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Extracellular Vesicles: Pathogenesis and Therapy

Intercellular Communication & Diseases Tumor Microenvironment Cancer Immunotherapy Chronic Inflammation

Extracellular vesicles (EVs) are membrane-enclosed particles released by cells and include endosome-derived exosomes and plasma-membrane-derived microvesicles; they transport proteins, lipids, RNA, and other cellular constituents between cells. Early observations of vesicle release emerged from studies of reticulocyte membrane trafficking in the 1980s, while subsequent work established EVs as active mediators of intercellular communication rather than simple cellular disposal products. A major conceptual advance came when exosomes were shown to contain transferable mRNAs and microRNAs, demonstrating a mechanism for intercellular genetic exchange. Modern EV research therefore spans cell biology, immunology, cancer, cardiovascular disease, infection, diagnostics, and therapeutic delivery, with substantial interest driven by the ability of vesicle cargo to reflect the physiological or pathological state of the source cell[1][2][3].

EV function depends on biogenesis, selective cargo incorporation, release, targeting, and uptake by recipient cells. Exosomes arise as intraluminal vesicles within multivesicular endosomes and are released after fusion of these compartments with the plasma membrane, whereas microvesicles bud directly outward from the plasma membrane. Once released, EVs can transfer bioactive RNAs, proteins, lipids, and metabolites and thereby alter gene expression, signaling pathways, and cellular phenotypes in recipient cells. In cancer, tumor-derived exosomal integrins help determine organ-specific uptake and pre-metastatic niche formation, linking EV surface composition to metastatic organotropism. EV-mediated immune regulation is also mechanistically important: melanoma-derived exosomes carrying PD-L1 suppress CD8 T-cell function through the PD-1 checkpoint axis, while interference with pathways controlling vesicle secretion and PD-L1 expression can modify this immunosuppressive activity. During infection, EVs can transport pathogen-derived proteins, nucleic acids, lipids, or carbohydrates that stimulate innate and adaptive immunity or contribute to immune evasion[1][4][5][6].

These mechanisms create parallel pathogenic and therapeutic opportunities. Tumor-derived EVs can promote metastasis and immune escape, whereas circulating EV cargo can provide diagnostic or prognostic information because it reflects molecular features of diseased cells. In cardiovascular disease, EVs participate in inter-tissue communication and have been investigated both as biomarkers and as cell-free therapeutic products derived from stem or progenitor cells. Their endogenous ability to transfer molecular cargo has also motivated development of EVs as delivery systems for RNAs, proteins, and other therapeutic agents. In infectious disease, their antigenic cargo supports investigation of EVs as vaccine components or diagnostic markers, while in oncology their targeting properties and immune-modulatory functions motivate strategies that either inhibit pathogenic EV signaling or engineer vesicles for therapeutic delivery[5][6][7][8].

Clinical translation remains limited by EV heterogeneity and by incomplete control over isolation, purification, characterization, cargo assignment, dosage, and manufacturing reproducibility. International guidance therefore emphasizes rigorous separation and characterization, appropriate positive and negative markers, and transparent reporting before biological functions are attributed to specific EV populations. Comparative analyses of clinical EV studies likewise show substantial variation in isolation methodology and incomplete characterization, complicating comparison across laboratories. Future work should define disease-relevant EV subpopulations more precisely, establish reproducible production and quality-control standards, clarify mechanisms of tissue targeting and uptake, and determine which EV components provide therapeutic benefit or pathogenic activity. Resolving these issues is essential for converting EV biology into reproducible biomarkers, drug-delivery systems, regenerative therapies, and interventions that block disease-promoting intercellular communication[8][9][10].

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Cat. No. Product Name Information Application Publication
HY-12031 U0126-EtOH
U0126 (U0126-EtOH) is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor.
MEK   Autophagy   Mitophagy   Influenza Virus  
Colorectal Cancer   Liver Cancer   Pancreatic Cancer   Viral Infection   Pain   Digestive System Inflammation   Obesity   Rheumatoid Arthritis  
500
HY-12031A U0126
U0126 is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor.
MEK   Autophagy   Mitophagy   Influenza Virus  
Colorectal Cancer   Liver Cancer   Pancreatic Cancer   Viral Infection   Pain   Digestive System Inflammation   Obesity   Rheumatoid Arthritis  
500
HY-12028 PD98059
PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 µM) and MEK2 (IC50 of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy.
MEK   ERK   Aryl Hydrocarbon Receptor   Autophagy  
Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Pain   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
434
HY-10201 Sorafenib
Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma.
Raf   VEGFR   FLT3   Autophagy   Apoptosis   STAT   Akt   MMP   Cadherin   p38 MAPK   ERK   MEK   PI3K   PARP   Bcl-2 Family   Ephrin Receptor   PDGFR  
Gastric Cancer   Liver Cancer   Ovarian Cancer   Digestive System Inflammation   Small Cell Lung Cancer   Non-Small Cell Lung Cancer   Metastatic Breast Cancer   Metastatic Colorectal Cancer   Metastatic Prostate Cancer   Multiple Myeloma   Metastatic Pancreatic Cancer   SARS-CoV-2 Infection   Alzheimer's Disease   Parkinson's Disease   Obesity   Lung Fibrosis  
323
HY-10999 Trametinib
Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis, cross the blood-brain barrier (BBB), used in research related to subarachnoid hemorrhage (SAH).
MEK   Autophagy   Apoptosis  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Pain   Digestive System Inflammation   Non-Small Cell Lung Cancer   Lung Adenocarcinoma   SARS-CoV-2 Infection   Obesity   Rheumatoid Arthritis  
318
HY-50846 SCH772984
SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 and 1 nM for ERK1 and ERK2, respectively. SCH772984 has antitumor activity in MAPK inhibitor-naive and MAPK inhibitor-resistant cells containing BRAF or RAS mutations.
ERK  
Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Pain  
209
HY-A0098 Tunicamycin
Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity.Tunicamycin increases exosome release in cervical cancer cells.

Source: Streptomyces lysosuperficus

Antibiotic   Bacterial   Fungal   Exosomes   Influenza Virus   Aminotransferases (Transaminases)  
Cancer   Infection   Inflammation or Immune System Disease  
183
HY-10254 Mirdametinib
Mirdametinib (PD0325901) is an orally active, selective and non-ATP-competitive MEK inhibitor with an IC50 of 0.33 nM. Mirdametinib exhibits a Kiapp of 1 nM against activated MEK1 and MEK2. Mirdametinib suppresses the expression of p-ERK1/2 and induces apoptosis. Mirdametinib has anti-cancer activity for a broad spectrum of human tumor xenografts.
MEK   Autophagy   Apoptosis  
Colorectal Cancer   Liver Cancer   Pancreatic Cancer   Pain   Digestive System Inflammation   Obesity   Rheumatoid Arthritis  
163
HY-50896 Erlotinib
Erlotinib (CP-358774) is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib also acts as a substrate and inhibitor of OATP2B1, with an IC50 of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2, GSK-3β and β-catenin signaling pathways, fibronectin, α-SMA, collagen deposition, and renal injury markers. Erlotinib is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib can be used in research related to non-small cell lung cancer, gastric cancer, papillary renal cell carcinoma, pancreatic cancer, renal fibrosis, and other conditions.
EGFR   OAT   ERK   GSK-3   β-catenin  
Gastric Cancer   Pancreatic Cancer   Renal Disease   Non-Small Cell Lung Cancer   Lung Adenocarcinoma  
154
HY-112735 Hexadimethrine bromide
Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer.
Biochemical Assay Reagents  
Cancer  
122
HY-18723 Yoda 1
Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation.
Piezo Channel   Akt   ERK   Potassium Channel  
Pancreatic Cancer   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Lung Fibrosis  
122
HY-19696 Tauroursodeoxycholate
Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an orally active endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
ERK   Caspase   Endogenous Metabolite   Apoptosis  
Colorectal Cancer   Prostate Cancer   Liver Cancer   Viral Infection   Neurodegenerative Disease   Pain   Digestive System Inflammation   Glucose Metabolism   Obesity  
114
HY-L025 Anti-Cancer Compound Library
Cancer is the second leading cause of death globally and seriously threatens human health. A neoplasm and malignant tumor are other common names for cancer. Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Target therapy, which targets proteins that control how cancer cells grow, divide and spread, plays an important role in cancer treatment. Recent studies mainly focus on targeting the key proteins for cancer surviving, cancer stem cells, the tumor microenvironment, tumor immunology, etc. MCE designs a unique collection of 11,280 anti-cancer compounds that target kinases, cell cycle key components, tumorigenesis related signaling pathways, etc. MCE Anti-cancer compound library is a useful tool for anti-cancer drug screening.

Disease Focused Libraries

114
HY-N6682 Cytochalasin D
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap.

Source: molds

Exosomes   Arp2/3 Complex   Antibiotic   YAP  
Cancer   Infection  
111
HY-L007 Immunology/Inflammation Compound Library
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation. MCE designs a unique collection of 8,743 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.

Signaling Pathway Targeting Libraries

104
HY-50706 Selumetinib
Selumetinib (AZD6244) is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation. Selumetinib can penetrate the blood brain barrier (BBB).
MEK   Apoptosis  
Colorectal Cancer   Liver Cancer   Pancreatic Cancer   Pain   Digestive System Inflammation   Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer   Obesity   Rheumatoid Arthritis  
103
HY-L031 Small Molecule Immuno-Oncology Compound Library
Immuno-Oncology is a type of immunotherapy that has the specific purpose of treating cancer. It works by stimulating our immune system to fight back. Normally, our immune system is able to destroy cancer cells in our body, however sometimes cancer cells can adapt and mutate, effectively hiding from our immune system. This is when tumors can develop and become a threat to our health. Immuno-oncology involves mobilizing lymphocytes to recognize and eliminate cancer cells using the body’s immune system. There are several immuno-oncology treatments available, including Immune cell therapy (CAR-T), monoclonal antibodies (mABs) and checkpoint inhibitors, cytokines and cancer vaccines. MCE Small Molecule Immuno-Oncology Compound Library offers 840 bioactive tumor immunology compounds that target some important checkpoints such as PD1/PD-L1, CXCR, Sting, IDO, TLR, etc. This library is a useful tool for Immuno-oncology research.

Disease Focused Libraries

102
HY-L017 Stem Cell Signaling Compound Library
Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy. MCE owns a unique collection of 2,970 compounds that can be used for stem cell regulatory and signaling pathway research.

Signaling Pathway Targeting Libraries

100
HY-L109 Protein-protein Interaction Inhibitor Library
Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. The classic drug targets are usually enzymes, ion channels, or receptors, the PPI indicate new potential therapeutic targets. Therefore, targeting PPI is a new direction in treating diseases and an essential strategy for the development of new drugs. However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures. With the development of high-throughput technology, high-throughput screening is also gradually used for the identification of PPI inhibitors, but the compound library used for conventional target screening is not very effective in screening PPI inhibitors. To improve screening efficiency, MCE carefully selected 836 PPI inhibitors and mainly targeting MDM2-p53, Keap1-Nrf2, PD-1/PD-L1, Myc-Max, etc. MCE Protein-protein Interaction Inhibitor Library is a useful tool for PPI drug discovery and related research.

Signaling Pathway Targeting Libraries

100
HY-L123 Human Metabolite Library
Human metabolism is an integral part of cellular function that reflects individual differences in health, disease, diet, and lifestyle. Many health conditions such as obesity, diabetes, hypertension, heart disease, and cancer are associated with abnormal metabolic states. In the pathological state of the human body, metabolic pathways are significantly altered, resulting in aberrant levels of intermediates or end-products that can be viewed as potential diagnostic biomarkers or even therapeutic targets. Therefore, detection, identification and quantification of human metabolites are very important for drug metabolism research in drug development. MCE offers a unique collection of 6,774 human metabolites, including endogenous metabolites and exogenous metabolites, covering multiple structure types, such as lipids, amino acids, nucleic acids, carbohydrates, organic acids, biogenic amines, vitamins,. MCE Human Metabolites Library is a helpful tool for studying the relationship between diseases and metabolism.

Metabolism Focused Libraries

99
HY-L013 Neuronal Signaling Compound Library
Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders. MCE designs a unique collection of 3,989 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

Signaling Pathway Targeting Libraries

98
HY-L034 Anti-Aging Compound Library
Aging is a complex biological process characterized by functional decline of tissues and organs, structural degeneration, and reduced adaptability and resistance, all of which contribute to an increase in morbidity and mortality caused by multiple chronic diseases, such as Alzheimer's disease, cancer, and diabetes. Many theories, which fall into two main categories: programmed and error theories, have been proposed to explain the process of aging, but neither of them appears to be fully satisfactory. The programmed theories imply that aging relies on specific gene regulation, and the error theories emphasize the internal and environmental damages accumulated to living organisms. The damage theories proposed the nine hallmarks that were generally considered to contribute to the aging process: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. MCE Anti-Aging Compound Library contains 7,843 compounds, mainly targeting Sirtuin, mTOR, IGF-1R, AMPK, p53, Telomerase, Mitophagy, Mitochondrial Metabolism, COX, Cytochrome P450, Oxidase, etc. This library is a useful tool for anti-aging research.

Disease Focused Libraries

98
HY-L075 Anti-Lung Cancer Compound Library
Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Lung cancer is divided into two categories: small cell lung cancer and non-small cell lung cancer (NSCLC). Non-small cell lung cancer accounts for about 85 percent of lung cancers. As with all cancers, lung cancer may be treated with surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. Targeted therapy is one of the most exciting developments in lung cancer medicine, especially for NSCLC. Extensive genomic characterization of NSCLC has led to the identification of molecular subtypes of NSCLC that are oncogene addicted and exquisitely sensitive to targeted therapies. These include activating mutations in epidermal growth factor receptor (EGFR) and BRAF or echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusions and ROS1 receptor tyrosine kinase fusions. These are important targets for target therapy. MCE offers a unique collection of 3,099 compounds with identified and potential anti-lung cancer activity. These compounds target lung cancer’s major targets and signaling pathways. MCE anti-lung cancer compound library is a useful tool for anti-lung cancer drugs screening and other related research.

Disease Focused Libraries

98
HY-L076 Drug-Induced Liver Injury (DILI) Compound Library
Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. Drugs are an important cause of liver injury. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug. DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural (e.g., mitochondrial dysfunction) and functional integrity of the liver; production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver. MCE Drug-induced Liver Injury (DILI) Compound Library contains a unique collection of 642 hepatotoxicity causing compounds and is a powerful tool to research DILI and other drug toxicities. This library can be used to understand the mechanisms of DILI, identify biomarkers for early DILI prediction, and allow timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.

