug formulations, thereby achieving better therapeutic effects. 1,2-Dioleoyl-sn-glycero-3-PA (ammonium)can be used in drug delivery research.
Biochemical Assay Reagents  
/
HY-P10509 IE1 peptide
IE1 peptide refers to an antigenic peptide encoded by the immediate early (IE) gene of mouse cytomegalovirus (mCMV). IE1 peptide is one of the key antigenic peptides expressed during mCMV infection, plays a role in transcriptional activation in the life cycle of mCMV, and is one of the earliest genes expressed in the viral replication cycle. IE1 peptide is an important target for CD8+ T cell response and can be used to study the host immune response to mCMV infection.
CMV  
/
HY-15602S Ledipasvir-d6
Ledipasvir-d6 is the deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.62 μM.
HCV   SARS-CoV  
/
HY-P5229 IHRIC
IHRIC is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, IHRIC joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi).
Others  
/
HY-D2966 TMR-NO-BG
TMR-NO-BG is a hybrid probe (Ex/Em: 557 nm/571 nm). TMR-NO-BG covalently connects the tetramethylrhodamine (TMR) lactone NO sensing unit with the SNAP-tag reactive benzyl guanine (BG) for achieving subcellular-specific nitric oxide (NO) detection.
Fluorescent Dye  
/
HY-D1770 NBD Dihexadecylamine
NBD Dihexadecylamine is a fluorescent probe used for labeling phospholipids.
Fluorescent Dye  
/
HY-112526 Thiofluor 623
Thiofluor 623 (Compound 3) is a fluorescent turn-on probe that can be used for the selective sensing and bioimaging of thiols. Thiofluor 623 displays excellent immunity to interference from nitrogen and oxygen nucleophiles. Thiofluor 623 is essentially nonfluorescent in the absence of thiols, which cleave the probe and release the red-emissive donor-acceptor fluorophore (Ex=563 nm, Em=623 nm).
Fluorescent Dye  
/
HY-N16314 Sunflower PG sodium
Sunflower PG sodium is a phospholipid extracted from sunflowers.

Source: Drosophila melanogaster

Biochemical Assay Reagents  
/
HY-150177 Mannose 6 phosphate
Mannose 6 phosphate is an essential precursor for mannosyl glycoconjugates, including lipid-linked oligosaccharides (LLO; glucose3mannose9GlcNAc2-P-P-dolichol) used for protein N-glycosylation. Mannose 6 phosphate causes specific LLO cleavage. Mannose 6 phosphate causes specific degradation of G3M9Gn2-P-P-Dol. Complexes containing Mannose 6 phosphate can remodel the dermal collagen network, improve skin biomechanical properties, and reverse visible signs of aging. Mannose 6 phosphate can be used in research related to skin aging.
Drug Intermediate  
Metabolic or Endocrine Disease  
/
HY-N0638R Dendrobine (Standard)
Dendrobine (Standard) is the analytical standard of Dendrobine. This product is intended for research and analytical applications. Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC50s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively. Dendrobine activates the JNK/p38/Nrf2 signaling pathway. Dendrobine exhibits antiviral, antitumor, anti-inflammatory, and neuroprotective properties.
Reference Standards   Influenza Virus   JNK   p38 MAPK   Apoptosis   CDK   Keap1-Nrf2   SOD   Reactive Oxygen Species (ROS)  
Cancer   Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P5228 KSDSC
KSDSC is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, KSDSC joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi).
Biochemical Assay Reagents  
/
HY-16461 Solenopsin
Solenopsin ((-)-Solenopsin A) is an ATP-competitive and selective Akt-1 inhibitor with an IC50 of 5-10 μM, and also acts as an RSK1 inhibitor. Solenopsin inhibits the activities of PDK1 in lipid rafts, downregulates PI3K, blocks PI3K-dependent generation of 3-phosphoinositides, and suppresses the phosphorylation of FOXO1a. Solenopsin induces Mitophagy and ROS production, reduces mitochondrial oxygen consumption, and exhibits antiproliferative and antiangiogenic activities. Solenopsin can be used in research related to hyperproliferative skin diseases and malignant diseases.

Source: Pseudomonas aeruginosa

Akt   Ribosomal S6 Kinase (RSK)   PI3K   PDK-1   FOXO   Mitophagy   Reactive Oxygen Species (ROS)   Mitochondrial Metabolism  
Cardiovascular Disease  
/
HY-P5836 Citrullinated LL-37 1cit
Citrullinated LL-37 1cit is a citrullinated LL-37 (HY-P1222) peptide. Citrullinated LL-37 1cit does not alter the antiviral effect of LL-37 toward human rhinovirus. Citrullinated LL-37 1cit shows antibacterial activity toward S. aureus. Citrullinated LL-37 1cit causes a reduction in the levels of IL-8, CCL5, and IL-6 mRNA induced by RV1B.
Interleukin Related   Enterovirus   Bacterial  
Inflammation or Immune System Disease  
/
HY-P4028 Herpes virus inhibitor 1
Herpes virus inhibitor 1 is a herpes virus inhibitor and disrupts herpes virus ribonucleotide reductase quaternary structure. Herpes virus inhibitor 1 inhibits viral replication.
Virus Protease  
Infection  
/
HY-N12660 Quorum sensing-IN-4
Quorum sensing-IN-4 (compound 2) is a quorum sensing inhibitor, and can be isolated from Thailand mangrove-derived Streptomyces strain, OUCMDZ-5511.

Source: OUCMDZ-5511

Bacterial  
Infection  
/
HY-P991574 MEDI-5884
MEDI-5884 (REG-101) is a humanized IgG4Pκ neutralizing monoclonal antibody targeting endothelial lipase (EL), with an IC50 of 1.3 nM and 1.7 nM against human and cynomolgus monkey EL, respectively; its Kd values for human and cynomolgus monkey EL are 4.1 nM and 1.6 nM, respectively. MEDI-5884 increases plasma levels of HDL-C, apolipoprotein A1 (ApoA1) and phospholipids, while causing a slight increase in LDL-C and apolipoprotein B (ApoB) levels. MEDI-5884 can be used in research related to cardiovascular diseases, coronary heart disease, coronary atherosclerosis and stable coronary artery disease.

Species: Human

Lipase   Apolipoprotein  
Atherosclerosis and Inflammation   Atherosclerosis  
/
HY-W317470 2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl cyanide
2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl cyanide is a nucleoside analogue with the activity of inhibiting viral replication and inhibiting tumor growth. 2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl cyanide is mainly used in nucleoside synthesis to interfere with biological processes in cells. 2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl cyanide shows potential application value in antiviral and antitumor research.
Biochemical Assay Reagents  
Infection  
/
HY-N19772 Echiguanine B
Echiguanine B is a phosphatidylinositol-4-kinase (PI4K) inhibitor with an IC50 of 0.11 μg/mL against human targets. Echiguanine B inhibits phosphatidylinositol-4-kinase activity in the cell membranes of epithelial cancer cells. Echiguanine B can be used in cancer-related research.

Source: STREPTOMYCES SP.

PI4K  
Cancer  
/
HY-P11137 LANA
LANA is a KSHV latency-associated nuclear antigen. The core function of LANA is to act as an "anchor" for the viral genome, attaching it to the chromatin of the host cell. LANA ensures that the episomal DNA of KSHV replicates together with the host chromosome and is evenly distributed among the daughter cells, thereby maintaining the latent infection of the virus in the cell population. LANA can regulate the transcription of viral and host cell genes, and regulate certain host cell genes to promote cell survival. LANA can be used to study the viral DNA tethering structure.
HSV  
Cancer  
/
HY-N19295 Echiguanine A
Echiguanine A is a phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.04 μg/mL. Echiguanine A inhibits phosphatidylinositol 4-kinase activity in cell membrane extracts. Echiguanine A is applicable for cancer research.

Source: Streptomyces sp.

