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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
PDE3A/B
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "PDE3A/B" in MCE Product Catalog:
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4 Cited Publications
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BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer (WO2019025562A1; example 135) .
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Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.
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Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders.
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BRD9500 is an orally active phosphodiesterases 3 (PDE3) inhibitor with IC50s of 10 and 27 nM for PDE3A and PDE3B, respectively. Antitumor activity .
Cat. No.: HY-U00186
CAS No.: 189362-06-9
Synonyms: OPC33509
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K134 is a phosphodiesterase 3 (PDE3) inhibitor. The IC50s of K134 toward PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 µM, respectively.
Cat. No.: HY-174383
CAS No.: 2857007-03-3
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PDE3/4-IN-2 is a dual PDE3A and PDE4B1 inhibitor, with an IC50 of 0.13 nM against PDE3A and 50 nM against PDE4B1. PDE3/4-IN-2 exhibits higher systemic exposure and longer retention time in lung tissues in ICR mice. PDE3/4-IN-2 can be used in research on respiratory diseases such as asthma and chronic obstructive pulmonary disease, as well as autoimmune inflammation-related studies .
Cat. No.: HY-111167
CAS No.: 906673-33-4
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AN-2898 is a selective PDE4 inhibitor with IC50 of 0.027 μM over other phosphodiesterase enzymes, such as PDE1A, PDE2A and PDE3A. AN-2898 also potently inhibits PDE4 subtypes (PDE4B1, PDE4A1A and PDE4D2). AN-2898 significantly inhibits the production of TNF-α, IL-2, IFN-γ, IL-5 and IL-10. AN-2898 can be used for mild to moderate atopic dermatitis (AD) and psoriasis research .
Cat. No.: HY-176524S
CAS No.: 2939748-69-1
Cat. No.: HY-112631
CAS No.: 189362-27-4
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OPC-33540 is a highly selective and competitive PDE3 inhibitor with IC50 values of 0.32 nM (PDE3A) and 1.5 nM (PDE3B). OPC-33540 exhibits IC50s against PDE1, PDE2, PDE4, PDE5, and PDE7 of 42.9, 52.3, 100.8, 2.5, and 51.3 μM, respectively. OPC-33540 significantly enhances cAMP accumulation in platelets and effectively inhibits thrombin-induced platelet aggregation. OPC-33540 can be used in antithrombotic studies .
Cat. No.: HY-190257
CAS No.: 2275773-39-0
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PDE3A/B-IN-1 (Example 12) is a PDE3A/B molecular glue inhibitor. PDE3A/B-IN-1 inhibits tumor cell proliferation by inducing and stabilizing the formation of a complex between PDE3A/B and SLFN12 protein. PDE3A/B-IN-1 can be used for cancer research .
Cat. No.: HY-190275
CAS No.: 2275774-55-3
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PDE3A/B-IN-3 is a PDE3A and PDE3B inhibitor. PDE3A/B-IN-3 can be used for cervical cancer research .
Cat. No.: HY-190259
CAS No.: 2275774-53-1
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PDE3A/B-IN-2 is a PDE3A/B inhibitor with IC50 values of 280 nM and 270 nM, respectively. PDE3A/B-IN-2 inhibits tumor cell proliferation and modulates the formation of PDE3A-SLFN12 and PDE3B-SLFN12 complexes. PDE3A/B-IN-2 is also a molecular glue (molecular glue). PDE3A/B-IN-2 can be used for cancer research .
Cat. No.: HY-190276
CAS No.: 2275775-70-5
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PDE3A/B-IN-4 is a PDE3A and PDE3B inhibitor with IC50 values of 65 nM and 180 nM, respectively. PDE3A/B-IN-4 is also a molecular glue. PDE3A/B-IN-4 can be used in research related to cervical cancer .
Cat. No.: HY-190258
CAS No.: 2275774-47-3
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PDE3A/B-IN-5 is a PDE3A and PDE3B inhibitor with IC50 values of 6 nM and 4 nM, respectively. PDE3A/B-IN-5 is also a molecular glue. PDE3A/SLFN12 stabilizer-1 can be used in research related to cervical cancer and melanoma .
Cat. No.: HY-101312R
CAS No.: 68550-75-4
Synonyms: OPC3689 (Standard)
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Cilostamide (Standard) is the analytical standard of Cilostamide. This product is intended for research and analytical applications. Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.
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(S)-BRD9500 is the isomer of BRD9500 (HY-136350), and can be used as an experimental control. BRD9500 is an orally active phosphodiesterases 3 (PDE3) inhibitor with IC50s of 10 and 27 nM for PDE3A and PDE3B, respectively. Antitumor activity .
Cat. No.: HY-171827
CAS No.: 2408152-69-0
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Giclanfentrine is a potent PDE3A inhibitor with an IC50 of 0.0058 μM. Giclanfentrine inhibits PDE4B1 activity with an IC50 of 12.9 μM. Giclanfentrine is applicable to studies related to PDE3/cAMP signaling .
Cat. No.: HY-190169
CAS No.: 2841750-38-5
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Antitumor agent-232 is a polycyclic compound derived from Anagrelide (HY-B0523) and also a molecular glue. Antitumor agent-232 modulates the PDE3A/SLFN12 protein interaction. Antitumor agent-232 can be used in cancer research .
Cat. No.: HY-181762
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Multitarget AD-IN-6 (Compound 39) is a multi-target inhibitor, with an IC50 of 15.54 μM against PDE4B, 15.15 μM against PDE7A, 8.39 μM against PDE3A, and a Kd of 37.7 μM against CHIT1. Multitarget AD-IN-6 acts as a TRPA1 antagonist, reduces the level of the NLRP3 inflammasome multiprotein complex to inhibit its activation, while inhibiting PDE4B, PDE7A and CHIT1, and decreasing the phosphorylation of NF-κB. Multitarget AD-IN-6 improves the pathology of elastase-induced emphysema in mice. Multitarget AD-IN-6 is applicable for the research of chronic obstructive pulmonary disease .
Cat. No.: HY-179503
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Phosphodiesterase (PDE) TRP Channel NOD-like Receptor (NLR) NF-κB TNF Receptor Interleukin Related
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PDE/TRPA1/CHIT1-IN-1 is a phosphodiesterases (PDEs), TRPA1, and hCHIT1 (KD of 37.7 μM) inhibitor. PDE/TRPA1/CHIT1-IN-1 is a broad-spectrum PDE inhibitor, potently targeting key isoforms including PDE4B, PDE7A, PDE3A, and PDE8A with IC50s of 15.54, 15.15, 8.39 and 16.46 μM. PDE/TRPA1/CHIT1-IN-1 suppresses NLRP3 inflammasome activation and inhibits NF-κB phosphorylation, downregulating the expression of pro-inflammatory genes (TNF-α and IL-6) in vivo. PDE/TRPA1/CHIT1-IN-1 can be used for chronic obstructive pulmonary disease (COPD) and related inflammatory lung disorders research .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