Compound Characteristic Classified Libraries

98
HY-L080 Targeted Therapy Drug Library
Targeted cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecular targets that are involved in the growth, progression, and spread of cancer. There are several different types of targeted therapy. The most common types are small-molecule drugs and monoclonal antibodies. Small-molecule drugs are small enough to enter cells easily, so they are used for targets that are inside cells, while monoclonal antibodies are usually used for targets that are located outside the cells. Because of high specificity, low side effect and potent anticancer activity, targeted therapy has become the mainstream of new anti-tumor drugs. Various targeted therapies have been approved by FDA and used in the treatment of diseases. MCE carefully collects a unique of 107 targeted therapy drugs used in cancer treatment. MCE Targeted therapy drug library is a useful tool for the research of targeted therapy.

Disease Focused Libraries

98
HY-L149 Membrane Protein-targeted Compound Library
A membrane protein is a protein molecule that is attached to or associated with the membrane of a cell or an organelle. Membrane proteins can be classified into two groups based on how the protein is associated with the membrane: integral membrane proteins and peripheral membrane proteins. In humans, about 30% genome encodes membrane proteins. Membrane proteins perform a variety of functions vital to the survival of organisms, for example, signal transduction, molecules or ion transportation, enzymatic catalysis, and intercellular communication. Membrane proteins also play important roles in drug discovery. As reported, more than 60% of current drug targets are membrane proteins. MCE supplies a unique collection of 8,052 compounds targeting a variety of membrane proteins. MCE Membrane Protein-targeted Compound Library can be used for membrane protein-focused screening and drug discovery.

Signaling Pathway Targeting Libraries

98
HY-L151 PROTAC Library
PROTACs (Proteolysis-targeting chimeras) is a class of molecules that utilize ubiquitin-proteasome system (UPS) to ubiquitinate and degrade target proteins. The PROTACs molecule consists of two ligands joined by a linker. The one-to-one interaction between PROTACs and target proteins determines the high efficiency of PROTACs, making it a potential molecule for targeted protein degradation (TPD) therapy. MCE supplies a unique collection of 555 PROTACs that effectively degrade target proteins with more powerful screening capability. MCE PROTAC Library is a useful tool for signal pathway research, protein degradation therapy research, drug discovery and drug repurposing, etc.

Compound Characteristic Classified Libraries

98
HY-L188 Anti-Brain Cancer Compound Library
Although brain cancer only accounts for 2% of all tumors, it has a poor prognosis, high mortality and high recurrence rate. Brain cancer can be divided into primary brain cancer and secondary brain cancer. According to the location of the cancer, brain cancer can also be divided into: brain glioma, pituitary adenoma, schwannoma, craniopharyngioma, meningioma and so on. Glioma is the most common primary brain tumor, accounting for about 1/3 of all brain tumors. At present, brain cancer lacks precision targeted therapeutic drugs, and there is still a great clinical demand that has not been met. With the continuous development of high-throughput screening technology, it may be able to help develop effective anti-brain cancer drugs by screening compounds targeting PKC, PD-1, c-Met, PARP, etc targets. MCE designs a unique collection of 2,148 small molecules with definite or potential anti-brain cancer activity, which is an important tool for studying the pathological mechanism of brain cancer and developing drugs for brain cancer.
98
HY-14596 Genistein
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
EGFR   Autophagy   Apoptosis   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Lung Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Ovarian Cancer   Digestive System Inflammation   SARS-CoV-2 Infection   Hepatitis C Virus Infection   Obesity  
97
HY-E0156 8-Channel Handheld Screw Cap Decapper

MCE 8-Channel Handheld Screw Cap Decapper is a necessary tool for handling thousands of screw cap tubes. It can cap and open various types of screw cap tubes, making it convenient and fast to operate. This improves experimental efficiency and meets different needs.
97
HY-E0285 Echo 384-Well Polypropylene Microplate
The Echo 384-well polypropylene microplate exhibits excellent resistance to DMSO, various buffers, and a wide range of organic solvents, making it suitable for compound and sample storage and ensuring precise and accurate liquid transfer when used with the Echo Liquid Handler.
97
HY-L0124V Chemspace CNS-Focused Library
The basic requirements for the compounds that are supposed to penetrate the blood-brain barrier are somewhat different from those for the majority of drug discovery projects. Alongside the known problem with delivery of the large and non-polar compounds and their penetrability through the cell membrane, the other issue arises as well: small and polar compounds are not able to pass the Blood-Brain Barrier. Chemspace CNS-focused library comprises quite small, non-polar compounds that are also free from PAINS/toxic fragments and aggregators.
97
HY-L038 Differentiation Inducing Compound Library
Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method. MCE Differentiation Inducing Compound Library contains a unique collection of 2,617 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.

Signaling Pathway Targeting Libraries

97
HY-L039 Reprogramming Compound Library
Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells. MCE Reprogramming Compound Library contains a unique collection of 3,257 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Signaling Pathway Targeting Libraries

97
HY-L072 Exosomes Compound Library
Exosomes are small membrane vesicles of endocytic origin that are secreted by most cells in culture. Exosomes contain nucleic acids, proteins, lipids, amino acids, and metabolites, etc. Their diverse constituents can reflect their cell of origin. Exosomes are associated with immune responses, viral pathogenicity, pregnancy, cardiovascular diseases, central nervous system-related diseases, and cancer progression. Proteins, metabolites, and nucleic acids delivered by exosomes into recipient cells effectively alter their biological response. Such exosome-mediated responses can be disease promoting or restraining. The biology of exosomes in disease is still emerging, and the number of studies addressing their utility in the diagnosis and treatment of various pathologies has increased substantially. MCE supplies a unique collection of 57 compounds with the activity of inhibiting or stimulating exsomes secretion/biosynthesis. MCE Exosomes Compound Library is a useful tool for exsomes research.

Signaling Pathway Targeting Libraries

97
HY-L074 Anti-Breast Cancer Compound Library
Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC). Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer. MCE supplies a unique collection of 3,445 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Disease Focused Libraries

97
HY-L079 Anti-Blood Cancer Compound Library
Blood cancers, also called hematologic cancers, occur when abnormal blood cells start growing out of control, interrupting the function of normal blood cells, which fight off infection and produce new blood cells. Most blood cancers start in the bone marrow, which is where blood is produced. There are three main types of blood cancers: leukemia, lymphoma and myeloma, which afflict millions of children and adults every year, and are often deadly. Some common blood cancer treatments include stem cell transplantation, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. As we begin to understand the key signaling pathways and molecular drivers of malignant transformation in haematological disorders, new treatment strategies will continue to be developed. MCE offers a unique collection of 4,372 compounds with identified and potential anti-blood cancer activity. These compounds target blood cancer’s major targets and signaling pathways. MCE anti-blood cancer compound library is a useful tool for anti-blood cancer drugs screening and other related research.

Disease Focused Libraries

97
HY-L105S Peptide Compound Library
Peptides, composed of amino acids, serve as crucial building blocks for proteins and have gained significant attention in drug development over the past decade. The advancements in production, modification, and analytical technologies have led to a surge in the potential applications of peptides in medicine. Peptides offer a number of advantages over small molecule drugs, including: greater target specificity and efficacy, more predictable metabolic profiles, easier delivery to where they are needed in the body, and fewer side effects. Peptides are increasingly appearing in all branches of medicine as components of innovative drugs, imaging agents, diagnostic agents, and other complex drugs such as peptide-drug conjugates. To date, more than 80 peptide drugs have been approved to treat a variety of diseases, including microbial infections, obesity, anti-diabetes, and cancer, as well as to develop cell targeting platforms and improve cell penetration properties. MCE designs a unique collection of 877 peptide compounds. HY-L105S is a peptide compound library that can be provided with solution form based on HY-L105, and can be applied to peptides-based drug development.

Structure Classified Libraries

97
HY-L112 Chemotherapy Drug Library
Chemotherapy is one of the most common treatments for cancer. It can be used alone for some types of cancer or in combination with other treatments such as radiation or surgery. Chemotherapy drugs usually target cells at different phases of the cell cycle and inhibit tumor proliferation and avoid cancer cell invasion and metastasis. It is a cancer treatment method that kills cancer cells with drugs. Chemotherapeutic agents can be classified into alkylating agents, antimetabolites, antimicrotubular agents, antibiotics, etc. according to the mechanism of action. MCE offers a unique collection of 156 chemotherapy drugs, which is a useful tool for cancer treatment research.

Disease Focused Libraries

97
HY-L132 Chemokine Compound Library
Chemokines, or chemotactic cytokines, are small cytokines or signaling proteins secreted by cells. They are a component of intercellular communication, controlling the directional movement of immune cells especially leukocytes, as well as other cell types, for instance, endothelial and epithelial cells, which are essential to maintain human health and the function of the immune system. The biological effects of chemokines are achieved by binding to chemokine receptors, which are G protein-coupled receptors found on the surface of leukocytes. Some chemokine receptors are involved in directing tumor metastasis and over-expression by certain tumors. So inhibiting the interaction between chemokine and chemokine receptors on the surface of tumor cells may be a new possible therapeutic approach. Some chemokine receptors are coreceptors for HIV entry, and related inhibitors have been approved by the FDA to treat patients with HIV. Obviously, chemokines and chemokine receptors have become new targets for studying cancer, HIV, inflammation, and other diseases. MCE supplies a unique collection of 262 chemokine or chemokine receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on chemokine or chemokine receptors. MCE Chemokine Library is a useful tool for drug research related to cancer, AIDS, and wound therapy.

Signaling Pathway Targeting Libraries

97
HY-L135 Cancer Stem Cells Compound Library
With the progress of modern cancer therapy, the life of cancer patients has been extended. However, after initial treatment and recovery, the development of secondary tumors often leads to cancer recurrence. Cancer stem cells are a small number of cells that tumor growth and reproduction depend on. Cancer stem cells have strong self-renewal ability, which is the direct cause of tumor occurrence. In addition, cancer stem cells also have the ability to differentiate into different cell types, playing a crucial role in tumor metastasis and development. Chemotherapy and radiotherapy induced DNA damage and apoptosis are common cancer treatments. However, cancer stem cells can effectively protect cancer cells from apoptosis by activating DNA repair ability. Cancer stem cells are regarded as the key "seed" of tumor occurrence, development, metastasis and recurrence. Since its first discovery in leukemia in 1994, cancer stem cells have been considered a promising therapeutic target for cancer treatment. MCE supplies a unique collection of 3,582 compounds targeting key proteins in cancer stem cells. MCE Cancer Stem Cells Compound Library is a useful tool for cancer stem cells related research and anti-cancer drug development.

Compound Characteristic Classified Libraries

97
HY-L150 Membrane Receptor-targeted Compound Library
Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules. There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery. MCE provides a unique collection of 7,190 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

Signaling Pathway Targeting Libraries

97
HY-L164 Serine/Threonine Kinase Inhibitor Library
Protein serine/threonine kinases (PSKs) are protein kinases that use ATP as a high-energy donor molecule to transfer phosphate groups to serine/threonine residues of target protein. As an important signal transduction regulator, serine/threonine kinases can affect the function of target proteins by disrupting enzyme activity or binding of target proteins to other proteins. Serine/threonine kinases are involved in the regulation of immune response, cell proliferation, differentiation, apoptosis and other physiological processes. Serine/threonine kinase inhibitors are an important class of compounds that have been widely studied in cancer, chronic inflammation, autoimmune diseases, aging and other diseases. MCE designs a unique collection of 2,311 serine/threonine kinase inhibitors, mainly targeting the receptor PKA, Akt, PKC, MAPK/ERK, etc, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases, anti-autoimmune diseases and anti-aging compounds.

Signaling Pathway Targeting Libraries

97
HY-L168 Extracellular Vesicles (EVs) Compound Library
Extracellular vesicles (EVs) are small membrane binding structures that are released from cells into the surrounding environment and play a crucial role in mediating and regulating intercellular communication related to physiological and pathological processes. EVs are lipid membrane vesicles composed of proteins, lipids, and nucleic acids. EVs can be divided into several types based on their source, such as extracellular vesicles, microcapsules, and apoptotic vesicles. The size range of exosomes is 30-150nm, which are endocrine in multi vesicular endosomes (MVEs); microvesicles (50-1000nm) are secreted directly through extracellular interactions, thereby releasing plasma membrane vesicles. In contrast, apoptotic bodies are usually larger, ranging in size from 1 to 5 μ m. This is generated during programmed cell death. EV plays a crucial role in transmitting information between cells and influencing the behavior and function of receptor cells. MCE designs a unique collection of 715 small molecules related to extracellular vesicles (EVs). It is a good tool to be used for research on metabolize, cancer and other diseases.

Signaling Pathway Targeting Libraries

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HY-L171 Anti-Hematopathy Compound Library
Hematopathy, also known as hematopoietic system diseases, are a class of diseases that hematopoietic system has abnormal changes. Common hematopathy include: aplastic anemia, myeloproliferative diseases, thalassemia, leukemia, lymphoma, myeloma and hemophilia, etc. In recent years, treatments for hematopathy have been developed. In particular, the treatment of malignant hematopathy developed from chemotherapy, radiotherapy, bone marrow development to immunotherapy, induced differentiation therapy, cell therapy, gene therapy and hematopoietic stem cell transplantation. Although these therapies have greatly improved the survival rate of patients, there are still problems such as low cure rate and easy recurrence in the treatment of hematopathy. Therefore, it is of great significance to actively search for new hematopathy therapeutic drugs. MCE designs a unique collection of 4,428 anti-hematopathy small molecules, which is an effective tool for development and research of anti-hematopathy compounds.

Disease Focused Libraries

97
HY-L178 Radioprotector Library
Radiation sickness is a general term for various types and degrees of damage (or disease) occurring in the human body after exposure to ionizing radiation. Although small amounts of ionizing radiation can also cause the body to produce free radicals and ROS, causing oxidative stress, resulting in DNA damage and chromosomal aberration. Radioprotector are compounds with radiation protection that can be used to prevent/protect non-tumor cells from the harmful effects of radiation. Radioprotective compounds can prevent the damage of radioactive substances to the human body and reduce the clinical symptoms of various radioactive diseases. In addition, radioprotectors can protect normal cells from damage during radiation therapy. The ideal anti-radiation drug should not affect the sensitivity of tumor cells to radiation therapy while protecting normal cells. MCE designs a unique collection of 3,112 radioprotectors. Radioprotector Library is an effective tool for acute Radiation Syndrome, drug combination research with radiation drugs.

Compound Characteristic Classified Libraries

97
HY-L184 Anti-Gastric Cancer Compound Library
Gastric Cancer (GC) is one of the most common malignant tumors in the world, ranking fourth in mortality rate globally. Because the early symptoms of stomach neoplasm are usually not obvious, are diagnosed with gastric cancer at terminal stage, and the relative survival rate within 5 years is very low. With the further understanding of the molecular characteristics of stomach neoplasm, many therapeutic targets for gastric cancer have been identified, and molecular targeted therapies such as CTLA-4, HER2 and immune checkpoint inhibitors have made rapid progress. Although survival rates for patients with gastric neoplasm have improved over the past few decades, the prognosis is still worrying. Therefore, there is an urgent need for new drugs to treat gastric cancer. MCE designs a unique collection of 1,225 small molecules with definite or potential anti-gastric cancer activity, which is an important tool for studying the pathological mechanism of stomach neoplasm and developing drugs for stomach neoplasm.