PI4K  
Cancer  
/
HY-W800741 Undecyl 8-bromooctanoate
Undecyl 8-bromooctanoate is a phospholipid. Phospholipids have good biocompatibility and significant amphiphilic characteristics, making them the main and suitable dosage form or excipient in drug formulations to achieve better therapeutic effects. Undecyl 8-bromooctanoate can be used in drug delivery research.
Biochemical Assay Reagents  
/
HY-133172 Zanamivir amine
Zanamivir amine is a neuraminidase inhibitor with antiviral activity. Zanamivir amine can effectively inhibit the proliferation of influenza virus. Zanamivir amine is clinically used to inhibit influenza infection. Zanamivir amine reduces viral load by interfering with the viral replication process.
Biochemical Assay Reagents  
/
HY-P4033 HCV Peptide (257-266)
HCV Peptide (257-266) is a peptide. HCV Peptide (257-266) can be used for the research of hepatitis C virus (HCV) .
HCV  
Infection   Inflammation or Immune System Disease  
/
HY-P11323 XIPSve peptide
XIPSve peptide is a ComRSve receptor agonist. XIPSve peptide is promising for research of streptococcal quorum-sensing systems and antibiotic.
Bacterial  
Infection  
/
HY-P3590 PQDVKFP
PQDVKFP is a synthetic peptide, recognizing antigenic domains within the hepatitis C virus (HCV) core protein.
HCV  
/
HY-154644B Soy lecithin-80
Soy lecithin-80 is a mixture containing 80% phospholipids. Soy lecithin-80 can be used as an emulsifier.
Biochemical Assay Reagents  
/
HY-P10975 P9R
P9R is an antiviral peptide. P9R has broad-spectrum antiviral activities against the coronaviruses (SARS-CoV-2, MERS-CoV and SARS-CoV), A(H1N1)pdm09, A(H7N9) virus, and rhinovirus. P9R directly binds to viruses and inhibits virus-host endosomal acidification. P9R significantly protects mice from A(H1N1)pdm09 infection without generating drug-resistant virus. P9R can be used for pH-dependent respiratory viruses research.
SARS-CoV   Influenza Virus   Enterovirus  
/
HY-144334 CHIKV-IN-3
CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC50 values of 1.55 and 0.14 μM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability (CC50>100 μM). Prophylactic effect.
CHIKV   DNA/RNA Synthesis  
Infection  
/
HY-W777503 Calindol hydrochloride-13C,D2
Calindol hydrochloride-13C,d2 is the deuterium and 13C labeled Calindol hydrochloride (HY-122819). Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.
Isotope-Labeled Compounds   CaSR  
Blood or Cardio-cerebrovascular Disease  
/
HY-P991414 FGI-1011A6
FGI-1011A6 is a human monoclonal antibody (mAb) targeting TSG101. FGI-1011A6 can be used in Prostate cancer and Viral infections research.

Species: Human

HIV  
Cancer   Infection  
/
HY-147170 (1,1'-Dipyrenyl)dimethyl ether
(1,1'-Dipyrenyl)dimethyl ether exhibits intramolecular excimer fluorescence in competition with fluorescence from the locally excited pyrene chromophore. (1,1'-Dipyrenyl)dimethyl ether is soluble in synthetic phospholipid membranes.
Fluorescent Dye  
/
HY-109025AS Baloxavir-d5
Baloxavir-d5 is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity.
Isotope-Labeled Compounds   Influenza Virus  
Infection  
/
HY-B0158S4 Cytidine-d1
Cytidine-d is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catechol
Isotope-Labeled Compounds   Endogenous Metabolite   Nucleoside Antimetabolite/Analog  
Neurological, Eye or Ear Disease  
/
HY-P1892 Competence-Stimulating Peptide-12261
Competence-Stimulating Peptide-12261, a sixteen peptide, is a fragment of competence-stimulating peptide. Competence-Stimulating Peptide, a quorum-sensing molecule, competence-stimulating peptide (CSP) which inhibits germ tube (GT) formation.
Others  
Infection  
/
HY-114773 N-Undecanoyl-L-homoserine lactone
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.
Biochemical Assay Reagents  
/
HY-D2334 AlF-NOTA-c-d-VAP
AlF-NOTA-c-d-VAP is a peptide positron emission tomography (PET) probe that used for targeted tumor imaging of GRP78. AlF-NOTA-c-d-VAP demonstrates high stability in vitro and in vivo.
Radionuclide-Drug Conjugates (RDCs)   HSP  
/
HY-116762 N-butyryl-L-Homocysteine thiolactone
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. The control of bacterial infection by quenching the quorum sensing system of bacteria is a promising research area. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR protein family, is coordinated by the synthesis of diffusible acyl homoserine lactone (AHL) molecules. N-butyryl-L-Homocysteine thio-lactone is an analog of N-butyryl-L-homoserine lactone, a small, diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and cellular metabolism . N-butyryl-L-homocysteine thiolactone induces violacein expression in Viola viola mutants that normally fail to produce AHL.
Biochemical Assay Reagents  
/
HY-17613S Evocalcet-d4
Evocalcet-d4 (KHK7580-d4) is deuterium labeled Evocalcet. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism.
Isotope-Labeled Compounds   CaSR  
Metabolic or Endocrine Disease  
/
HY-W099725 Sarmentine
Sarmentine is a broad-spectrum contact herbicide and PSII inhibitor, with an IC50 of 3.0 μM and a Ki of 1.5 μM against spinach, an IC50 of 1.72 μM against wild-type Amaranthus retroflexus, and an IC50 of 0.97 μM against triazine-resistant Amaranthus retroflexus. Sarmentine competitively binds to the QB binding site of plastoquinone on PSII, thereby blocking photosynthetic electron transport. Sarmentine inhibits enoyl-ACP reductase in Arabidopsis thaliana by targeting the early fatty acid synthesis process, with an IC50 of 18.3 μM. Sarmentine induces light-independent loss of plasma membrane integrity and electrolyte leakage. Sarmentine also exhibits antiplasmodial, antimycobacterial, antituberculous, and antiplatelet aggregation activities.
Herbicide   Photosystem II  
Blood Disease   Mycobacterium Tuberculosis Infection   Plasmodium Infection  
/
HY-135330 Lamivudine-13C,15N2
Lamivudine-13C,15N2 is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus.
HIV   Reverse Transcriptase  
Infection  
/
HY-N20719 Vulgarin
Vulgarin is an orally active, naturally occurring eudesmane sesquiterpene with multiple biological activities including anti-inflammatory and antioxidant properties. Vulgarin targets and inhibits HMGB1, NF-κB and iNOS, while regulating key genes involved in hepatic gluconeogenesis; it also blocks inflammatory signaling pathways and inhibits the production and release of pro-inflammatory cytokines such as TNF-α and IL-1β. Vulgarin effectively alleviates pancreatic oxidative stress by reducing lipid peroxidation levels and restoring antioxidant enzyme activity. Vulgarin reverses abnormally elevated serum pancreatic enzyme levels, preserves the integrity of pancreatic acinar cells, and reduces pancreatic edema, hemorrhage and inflammatory infiltration. Vulgarin remodels the function of pancreatic endocrine cells, restores insulin content in β cells, and downregulates glucagon levels in α cells and somatostatin levels in δ cells. Vulgarin can be used in studies related to pancreatic injury and diabetes.
NF-κB   TNF Receptor   NO Synthase   Interleukin Related   Amylases   Lipase  
Digestive System Disease   Type 1 Diabetes   Type 2 Diabetes  
/
HY-N12612 CNP0296775
CNP0296775 is an inhibitor of dengue virus methyltransferase (DENV MTase) that has the potential to disrupt the viral replication process.
DNA Methyltransferase   Dengue Virus  
Infection  
/
HY-N18891 Phosphatidylcholine
Phosphatidylcholine is a phospholipid found in the seeds of Heracleum lehmannianum and constitutes the most abundant phospholipid component in the plant's seed lipid complex.
Others  
/
HY-P991766 Anti-Venezuelan equine encephalitis virus E2 protein Antibody (VEEV-57)
Anti-Venezuelan equine encephalitis virus E2 protein Antibody (VEEV-57) reacts with the E2 protein of the Venezuelan equine encephalitis virus (VEEV). Anti-Venezuelan equine encephalitis virus E2 protein Antibody (VEEV-57) inhibits VEEV attachment to Vero cells, viral egress, viral fusion, and LDLRAD3-D1-Fc binding. Recommend Isotype Controls: Mouse IgG2c kappa, Isotype Control (HY-P99981).

Species: Virus

Flavivirus  
Infection  
/
HY-W750902 Oxymatrine-d3
Oxymatrine-d3 is the deuterium labeled Oxymatrine (HY-N0158). Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection.
Isotope-Labeled Compounds   TGF-beta/Smad   Apoptosis  
Cancer   Infection   Inflammation or Immune System Disease  
/
HY-N19037 1,2-Dilinoleoyl phosphatidylinositol
1,2-Dilinoleoyl phosphatidylinositol is a phosphatidylinositol. 1,2-Dilinoleoyl phosphatidylinositol acts as a substrate for phosphorylation by Phosphatidylinositol-4-phosphate 5-kinase (PI4P5K) isoforms α, β, and γ in in vitro assays.
PI4P5K  
/
HY-N12616 2-Deoxy-D-ribose 1-phosphate
2-Deoxy-D-ribose 1-phosphate is an intermediate in the metabolism of phosphoinositide, which is found in the rat cerebral cortex.
Drug Intermediate  
/
HY-106161S1 Rupintrivir-d7
Rupintrivir-d7 is a deuterated labeled Rupintrivir. Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.
Isotope-Labeled Compounds   Enterovirus   Virus Protease  
Infection  
/
HY-113209S1 8-Isoprostaglandin F2α-d9
8-iso Prostaglandin F2α-d9 is the deuterium labeled 8-Isoprostaglandin F2α. 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.
Endogenous Metabolite  
/
HY-P11546 Antiviral agent 76
Antiviral agent 76 is an antiviral peptide containing azide groups, which has anti-hepatitis C virus (HCV) activity.
HCV  
Hepatitis C Virus Infection  
/
HY-N14780 Pochonin D
Pochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affects the homeostasis, folding and assembly processes of viral proteins, and reduces the replication capacity of viruses. Pochonin D is a copper ion carrier that can induce cuproptosis in triple-negative breast cancer cells by targeting PRDX1. Pochonin D reduces the infiltration of inflammatory cells, decreases the secretion of inflammatory cytokines such as TNF-α and IL-1β, and alleviates inflammatory responses. Pochonin D is a promising candidate for research on human rhinovirus (HRV) infection and cancer.

