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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
light-chain dimer
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "light-chain dimer" in MCE Product Catalog:
Cat. No.: HY-145889
CAS No.: 2495750-19-9
Target:
Research Areas:
LC kinetic stabilizer-1 (compound 21) is a potent and selective amyloidogenic immunoglobulin light chain kinetic stabilizer with EC50s of 140 and 74.1 nM for WIL-FL * and WIL-FL * T46L/F49Y, respectively. WIL-FL is an amyloidogenic FL LC dimer .
Cat. No.: HY-186370
CAS No.: 2495749-21-6
Target:
Research Areas:
Coumarin-based kinetic stabilizer-1 is an immunoglobulin light chain dimer stabilizer (human EC50 = 1880 nM) that stabilizes native LC dimers by binding to the VL-VL interface, reduces misfolding and proteolysis, and prevents aggregation of amyloidogenic light chains. Coumarin-based kinetic stabilizer-1 can be used in research on immunoglobulin light chain amyloidosis .
Cat. No.: HY-186371
CAS No.: 2495748-86-0
Research Areas:
Coumarin-based kinetic stabilizer-2 is a 3-substituted coumarin-carbamate-distal substructure derivative and a kinetic stabilizer of amyloidogenic immunoglobulin light chain (FL LC) dimers. Coumarin-based kinetic stabilizer-2 stabilizes the native conformation of immunoglobulin light chains, reduces protein misfolding and proteolytic hydrolysis, with an EC50 value of 77.1 nM for the human target and an EC50 value of 27.9 nM for the WIL-FL T46L/F49Y variant. Coumarin-based kinetic stabilizer-2 can be used in research related to immunoglobulin light chain amyloidosis .
Cat. No.: HY-186372
CAS No.: 2770023-22-6
Target:
Research Areas:
Coumarin-based kinetic stabilizer-3 (compound (R)-83) is a full-length immunoglobulin light chain (FL LC) kinetic stabilizer and a derivative of coumarin. Coumarin-based kinetic stabilizer-3 binds to and stabilizes the amyloidogenic WIL-FL T46L/F49Y dimer (EC50 < 2.5 nM) and the native state of WIL-FL (EC50 = 4.1 nM), slows misfolding, proteolysis, and aggregation, and antagonizes amyloidogenic unfolding. Coumarin-based kinetic stabilizer-3 can be used in research on immunoglobulin light chain (AL) amyloidosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