Disease Focused Libraries

97
HY-L185 Anti-Fibrosis Compound Library
Fibrosis is a kind of repair response to long-term tissue damage, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and scar formation. Myofibroblasts are the main generating cells of extracellular matrix, and their activation process is related to various pathological mechanisms including Oxidative stress, chronic inflammation and cytokine secretion. Fibrosis can occur in many organs, such as kidneys, liver, heart, lungs, etc. Continuous fibrosis can lead to the destruction of the normal structure of tissues and organs, and if not controlled in time, may cause organ failure or even life-threatening. MCE contains 2,614 compounds targeting ant-fibrosis targets such as TGF-β, PI3K, Wnt, MMP, etc. These compounds have clear or potential anti-fibrosis activity and can be used for mechanism research and drug screening of fibrosis diseases.

Disease Focused Libraries

97
HY-L197 Vitamin Compound Library
Vitamins are a category of trace organic compounds essential for maintaining normal physiological functions in living organisms. They are classified into fat-soluble and water-soluble vitamins. Fat-soluble vitamins play a role in maintaining vision, bone health, reproductive functions, and blood coagulation. Water-soluble vitamins are involved in energy metabolism, nervous system function, and cellular repair processes. Most vitamins cannot be synthesized by the organism and must be obtained through diet. In recent years, vitamins and their derivatives have become increasingly important in the field of drug development due to their extensive physiological activities. Additionally, vitamins and their derivatives can be used to construct research platforms for vitamin metabolism, which helps to delve into the metabolic pathways and dynamic changes of vitamins within the body and aids in identifying new biomarkers for certain diseases. MCE included 136 vitamins and their derivatives, including Vitamin A, Vitamin B, Vitamin D, etc., which is a good tool for studying vitamin metabolism.
97
HY-L204 Lactic Acid Metabolic Compound Library
Lactic acid metabolism is one of the key metabolic pathways within living organisms. It plays a crucial role not only in cellular energy conversion but is also closely related to a variety of physiological and pathological processes. The production and clearance of lactic acid are important indicators of cellular metabolic balance, and its abnormal regulation may lead to conditions such as lactic acidosis, muscle fatigue, and hereditary metabolic diseases. Moreover, lactic acid is closely related to the malignancy of tumors and is considered a biomarker for malignant tumors and poor prognosis. Lactic acid can serve as a metabolic substrate to support the metabolic needs of tumor cells under hypoxic conditions, and it can also cause acidification of the tumor microenvironment, suppress immune cell function to promote immune evasion, and induce drug resistance in tumor cells. Currently, targeting lactic acid-lactylation and its related metabolic pathways has become a new research avenue for cancer treatment. In-depth exploration of the molecular mechanisms of lactic acid metabolism can help in screening lead compounds that regulate the lactic acid metabolism. MCE contains 589 small molecule compounds targeting enzymes involved in lactic acid metabolism. This library is of significant value for researching the role of lactate metabolism in the mechanisms of diseases.
97
HY-L208 Bile Acids Library
Bile acids are a class of amphiphilic molecules derived from the metabolic breakdown of cholesterol, primarily synthesized in the liver, and play a crucial role in the intestines. Based on their structural characteristics, bile acids are mainly divided into two categories: free bile acids (including Cholic acid, Deoxycholic acid, Chenodeoxycholic acid) and conjugated bile acids (including Glycocholic acid, Glycochenodeoxycholic acid, Taurocholic acid, etc.). Bile acids play a significant role in the pathophysiological research of liver and gastrointestinal diseases and are closely associated with the occurrence of metabolic diseases such as obesity, type II diabetes, non-alcoholic fatty liver disease, and atherosclerosis. Bile acids maintain metabolic balance within the body by regulating sugar metabolism, lipid metabolism, and amino acid metabolism, and they influence the activity of metabolism-related enzymes and transporters. In addition, Bile acids can also be used to construct a bile acid metabolism research platform, which helps to delve into the metabolic pathways and dynamic changes of bile acids in living organisms and aids in identifying new biomarkers for certain diseases. MCE included 61 bile acids, including Cholic acid, Deoxycholic acid, Glycocholic acid, etc., which are effective tools for the study of liver and gallbladder diseases.
97
HY-L213 Anti-Cancer Approved Drug Library
The anti-cancer drug library meticulously collects all drugs approved by FDA and other major national drug regulatory authorities for cancer treatment. These drugs cover a variety of cancer types, including but not limited to lung cancer, breast cancer, colorectal cancer, leukemia, and other common cancers. The library includes a wide range of drugs, from classic chemotherapeutic agents to cutting-edge targeted therapies and immunotherapies. It contains various types of drug compounds with different mechanisms of action. There are cytotoxic drugs that directly kill cancer cells, as well as drugs that work by modulating the tumor microenvironment, inhibiting tumor angiogenesis, and activating the immune system. This diversity provides researchers with a broad range of perspectives and options for intervention strategies. This library can be used for basic research on cancer treatment, exploring new targets and new mechanisms of drug action; Conducting drug reuse research to look for potential therapeutic effects of existing drugs on other cancer types or diseases; Or conducting research into combination drugs to optimize cancer treatment. MCE has collected 265 small-molecule compounds with cancer indications, which are good tools for drug repurposing.
97
HY-L214 Liposome Library
Liposomes are spherical or multilayered spherical vesicles formed by the self-assembly of diacyl chain phospholipids (lipid bilayers) in aqueous solutions, which can be made from natural or synthetic phospholipids and exhibit good biocompatibility and low toxicity. They can serve as delivery carriers for various bioactive substances (such as drugs, proteins, nucleic acids, etc.) and are widely used in biomedical and chemical research. The main advantages of liposomes include 1) Protective effect: Their bilayer structure can protect encapsulated molecules from enzymatic degradation, oxidation, and other influences, extending stability and activity; 2) Active targeting: Surface modifications enable active targeting, enhancing the concentration of drugs or molecules in specific tissues or cells; 3) Customizability: The composition and structure of liposomes can be adjusted according to needs, such as altering phospholipid types or adding targeting ligands. These properties make liposomes highly valuable in developing novel drug delivery systems, serving as nucleic acid carriers for gene transfection, studying cellular uptake mechanisms and drug release kinetics, as well as developing functional food additives to improve the bioavailability of nutritional components. MCE contains 130 liposome compounds, which is a good tool for drug delivery-related studies.
97
HY-L216 Polysaccharides Compound Library
Polysaccharides are long chains of carbohydrate molecules, consisting of multiple smaller monosaccharides. Polysaccharides are found mainly in natural sources such as plants, microorganisms, algae and animals. Polysaccharides have a large number of active functional groups, different chemical compositions and different molecular weight ranges, which determines their diversity in nature and structure. Also in the field of medical research, polysaccharides act as a class of functional compounds and thus play a role. For example, nanocarrier construction, immunomodulation and vaccine development, new strategies for antitumor therapy, tissue regeneration engineering applications and disease diagnosis. With the advancement of glycomics and synthetic biotechnology, human beings are moving from “knowing polysaccharides” to “designing polysaccharides”, which will provide innovative solutions for materials science, precision medicine and sustainable development. MCE offers 70 polysaccharides that can be used in biomedical studies.
97
HY-L225 Cardiotoxic Compound Library
Drug development is both expensive and time-consuming, with approximately one-third of drug discontinuations caused by severe adverse drug reactions (ADRs). Among these, drug-induced cardiotoxicity (DICT) is one of the primary reasons for late-stage clinical drug failures and market withdrawals. To date, cardiotoxicity has been observed in multiple drug classes, such as anticancer drugs, antipsychotics, antidepressants, antibiotics, and neurodegenerative disease medications. To reduce cardiac ADRs, it is crucial to determine the clinical relevance of DICT to treatment, elucidate the underlying molecular mechanisms, identify reliable biomarkers, and develop new diagnostic and therapeutic approaches. MCE offers 260 cardiotoxicity compounds, including some FDA-approved drugs as well as inhibitors/blockers of the hERG potassium channel.
97
HY-L228 Lipid Metabolite Compound Library
Lipids are important energy storage substances in the human body. They are involved in the regulation of cell structure and function, as well as signaling pathways and gene expression. Abnormal lipid levels in tissues or their dysregulation can lead to various diseases. These include obesity, type 2 diabetes, non-alcoholic fatty liver disease, neurodegenerative diseases, infections, and cancer. Therefore, maintaining normal levels of lipid metabolism is critical to overall health. One of the key features of cancer is aberrant lipid metabolism. This includes alterations in lipid uptake, lipid desaturation, neolipogenesis, lipid droplets, and fatty acid oxidation in cancer cells. These changes all contribute to cellular survival in an ever-changing microenvironment. They do this by modulating feed-forward oncogenic signals and key oncogenic functions. Additionally, they affect oxidative stress, other types of stress, immune responses, and intercellular communication. Alterations in lipid metabolism have a strong impact on the properties of cancer stem cells. This includes aspects such as self-renewal, differentiation, invasion, metastasis, drug sensitivity, and resistance. Furthermore, these alterations also modulate T cell responses. MCE can offer 144 metabolites of lipid metabolism pathways, which can be used for drug screening in cancer, immune-based diseases, metabolic diseases, and other diseases.

Metabolism Focused Libraries

97
HY-L229 Nephrotoxicity Compound Library
Kidneys are one of the vital organs in the human body. Due to their exposure to higher concentrations of circulating drugs or metabolites, they are highly susceptible to drug-induced renal injury (DIRI). According to statistics, drug-induced kidney injury accounts for approximately 20% of nephrotoxicity reports and can lead to acute kidney injury (AKI), chronic kidney disease (CKD), or even end-stage renal disease (ESRD). Early detection of drug nephrotoxicity is crucial for preventing irreversible kidney damage. Research into its mechanisms can help optimize clinical medication by adjusting dosages or avoiding combinations of nephrotoxic drugs. Additionally, predicting drug-induced nephrotoxicity in early drug development can reduce the risk of late-stage R&D failure. MCE offers 160 nephrotoxicity compounds that have been clearly reported by the FDA to be associated with kidney injury. This library can be used for studying molecular mechanisms of nephrotoxicity or developing novel biomarkers.
97
HY-L234 Nucleotide Metabolite Compound Library
Nucleotide metabolism is central to cancer aggressiveness, underpinning uncontrolled proliferation, chemotherapy resistance, immune evasion, and metastasis. It is transcriptionally regulated by oncogenes (e.g., MYC) and tumor suppressors (e.g., pRb). Nucleotide imbalance and nucleoside degradation further regulate cell state transitions, especially following replication stress. Additionally, secretion of nucleotides/nucleosides into the tumor microenvironment modulates immune responses and influences treatment efficacy. Therefore, nucleotide metabolites have roles in disease response and indication in cancer research, and can be utilized to develop cancer-related mechanisms and drugs. MCE can provide 82 metabolites produced by nucleotide metabolic pathways, which can be used for disease mechanism research and drug research.

Metabolism Focused Libraries

97
HY-L250 Lactic Acid Metabolite Compound Library
In the progression of various diseases, metabolic reprogramming has emerged as a key hallmark. Lactate, as an important metabolic signaling molecule, is widely involved in tumorigenesis, immune regulation, and inflammatory responses. Particularly within the tumor microenvironment, the abnormal accumulation of lactate not only affects cellular energy metabolism but also promotes disease progression by modulating immune cell functions and mediating protein lactylation, thereby participating in epigenetic regulation and signaling networks. Therefore, systematic investigation of lactate metabolic pathways and their associated metabolites is of great significance for understanding disease mechanisms and developing novel therapeutic strategies. The MCE lactic acid metabolite compound library contains 59 compounds and is constructed around key metabolic pathways involving lactate production, transport, and utilization. This library systematically includes core intermediates from glycolysis, the tricarboxylic acid (TCA) cycle, and the lactate cycle. Focusing on disease-associated metabolic reprogramming, it is suitable for research in oncology, inflammation, and metabolic disorders. The library can be used to elucidate the roles of lactate in tumor microenvironment regulation, immune evasion, and epigenetic modifications (such as protein lactylation). In addition, it provides high-quality small-molecule resources for drug screening, facilitating the discovery of potential modulators targeting key enzymes (such as LDH) or transporters (such as MCTs) involved in lactate metabolism.

Signaling Pathway Targeting Libraries

97
HY-L251 Ionizable Lipid Compound Library
Ionizable lipids are a class of specialized, functional lipid molecules with pH-sensitive charge characteristics. They are primarily divided into two major categories: ionizable cationic lipids and ionizable anionic lipids, though the term typically specifies ionizable cationic lipids within the biomedical field. Structurally, these lipids consist of an ionizable hydrophilic headgroup, a biodegradable linker, and hydrophobic tails. Their primary application is serving as the key delivery vehicle in lipid nanoparticles (LNPs) to encapsulate negatively charged nucleic acid macromolecules, such as mRNA vaccines, siRNA therapeutics, and CRISPR gene-editing components. In a physiological, neutral environment, they remain electrically neutral to minimize systemic toxicity and prolong circulation time. Upon entering the acidic microenvironment of cellular endosomes, however, they undergo protonation to become positively charged, thereby inducing membrane fusion and enabling the highly efficient intracellular release of the nucleic acid cargo. Consequently, they serve as the technological cornerstone for bringing nucleic acid therapies into clinical application. To accelerate the translational process of cutting-edge nucleic acid drugs, MCE has meticulously constructed an ionizable lipid compound library containing 91 high-performance molecules, aiming to provide researchers and pharmaceutical professionals with a high-throughput, multi-dimensional lipid screening platform.

Structure Classified Libraries

97
HY-L256 Azide Compound Library
In modern drug discovery and chemical biology research, the azide group (-N3) is an important functional moiety that is widely used in click chemistry, biomolecular labeling, drug delivery systems, and prodrug design due to its unique reactivity and bioorthogonality. The MCE Azide Structural Compound Library contains 100 compounds featuring -N3 functional groups. It is designed for the construction of click chemistry reaction systems and the subsequent development of functional molecules. This library enables the rapid assembly of targeting ligands, linkers, and functional molecular modules, thereby accelerating PROTAC assembly, optimization of antibody-drug conjugate (ADC) linkers, and the development of biological labeling probes. In addition, the high reaction selectivity and excellent biocompatibility of the azide group allow it to maintain stable reactivity even in complex biological environments, improving controllability and efficiency in drug design. It serves as an indispensable molecular tool in modern medicinal chemistry and chemical biology research.