Source: Humicola sp. FO-2942

HSP   Interleukin Related   TNF Receptor   Enterovirus   Cuproptosis  
Cancer   Inflammation or Immune System Disease   Parasitic Infection  
/
HY-Y1309S1 1-Naphthol-d7
1-Naphthol-d7 (Furro ER-d7) is the deuterium labeled Naphthol (HY-Y1309). 1-Naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe. 1-naphthol can sense the hydrophobic domains in micellar aggregation and accurately sense the sol-gel transition. 1-naphthol can be used to study the thermally induced microenvironmental changes and hydration levels of Pluronic F127 (PF127) in different microenvironments in aqueous media.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-N6610 Protoanemonin
Protoanemonin is a natural unsaturated γ-lactone small molecule derived from plants of the Ranunculaceae family, possessing various activities such as plant growth regulation, antibacterial, and antifungal effects. Protoanemonin is a quorum sensing inhibitor that inhibits Pseudomonas aeruginosa quorum sensing, downregulates virulence factor expression, and activates the iron starvation response pathway. Protoanemonin possesses broad-spectrum antibacterial and antifungal activities, and also has antimutagenic activity. Protoanemonin exhibits bidirectional plant growth regulatory effects, promoting plant tissue elongation at low concentrations and inhibiting plant tissue elongation at high concentrations. Protoanemonin can be used in research related to bacterial quorum sensing, microbial metabolism, antibacterial and antifungal activity, antimutagenesis, and plant growth regulation.
Bacterial   Fungal   Drug Derivative  
Metabolic or Endocrine Disease   Bacterial Infection   Fungal Infection  
/
HY-W749691 (S)-Velpatasvir-13c,d3
(S)-Velpatasvir-13C,d3 ((S)-GS-5816-13C,d3) is 13C labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.16 μM.
Isotope-Labeled Compounds   HCV   SARS-CoV  
Cancer   Infection   Inflammation or Immune System Disease  
/
HY-B0250S2 Lamivudine-13C,15N3
Lamivudine-13C,15N3 (BCH-189-13C,15N3) is 13C and 15N labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS.
Isotope-Labeled Compounds   HBV   HIV   Reverse Transcriptase  
Cancer   Infection  
/
HY-P99323 Timolumab
Timolumab (BTT1023 ), a recombinant fully human monoclonal antibody that specifically binds VAP-1. Timolumab (BTT1023 ) could be used in the study of chronic inflammatory diseases.

Species: Human

VAP-1  
Inflammation or Immune System Disease  
/
HY-P5433 IRS1-derived peptide
IRS1-derived peptide is a biological active peptide. (This is a peptide fragment (979-989) of the insulin receptor substrate-1 containing the sequence motif YMXM known to bind to the two domains of SH2 on the 85kDa subunit of phosphoinositide 3-kinase.)
Others  
/
HY-D1258 AC-green
AC-green (VDP-green) is a β-allyl carbamate fluorescent probe for specifically imaging vicinal dithiol proteins (VDPs) in living systems (λex/λem=400/475 nm). AC-green can detect the reduced bovine serum albumin (rBSA) with high sensitivity. AC-green displays low toxicity and features high sensitivity, and is suitable for sensing VDPs in living cells and zebrafishes.
Fluorescent Dye  
/
HY-W555382 Pseudane IX
Pseudane IX, a compound isolated from the leaves of Ruta angustifolia, has strong anti-HCV activity with an IC50 value of 1.4 μg/mL. Pseudane IX reduces HCV RNA replication and viral protein synthesis levels.
HCV  
Viral Infection   Hepatitis C Virus Infection  
/
HY-101541S Docosahexaenoic acid-d5 methyl ester
Docosahexaenoic acid-d5 methyl ester is the deuterium labeled Docosahexaenoic Acid methyl ester. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.
Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
/
HY-N7788 cis-2-Dodecenoic acid
cis-2-Dodecenoic acid, originally discovered in Burkholderia cenocepacia, can interfere with the bacterial quorum sensing system and inhibit bacterial biofilm formation and virulence factor production.

Source: Trichosurus vulpecula

Bacterial  
Infection  
/
HY-17514S2 Itraconazole-d9
Itraconazole-d9 is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
Fungal   Hedgehog   Bacterial   Autophagy   Cytochrome P450   Antibiotic  
Infection  
/
HY-W751835 Baloxavir-d4
Baloxavir-d4 (Baloxavir acid-d4; S-033447-d4) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d4 (Baloxavir-d4 acid), derived from the proagent Baloxavir-d4 marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d4 inhibits viral RNA transcription and replication and has potently antiviral activity.
Isotope-Labeled Compounds  
Cancer  
/
HY-N1067R Xanthohumol (Standard)
Xanthohumol (Standard) is the analytical standard of Xanthohumol. This product is intended for research and analytical applications. Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).
Reference Standards   COX   Acyltransferase   Apoptosis   HSV   CMV   Influenza Virus  
Cancer   Cytomegalovirus Infection  
/
HY-145539SA 1,2-Dipalmitoyl-sn-glycero-3-PS-d62 ammonium
1,2-Dipalmitoyl-sn-glycero-3-PS-d62 ammonium is the deuterium labeled 1,2-Dipalmitoyl-sn-glycero-3-PS ammonium. 1,2-Dipalmitoyl-sn-glycero-3-PS is a phosphatidylserine phospholipid. 1,2-Dipalmitoyl-sn-glycero-3-PS is used for the preparation of phospholipid bilayers.
Isotope-Labeled Compounds  
/
HY-17514S1 Itraconazole-d3
Itraconazole-d3 (R51211-d3) is the deuterium labeled Itraconazole (HY-17514). Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
Antibiotic   Cytochrome P450   Bacterial   Hedgehog   Autophagy   Fungal  
Cancer   Infection  
/
HY-W394106 5-Hydroxymethyl uridine
5-Hydroxymethyl uridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
Nucleoside Antimetabolite/Analog  
Lung Cancer   Leukemia/Lymphoma/Myeloma  
/
HY-P1358 Alisporivir intermediate-1
Alisporivir intermediate-1 is an intermediate in the synthesis of Alisporivir. Alisporivir is used for the treatment of inflammatory and viral diseases.
Drug Intermediate  
Infection   Inflammation or Immune System Disease  
/
HY-135367 pyCTZ
pyCTZ (Pyridyl CTZ), a pyridyl Coelenterazine (CTZ) analog, and is an ATP-independent pyridyl substrate of LumiLuc luciferase. pyCTZ generates strong blue bioluminescence in the presence of luciferases. pyCTZ can be used for aequorin-based calcium sensing.
Fluorescent Dye  
/
HY-125728 Micrococcin P1
Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC50 range of 0.1-0.5 μM. Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against S. aureus 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively. Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum.

Source: B. pumilus

Antibiotic   Bacterial   Parasite   HCV  
Bacterial Infection  
/
HY-N17251 Cusculine
Cusculine (FAC21) is an oropouche virus (OROV) endonuclease inhibitor with an IC50 of 1.4 μM. Cusculine strongly interacts with OROV endonuclease, possibly limiting viral RNA interaction with other proteins, intercalates into double-stranded RNA (a viral replication intermediate), and efficiently inhibits OROV viral replication in vitro. Cusculine can be used for the research of oropouche fever.
Endonuclease  
Infection  
/
HY-P991278 ABM-125
ABM-125 is a IL-25 neutralizer and immune response modulator. ABM-125 neutralizes human and mouse IL-25 and blocks type 2 immune activation function. ABM-125 regulates virus-induced inflammatory cytokine expression and increases the expression level of antiviral interferons in rhinovirus-infected asthmatic bronchial epithelial cells. For the isotype control of ABM-125, refer to Human IgG1 kappa, Isotype Control (HY-P99001). ABM-125 is applicable to research related to virus-induced acute asthma exacerbations.

Species: Human

Interleukin Related  
Asthma  
/
HY-P99346 Regdanvimab
Regdanvimab (CT-P59) is a human monoclonal antibody that targets the receptor-binding domain of SARS-CoV-2 spike protein, blocking interaction with ACE2 for viral entry. Regdanvimab can be used for the research of COVID-19.