Compound Characteristic Classified Libraries

97
HY-L263 Energy Metabolites Library
Energy metabolism is the most fundamental biochemical process in living organisms, encompassing glycolysis, the TCA cycle, oxidative phosphorylation, the pentose phosphate pathway, and fatty acid oxidation. These core pathways directly regulate cell survival, proliferation, differentiation, and apoptosis. Dysregulation of energy metabolism is closely linked to major diseases including cancer, diabetes, obesity, cardiovascular diseases, neurodegenerative disorders, and ischemia‑reperfusion injury. Targeting these metabolic pathways has become a frontier in drug discovery and mechanistic research. The MCE Energy Metabolite Compound Library features 89 structurally defined small‑molecule compounds. It covers energy substrates, pathway intermediates, coenzymes and redox carriers, nucleotide derivatives, and microenvironmental modulators. This library is applicable to research areas including tumor metabolism, insulin resistance, mitochondrial dysfunction, oxidative stress, neuroprotection, and cardiometabolic diseases, providing a high‑quality tool for mechanistic studies, biomarker discovery, and high‑throughput drug screening.

Signaling Pathway Targeting Libraries

97
HY-L266 PD-1 Compound Library
PD-1/PD-L1 signaling is a central negative regulatory axis that maintains immune homeostasis. It involves the specific binding of PD-1 to its ligands PD-L1/PD-L2 and the subsequent transduction of inhibitory signals, which suppress T cell activation and proliferation, drive T cell exhaustion, and contribute to tumor immune evasion. Dysregulation of this pathway is closely linked to major diseases including cancer, chronic viral infections, autoimmune disorders, and transplant rejection. Immune checkpoint blockade targeting PD-1/PD-L1 has emerged as a leading frontier in cancer therapy and mechanistic research. The MCE PD-1 Compound Library contains 101 structurally defined small molecules, covering modulators related to the PD-1/PD-L1 signaling pathway. It can be used for cancer immunotherapy research, studies of immune resistance mechanisms, and candidate compound screening, providing chemical tools for immune checkpoint mechanism research, drug discovery, and high-throughput screening.
97
HY-L907 MCE Kinase Hinge Binder Fragment Library
The most prominent mechanism of action of kinase inhibitors is their competition with ATP by binding to the hinge region of the kinase protein. Once the kinase is blocked by an inhibitor, it loses the ability to transfer phosphate groups from ATP to other molecules, resulting in the loss of kinase activity. The hinge-binding region of kinase inhibitors mimics the interaction pattern between the ATP nucleobase and the kinase. MCE extracted thousands of kinase inhibitors from the ChEMBL database and isolated their molecular fragments. In certain cases, the amino and amide groups on the molecular fragments are crucial for binding in the hinge region. Therefore, we enhanced the diversity of the collected results by adding these two groups to unoccupied positions on the ring system. Subsequently, the fragments were assessed for their hinge region binding ability via docking at distinct kinases, we also applied pharmacophore constraints to ensure interactions with key amino acids in the kinase hinge region, ultimately obtaining kinase-related molecular fragments. MCE provides over 12,372 kinase fragment molecules that meet the above requirements and are available off the shelf, serving as an effective tool for screening and developing drugs targeting kinases.

Functional Fragment Libraries

97
HY-L948 PD-1/PD-L1 Lead-like Library
PD-1/PD-L1 are key immune checkpoint targets that suppress T-cell-mediated anti-tumor immunity, representing a major focus in cancer immunotherapy. While antibody drugs dominate the clinic, they are limited by administration challenges and immune-related side effects. Small-molecule PD-1/PD-L1 inhibitors, with oral availability, good tissue penetration and low cost, have emerged as a promising next-generation strategy. A PD-1/PD-L1 lead-like library was built via a five-step virtual screening process. After collecting 8,947 inhibitors from BindingDB and PubChem and filtering by activity and duplicates, AI similarity screening was performed using GeminiMol. Key pharmacophores were extracted from the PPI interface of co-crystal structures, and molecular was screened via a pharmacophore model, effectively enhancing target activity. Containing 10,000 structurally diverse and drug-like molecules well-matched to the PD-L1 pocket, the library supports virtual docking, high-throughput screening and hit discovery, enabling efficient and rapid development of small-molecule immunotherapies.

Focused and target libraries

97
HY-K1057 Puromycin, Sterile

Puromycin is an aminonucleoside antibiotic produced by Streptomyces alboniger. It inhibits protein synthesis by disrupting peptide transfer on ribosomes, causing premature chain termination during translation. It can kill most gram-positive bacteria and various animal or insect cells.

Cell Biology Cell Culture Sterile Antibiotic Solution

83
HY-N1446A Glycerol Monoleate
Glycerol Monoleate is a non-toxic, biodegradable, biocompatible, lipophilic glycerol fatty acid ester. Glycerol Monoleate exhibits hemolytic properties. Glycerol Monoleate is combined with bile salts for use as an emulsifier and absorption enhancer. Glycerol Monoleate can be applied in drug delivery systems and in vitro siRNA delivery.
Endogenous Metabolite  
79
HY-16141 Cilengitide
Cilengitide (EMD 121974) is an integrin (integrin) inhibitor with blood-brain barrier permeability, with IC50 values against human targets as follows: 0.61 nM for αvβ3, 8.4 nM for αvβ5, 14.9 nM for α5β1, 5400 nM for αIIbβ3, 2050 nM for αvβ6, 2350 nM for αvβ8. Cilengitide inhibits the binding of integrins to vitronectin, fibronectin, fibrinogen and LAP (TGF-β), and serves as an internal standard for solid-phase integrin binding assays. Cilengitide inhibits tumor cell viability, induces apoptosis, reduces the phosphorylation levels of STAT3, AKT and mTOR, downregulates the expression of PD-L1, inhibits cell viability and angiogenesis, regulates anti-tumor immune responses and slows tumor growth. Cilengitide can be used in research related to glioblastoma, melanoma, advanced solid tumors and refractory brain tumors.
Integrin   TGF-β Receptor   Apoptosis   PD-1/PD-L1   STAT   Akt   mTOR  
Melanoma   Glioblastoma  
78
HY-N0822 Shikonin
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
Exosomes   Chloride Channel   Pyruvate Kinase   NF-κB   TNF Receptor   HIV   AIM2  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Depression   Pain   Digestive System Inflammation   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
76
HY-18234A Leupeptin hemisulfate
Leupeptin hemisulfate is a broad-spectrum protease inhibitor. By inhibiting the activation of the PTEN/PI3K/Akt/NF-κB/ERK1/2/p38 signaling pathway, Leupeptin hemisulfate significantly reduces LPS-induced NO and ROS production, mitochondrial membrane potential hyperpolarization, phagocytic activity, pro-inflammatory cytokine release, and M1 polarization in mouse peritoneal macrophages, and reverses autophagic flux impairment. It also decreases Concanavalin A (HY-P2149)-induced proliferation index of mouse splenic lymphocytes and the Th1/IL-10 and Th2/IL-10 cytokine ratios, thereby modulating innate and adaptive immune responses. Leupeptin hemisulfate inhibits blood coagulation and tumorigenesis in mouse skin. Leupeptin hemisulfate can be used in research on chronic inflammatory diseases and skin tumorigenesis.

Source: Streptomyces roseus MB-26-AI

Ser/Thr Protease   Cathepsin   Autophagy   SARS-CoV   Atg8/LC3   NO Synthase   COX   p62   Arginase   PTEN   NF-κB   PI3K   Akt   p38 MAPK   ERK   Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease   Respiratory Disease   Coronavirus Infection   Skin Disease  
70
HY-50876 Daporinad
Daporinad (FK866) is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a Ki value of 0.3 nM. Daporinad depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad causes the depletion of the endoplasmic reticulum Ca²⁺ pool, ultimately weakening the mitogen-induced Ca²⁺ signal and the activation and function of T cells. Daporinad induces cell cycle arrest and apoptosis, and inhibits cell proliferation. Daporinad can be used for the study of myeloma, liver cancer, and immunosuppression.
NAMPT   Autophagy   Apoptosis   mTOR   p38 MAPK   ERK  
Cancer  
68
HY-13064 Cobimetinib
Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK1 inhibitor with an IC50 of 4.2 nM for MEK1.
MEK   Apoptosis  
Lung Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Pain   Digestive System Inflammation   Obesity   Rheumatoid Arthritis  
63
HY-15202 Binimetinib
Binimetinib (MEK162) is an oral and selective MEK1/2 inhibitor. Binimetinib (MEK162) inhibits MEK with an IC50 of 12 nM.
MEK   Autophagy  
Colorectal Cancer   Prostate Cancer   Pancreatic Cancer   Non-Small Cell Lung Cancer   Lung Adenocarcinoma   Triple-Negative Breast Cancer   Rheumatoid Arthritis  
56
HY-N0431 Astragaloside IV
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
MMP   ERK   JNK  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Depression   Pain   Parkinson's Disease   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
46
HY-N4302 Monensin
Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects.

Source: Streptomyces spp.

Exosomes   Bacterial   Apoptosis   Antibiotic   Parasite   Na+/H+ Exchanger (NHE)   Fungal   Wnt  
Cancer   Infection  
45
HY-108635 C16-PAF
C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability.
p38 MAPK   MEK   ERK   Endogenous Metabolite  
Inflammation or Immune System Disease   Lung Cancer   Neurodegenerative Disease   Depression   Pain   Cardiovascular Disease  
45
HY-N0150 Monensin sodium
Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects.

Source: Streptomyces spp

Exosomes   Bacterial   Antibiotic   Na+/H+ Exchanger (NHE)   Parasite   Apoptosis   Fungal   Wnt  
Neurological, Eye or Ear Disease   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Bacterial Infection   Fungal Infection   Parasitic Infection   Digestive System Inflammation   Hypertension   Lung Fibrosis   Rheumatoid Arthritis  
45
HY-P9904 Atezolizumab
Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.

Species: Human

PD-1/PD-L1   Apoptosis   Autophagy  
Colorectal Cancer   Liver Cancer   Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
42
HY-P9902 Pembrolizumab
Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy.

Species: Human

PD-1/PD-L1  
Non-Small Cell Lung Cancer   Lung Adenocarcinoma   HER-2 Positive Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
37
HY-19991 BMS-1
BMS-1 is an inhibitor of the PD-1/PD-L1 protein/protein interaction (IC50 between 6 and 100 nM).
PD-1/PD-L1   Apoptosis  
Lung Cancer   Breast Cancer   Colorectal Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer   Digestive System Inflammation  
35
HY-D0886 β-Glycerophosphate disodium salt pentahydrate
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells.
Phosphatase   Endogenous Metabolite   ERK  
Cancer   Metabolic or Endocrine Disease  
35
HY-P99144 Anti-Mouse PD-1 Antibody (RMP1-14)
Anti-Mouse PD-1 Antibody (RMP1-14) is an anti-mouse PD-1 IgG2a antibody. Anti-Mouse PD-1 Antibody (RMP1-14) can be used for the study of colon carcinoma.

Species: Mouse

PD-1/PD-L1  
Cancer   Inflammation or Immune System Disease  
31
HY-19745 BMS-202
BMS-202 is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 has antitumor activity.
PD-1/PD-L1   Apoptosis  
Neurological, Eye or Ear Disease   Lung Cancer   Breast Cancer   Colorectal Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer   Digestive System Inflammation  
29
HY-N7131 Coumarin 6
Coumarin 6, a fluorescent dye, is used as a fluorescent probe in a microparticle drug delivery system to conduct in vivo tracking, cell uptake, and transport mechanism studies of drug delivery systems (λexc=450 nm, λem=505 nm).
Fluorescent Dye  
25
HY-P9903 Nivolumab
Nivolumab is a programmed death receptor-1 (PD-1) blocking human IgG4 antibody to treat advanced (metastatic) non-small cell lung cancer.

Species: Human

PD-1/PD-L1  
Non-Small Cell Lung Cancer   Lung Adenocarcinoma   Triple-Negative Breast Cancer   Metastatic Breast Cancer   SARS-CoV-2 Infection  
24
HY-N0140 Ursolic acid
Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.
Autophagy   Endogenous Metabolite  
Prostate Cancer   Leukemia/Lymphoma/Myeloma  
22
HY-P99145 Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2)
Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) is an anti-mouse PD-L1/B7-H1 IgG2b antibody inhibitor derived from host rat. Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) blocks PD-1 signaling. Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) can be used for the research of cancer, such as colon cancer.

Species: Mouse

PD-1/PD-L1  
Colorectal Cancer  
21
HY-P1860A TNF-α (31-45), human TFA
TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis.
TNF Receptor   NF-κB   Apoptosis  
Inflammation or Immune System Disease  
15
HY-P1860 TNF-α (31-45), human
TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis.
TNF Receptor   NF-κB   Apoptosis  
Inflammation or Immune System Disease  
15
HY-108535 HEPES sodium
HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis.
Biochemical Assay Reagents  
12
HY-12695B Guanosine triphosphate trisodium salt hydrate
Guanosine triphosphate (GTP) trisodium salt hydrate is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate trisodium salt hydrate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate trisodium salt hydrate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate trisodium salt hydrate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate trisodium salt hydrate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism.
Endogenous Metabolite   DNA/RNA Synthesis   Apoptosis   Mitosis  
Liver Cancer   Small Cell Lung Cancer  
11
HY-108730A Avelumab (anti-PD-L1)
Avelumab (anti-PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab (anti-PD-L1) enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab (anti-PD-L1) can be used for the study of chordoma.

Species: Human

PD-1/PD-L1  
Inflammation or Immune System Disease   Non-Small Cell Lung Cancer   Luminal Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
11
HY-108730 Avelumab
Avelumab (Anti-Human PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab can be used for the study of chordoma.

Species: Human

PD-1/PD-L1  
Cancer   Inflammation or Immune System Disease  
11
HY-W074143 Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride
Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride ([Ru(dpp)3]2+) is an electrochemiluminescent (ECL) probe and oxygen-sensitive sensor. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can be used to modify electrode surfaces for the detection of sulfates (S2O82-) and oxalates, based on electrochemical reactions that generate excited-state species, releasing photons through irreversible redox reactions. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride utilizes the oxygen quenching of fluorescence mechanism, where fluorescence intensity reflects the metabolic rate of living microorganisms or oxygen levels within cells/tumors, allowing for real-time detection. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride's main applications include microbial detection, antibacterial activity studies, and tumor microenvironment research.
Fluorescent Dye  
Cancer  
11
HY-W010737 Guanosine triphosphate disodium
Guanosine triphosphate (GTP) disodium is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate disodium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate disodium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate disodium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate disodium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism.
Endogenous Metabolite   DNA/RNA Synthesis   Apoptosis   Mitosis  
Liver Cancer   Small Cell Lung Cancer  
11
HY-17567 Heparin
Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. Heparin significantly inhibits exosome-cell interactions.
Exosomes   Thrombin   Autophagy   Endogenous Metabolite   Bacterial  
Cancer   Blood or Cardio-cerebrovascular Disease   Coronavirus Infection   Bacterial Infection  
11
HY-P99045A Sacituzumab (powder)
Sacituzumab (powder) is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab (powder) demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab (powder) can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan (HY-132254). Sacituzumab govitecan can be used in the field of triple-negative breast cancer.