Species: Virus

SARS-CoV   Angiotensin-converting Enzyme (ACE)  
Coronavirus Infection  
/
HY-P990236 Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is an anti-mouse/rat/monkey/human ICOS/CD278 IgG monoclonal antibody. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) has limited effectiveness in improving T cell function and immune activation. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) can be used for researches on cancer and infection conditions such as gliomas and hepatitis B virus infection .

Species: Human/Mouse/Rat/Monkey

Transmembrane Glycoprotein  
Cancer   Infection   Inflammation or Immune System Disease  
/
HY-D0948 Celestine Blue
Celestine Blue is a electroactive indicator in DNA biosensors. Celestine Blue is strongly adsorbed on the spinel phases and CNT (carbon nanotubes), facilitates dispersion, acts as a capping agent and allows for the fabrication of spinel decorated CNT. Celestine Blue is an efficient charge transfer mediator, which allows for significant improvement of capacitive behavior. TiO2 nanoparticles doped with Celestine Blue can be used as a label in a sandwich immunoassay for the hepatitis C virus (HCV) core antigen.
Fluorescent Dye  
Infection  
/
HY-DY1025 Laurdan (solution)
Laurdan (solution) is a membrane-permeable fluorescent probe that displays spectral sensitivity to the phospholipid phase of the cell membrane to which it is bound. Quantitation of generalized polarization (GP) of Laurdan can be used to identify phospholipid phase.
Solvent and concentration: DMSO: 5 mM
Fluorescent Dye  
/
HY-P11175 Competence-stimulating peptide
Competence-stimulating peptide is a competence-stimulating peptide. Competence-stimulating peptide activates the Com-dependent quorum sensing system of S. mutans. Competence-stimulating peptide restores bacteriocin production.
Bacterial  
Infection  
/
HY-P990782 Efzofitimod
Efzofitimod is a splice variant of the aminoacyl-tRNA synthetase HARS1, which is fused with the Fc segment of a human antibody. Efzofitimod targets the neuronal phospholipid NRP2 (neuropilin-2) and has anti-inflammatory and immunomodulatory activities. Efzofitimod can downregulate the innate and adaptive immune responses in inflammatory disease states, suppressing indirect lung disease (ILD).

Species: Human

Aminoacyl-tRNA Synthetase  
Inflammation or Immune System Disease  
/
HY-P11200 γ-Glu-Asn
γ-Glu-Asn (γ-Glutamylasparagine) is a calcium sensing receptor (CaSR) agonist. γ-Glu-Asn is a dipeptide composed of glutamic acid and asparagine.
Calcium Channel  
Neurological, Eye or Ear Disease  
/
HY-W843885 H-Glu-Thr-OH
H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide made up of two amino acids—glutamic acid (Glu) and threonine (Thr)—connected by a peptide bond, and it acts as an agonist for the extracellular calcium-sensing receptor (CaSR).
CaSR  
/
HY-DY1012 DiI (solution)
DiI (solution) is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins.
Solvent and concentration: DMSO: 5 mM
Fluorescent Dye  
/
HY-133683 N-(3-Oxotetradecanoyl)-DL-homoserine lactone
N-(3-Oxotetradecanoyl)-DL-homoserine lactone, a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, is a quorum sensing (QS) signaling molecule.

Source: Gram-negative bacteria

Bacterial  
Metabolic or Endocrine Disease   Bacterial Infection  
/
HY-D1076 DiIC16(3)
DiIC16(3) is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins.
Fluorescent Dye  
Metabolic or Endocrine Disease  
/
HY-139201D Poly-D-lysine hydrobromide (MW 4000-15000)
Poly-D-lysine hydrobromide (MW 4000-15000) (PDLHB (MW 4000-15000)) is an artificially synthesized polymer matrix widely used in neuronal cell culture. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide.
CaSR  
/
HY-P990828 Anti-PD-L1/B7-H1 Antibody (29E.2A3)
Anti-PD-L1/B7-H1 Antibody (29E.2A3) is a kind of mouse IgG2b κ chimeric antibody inhibitor, targeting to human PD-L1/B7-H1. Anti-PD-L1/B7-H1 Antibody (29E.2A3) can block the binding of PD-1 to PD-L1. Anti-PD-L1/B7-H1 Antibody (29E.2A3) can be used for the research of infection, such as hepatitis C virus (HCV).

Species: Human

PD-1/PD-L1  
Infection  
/
HY-P991246 VRC01LS
VRC01LS is a humanized monoclonal antibody inhibitor targeting the CD4-binding site of HIV-1 envelope glycoprotein (Env). VRC01LS blocks the binding of HIV-1 to host cell CD4 receptor, inhibiting viral entry. VRC01LS is promising for research of HIV-1 infection.

Species: Human

Virus Protease   HIV  
Infection  
/
HY-100993 α-Methylserotonin maleate
α-Methylserotonin maleate is a potent and selective agonist of 5-HT2 receptor. α-Methylserotonin maleate is an analogue of serotonin formed in vivo from α-Methyltryptophan. α-Methylserotonin maleate mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis.
5-HT Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-W009313 2',3'-O-Isopropylideneuridine
2',3'-O-Isopropylideneuridine is a modified uridine. 2',3'-O-Isopropylideneuridine can be used in the research of viral diseases (such as cytomegalovirus and varicella-zoster virus).
Nucleoside Antimetabolite/Analog  
/
HY-P990060 Denecimig
Denecimig (Mim8) is a factor VIII-mimetic bispecific antibody with micromolar human binding affinity for Factor X and Factor IXa. Denecimig binds Factor X and Factor IXa, localizes both to the phospholipid surface, enhances the Factor IXa-mediated activation of Factor X to Factor Xa, and stimulates the proteolytic activity of Factor IXa via its monovalent anti-Factor IXa arm. Denecimig is applicable to research related to hemophilia A.

Species: Human

Factor Xa  
Platelet Disease  
/
HY-P99900 Sevirumab
Sevirumab (MSL-109) is a human IgG1 neutralizing monoclonal antibody against cytomegalovirus (CMV). Sevirumab recognizes CMV gH complexes and inhibits CMV replication with an EC50 of 0.3 μg/mL.

Species: Virus

CMV  
Cytomegalovirus Infection  
/
HY-17514R Itraconazole (Standard)
Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
Reference Standards   Fungal   Hedgehog   Cytochrome P450   Autophagy   Antibiotic   Bacterial  
Cancer   Infection  
/
HY-P991200 OM-7D3-B3
OM-7D3-B3 is an antibody-based antiviral agent targeting the tight junction protein CLDN1 (Kd=4 nM). By binding to the first extracellular domain of CLDN1, OM-7D3-B3 disrupts the formation of the CLDN1-CD81 co-receptor complex, thereby effectively inhibiting the entry of hepatitis C virus (HCV). OM-7D3-B3 not only prevents de novo and chronic HCV infections in humanized liver chimeric mice and uPA-SCID mice transplanted with human livers, but also exhibits favorable safety with no toxic effects observed. OM-7D3-B3 serves as a critical tool for research on HCV infection mechanisms and antiviral drug development.