Species: Human

ADC Antibodies   TROP2  
Cancer  
10
HY-B1142 Lipoamide
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway.
NO Synthase  
Lung Cancer  
10
HY-16938 5'-Methylthioadenosine
5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis.
Endogenous Metabolite   Apoptosis   Parasite  
Cancer   Metabolic or Endocrine Disease   Digestive System Disease   Parasitic Infection   Digestive System Inflammation  
10
HY-P73361 PD-L1 Protein, Human (HEK293)
The PD-L1 protein critically regulates immune tolerance by acting as a ligand for PDCD1/PD-1, regulating T cell activation threshold, and limiting effector responses. It may act as a costimulatory molecule for IL10-producing T cell subsets. PD-L1 Protein, Human (HEK293) is the recombinant human-derived PD-L1 protein, expressed by HEK293 , with tag free.

Species: Human; Source: HEK293

Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins PD-L1

10
HY-B2156 Menaquinone-4
Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
Endogenous Metabolite  
Cancer  
9
HY-113225 Guanosine triphosphate
Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism.
Endogenous Metabolite   DNA/RNA Synthesis   Apoptosis   Mitosis  
Liver Cancer   Small Cell Lung Cancer  
8
HY-12695 Guanosine triphosphate trisodium
Guanosine triphosphate (GTP) trisodium is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate trisodium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate trisodium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate trisodium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate trisodium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism.
Endogenous Metabolite   DNA/RNA Synthesis   Apoptosis   Mitosis  
Liver Cancer   Small Cell Lung Cancer  
8
HY-P9919A Durvalumab (anti-PD-L1)
Durvalumab (anti-PD-L1)(MEDI 4736) is a human anti-PD-L1 protein monoclonal antibody. Durvalumab (anti-PD-L1) completely blocks PD-L1 binding to PD-1 and CD80, IC 50 are 0.1 and 0.04 nM respectively, has anti-tumor activity.

Species: Human

PD-1/PD-L1  
Colorectal Cancer   Liver Cancer   Bladder Cancer   Small Cell Lung Cancer   Lung Adenocarcinoma   Luminal Breast Cancer   HER-2 Positive Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer   Multiple Myeloma   Pancreatic Ductal Adenocarcinoma   Metastatic Pancreatic Cancer  
7
HY-103638A 3-Methoxytyramine
3-Methoxytyramine, a well known extracellular metabolite of 3-hydroxytyramine/dopamine, is a neuromodulator.
Endogenous Metabolite  
Neurological, Eye or Ear Disease  
7
HY-W011540 8-Hydroxy-2'-deoxyguanosine
8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis.
Endogenous Metabolite  
Cancer   Parkinson's Disease  
7
HY-P9919 Durvalumab
Durvalumab (MEDI 4736) is an human anti-PD-L1 monoclonal antibody. Durvalumab (MEDI4736) completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04 nM, respectively.

Species: Human

PD-1/PD-L1  
Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Non-Small Cell Lung Cancer   Lung Adenocarcinoma   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
7
HY-N0746 Oxysophocarpine
Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides.?Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems. Oxysophocarpine inhibits the?growth?and?metastasis?of ?oral?squamous?cell?carcinoma?(OSCC).
Others  
Cancer   Neurological, Eye or Ear Disease  
6
HY-N0084 Betulinaldehyde
Betulinaldehyde (Betunal) Has anti-cancer and anti-staphylococcus aureus activity. Betulinaldehyde Suppressible Akt, MAPK sum STAT3 Signal path, increase self-transfer, Suppression A549 Cellular vitality, increase and transfer. Betulinaldehyde suppresses PLCγ1/Ca2+/MMP9 signal pathway, has a key effect on vascular plasticity, and is available for cardiovascular disease (CVD) research.
Bacterial  
Cancer   Bacterial Infection   Cardiovascular Disease  
5
HY-N0866 20-Deoxyingenol
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA).
Autophagy  
Inflammation or Immune System Disease  
5
HY-101410A SDMA (p-hydroxyazobenzene-p′-sulfonate)
SDMA p-hydroxyazobenzene-p′-sulfonate is the p-hydroxyazobenzene-p′-sulfonate salt form of SDMA (HY-101410). SDMA p-hydroxyazobenzene-p′-sulfonate is an endogenous inhibitor of nitric oxide synthase (NO synthase) activity. SDMA p-hydroxyazobenzene-p′-sulfonate is an activator for NF-κB, and promotes the expression of IL-6 and TNF-α. SDMA p-hydroxyazobenzene-p′-sulfonate is stable in serum and plasma, and can be used as a kidney biomarker of hepatic and renal dysfunction.
Endogenous Metabolite   NO Synthase   NF-κB  
Inflammation or Immune System Disease  
4
HY-15435A CHAPS hydrate
CHAPS hydrate is a cholic acid-derived, sulfobetaine-type zwitterionic detergent and micelle-forming agent. CHAPS hydrate exhibits properties of weak cationic or nonionic surfactants in different solution systems, undergoes micellization, and forms small, loose hydrophilic aggregates that are temperature-dependent. CHAPS hydrate stabilizes mononucleosomes under different ionic strengths, reduces nucleosome sequence specificity, promotes sliding of histone cores along DNA, solubilizes Tamm‑Horsfall protein to reduce its interference with urinary exosome isolation, and maintains vesicle structure and the activity of related proteins at the same time. CHAPS hydrate is used to recover native folded fusion proteins, enhance the binding capacity of GST fusion proteins, and restore GST enzyme activity. However, CHAPS hydrate cannot refold proteins denatured by urea, guanidine hydrochloride or heat, nor can it construct the structure of intrinsically disordered proteins. CHAPS hydrate is commonly used in research on the separation and purification of membrane proteins.
Biochemical Assay Reagents   Exosomes  
4
HY-N0596 Panaxadiol
Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities.
PD-1/PD-L1   HIF/HIF Prolyl-Hydroxylase   STAT  
Inflammation or Immune System Disease   Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Obesity  
4
HY-N0242 Fraxinellone
Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1.
PD-1/PD-L1   HIF/HIF Prolyl-Hydroxylase   STAT  
Inflammation or Immune System Disease   Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Obesity  
4
HY-W017386 3-Methyl-2-oxovaleric acid sodium
3-Methyl-2-oxovaleric acid sodium is a degradation product from Isoleucine. 3-Methyl-2-oxovaleric acid sodium is a biomarker of mustard airway diseases (MADs) and uric acid stone.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
4
HY-101410 SDMA
SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. SDMA, a novel kidney biomarker, permits earlier diagnosis of kidney disease than traditional creatinine testing.
Endogenous Metabolite   NO Synthase   NF-κB  
Breast Cancer   Pancreatic Cancer   Pain   Renal Disease  
4
HY-W008253 5-Hydroxyindole-3-acetic acid
5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease  
4
HY-K1011A 3-Color Prestained Protein Marker (10-180 kDa)

MCE 3-Color Prestained Protein Marker (10-180 kDa) consists of 10 prestained recombinant proteins with an apparent molecular weight range of 10–180 kDa. This marker enables real-time monitoring of protein migration during SDS-PAGE and facilitates evaluation of protein transfer efficiency. The 250 μL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Protein Biology Protein Electrophoresis & WB Protein Marker

4
HY-76082A L-Pyroglutamic acid sodium
L-Pyroglutamic acid sodium is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid sodium is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism. L-Pyroglutamic acid sodium can be used as a biomarker for systemic lupus erythematosus (SLE).
Endogenous Metabolite  
Inflammation or Immune System Disease  
3
HY-P6306A CS-6253 TFA
CS-6253 TFA is an agonist of ABCA1. CS-6253 TFA can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 TFA also has certain neuroprotective effects and can clear Aβ from the brain. CS-6253 TFA can be used for research on cholesterol metabolism and diseases such as Alzheimer’s disease.
Apolipoprotein   Amyloid-β  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
3
HY-N0914 Ajugol
Ajugol is an orally active iridoid glycoside found in the traditional Chinese medicine Leonurus japonicus. Ajugol is an autophagy activator. Ajugol activates TFEB-mediated autophagy and lysosomal biogenesis. Ajugol also has anti-inflammatory effects. Ajugol has great potential in the research of asthma, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis.
Parasite   Autophagy   Interleukin Related   Reactive Oxygen Species (ROS)   mTOR  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Parasitic Infection   Pain   Digestive System Inflammation   Cardiovascular Disease   Obesity   Lung Fibrosis  
3
HY-D1080 EDANS
EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET).
Fluorescent Dye  
3
HY-B1180 Vinburnine
Vinburnine ((-)-Eburnamonine; (-)-Vincamone) is an orally active, blood-brain barrier permeable immunomodulator and apoptosis inducer. Vinburnine drives the secretion of IL-24 by activating the P38/MAPK/ATF3 signaling axis. Vinburnine induces reactive oxygen species production and DNA damage in cancer cells, thereby inhibiting cancer cell proliferation, activating the apoptotic cascade, and enhancing CD8+ T cell function to remodel the tumor immune microenvironment. Vinburnine can be used in the research of diseases such as melanoma.
Apoptosis   p38 MAPK  
Melanoma  
3
HY-112175 N-Acetylhistamine
N-Acetylhistamine is a histamine metabolite. N-acetylhistamine can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions.
Histamine Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
3
HY-P6306 CS-6253
CS-6253 is an agonist of ABCA1. CS-6253 can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 also has certain neuroprotective effects and can clear Aβ from the brain. CS-6253 can be used for research on cholesterol metabolism and diseases such as Alzheimer’s disease.
Apolipoprotein   Amyloid-β  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
3
HY-76082 L-Pyroglutamic acid
L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism. L-Pyroglutamic acid can be used as a biomarker for systemic lupus erythematosus (SLE).
Endogenous Metabolite  
Systemic Lupus Erythematosus  
3
HY-P99037 Nipocalimab
Nipocalimab (M281) is a fully humanized, recombinant, and non-glycosylated IgG1 monoclonal antibody. Nipocalimab can bind to the IgG-binding site of FcRn with high affinity and inhibit the transplacental transfer of IgG. Nipocalimab can be used in the research of fetal and neonatal hemolytic disease, myasthenia gravis, and various IgG-mediated autoimmune diseases.

Species: Human

Fc Receptor (FcR)  
Myasthenia gravis   Rheumatoid Arthritis  
3
HY-108910 Chymotrypsin
Chymotrypsin (EC 3.4.21.1; Chymotrypsin A) is an orally effective inhibitor targeting molecules such as TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6. Chymotrypsin downregulates the TLR4/NF-κB signaling pathway, inhibiting the release of inflammatory factors, reducing cell infiltration and tissue damage. It also reduces the expression of tumor cell adhesion molecules (such as CD44 and CD54) and can be specifically detected by fluorescent probes (such as NBD-3). Chymotrypsin has anti-inflammatory, hepatoprotective, joint damage-reducing, liver protection against lipotoxicity, and anti-tumor metastasis functions. It can be used in research on diseases such as rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Chymotrypsin can be used in studies of inflammation, edema, and expectoration.
Toll-like Receptor (TLR)   NF-κB   MMP  
Breast Cancer   Digestive System Inflammation   Gastric Disease   Metastatic Melanoma   Pharyngitis   Rheumatoid Arthritis  
3
HY-D1815 Allophycocyanin
Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I.
Fluorescent Dye  
2
HY-P990173 Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1)
Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) is a mouse-derived PD-L1 IgG1 κ type antibody inhibitor. Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) increases IFN-γ levels in organoid-primed T cells. Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) can be used for the researches of cancer, such as oral squamous cell carcinoma and mammary cancer.

Species: Human/Mouse/Rat

PD-1/PD-L1  
Cancer  
2
HY-N6985 Baccatin III
Baccatin III is an orally available, selective inhibitor of the TGF-β1 signaling pathway and myeloid-derived suppressor cell (MDSC) activation. Baccatin III targets the AKT/STAT6 and Smad2/3 pathways, blocking TGF-β1-induced fibroblast differentiation and MDSC-mediated immunosuppression. Baccatin III exerts anti-inflammatory and anti-fibrotic effects by inhibiting macrophage activation and extracellular matrix deposition, and shows potential in the treatment of pulmonary fibrosis and cancer in terms of regulating the tumor immune microenvironment.
Others  
Breast Cancer   Lung Fibrosis  
2
HY-N6796 Manumycin A
Manumycin A is a polyketide antibiotic and an inhibitor of thioredoxin reductase 1 (TrxR-1). Manumycin A can inhibit the growth of breast cancer cells and exert its anti-tumor activity through LC3. Manumycin A can downregulate the release of pro-inflammatory cytokines in human monocytes stimulated by TNF α, and has potential anti-inflammatory activity. Manumycin A can inhibit the Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration resistant prostate cancer cells to suppress exosome biogenesis and secretion.

Source: new Streptomyces strain

Antibiotic   Exosomes   Farnesyl Transferase   Ras   Apoptosis   Phospholipase   TNF Receptor   Atg8/LC3  
Infection   Inflammation or Immune System Disease   Lung Cancer   Triple-Negative Breast Cancer  
2
HY-P4094 CTP
CTP (cardiac targeting peptide) can transduce cardiomyocytes in vitro. CTP leads to efficient and specific transduction of heart tissue in mice model. CTP can be reversibly linked (e.g. via enolases, thiol groups) to cargo (e.g. miRNAs) for delivery specifically to cardiomyocytes over all other organs.
Others  
Cardiovascular Disease  
2
HY-P99507 Zenocutuzumab
Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3.

Species: Human

EGFR  
Breast Cancer  
2
HY-K0001 Exosome Protein Lysis Buffer

MCE Exosome Protein Lysis Buffer is a lysis buffer specifically designed for exosome samples, capable of efficiently lysing exosome proteins.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

2
HY-K6008 Basement Membrane Matrix HC

MCE High-Concentration Basement Membrane Matrix (Phenol Red-Free) is primarily composed of natural basement membrane matrix extracted from mouse tumors. It is rich in extracellular matrix components and various naturally occurring growth factors, and is mainly used for the establishment of animal models and 3D tumor models.