Species: Human

HCV   Claudin  
Hepatitis C Virus Infection  
/
HY-W015800 L-Homoserine lactone hydrochloride
L-Homoserine lactone hydrochloride is the core structural unit of the bacterial quorum-sensing signal molecule N-acyl-L-homoserine lactone (AHLs). As an important intermediate, L-Homoserine lactone hydrochloride acylated derivatives have potent immunosuppressive activity.
Drug Intermediate  
/
HY-D1599 Rhodamine 6G hydrazide
Rhodamine 6G hydrazide (R6GH) is a fluorescent dye. Rhodamine 6G hydrazide can be used in selective colorimetric and fluorescent sensing.
Fluorescent Dye  
/
HY-W110927 Alizarin Red S Indicator (4.3-6.3), IND
Alizarin red S indicator (C.I. 58005) is a reductively active (quinone-based) anthraquinone dye that forms complexes with metal ions (such as zirconium, calcium) or boric acid to label calcium deposition and perform electrochemical sensing functions. Alizarin Red S undergoes reversible redox reactions (for electrochemical detection) and irreversible chelation (for bone staining). Alizarin Red S is mainly used in bone metabolism research (labeling mineralized tissue), sugar detection (boric acid-sugar competition system) and metal ion sensing (such as zirconium ion detection)， and can be used in osteoporosis and metabolic disease research.
Biochemical Assay Reagents   Fluorescent Dye  
/
HY-N8533 Sodium Camptothecin
Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA.
DNA/RNA Synthesis  
Cancer   Infection  
/
HY-W031126 7-Hydroxyisoflavone
7-Hydroxyisoflavone is an enterovirus replication inhibitor. 7-Hydroxyisoflavone inhibits enterovirus 71 viral RNA synthesis, viral protein synthesis, and early replication steps. 7-Hydroxyisoflavone also inhibits coxsackievirus replication. 7-Hydroxyisoflavone enhances AMPK activity and prevents serum-induced reduction of AMPK phosphorylation. 7-Hydroxyisoflavone can be used in research related to enterovirus infection.
Enterovirus   AMPK  
Viral Infection  
/
HY-W250152 Polycytidylic acid potassium
Polycytidylic acid potassium is an immunostimulant and synthetic double-stranded RNA. Polycytidylic acid potassium can be used experimentally to model viral infections in vivo. Polycytidylic acid potassium is a common tool in immune system research.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-Y0248 (E,​E)​-​Farnesol
(E,E)-Farnesol (trans,trans-Farnesol) is a quorum-sensing molecule of Candida species. (E,E)-Farnesol can inhibit the growth, metabolism and biofilm formation of various Candida species, and affect their morphology and invasiveness.
Fungal  
Infection  
/
HY-100603 GSK-F1
GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1 can be used for HCV infection research.
PI4K   PI3K  
Infection   Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Pain   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
/
HY-142028A Acyclovir triphosphate sodium (100 mM)
Acyclovir triphosphate (Synonyms: AcycloGTP) sodium is a Acyclovir (HY-17422) derivative that competitively inhibits viral DNA polymerase by acting as an analog to deoxyguanosine triphosphate (dGTP). Acyclovir triphosphate (sodium) (100 mM) is an inhibitor of HIV-1 reverse transcriptase. Acyclovir triphosphate (sodium) (100 mM) causes termination of viral DNA synthesis.
DNA/RNA Synthesis   Nucleoside Antimetabolite/Analog   HIV   Reverse Transcriptase  
Infection  
/
HY-W008351 L-Ribose
L-Ribose is the enantiomer of D-ribose (HY-113375). L-Ribose replaces D-ribose to synthesize L-ribonucleic acid in cells, leading to erroneous gene transcription. L-Ribose serves as a starting material for L-nucleoside analogs, glycoconjugates and oligonucleotides. L-Ribose can be used in research related to hepatitis B virus infection, hepatitis C virus infection, hepatitis D virus infection, Epstein-Barr virus infection and cytomegalovirus infection.
Drug Intermediate   Drug Isomer  
Cytomegalovirus Infection   Hepatitis B Virus Infection   Hepatitis C Virus Infection  
/
HY-114437 Fusion Inhibitory Peptide
Fusion Inhibitory Peptide (Z-D-Phe-Phe-Gly-OH, FIP, Virus Replication Inhibitory Peptide) is a potent inhibitor of the virus replication, by inhibiting the membrane fusing activity of a viral glycoprotein.
Influenza Virus  
Viral Infection  
/
HY-P4113 TAT-NSF700 Fusion Peptide
TAT-NSF700 Fusion Peptide is a potent N-ethyl-maleimide-sensitive factor (NSF) inhibitor. TAT-NSF700 Fusion Peptide can readily permeate the cell membrane and interact with the intracellular organelle directly.
Others  
Neurological, Eye or Ear Disease  
/
HY-P99697 Leronlimab
Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer.

Species: Human

CCR   HIV  
Cancer   Infection  
/
HY-N1860 3-O-Methylquercetin
3-O-Methylquercetin is an inhibitor of cAMP and CGMP-phosphodiesterase (PDE) with IC50 at 13.8 μM and 14.3 μM, respectively. 3-O-Methylquercetin is an inhibitor of β-secretase with an IC50 of 6.5 μM. 3-O-Methylquercetin has a neuroprotective effect against neuronal death caused by oxidative damage. 3-O-Methylquercetin has strong antiviral activity against poliovirus, coxsackie virus and human rhinovirus. 3-O-Methylquercetin has anti-inflammatory and trachea-relaxing effects and can be used in the study of inflammatory diseases and asthma.
Phosphodiesterase (PDE)   NO Synthase  
Infection   Inflammation or Immune System Disease   Colorectal Cancer   Alzheimer's Disease  
/
HY-115675 NC03
NC03 is a PI4K2A inhibitor and reducing agent. NC03 inhibits the activity of PI4K2A, thereby reducing the production of PI4P in the cellular compartments where PI4K2A functions. NC03 rapidly induces a decrease in PI4P pools in the Golgi and endosomal compartments. NC03 reduces PI4P production in Rab7-positive late endosomes.
PI4K  
/
HY-124081 N-Oleoyl-L-serine
N-Oleoyl-L-Serine is an endogenous amide of long-chain fatty acids with ethanolamine (N-acyl amides). N-Oleoyl-L-Serine is a lipid regulator of bone remodeling and stimulates osteoclast apoptosis. N-Oleoyl-L-Serine can be used for antiosteoporotic drug discovery development.
Apoptosis  
Metabolic or Endocrine Disease  
/
HY-P99853 Diridavumab
Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus.

Species: Virus

Influenza Virus  
Infection  
/
HY-P991446 MEDI-8852
MEDI-8852 is a human IgG1 monoclonal antibody against influenza A virus hemagglutinin (HA). MEDI-8852 binds to the conserved HA stalk epitope and neutralizes viral infectivity. MEDI-8852 reduces viral titers in mouse lung tissues. MEDI-8852 is applicable to research related to pandemic influenza. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Virus

Influenza Virus  
Influenza Virus Infection  
/
HY-P99344 Bamlanivimab
Bamlanivimab (Anti-Human SARS-CoV-2; LY-CoV555) is an antiviral agent targeting the SARS-CoV-2 spike protein receptor-binding domain (RBD) with a mean Kd of 5.3 nM. Bamlanivimab binds epitopes overlapping the ACE2 binding site on both active and resting RBD conformations, blocks ACE2 attachment, mediates antibody-dependent cell-mediated cytotoxicity, and reduces viral replication and respiratory tract viral load. Bamlanivimab can be used for the research of COVID-19.

Species: Virus

SARS-CoV  
SARS-CoV-2 Infection  
/
HY-Y1309 1-Naphthol
1-naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe. 1-naphthol can sense the hydrophobic domains in micellar aggregation and accurately sense the sol-gel transition. 1-naphthol can be used to study the thermally induced microenvironmental changes and hydration levels of Pluronic F127 (PF127) in different microenvironments in aqueous media.
Endogenous Metabolite  
/
HY-P10373 pJAK2(1001-1013)
pJAK2(1001-1013) is a cell-penetrating peptide that corresponds to the activation loop of JAK2 tyrosine kinase and functions as a SOCS1/3antagonist. pJAK2 (1001-1013) blocks SOCS1-mediated negative regulation of immune function, and enhances the biological activity of cytokines such as IFNγ and IL6. pJAK2(1001-1013) inhibits the replication of a broad range of viruses and exerts dose-dependent protective efficacy against lethal viral infections. pJAK2(1001-1013) can be used for the study of immune regulation and infection.
JAK   IFNAR   Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P72621 ICAM-1/CD54 Protein, Human (HEK293, His)
The ICAM-1/CD54 protein plays a crucial role in cell interactions, acting as a ligand for the leukocyte adhesion protein LFA-1. It promotes leukocyte transendothelial migration by promoting the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. ICAM-1/CD54 Protein, Human (HEK293, His) is the recombinant human-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

CD Antigens Receptor Proteins Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs) ICAM-1/CD54 Immunoglobulin-like Cell Adhesion Molecules

/
HY-P73910 ICAM-1/CD54 Protein, Human (HEK293, Fc)
The ICAM-1/CD54 protein plays a crucial role in cell interactions, acting as a ligand for the leukocyte adhesion protein LFA-1. It promotes leukocyte transendothelial migration by promoting the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. ICAM-1/CD54 Protein, Human (HEK293, Fc) is the recombinant human-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

CD Antigens Receptor Proteins Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs) ICAM-1/CD54 Immunoglobulin-like Cell Adhesion Molecules

/
HY-P702646 GPX4 Protein, Human (U73S, His)
GPX4 Protein, Human (U73S, His) is the recombinant human-derived GPX4, expressed by E. coli , with N-6*His labeled tag. ,

Species: Human; Source: E. coli

/
HY-P71936A Uteroglobin/SCGB1A1 Protein, Mouse (His)
Uteroglobin/SCGB1A1 protein has multiple binding abilities and can interact with phosphatidylcholine, phosphatidylinositol, PCB, and binds weakly to progesterone.As a potent phospholipase A2 inhibitor, its antiparallel homodimer structure is maintained by disulfide bonds.Uteroglobin/SCGB1A1 Protein, Mouse (His) is the recombinant mouse-derived SCGB1A1 protein, expressed by E.coli , with N-6*His labeled tag.