Cell Biology 3D Cell Culture Basement Membrane Matrix

2
HY-128420 Lobeline sulfate
Lobeline (α-Lobeline) sulfate is a brain-penetrant nicotinic receptor agonist. Lobeline sulfate increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline sulfate is effective in smoking cessation.
nAChR   Dopamine Transporter  
Neurological, Eye or Ear Disease  
1
HY-B1423 Lobeline
Lobeline (α-Lobeline) is a brain-penetrant nicotinic receptor agonist. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline is effective in smoking cessation.
nAChR   Dopamine Transporter  
Neurological, Eye or Ear Disease  
1
HY-W073074 Mesoporphyrin IX dihydrochloride
Mesoporphyrin IX (dihydrochloride) is a photosensitizer that can be used to modify liposomes. Mesoporphyrin IX (dihydrochloride) can insert into lipid vesicles and disrupt the viral membrane structure in vesicular stomatitis virus (VSV), inducing cross-linking of VSV glycoproteins, thereby inhibiting viral activity.
VSV  
Infection  
1
HY-P10218 MANS peptide
MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis.
MARCKS   PKC  
Inflammation or Immune System Disease  
1
HY-N0554 Escin IA
Escin IA is an oral LOXL2 inhibitor and EMT inhibitor, with selectivity for LOXL2-expressing cells. Escin IA suppresses invasion, migration, and metastasis of breast cancer cells, and acts as the primary anti-TNBC metastasis constituent of Aesculus chinensis Bunge fruit saponin fraction. Escin IA can be used for the research of triple-negative breast cancer, acute inflammation, and ethanol-induced gastric mucosal lesions.
HIV Protease   Monoamine Oxidase  
Cancer   Infection   Gastric Disease  
1
HY-P990114 Anti-Canine PD-L1/B7-H1 Antibody (JC071)
Anti-Canine PD-L1/B7-H1 Antibody (JC071) is an anti-canine PD-L1/B7-H1 IgG1 monoclonal antibody. Anti-Canine PD-L1/B7-H1 Antibody (JC071) can specifically bind to CHO-PDL1 cells and K562-cCD20-cPD-L1 cells. Anti-Canine PD-L1/B7-H1 Antibody (JC071) can enhance the level of IFN-γ. Anti-Canine PD-L1/B7-H1 Antibody (JC071) is often used in western blot experiments.

Species: Canine

PD-1/PD-L1  
1
HY-N2456 Mogroside IV-E
Mogroside IV-E is a PUS1 inhibitor that reduces PUS1 expression and inhibits bone metastasis of prostate cancer. Mogroside IV-E can be used in prostate cancer-related research.
DNA/RNA Synthesis  
Prostate Cancer  
1
HY-148978 18:0,18:1 PS sodium
18:0,18:1 PS sodium is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS sodium mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS sodium to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage.
Exosomes   Endogenous Metabolite   Liposome  
Metabolic or Endocrine Disease  
1
HY-P9976A Isatuximab (anti-CD38)
Isatuximab (anti-CD38) is a monoclonal antibody that targets the transmembrane receptor and extracellular enzyme CD38, a protein highly expressed in hematological malignancies, including multiple myeloma. Isatuximab (anti-CD38) exhibits anti-tumor activity through multiple biological mechanisms, including antibody-dependent cell-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cell phagocytosis, and non-crosslinking direct induction of apoptosis. Isatuximab (anti-CD38) also directly inhibits the extracellular enzyme activity of CD38, which is related to many cellular functions.

Species: Human

CD38   Apoptosis  
Non-Small Cell Lung Cancer  
1
HY-D0857S HEPES-d18
HEPES-d18 is the deuterium labeled HEPES. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis.
Isotope-Labeled Compounds  
1
HY-14596S Genistein-d4
Genistein-d4 is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
EGFR   Autophagy   Apoptosis   Endogenous Metabolite  
Cancer  
1
HY-P3448 Certepetide
Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors.
Integrin   Complement System  
1
HY-P10409 SHLP2
SHLP2 (Small humanin-like peptide 2) is a small molecule peptide encoded by mitochondrial DNA, belonging to mitochondria derived peptide. SHLP2 has the activity of regulating apoptosis and inhibits cell death. SHLP2 binds to mitochondrial complex 1. SHLP2 improves mitochondrial metabolism by increasing respiration and biogenesis, reducing ROS, and decreasing mtDNA oxidation. SHLP2 also regulated energy homeostasis through the activation of hypothalamic neurons. SHLP2 can be used in the study of diseases related to mitochondrial dysfunction and anti-aging diseases, such as age-related macular degeneration and Parkinson’s disease.
Apoptosis   Reactive Oxygen Species (ROS)  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-16938S1 5'-Methylthioadenosine-d3
5'-Methylthioadenosine-d3 is the deuterium labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis.
Apoptosis   Parasite   Endogenous Metabolite  
Inflammation or Immune System Disease  
1
HY-W329357 15:0 Lyso PC
15:0 Lyso PC is a lysophosphatidylcholine (Lyso PC), a product of phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine (PC) and is involved in cell membrane remodeling and inflammatory signaling. 15:0 Lyso PC demonstrates significant lipid metabolism disturbances in the serum with ischemic heart disease (IHD) and ischemic cardiomyopathy (ICM). 15:0 Lyso PC can be used as a lipid biomarker for cardiovascular disease.
Endogenous Metabolite  
Cardiovascular Disease  
1
HY-P0132 YIGSR
YIGSR (Laminin Fragment 929-933) is a polypeptide that inhibits tumor growth and metastasis of leukemia cells. YIGSR specifically binds to the 67kDa laminin receptor and regulates the expression of eNOS in endothelial cells. YIGSR can be used in leukemia-related research.
NO Synthase  
Cancer  
1
HY-D2452 Cy3-Cisplatin
Cy3-Cisplatin is a Cyanine 3 fluorescent dye CY3 (HY-D0822) labled Cisplatin (HY-17394). Cy3-Cisplatin can be used for drug delivery, fluorescent labeling, cell imaging and tracking.
Fluorescent Dye  
1
HY-W014075 1-Hydroxypyrene
1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis.
Aryl Hydrocarbon Receptor   Cytochrome P450   Collagen  
Inflammation or Immune System Disease  
1
HY-P99039 Oleclumab
Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity.

Species: Human

CD73  
Leukemia/Lymphoma/Myeloma   Ovarian Cancer   Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer  
1
HY-W018499 (S)-2-Hydroxybutanoic acid
(S)-2-Hydroxybutanoic acid is the S-enantiomer of 2-Hydroxybutanoic acid. 2-Hydroxybutanoic acid, a coproduct of protein metabolism, is an insulin resistance (IR) biomarker.
Endogenous Metabolite  
1
HY-P99742 Mitazalimab
Mitazalimab (ADC-1013; JNJ-64457107) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab remodels the tumor-infiltrating myeloid microenvironment.

Species: Human

TNF Receptor  
Cancer  
1
HY-W591424 m-PEG2000-NHS ester
m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of MMP-2-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize MMP-2-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions.
Biochemical Assay Reagents   MMP  
Colorectal Cancer  
1
HY-P10128 GE11
GE11 is a active peptide and combines with colloidal drug delivery systems as smart carriers for antitumor drugs and can be used for cancer study.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
1
HY-N0819 Raddeanin A
Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, Wnt/β-catenin, Wee1, PI3K/AKT signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma.
Apoptosis   PI3K   Akt   ERK   mTOR   Wnt   β-catenin   Wee1   JNK   VEGFR   CDK  
Colorectal Cancer   Leukemia/Lymphoma/Myeloma   Cancer Immunology   Digestive System Inflammation   Non-Small Cell Lung Cancer   Immunotherapy for Melanoma   Alzheimer's Disease  
1
HY-B0979 Lobeline hydrochloride
Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation.
nAChR   Dopamine Transporter  
Alzheimer's Disease  
1
HY-108750 Soybean oil
Soybean oil (VT 18 (oil); Vegetoil; Wesson) is an edible vegetable oil. Soybean oil reduces circulating blood cholesterol levels when it replaces dietary saturated fats. Soybean oil does not affect inflammatory biomarkers or increase oxidative stress. Soybean oil contains γ-tocopherol and δ-tocopherol, which possess antioxidant properties. Soybean oil can be used in research related to coronary heart disease.
Environmental Pollutants  
Heart Disease  
1
HY-N2124 Parishin B
Parishin B is a multi-target biological agent with anti-epileptic, anti-fascioliasis and anti-breast cancer lung metastasis activities. Parishin B regulates the gene/protein activities of ACLY, unc13c, γ-aminobutynergic system, pro-inflammatory system, antioxidant system, monoaminergic system, ferroptosis-related pathways, as well as GST, CatL, Trx and TRIB3. Parishin B modulates energy-lipid metabolism, synaptic function, neurotransmitter balance, neuroinflammation, oxidative stress, parasite detoxification/invasion processes, as well as apoptosis, cell cycle, proliferation and metastasis of cancer cells. Parishin B can be used for related research of epilepsy, fascioliasis and breast cancer lung metastasis
Reactive Oxygen Species (ROS)   Ferroptosis   Apoptosis  
Lung Cancer   Breast Cancer   Parasitic Infection   Epilepsy   Antioxidant Agent  
1
HY-N3005 Britannin
Britannin is an NLRP3 inhibitor with an IC50 of 3.630 μM, exhibiting anti-inflammatory activity. Britannin inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and NEK7. Additionally, Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. Britannin holds promise for research in the fields of anti-inflammatory and antitumor therapeutics.
Apoptosis   Autophagy   NOD-like Receptor (NLR)   Pyroptosis  
Prostate Cancer   Liver Cancer   Depression   Autoimmune Disease   Digestive System Inflammation  
1
HY-D1056B3 Lipopolysaccharides, from Klebsiella pneumoniae
Lipopolysaccharides, from Klebsiella pneumoniae (LPS, from bacterial (Klebsiella pneumoniae)) are lipopolysaccharide endotoxins and TLR4 activators derived from Klebsiella pneumoniae, and are classified as S-type LPS. Lipopolysaccharides, from Klebsiella pneumoniae exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from Klebsiella pneumoniae may participate in bacterial immune evasion by inhibiting complement-mediated killing and suppressing the host's secretion of antimicrobial peptides, thereby allowing the bacteria to escape immune defenses. Lipopolysaccharides, from Klebsiella pneumoniae possess high viscosity and resistance to serum-mediated killing, which may lead to sepsis. Lipopolysaccharides, from Klebsiella pneumoniae can be used to construct Acute Lung Injury Model.
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
Toll-like Receptor (TLR)  
Inflammation or Immune System Disease  
1
HY-P99675 Ivonescimab
Ivonescimab (AK112) is a PD-1/VEGF bispecific antibody. Ivonescimab competitively inhibiting PD-1/PD-L1 interaction, reversing the immunosuppression mediated by it, and blocks the binding of VEGF-A to VEGFR2, inhibiting tumour angiogenesis in the tumour microenvironment. Ivonescimab also has significantly anticancer activity against EGFR-mutated locally advanced or metastatic non-squamous non-small cell lung cancer (NSCL).

Species: Human

PD-1/PD-L1   VEGFR  
Respiratory Disease   Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer  
1
HY-P700879 PLVAP Protein, Human (HEK293, His)
The PLVAP protein is an endothelial cell-specific membrane protein that plays a key role in the complex structure of endothelial fenestrae by participating in the formation of septa that bridge these fenestrae. Furthermore, it plays a crucial role in the development of stomata within caveolae and transendothelial channels. PLVAP Protein, Human (HEK293, His) is the recombinant human-derived PLVAP protein, expressed by HEK293 , with N-His labeled tag.

Species: Human; Source: HEK293

1
HY-P84982 PD-L1 Antibody (YA4674)
PD-L1 Antibody (YA4674) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PD-L1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

1
HY-K1103 Coomassie Blue Fast Staining Solution (No Heating, 10×)

MCE Coomassie Blue Fast Staining Solution (No Heating, 10×) uses Coomassie Brilliant Blue G250 as the dye. It can be used for rapid, sensitive staining of protein gels in SDS-PAGE or Native-PAGE without contamination, or for detecting residual proteins on PAGE gels after Western Blot transfer. The 25 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Protein Biology Protein Electrophoresis & WB Protein Staining Solution

1
HY-K6005 Basement Membrane Matrix HC (Phenol Red)

MCE Basement Membrane Matrix HC (High Concentration, Phenol Red) is primarily composed of natural basement membrane matrix extracted from mouse tumorsand contains abundant extracellular matrix components and a variety of naturally occurring growth factors. This product is mainly used for angiogenesis experiments, construction of animal models and 3D tumor models.

Cell Biology 3D Cell Culture Basement Membrane Matrix

1
HY-103048 PD-1/PD-L1-IN 3
PD-1/PD-L1-IN 3, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 can be used for the research of various diseases, including cancer and infectious diseases.
PD-1/PD-L1  
/
HY-N0565AS Doxycycline-d3 (hydrochloride)
Doxycycline-d3 hydrochloride is deuterium labeled Doxycycline hydrochloride (HY-N0565A). Doxycycline hydrochloride is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hydrochloride is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hydrochloride also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hydrochloride induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hydrochloride also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hydrochloride has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers.
Isotope-Labeled Compounds   MMP   Parasite   Bacterial   Antibiotic   Apoptosis   Akt   PI3K  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Bacterial Infection  
/
HY-N0565S3 Doxycycline-13C,d3
Doxycycline-13C,d3 is 13C and deuterium labeled Doxycycline (HY-N0565). Doxycycline is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers.
Isotope-Labeled Compounds   MMP   Parasite   Bacterial   Antibiotic   Apoptosis   Akt   PI3K  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Bacterial Infection  
/
HY-14648S2 Dexamethasone-d4
Dexamethasone-d4 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
Exosomes   Isotope-Labeled Compounds   Glucocorticoid Receptor   SARS-CoV   Autophagy   Complement System   Mitophagy   Bacterial   Antibiotic  
Cancer   Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P2473 Neurogranin (48-76), human
Neurogranin (48-76), human is a dominant endogenous peptide in Alzheimer's disease (AD) brain tissue. Neurogranin (48-76) is a potential biomarker for synaptic function in AD.
Others  
Neurological, Eye or Ear Disease  
/
HY-166975 Polysarcosine 100
Polysarcosine 100 (pSar 100) is a hydrophilic alternative to PEG that has good targeted drug delivery properties and can remain in the bloodstream longer. Polysarcosine 100 can be used in drug delivery research.
Biochemical Assay Reagents  
/
HY-D1317A Cyanine7.5 carboxylic
Cyanine7.5 carboxylic is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid functional groups. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Cyanine7.5 carboxylic can be covalently bound to some biological molecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-N15786 DSPE-RGD Lipid sodium
DSPE-RGD Lipid sodium is a lipid containing DSPE and RGD peptides that can be used to prepare lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
Cancer  
/
HY-W018772S D-Ribose-18O
D-Ribose-18O is the 18O labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glycati
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
/
HY-B1511G Cyclic AMP (GMP)
Cyclic AMP (GMP) (Cyclic adenosine monophosphate (GMP)) is Cyclic AMP (HY-B1511) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes.
Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-DP99144F1 Anti-Mouse PD-1 Antibody (RMP1-14), CY7 labeled
Anti-Mouse PD-1 Antibody (RMP1-14), CY7 labeled, is an Anti-Mouse PD-1 Antibody (RMP1-14) (HY-P99144) derivative carrying dye CY7 (HY-D0825). Anti-Mouse PD-1 Antibody (RMP1-14) is an anti-mouse PD-1 IgG2a antibody. Anti-Mouse PD-1 Antibody (RMP1-14) can be used for the study of colon carcinoma.
PD-1/PD-L1  
Cancer   Inflammation or Immune System Disease  
/
HY-P2004 FFAGLDD
FFAGLDD is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release.
MMP  
Cancer  
/
HY-N0596R Panaxadiol (Standard)
Panaxadiol (Standard) is the analytical standard of Panaxadiol. This product is intended for research and analytical applications. Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities.
Reference Standards   PD-1/PD-L1   HIF/HIF Prolyl-Hydroxylase   STAT  
Cancer  
/
HY-P5007 Copeptin (human)
Copeptin (human) is a peptide biochemical reagent corresponding to the 39 amino acid sequence at the C-terminus of human pre-provasopressin, which serves as a stable surrogate biomarker reflecting the secretion of arginine vasopressin (AVP). Copeptin (human) can be used in studies related to AVP secretion, fluid and osmotic homeostasis, stress responses, and cardiovascular biomarkers.
Cardiovascular Disease  
/
HY-P990292 Anti-Mouse CD132 (common γ chain) Antibody (3E12)
Anti-Mouse CD132 (common γ chain) Antibody (3E12) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse CD132. Anti-Mouse CD132 (common γ chain) Antibody (3E12) can block IL-2, IL-4 and IL-7. Anti-Mouse CD132 (common γ chain) Antibody (3E12) can inhibit T cells and B cells. Anti-Mouse CD132 (common γ chain) Antibody (3E12) can be used for the researches of cancer, immunology, inflammation and metabolic disease, such as tumor, skin transfer and diabetes.

Species: Mouse

Interleukin Related  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-112005G DOPE (GMP)
DOPE GMP is DOPE (HY-112005) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease.
Ferroptosis   Glutathione Peroxidase   ACSL Family   Amino acid Transporter  
Digestive System Disease   Alzheimer's Disease   Colitis  
/
HY-143202S1 DPhPC-d78
DPhPC-d78 is the deuterium labeled DPhPC (HY-143202). DPhPC is a phospholipid compound characterized by high mechanical and chemical stability, broad temperature phase stability, and high electrical resistance. DPhPC readily forms unilamellar vesicles and solid-supported bilayers. DPhPC is commonly used as a component of nanoliposomal drug carriers or as a model membrane material for studies on membrane proteins/ion channels.
Isotope-Labeled Compounds  
/
HY-P4131 MPS-Gαi3
MPS-Gαi3 is a cell penetrating peptide that can be used for drug delivery.
Others  
/
HY-P11552 (Asp-Ser-Ser)6
(Asp-Ser-Ser)6 ((DSS)6) is an artificially designed bone-targeting peptide. (Asp-Ser-Ser)6 is used as a ligand to modify apoptotic extracellular vesicles (ApoEVs) in order to enhance the bone targeting and efficacy of ApoEVs in the treatment of osteoporosis. (Asp-Ser-Ser)6 can be used for research on osteoporosis.
Others  
Osteoporosis  
/
HY-Y0791S Tetrabutylammonium-d36 iodide
Tetrabutylammonium-d36 iodide (Tetra-n-butylammonium-d36 iodide) is the deuterium labeled Tetrabutylammonium iodide (HY-Y0791). Tetrabutylammonium iodide is a quaternary ammonium salt commonly used as a phase transfer catalyst, surfactant, and stabilizer in various chemical reactions, especially in organic synthesis. Tetrabutylammonium iodide has unique chemical properties that facilitate the transfer of ions or molecules from one phase to another, making it an important ingredient in a variety of industrial processes.
Isotope-Labeled Compounds   Biochemical Assay Reagents  
/
HY-123550 Rosenonolactone
Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin and cholesterol ester transfer protein.

Source: Engleromyces goetzii

Thrombin   CETP  
Inflammation or Immune System Disease  
/
HY-158220D Hyaluronic acid methacryloyl (MW 300000)
Hyaluronic acid methacryloyl (MW 300000) (HAMA (MW 300000)), a natural extracellular matrix (ECM) with anti-inflammatory effects, promoting cell adhesion and proliferation. Hyaluronic acid methacryloyl (MW 300000) can be widely used in tissue engineering and regenerative medicine. Hyaluronic acid methacryloyl (MW 300000) can rapidly form a hydrogel after exposure to UV light.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-D3002 ONOO-/O2- tracker probe
ONOO-/O2- tracker probe is a dual-responsive near-infrared fluorescent probe. ONOO-/O2- tracker probe will only emit a strong fluorescence signal when both peroxynitrite (ONOO⁻) and superoxide anion (O₂•⁻), the two key reactive oxygen/nitrogen species, are present simultaneously. ONOO-/O2- tracker probe can be used as a biomarker detection tool for drug-induced liver injury (DILI).
Fluorescent Dye  
/
HY-D3275 PE-Cy5.5
PE-Cy5.5 is a far-red emitting tandem dye designed based on the principle of fluorescence resonance energy transfer (FRET), and is widely used in multicolor flow cytometry. PE-Cy5.5 consists of phycoerythrin (PE) as the energy donor and the cyanine dye Cy5.5 as the energy acceptor. Upon excitation by blue or green laser light, PE absorbs energy and transfers it to Cy5.5 via FRET, ultimately resulting in Cy5.5 emitting characteristic far-red fluorescence (Ex/Em = 450-500 nm/698 nm).
Fluorescent Dye  
/
HY-P99723 Manelimab
Manelimab (BCD-135) is a monoclonal antibody targeting PD-L1 with PD-L1 inhibitory activity. Manelimab blocks the interaction between PD-L1 and PD-1 to abrogate the immunosuppressive signals of T cells in the tumor microenvironment. Manelimab is applicable for tumor-related research.

Species: Human

PD-1/PD-L1  
Cancer  
/
HY-N0131S1 Stigmasterol-d5-1
Stigmasterol-d5-1 is deuterium labeled Stigmasterol. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.
Isotope-Labeled Compounds   MMP   Endogenous Metabolite  
Inflammation or Immune System Disease  
/
HY-B0094S3 Artemisinin-13C,d4
Artemisinin-13C,d4 is 13C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects.
Ferroptosis   HCV   Parasite   Akt   Isotope-Labeled Compounds  
Infection   Neurological, Eye or Ear Disease  
/
HY-D3000 NIR-RED ROS-H2O2 Probe
NIR-RED ROS-H2O2 Probe is a near-infrared fluorescent probe used for detecting hydrogen peroxide (H₂O₂) and featuring dual-modal fluorescence/photoacoustic imaging capabilities. NIR-RED ROS-H2O2 Probe successfully detects the upregulated fluorescence signal of H₂O₂ in HepG2 cells and a mouse liver injury model. NIR-RED ROS-H2O2 Probe can be used as a biomarker detection tool for drug-induced liver injury (DILI).
Fluorescent Dye  
Liver Injury  
/
HY-16938R 5'-Methylthioadenosine (Standard)
5'-Methylthioadenosine (Standard) is the analytical standard of 5'-Methylthioadenosine. This product is intended for research and analytical applications. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].
Reference Standards   Endogenous Metabolite   Apoptosis   Parasite  
Cancer   Metabolic or Endocrine Disease  
/
HY-158498 FA2 glycan (G0F)
FA2 glycan (G0F) (FA2 N-linked oligosaccharide; F(6)A2 glycan) is a core-fucosylated biantennary N-linked oligosaccharide that serves as a prostate cancer biomarker. The level of FA2 glycan (G0F) is higher in prostate cancer than in benign prostatic hyperplasia, and it is further elevated in advanced prostate cancer with a Gleason score ≥8 compared with both benign prostatic hyperplasia and low-/intermediate-risk prostate cancer. FA2 glycan (G0F) can be used in prostate cancer research.
Biochemical Assay Reagents  
Prostate Cancer  
/
HY-P5044 α-Synuclein (45-54) (human)
α-Synuclein (45-54) (human) is the 45-54 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly abundant in presynaptic nerve terminals. α-Synuclein is a biomarker for Parkinson's disease (PD).
α-synuclein  
Neurological, Eye or Ear Disease  
/
HY-B0106S Levetiracetam-d6
Levetiracetam-d6 is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent.
Isotope-Labeled Compounds   DNA Methyltransferase  
Cancer   Neurological, Eye or Ear Disease  
/
HY-170424 D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium
D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium increases the extracellular Ca2+ entry through upregulation of voltage-gated calcium channels.
Biochemical Assay Reagents  
/
HY-P4075 Antennapedia Leader Peptide (CT)
Antennapedia Leader Peptide (CT) is a cell penetrating peptide that can be used for drug delivery.
Others  
/
HY-P5041 α-Synuclein (34-45) (human)
α-Synuclein (34-45) (human) is the 34-45 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly abundant in presynaptic nerve terminals. α-Synuclein is a Parkinson's disease (PD) biomarker.
α-synuclein  
Neurological, Eye or Ear Disease  
/
HY-P992446 PUR001
PUR001 is a monoclonal antibody targeting NTPDase 1 (CD39). PUR001 blocks the hydrolysis of extracellular ATP and ADP into AMP by inhibiting CD39, reduces the production of immunosuppressive adenosine, and increases extracellular ATP concentration to activate anti-tumor immune responses. PUR001 can be used in studies related to solid tumors.

Species: Human

NTPDase  
Cancer  
/
HY-P10542 Dodecapeptide AR71
Dodecapeptide AR71 is an inhibitor of melanoma inhibitory activity (MIA). Dodecapeptide AR71 can reduce cell migration, reduce metastasis formation, and increase immune response. Dodecapeptide AR71 can be used in research on the treatment of malignant melanoma.
Others  
Cancer  
/
HY-N3955 Alnusenone
Alnusenone (Glutinone) is a stabilised intermediate int he biogenesis of friedelin (XV) from squalene. Alnusenone is the major natural compound in fractions.
Others  
/
HY-D3027 Human Serum Albumin-Rhodamine
Human Serum Albumin-Rhodamine (HSA-Rhodamine) is a Rhodamine B (HY-Y0016) labeled serum albumin. Human Serum Albumin-Rhodamine plays an important role in fluorescent labeling, drug delivery research, and other fields (Ex/Em = 546/610 nm).
Fluorescent Dye  
/
HY-145771 PD-1/PD-L1-IN-20
PD-1/PD-L1-IN-20 (Example 21) is a small-molecule inhibitor of the PD-1/PD-L1 protein-protein interaction. PD-1/PD-L1-IN-20 blocks PD-1/PD-L1 with the IC50 of 5.29 nM. PD-1/PD-L1-IN-20 can be used for the research of cancers, infectious diseases and autoimmune diseases.
PD-1/PD-L1  
Cancer  
/
HY-D2132 Sulfo-Cy5.5-ALN
Sulfo-Cy5.5-ALN is a fluorescent labeled alendronate, which targets bone. Sulfo-Cy5.5-ALN binds to hydroxyapatite and differentiated osteoblasts in vitro. Sulfo-Cy5.5-ALN selectively binds to the mineralized areas of the tumor. Sulfo-Cy5.5-ALN can be used to detect bone overgrowth in prostate bone metastasis.
Fluorescent Dye  
Cancer  
/
HY-N15951 C16 Ceramide-suc-PEG2K-maleimide
C16 Ceramide-suc-PEG2K-maleimide is functionalized PEG lipid that can be used to synthesize lipid nanoparticles for drug delivery.
Liposome  
/
HY-P5046 α-Synuclein (71-82) (human)
α-Synuclein (71-82) (human) is the 71-82 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly abundant in presynaptic nerve terminals. α-Synuclein is a biomarker for Parkinson's disease (PD).
α-synuclein  
Neurological, Eye or Ear Disease  
/
HY-N21955 Merenskine
Merenskine is a chlorinated 1,2-unsaturated senecionine-type pyrrolizidine alkaloid and serves as a substrate for epoxidation reactions. Merenskine forms merepoxine N-oxide upon evaporation in ammoniated solvents, while it generates merepoxine under alkaline sample preparation conditions. Merenskine exhibits a pH-dependent transfer rate in black tea infusion, and the transfer rate decreases sharply under alkaline conditions.
Biochemical Assay Reagents  
/
HY-P10950 PD-L1 inhibitory peptide
PD-L1 inhibitory peptide is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1). PD-L1 inhibitory peptide binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells. PD-L1 inhibitory peptide is promising for research of cancers.
PD-1/PD-L1  
Cancer   Inflammation or Immune System Disease  
/
HY-D1005I Poloxamer L61
Poloxamer L61 is a non-ionic triblock copolymer surfactant. Poloxamer L61 effectively achieves intracellular molecular delivery to cancer cells during photoacoustic molecular delivery, and maintains cell viability by promoting cell membrane resealing, thus avoiding irreversible damage caused by laser-induced membrane permeabilization. Poloxamer L61 is a key component of SP1017, a compound related to gene therapy, which regulates the interaction between DNA and extracellular matrix as well as cellular uptake, and significantly enhances the distribution and bioavailability of plasmid DNA in skeletal muscle. Poloxamer L61 can be used in studies on local or systemic therapeutic protein production.
Biochemical Assay Reagents  
/
HY-P10565 (RFR)4XB
(RFR)4XB is a cationic membrane-penetrating peptide. (RFR)4XB carries its cargo (the antisense oligomer) across the outer membrane of gram-negative bacteria.
Bacterial  
Infection  
/
HY-109541S3 Colfosceril miristate-d13
Colfosceril miristate-d13 (DMPC-d13) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery.
Isotope-Labeled Compounds  
/
HY-B2156S1 Menaquinone-4-13C6
Menaquinone-4-13C6 is the 13C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer  
/
HY-109541S Colfosceril miristate-d58
Colfosceril miristate-d58 (DMPC-d58) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery.
Isotope-Labeled Compounds  
Cancer  
/
HY-B1436S Nifuroxazide-d4
Nifuroxazide-d4 is the deuterium labeled Nifuroxazide. Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity.
STAT   Bacterial   Antibiotic  
Cancer   Infection  
/
HY-P992362 HBM1007
HBM1007 is a fully human monoclonal antibody targeting CD73. HBM1007 is an extracellular enzyme expressed on the surface of stromal cells and tumor cells, capable of converting extracellular adenosine monophosphate (AMP) into adenosine, and recognizing CD73 via a unique antigenic epitope. HBM1007 inhibits both CD73-dependent and CD73-independent enzyme activities.