Species: Mouse; Source: E. coli

/
HY-P71933 Uteroglobin/SCGB1A1 Protein, Human
Uteroglobin/SCGB1A1 Protein displays diverse binding, including phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB), and weakly binds progesterone. It acts as a robust inhibitor of phospholipase A2, structurally forming a disulfide-linked antiparallel homodimer. Controversy surrounds its interaction with LMBR1L, necessitating further investigation. Uteroglobin/SCGB1A1 Protein, Human is the recombinant human-derived Uteroglobin/SCGB1A1 protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

/
HY-P70065 AOC3 Protein, Human (HEK293, His)
As a cell adhesion molecule, AOC3 protein plays a key role in lymphocyte extravasation and recycling by promoting the binding of lymphocytes to peripheral lymph node vascular endothelial cells, independent of L-selectin. In addition to its role in cell adhesion, AOC3 exhibits semicarbazide-sensitive monoamine oxidase activity, contributing to its enzymatic function. AOC3 Protein, Human (HEK293, His) is the recombinant human-derived AOC3 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Oxidoreductases (EC 1)

/
HY-P70252 LCAT Protein, Human (HEK293, His)
LCAT protein is synthesized in the liver and plays a vital role in the metabolism of plasma lipoproteins by converting cholesterol and phosphatidylcholine in HDL and LDL. LCAT Protein, Human (HEK293, His) is the recombinant human-derived LCAT protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Transferases (EC 2)

/
HY-P74625 PLTP Protein, Human (HEK293, His)
PLTP proteins are centrally involved in lipid metabolism, mediating the transfer of phospholipids and free cholesterol between lipoproteins and HDL. This includes the exchange of various molecules such as diacylglycerol, sphingomyelin, and phosphatidylcholine. PLTP Protein, Human (HEK293, His) is the recombinant human-derived PLTP protein, expressed by HEK293 , with C-10*His labeled tag.

Species: Human; Source: HEK293

/
HY-P79408 Calcium-sensing Receptor/CaSR Protein, Human (HEK293, His)
Calcium-sensing receptor (CaSR) is a G-protein-coupled receptor that is essential for maintaining calcium homeostasis. It senses changes in extracellular calcium concentration, regulates parathyroid hormone (PTH) production, and activates the phosphatidylinositol-calcium second messenger system. Calcium-sensing Receptor/CaSR Protein, Human (HEK293, His) is the recombinant human-derived Calcium-sensing Receptor/CaSR Protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

/
HY-P73112 ICAM-1/CD54 Protein, Mouse (HEK293, His-Fc)
ICAM-1/CD54 protein is a key player in cellular interactions, acting as a ligand for LFA-1. It facilitates endothelial cup assembly during leukocyte migration and regulates immune responses. ICAM-1 also interacts with MUC1, promoting cell aggregation, and participates in immunological synapse formation between antigen-presenting cells and T cells. These interactions showcase ICAM-1's diverse role in cellular adhesion and immune modulation. ICAM-1/CD54 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

Species: Mouse; Source: HEK293

CD Antigens Receptor Proteins Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs) ICAM-1/CD54 Immunoglobulin-like Cell Adhesion Molecules

/
HY-P73113 ICAM-1/CD54 Protein, Mouse (HEK293, His)
ICAM-1/CD54 protein is a key player in cellular interactions, acting as a ligand for LFA-1. It facilitates endothelial cup assembly during leukocyte migration and regulates immune responses. ICAM-1 also interacts with MUC1, promoting cell aggregation, and participates in immunological synapse formation between antigen-presenting cells and T cells. These interactions showcase ICAM-1's diverse role in cellular adhesion and immune modulation. ICAM-1/CD54 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

CD Antigens Receptor Proteins Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs) ICAM-1/CD54 Immunoglobulin-like Cell Adhesion Molecules

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HY-P73114 ICAM-1/CD54 Protein, Rat (HEK293, His)
ICAM-1/CD54 protein is a crucial ligand for leukocyte adhesion, promoting endothelial apical cup assembly during migration.It regulates immune responses and inflammation.ICAM-1 also interacts with MUC1, promoting cell aggregation, and contributes to immunological synapse formation between antigen-presenting cells and T cells.These interactions showcase ICAM-1's diverse functions in cellular adhesion and immune modulation.ICAM-1/CD54 Protein, Rat (HEK293, His) is the recombinant rat-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-His labeled tag.

Species: Rat; Source: HEK293

CD Antigens Receptor Proteins Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs) ICAM-1/CD54 Immunoglobulin-like Cell Adhesion Molecules

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HY-P75798 GPX7 Protein, Human (HEK293, Fc)
GPX7, a protein with catalase activity, is predicted to respond to oxidative stress. It is located in the endoplasmic reticulum and is expressed in various tissues, including placenta (RPKM 15.6) and thyroid (RPKM 9.2). This highlights the potential importance of GPX7 in antioxidative processes throughout the body. GPX7 Protein, Human (HEK293, Fc) is the recombinant human-derived GPX7 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Oxidoreductases (EC 1)

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HY-P77979 LCAT Protein, Mouse (HEK293, His)
LCAT protein, synthesized in the liver and brain, converts cholesterol and phosphatidylcholines on lipoproteins to cholesteryl esters and lysophosphatidylcholines.It transports cholesterol esters to the liver and influences cerebral spinal fluid levels.LCAT also remodels high-density lipoprotein particles, hydrolyzes platelet-activating factor, and esterifies (24S)-hydroxycholesterol to produce 24(S)OH-C monoesters.LCAT Protein, Mouse (HEK293, His) is the recombinant mouse-derived LCAT protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

Enzymes & Regulators Transferases (EC 2)

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HY-P702864 FOS Protein, Human (His, Myc)
FOS Protein, Human (His, Myc) is the recombinant human-derived FOS, expressed by E. coli , with N-10*His, C-Myc labeled tag.

Species: Human; Source: E. coli

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HY-P705531 RPA1 Protein, Human (His-SUMO)

Species: Human; Source: E. coli

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HY-P71044 VAPB Protein, Human (His)
VAPB protein interacts with STARD3 through a phosphorylation-dependent mechanism to form a contact site between the endoplasmic reticulum (ER) and late endosomes. VAPB Protein, Human (His) is the recombinant human-derived VAPB protein, expressed by E. coli , with C-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P73606 TIM-1/KIM-1/HAVCR Protein, Human (270a.a, HEK293, His)
TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, His) belongs to a family of immunoglobulin-like domain-containing transmembrane proteins is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual, hepatotropic human picornavirus. TIM1 (HAVCR1) facilitates attachment of a variety of enveloped viruses, including filoviruses, alphaviruses, and flaviviruses, that display highly conserved phosphatidylserine (PtdSer) on their surface. TIM1 undergoes tyrosine phosphorylation of its C-terminal cytoplasmic tail. TIM-1 can function as a co-stimulatory molecule for T cell activation. TIM-1/KIM-1/HAVCR Protein, Human (270a.a, HEK293, His) is the recombinant human-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with N-His labeled tag.

Species: Human; Source: HEK293

Receptor Proteins

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HY-P74184 E2/Envelope Protein, Hepatitis C virus (BAA03581, HEK293, His)
E2/Envelope Protein, Hepatitis C virus (BAA03581, HEK293, His) is the recombinant Virus-derived E2/Envelope protein, expressed by HEK293, with C-His labeled tag.

Species: Virus; Source: HEK293

Viral Proteins Hepatitis C Virus Proteins Hepatitis C virus E2 Proteins

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HY-P74899 Envelope Glycoprotein E1 Protein, HCV (HEK293, His)
Envelope Glycoprotein E1 Protein, one of two subunits of the envelope glycoprotein found in the hepatitis C virus, is a type 1 transmembrane protein.It associates with envelope glycoprotein E2 as a noncovalent heterodimer, which mediates virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane.E1/E2 heterodimer binds host apolipoproteins.And it also binds to CD81 and activates the epithelial growth factor receptor (EGFR) signaling pathway.Envelope Glycoprotein E1 Protein, HCV (HEK293, His) is the recombinant Virus-derived Envelope Glycoprotein E1 protein, expressed by HEK293 , with N-His labeled tag.

Species: Virus; Source: HEK293

Viral Proteins Hepatitis C Virus Proteins Hepatitis C virus E1 Proteins

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HY-P76171 BLOC1S2 Protein, Human
BLOC1S2 is an essential component of the BLOC-1 complex and is critical for the biogenesis of lysosome-related organelles (LROs), including platelet dense granules and melanosomes. BLOC-1 cooperates with the AP-3 complex to direct membrane protein cargo into vesicles for delivery to neurites and nerve terminals, suggesting that it is involved in neurite extension. BLOC1S2 Protein, Human (GST) is the recombinant human-derived BLOC1S2 protein, expressed by E. coli , with no tagged.

Species: Human; Source: E. coli

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HY-P76171A BLOC1S2 Protein, Human (N-GST)
BLOC1S2 is an essential component of the BLOC-1 complex and is critical for the biogenesis of lysosome-related organelles (LROs), including platelet dense granules and melanosomes. BLOC-1 cooperates with the AP-3 complex to direct membrane protein cargo into vesicles for delivery to neurites and nerve terminals, suggesting that it is involved in neurite extension. BLOC1S2 Protein, Human (N-GST) is the recombinant human-derived BLOC1S2 protein, expressed by E. coli , with N-GST labeled tag.

Species: Human; Source: E. coli

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HY-P71489 RecF/UvrF Protein, E.coli (His-SUMO)
RecF/UvrF Protein is crucial in DNA metabolism, essential for DNA replication and inducing the SOS response. Its preference for binding to single-stranded DNA underscores its role in DNA maintenance. RecF also displays an affinity for ATP binding, emphasizing its involvement in regulating DNA-related functions. RecF/UvrF Protein, E.coli (His-SUMO) is the recombinant E. coli-derived RecF/UvrF protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

Species: E.coli; Source: E. coli

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HY-P72622 ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, Fc)
The ICAM-1/CD54 protein is a ligand of the leukocyte adhesion protein LFA-1 and is critical for leukocyte transendothelial migration. Its involvement activates ARHGEF26/SGEF and RHOG, coordinating endothelial apical cup assembly. ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Rhesus Macaque; Source: HEK293

CD Antigens Receptor Proteins Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs) ICAM-1/CD54 Immunoglobulin-like Cell Adhesion Molecules

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HY-P73609 TIM-1/KIM-1/HAVCR Protein, Canine (HEK293, Fc)
TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, His) belongs to a family of immunoglobulin-like domain-containing transmembrane proteins is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual, hepatotropic human picornavirus. TIM1 (HAVCR1) facilitates attachment of a variety of enveloped viruses, including filoviruses, alphaviruses, and flaviviruses, that display highly conserved phosphatidylserine (PtdSer) on their surface. TIM1 undergoes tyrosine phosphorylation of its C-terminal cytoplasmic tail. TIM-1 can function as a co-stimulatory molecule for T cell activation. TIM-1/KIM-1/HAVCR Protein, Canine (HEK293, Fc) is the recombinant canine-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with N-mFc labeled tag.

Species: Canine; Source: HEK293

Receptor Proteins

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HY-P73909 ICAM-1/CD54 Protein, Rat (HEK293, Fc)
ICAM-1/CD54 protein is a crucial ligand for leukocyte adhesion, promoting endothelial apical cup assembly during migration.It regulates immune responses and inflammation.ICAM-1 also interacts with MUC1, promoting cell aggregation, and contributes to immunological synapse formation between antigen-presenting cells and T cells.These interactions showcase ICAM-1's diverse functions in cellular adhesion and immune modulation.ICAM-1/CD54 Protein, Rat (HEK293, Fc) is the recombinant rat-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Rat; Source: HEK293

CD Antigens Receptor Proteins Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs) ICAM-1/CD54 Immunoglobulin-like Cell Adhesion Molecules

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HY-P74183 E2/Envelope Protein, Hepatitis C virus (AAC15723, HEK293, His)
E2/Envelope Protein, Hepatitis C virus (AAC15723, HEK293, His) is the recombinant Virus-derived E2/Envelope protein, expressed by HEK293, with C-His labeled tag.

Species: Virus; Source: HEK293

Viral Proteins Hepatitis C Virus Proteins Hepatitis C virus E2 Proteins

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HY-P74185 E2/Envelope Protein, Hepatitis C virus (278a.a, HEK293, His)
E2/Envelope Protein, Hepatitis C virus (278a.a, HEK293, His) is the recombinant Virus-derived E2/Envelope protein, expressed by HEK293, with C-His labeled tag.

Species: Virus; Source: HEK293

Viral Proteins Hepatitis C Virus Proteins Hepatitis C virus E2 Proteins

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HY-P74898 NS3 protease Protein, HCV (GST)
NS3 protease Protein is a zinc-dependent serine protease.NS3 needs to bind to the viral protein NS4A to enable additional conformation changes that enhance activity and appropriate intracellular localization.NS3 protein induces Caspase-8-mediated apoptosis independently of its protease or helicase activity.NS3 protease Protein, HCV (GST) is the recombinant Virus-derived NS3 protease protein, expressed by E.coli , with N-GST labeled tag.

Species: Virus; Source: E. coli

Viral Proteins Hepatitis C Virus Proteins

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HY-P75757 EVI2A Protein, Human (HEK293, Fc)
EVI2A may be a component of a cell surface receptor that forms a complex with itself or other proteins within the membrane, suggesting a role in mediating cellular responses through complex molecular interactions. Its ability to participate in self-complex formation or to interact with other proteins implies involvement in the organization of membrane-associated receptor structures. EVI2A Protein, Human (HEK293, Fc) is the recombinant human-derived EVI2A protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

Receptor Proteins

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HY-P706250 GPX1 Protein, Human (U49S, His)

Species: Human; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

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HY-P701742 PI4KB Protein, Human (Active, sf9, His, GST)
The PI4KB protein is a key enzyme that initiates the production of 1,4,5-trisphosphate inositol (PIP) by phosphorylating phosphatidylinositol (PI). In addition to myo-inositol signaling, it is involved in mitotic Golgi disassembly and Golgi-to-plasma membrane trafficking, which is critical for cell membrane dynamics. PI4KB Protein, Human (sf9, His, GST) is the recombinant human-derived PI4KB protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Lipid Kinase PI4K PI4KB

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HY-P701849 GMNN Protein, Human
GMNN proteins are important inhibitors of DNA replication and prevent the incorporation of MCM complexes into prereplication complexes. During mitosis, GMNN undergoes degradation, enabling replication in subsequent cell cycles. GMNN Protein, Human is the recombinant human-derived GMNN protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

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HY-P701850 GMNN Protein, Human (His, StrepⅡ)
GMNN proteins are important inhibitors of DNA replication and prevent the incorporation of MCM complexes into prereplication complexes. During mitosis, GMNN undergoes degradation, enabling replication in subsequent cell cycles. GMNN Protein, Human (His, Strep) is the recombinant human-derived GMNN protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P703333 PI4K2B Protein, Human (sf9, His, GST)
PI4K2B Protein, Human (sf9, His, GST) is the recombinant human-derived PI4K2B, expressed by sf9 insect cells , with His, GST labeled tag. ,

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Transferases (EC 2)

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HY-P703335 PI4K2A Protein, Human (His, GST)
PI4K2A Protein, Human (His, GST) is the recombinant human-derived PI4K2A, expressed by E. coli , with His, GST labeled tag. ,

Species: Human; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

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HY-P706345 TIM-1/KIM-1/HAVCR Protein, Human (275a.a, HEK293, His)
TIM-1/KIM-1/HAVCR Protein belongs to a family of immunoglobulin-like domain-containing transmembrane proteins is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual, hepatotropic human picornavirus. TIM1 (HAVCR1) facilitates attachment of a variety of enveloped viruses, including filoviruses, alphaviruses, and flaviviruses, that display highly conserved phosphatidylserine (PtdSer) on their surface. TIM1 undergoes tyrosine phosphorylation of its C-terminal cytoplasmic tail. TIM-1 can function as a co-stimulatory molecule for T cell activation. TIM-1/KIM-1/HAVCR Protein, Human (275a.a, HEK293, His) is the recombinant human-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

Receptor Proteins

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HY-P701920 3C protease Protein, Human rhinovirus 14
The 3C protease protein forms an icosahedral capsid with the VP2 and VP3 proteins, with a diameter of 300 angstroms. 3C protease Protein, Human rhinovirus 14 is the recombinant Virus-derived 3C protease protein, expressed by E. coli , with tag free.

Species: Virus; Source: E. coli

Viral Proteins

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HY-P701921 3C protease Protein, Human rhinovirus 14 (GST)
The 3C protease protein forms an icosahedral capsid with the VP2 and VP3 proteins, with a diameter of 300 angstroms. 3C protease Protein, Human rhinovirus 14 (GST) is the recombinant Virus-derived 3C protease protein, expressed by E. coli , with N-GST labeled tag.

Species: Virus; Source: E. coli

Viral Proteins

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HY-P704061 Vpr Protein, HIV-1 group M subtype G (GST)
Vpr Protein, HIV-1 group M subtype G (GST) is the recombinant virus-derived Vpr protein, expressed by E. coli, with N-GST tag.

Species: Virus; Source: E. coli

Viral Proteins HIV Proteins

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HY-P706178 genotype C subtype ayr External core antigen Protein, Hepatitis B virus (Biotinylated, MBP, His-Avi)

Species: Virus; Source: E. coli

Viral Proteins Biotinylated Proteins

/
HY-P80716 ICAM1/CD54 Antibody (YA352)
ICAM1/CD54 Antibody (YA352) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ICAM1/CD54.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P89744 VAP-B/C Antibody (YA9088)
VAP-B/C Antibody (YA9088) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to VAP-B/C.

Host: Mouse; Reactivity: human

Monoclonal Antibodies Primary Antibodies

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HY-P81732 ORP1 Antibody (YA1477)
ORP1 Antibody (YA1477) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ORP1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82975 Phospho-RPA32/RPA2 (Thr21) Antibody (YA2720)
Phospho-RPA32/RPA2 (Thr21) Antibody (YA2720) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RPA32/RPA2 (Thr21).

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P89423 DRD2 Antibody (YA8862)
DRD2 Antibody (YA7708) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DRD2.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811346 RBCK1 Antibody
RBCK1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to RBCK1.

Host: Rabbit; Reactivity: Human, Mouse

Polyclonal Antibodies Primary Antibodies

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HY-P86831 CaSR Antibody (YA6524)
CaSR Antibody (YA6524) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaSR.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81401 MCM6 Antibody (YA1146)
MCM6 Antibody (YA1146) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MCM6.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80975A RPA32/RPA2 Antibody (YA679)(PBS only)
RPA32/RPA2 Antibody (YA679) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to RPA32/RPA2.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P811585 PIP5K1A Antibody
PIP5K1A Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PIP5K1A.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P811752 PEAMT Antibody (YA10223)
PEAMT Antibody (YA10223) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to PEAMT.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811752A PEAMT Antibody (YA10223) (PBS only)
PEAMT Antibody (YA10223) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to PEAMT.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811938 Cytohesin 3 Antibody(YA10409)
Cytohesin 3 Antibody(YA10409) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cytohesin 3.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P811938A Cytohesin 3 Antibody(YA10409) (PBS only)
Cytohesin 3 Antibody(YA10409) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cytohesin 3.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P81671 NOLC1 Antibody (YA1416)
NOLC1 Antibody (YA1416) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NOLC1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81671A NOLC1 Antibody (YA1416)(PBS only)
NOLC1 Antibody (YA1416) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NOLC1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81732A ORP1 Antibody (YA1477)(PBS only)
ORP1 Antibody (YA1477) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ORP1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81899 PIP5K1C Antibody (YA1644)
PIP5K1C Antibody (YA1644) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIP5K1C.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81899A PIP5K1C Antibody (YA1644)(PBS only)
PIP5K1C Antibody (YA1644) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIP5K1C.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81927 PLSCR3 Antibody (YA1672)
PLSCR3 Antibody (YA1672) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PLSCR3.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81927A PLSCR3 Antibody (YA1672)(PBS only)
PLSCR3 Antibody (YA1672) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PLSCR3.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81976 WIPI1 Antibody (YA1721)
WIPI1 Antibody (YA1721) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WIPI1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82674 Scramblase 1 Antibody (YA2419)
Scramblase 1 Antibody (YA2419) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Scramblase 1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P83009 PLTP Antibody (YA2754)
PLTP Antibody (YA2754) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PLTP.

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P84119A RPA32/RPA2 Antibody (YA3816)(PBS only)
RPA32/RPA2 Antibody (YA3816) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RPA32/RPA2.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P85591 RPA32/RPA2 Antibody (YA5283)
RPA32/RPA2 Antibody (YA5283) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to RPA32/RPA2.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P86488 RPA32/RPA2 Antibody (YA6180)
RPA32/RPA2 Antibody (YA6180) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RPA32/RPA2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86708 ICAM1/CD54 Antibody (YA6400)
ICAM1/CD54 Antibody (YA6400) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ICAM1/CD54.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P86708A ICAM1/CD54 Antibody (YA6400)(PBS only)
ICAM1/CD54 Antibody (YA6400) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ICAM1/CD54.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P87011 PIP5K1C Antibody (YA6704)
PIP5K1C Antibody (YA6704) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIP5K1C.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87226 VAPA Antibody (YA6914)
VAPA Antibody (YA6914) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VAPA.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87480 ACBD3 Antibody (YA7167)
ACBD3 Antibody (YA7167) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ACBD3.

Host: Rabbit

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87572 PLSCR3 Antibody (YA7256)
PLSCR3 Antibody (YA7256) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PLSCR3.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P87690 ICAM-1 Antibody (YA7375)
ICAM-1 Antibody (YA7375) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to ICAM-1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87759 ORP1 Antibody (YA7444)
ORP1 Antibody (YA7444) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to ORP1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P88333 PIK3C2B Antibody (YA8017)
PIK3C2B Antibody (YA8017) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PIK3C2B.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P88333A PIK3C2B Antibody (YA8017)(PBS only)
PIK3C2B Antibody (YA8017) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PIK3C2B.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P88406 ACY3 Antibody (YA8090)
ACY3 Antibody (YA8090) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ACY3.

Host: Mouse; Reactivity: Human, Monkey

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P88406A ACY3 Antibody (YA8090)(PBS only)
ACY3 Antibody (YA8090) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ACY3.

Host: Mouse; Reactivity: Human, Monkey

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P88527 OSBP Antibody (YA8211)
OSBP Antibody (YA8211) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to OSBP.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P88527A OSBP Antibody (YA8211)(PBS only)
OSBP Antibody (YA8211) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to OSBP.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P88549 OSBPL11 Antibody (YA8233)
OSBPL11 Antibody (YA8233) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to OSBPL11.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P88549A OSBPL11 Antibody (YA8233)(PBS only)
OSBPL11 Antibody (YA8233) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to OSBPL11.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P88558A PIK3C2A Antibody (YA8242)(PBS only)
PIK3C2A Antibody (YA8242) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PIK3C2A.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P88766 C20orf43 Antibody (YA8450)
C20orf43 Antibody (YA8450) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to C20orf43.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P88766A C20orf43 Antibody (YA8450)(PBS only)
C20orf43 Antibody (YA8450) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to C20orf43.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P89621 VAP-1 Antibody (YA8965)
VAP-1 Antibody (YA8965) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to VAP-1.

Host: Mouse; Reactivity: human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P80716A ICAM1/CD54 Antibody (YA352)(PBS only)
ICAM1/CD54 Antibody (YA352) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ICAM1/CD54.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P810977 PIP5K1C Antibody
PIP5K1C Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to PIP5K1C.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P84119 RPA32/RPA2 Antibody (YA3816)
RPA32/RPA2 Antibody (YA3816) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RPA32/RPA2.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P88558 PIK3C2A Antibody (YA8242)
PIK3C2A Antibody (YA8242) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PIK3C2A.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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Targets/Pathways

References

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[2]. Barajas D, et al. Tombusviruses upregulate phospholipid biosynthesis via interaction between p33 replication protein and yeast lipid sensor proteins during virus replication in yeast. Virology. 2014;471-473:72-80.  

[3]. Sharma M, et al. Inhibition of phospholipid biosynthesis decreases the activity of the tombusvirus replicase and alters the subcellular localization of replication proteins. Virology. 2011;415(2):141-152.  

[4]. Panavas T, et al. The role of the p33:p33/p92 interaction domain in RNA replication and intracellular localization of p33 and p92 proteins of Cucumber necrosis tombusvirus. Virology. 2005;338(1):81-95.  

[5]. Nagy PD, et al. Tombusviruses orchestrate the host endomembrane system to create elaborate membranous replication organelles. Curr Opin Virol. 2021;48:30-41.  

[6]. Li Z, et al. Translation elongation factor 1A is a component of the tombusvirus replicase complex and affects the stability of the p33 replication co-factor. Virology. 2009;385(1):245-260.  

[7]. Berger KL, et al. Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication. J Virol. 2011;85(17):8870-8883.  

[8]. Cho NJ, et al. Phosphatidylinositol 4,5-bisphosphate is an HCV NS5A ligand and mediates replication of the viral genome. Gastroenterology. 2015;148(3):616-625.  

[9]. Wong MT, et al. Hepatitis C virus subverts human choline kinase-α to bridge phosphatidylinositol-4-kinase IIIα and NS5A and upregulates PI4KIIIα activation, thereby promoting the translocation of the ternary complex to the endoplasmic reticulum for viral replication. J Virol. 2017;91(16):e00355-17.  

[10]. Roulin PS, et al. Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface. Cell Host Microbe. 2014;16(5):677-690.  

[11]. Ishikawa-Sasaki K, et al. A complex comprising phosphatidylinositol 4-kinase IIIβ, ACBD3, and Aichi virus proteins enhances phosphatidylinositol 4-phosphate synthesis and is critical for formation of the viral replication complex. J Virol. 2014;88(12):6586-6598.  

[12]. Wang H, et al. Nir2 is an effector of VAPs necessary for efficient hepatitis C virus replication and phosphatidylinositol 4-phosphate enrichment at the viral replication organelle. J Virol. 2019;93(22):e00742-19.  

Keywords

phospholipid sensing | viral replication complex assembly | viral replication organelles | phosphatidylinositol 4-phosphate | PI4P | phosphoinositides | lipid remodeling | membrane contact sites | positive-strand RNA viruses | tombusvirus | hepatitis C virus | rhinovirus | Aichi virus | PI4K | ACBD3 | OSBP | VAP | viral replicase