Species: Human

CD73  
Cancer  
/
HY-W127487 N-Octadecanoyl-L-homoserine lactone
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.
Biochemical Assay Reagents  
/
HY-D1864 Sulfo-Cy7.5 dicarboxylic acid
Sulfo-Cy7.5 dicarboxylic acid is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid and sulfonate functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Sulfo-Cy7.5 dicarboxylic acid can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-142985 Oleyl Mesylate
Oleyl Mesylate is a derivative of Oleyl Alcohol. Oleyl Alcohol has been incorporated into various formulations for drug delivery.
Liposome  
Metabolic or Endocrine Disease  
/
HY-N7764 Tellimagrandin I
Tellimagrandin I is a gap junction protein 43 (Cx43) activator, which is a hydrolyzable ellagitannin (ellagitannin) secondary metabolite extractable from various plants. Tellimagrandin I mainly restores gap junction intercellular communication (GJIC) and induces S-phase arrest in tumor cells by upregulating Cx43; activates inflammatory cells to release TNF-α and VEGF to promote angiogenesis in vivo; and protects DNA from damage via antioxidant and metal chelating effects. Tellimagrandin I can be used in research related to human cervical cancer.
Endogenous Metabolite   Gap Junction Protein   TNF Receptor   VEGFR  
Cervical Cancer  
/
HY-D3328 APC-Cy5.5
APC-Cy5.5 is a tandem dye widely used in flow cytometry. It consists of the energy donor allophycocyanin (APC) and the energy acceptor Cy5.5, and operates via the fluorescence resonance energy transfer mechanism (Ex/Em = 650 nm/690 nm).
Fluorescent Dye  
/
HY-P992516 DNL-919 (ATV)
DNL-919 ATV is a brain-penetrant TREM2 agonist. DNL-919 ATV induces responsive microglial cell state changes and modulates microglial biomarkers. DNL-919 ATV can be used for the research of Alzheimer's disease.
TREM receptor  
Alzheimer's Disease  
/
HY-D1866 Sulfo-Cy7.5 carboxylic acid
Sulfo-Cy7.5 carboxylic acid is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid and sulfonate ion (sulfonate) functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Sulfo-Cy7.5 carboxylic acid can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-P10282 Synapsin I-(3-13)
Synapsin I-(3-13), a substrate for CaMK1, is a glycoprotein. Synapsin I is a phosphoprotein that coats the cytoplasmic side of synaptic vesicles and regulates their trafficking within nerve terminals.
CaMK  
Neurological, Eye or Ear Disease  
/
HY-N21956 Merenskine N-oxide
Merenskine N-oxide is a jacobine-like chlorinated 1,2-unsaturated pyrrolizidine alkaloid N-oxide with a hydroxyl group at the α-position. Merenskine N-oxide has a halohydrin side-chain configuration and serves as a substrate for epoxidation reactions. The transfer rate of Merenskine N-oxide into black tea leachate is pH-dependent, and its transfer rate decreases significantly under alkaline conditions.
Biochemical Assay Reagents  
/
HY-167807 1-Palmitoyl-2-(6,7-dibromo)stearoyl-sn-glycero-3-phosphocholine
1-Palmitoyl-2-(6,7-dibromo)stearoyl-sn-glycero-3-phosphocholine is a phospholipid with good biocompatibility. 1-Palmitoyl-2-(6,7-dibromo)stearoyl-sn-glycero-3-phosphocholine can be used to prepare large unilamellar vesicles.
Biochemical Assay Reagents  
/
HY-P11197 ACT1
ACT1 is a peptide that targets endogenous Cx43 by stabilizing its activity at gap junctions. ACT1 stabilizes gap junction intercellular communication in breast cancer cells. ACT1 enhances the activity of Tamoxifen (HY-13757A) and Lapatinib (HY-50898) in breast cancer. ACT1 can be used for breast cancer research.
Gap Junction Protein  
Cancer  
/
HY-N12537A (2R,3S)-PD-1/PD-L1-IN-38
(2R,3S)-PD-1/PD-L1-IN-38 (Compound (±)-13e) is an orally active Ah receptor (AhR) antagonist with in vivo and in vitro anticancer activity. (2R,3S)-PD-1/PD-L1-IN-38 promotes the secretion of INF-γ by CD8+T cells and inhibits the signal transduction of PD-1/PD-L1.
Aryl Hydrocarbon Receptor   PD-1/PD-L1  
Cancer  
/
HY-N0242R Fraxinellone (Standard)
Fraxinellone (Standard) is the analytical standard of Fraxinellone. This product is intended for research and analytical applications. Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1.
Reference Standards   PD-1/PD-L1   HIF/HIF Prolyl-Hydroxylase   STAT  
Cancer   Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
/
HY-W251598I Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500
Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500 is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort.
Bacterial   NO Synthase  
Gastric Disease   Triple-Negative Breast Cancer  
/
HY-W040073S Nifurtimox-d4
Nifurtimox-d4 is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).
Isotope-Labeled Compounds   Parasite   Lactate Dehydrogenase  
Cancer   Infection  
/
HY-P10988 LVTX-8
LVTX-8 is a peptide toxin, exacted from Lycosa vittata. LVTX-8 has potent anticancer and and anti-metastasis activities towards lung cancer with strong cytotoxicity. LVTX-8 significantly induces apoptosis and inhibits the proliferation, invasion and migration of lung cancer cells through P53 hypoxia pathways and integrin signaling. LVTX-8 significantly inhibits the tumor growth and metastasis in A549/H460 xenograft mice model.
Apoptosis   MDM-2/p53   Integrin  
/
HY-P11886 GNYTCEVTELTREGETIIELK-N3
GNYTCEVTELTREGETIIELK-N3 (GNYTCEVTELTREGETIIELK-Azide) is a conjugate of an azide (-N3) group and a CD47 functional peptide (GNYTCEVTELTREGETIIELK). Modifying the surface of LNPs with GNYTCEVTELTREGETIIELK significantly reduces the recognition and clearance of LNPs by the mononuclear phagocytic system (MPS) and reduces their accumulation in non-target tissues such as the liver and spleen. The azide group in GNYTCEVTELTREGETIIELK-N3 can undergo click chemistry reactions for applications such as constructing targeted drug delivery systems and nanoparticle modification.
Biochemical Assay Reagents  
/
HY-P10878 UK140
UK140 is the inhibitor for urokinase-type plasminogen activator (uPA) with Ki of 0.20 µM and 2.79 µM for huPA anf muPA. UK140 can be used in metastasis-related research.
PAI-1  
Cancer  
/
HY-W324458 MCA succinimidyl ester
MCA succinimidyl ester is a derivative of MCA (HY-W027544). MCA succinimidyl ester has succinimidyl ester can react selectively with amines. MCA succinimidyl ester can be used as peptide substrate for fluorescence resonance energy transfer.
Fluorescent Dye  
/
HY-W775262S Δ9-Tetrahydrocannabinolic acid-d3
Δ9-Tetrahydrocannabinolic acid-d3 is the deuterium labeled Δ9-Tetrahydrocannabinolic acid. Δ9-Tetrahydrocannabinolic acid is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Isotope-Labeled Compounds  
/
HY-113247S1 Muconic acid-d4
trans-trans-Muconic acid-d4-1 is a deuterium labeled trans-trans-Muconic acid (HY-113247). trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human.
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-16938S2 5'-Methylthioadenosine-13C5
5'-Methylthioadenosine-13C5 (5'-(Methylthio)-5'-deoxyadenosine-13C5) is the 13C--labeled 5'-Methylthioadenosine (HY-16938). 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis.
Isotope-Labeled Compounds   Endogenous Metabolite   Apoptosis   Parasite  
Cancer   Metabolic or Endocrine Disease  
/
HY-P990038 Eurestobart
Eurestobart (ES002023) is a recombinant human IgG1 antibody against CD39. Eurestobart restores antitumor immunity by stabilizing the pro-inflammatory extracellular ATP (eATP) and interfering with synthesis of the immunosuppressive adenosine within the tumor microenvironment (TME). Eurestobart is used in the research of locally advanced and metastatic solid tumors.

Species: Human

NTPDase  
Neurological, Eye or Ear Disease  
/
HY-W414069 Thiocholesterol
Thiocholesterol is a member of the class of cholesteric liquid crystals (CLCs) that can be used to synthesis cationic lipid. Thiocholesterol is a stronger stabilizer of silver nanoparticles (SNPs). Thiocholesterol can be used for plasma membrane research and drug delivery.
Endogenous Metabolite   Liposome  
/
HY-D3277 PE-VF594
PE-VF594 is a high-brightness fluorescent dye used in flow cytometry, primarily for labeling antibodies or streptavidin to help identify specific cell subpopulations. PE-VF594 is a tandem dye composed of two covalently linked fluorescent groups: one is phycoerythrin (PE), responsible for absorbing laser energy; the other is the receptor molecule VF594. Energy is transferred from PE to VF594 via fluorescence resonance energy transfer (FRET) mechanism (Ex/Em = 450-500 nm/614 nm) .
Fluorescent Dye  
/
HY-P2004A FFAGLDD TFA
FFAGLDD TFA is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release.
MMP  
Cancer  
/
HY-P11798 P-Selectin binding peptide
P‑Selectin binding peptide is a short peptide that specifically targets P‑selectin. P‑Selectin binding peptide binds with high affinity to P‑selectin, which is highly expressed on activated platelets, inflamed endothelium, and in the tumor microenvironment. P‑Selectin binding peptide is used for precise targeted delivery and intervention in inflammation, thrombosis, and tumors.
P-selectin  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-176346S PDL1, Arg-13C6,15N4, Lys-13C6,15N2
PDL1, Arg-13C36, 15N4, Lys-13C6, 15N2 is the 13C- and 15N-labeled PDL1.
Isotope-Labeled Compounds  
Cancer  
/
HY-P991609 ABX-MA1
ABX-MA1 is a humanized IgG2 monoclonal antibody inhibitor targeting MCAM/MUC18. ABX-MA1 significantly decreases homotypic aggregation and heterotypic adhesion to HUVECs, and the formation of experimental lung metastasis. ABX-MA1 potently inhibits tumor growth, angiogenesis, and MMP-2 expression in A375SM/WM2664 xenograft mice model, promising for melanoma research.

Species: Human

MMP  
Cancer  
/
HY-152014S Stearoylcarnitine-d3-1 hydrochloride
Stearoylcarnitine-d3-1 (hydrochloride) is deuterium labeled Stearoylcarnitine. Stearoylcarnitine, a fatty ester lipid molecule, is a human endogenous metabolite. Stearoylcarnitine acts as a metabolomics biomarker for early-onset-preeclampsia and late-onset-preeclampsia.
Isotope-Labeled Compounds   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-166973 Polysarcosine 20
Polysarcosine 20 (pSar 20) is a hydrophilic alternative to PEG that has good targeted drug delivery properties and can remain in the bloodstream longer. Polysarcosine 20 can be used in drug delivery research.
Biochemical Assay Reagents  
/
HY-W724370 Tetraethylammonium bromide-d20
Tetraethylammonium bromide-d20 (TEA bromide-d20) is the deuterium labeled Tetraethylammonium bromide (HY-W014408). Tetraethylammonium bromide is a quaternary ammonium salt consisting of a positively charged tetraethylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a reagent for the synthesis of various organic compounds, an electrolyte in electrochemical experiments, and a source of tetraethylammonium ions in biochemical and pharmacological research.
Isotope-Labeled Compounds   Biochemical Assay Reagents  
/
HY-109541S1 Colfosceril miristate-d4
Colfosceril miristate-d4 (DMPC-d4) is deuterium labeled Colfosceril miristate. Colfosceril miristate is a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery.
Isotope-Labeled Compounds  
Cancer  
/
HY-N20707 Castalagin
Castalagin is an orally active natural product with multiple biological activities including antibacterial activity against bacteria and anti-leishmanial activity against Leishmania aethiopica. Castalagin exhibits inhibitory activity against PARP1 and DNA topoisomerase II, with an IC50 of 0.86 μM for bovine PARP1. Castalagin reduces poly (ADP-ribosyl) ation modification in cells. Castalagin binds to the cell envelope of Ruminococcus bromii, increases the ratio of CD8+/FOXP3+CD4+ T cells in the tumor microenvironment, and acts as a prebiotic to enhance the activity of anti-PD-1 therapy. Castalagin induces morphological changes in Leishmania aethiopica promastigotes and inhibits their proliferation. Castalagin inhibits PBP2a-mediated peptidoglycan layer stabilization, disrupts bacterial peptidoglycan assembly, and inhibits and disintegrates bacterial biofilms. Castalagin can be used in research related to diseases such as cancer, leishmaniasis, and bacterial infections.
PARP   Topoisomerase   Penicillin-binding protein (PBP)   PD-1/PD-L1   Bacterial   Parasite  
Cancer   Bacterial Infection   Leishmania Infection  
/
HY-Y0607S1 4-Nitrobenzoic acid-d2
4-Nitrobenzoic acid-d2 is the deuterium labeled 4-Nitrobenzoic acid (HY-Y0607). 4-Nitrobenzoic acid acts as a redox mediator and electron transfer promoter. 4-Nitrobenzoic acid accepts electrons from reduced glucose oxidase and transfers them to the electrode to facilitate the glucose oxidation reaction, while minimizing the formation of protonated amino groups.
Isotope-Labeled Compounds   Drug Intermediate  
/
HY-P11232 NAB815
NAB815 is a specific inhibitor of the Stx2a (Kd = 0.01 μM)/TLR4 interaction. NAB815 inhibits the neutrophil/Stx2a interaction (IC50 = 0.057 μg/mL). NAB815 inhibits the formation of Stx2-containing extracellular vesicles (EVs) produced by leukocytes and platelets and reduces their toxic effects in cellular (Vero cells) and animal models (CD-1 mice). NAB815 reduces bacterial loads in the kidneys, urine, and bladders of Escherichia coli-infected mice. NAB815 is useful in the study of hemolytic uremic syndrome (HUS).
Toll-like Receptor (TLR)   Bacterial  
Infection  
/
HY-P3436A WLSEAGPVVTVRALRGTGSW TFA
WLSEAGPVVTVRALRGTGSW TFA is a cardiomyocyte-targeting peptide that specifically recognizes tenascin X on the surface of cardiomyocytes. WLSEAGPVVTVRALRGTGSW TFA can serve as a targeting ligand to conjugate with various therapeutic carriers (drugs, genes, exosomes, nanoparticles, etc.) for research on cardiovascular diseases (such as myocardial infarction, heart failure).
Exosomes  
Blood or Cardio-cerebrovascular Disease  
/
HY-N15803 DOPE-RGD Lipid sodium
DOPE-RGD Lipid sodium is a lipid containing DOPE and RGD peptides that can be used to prepare lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
Cancer  
/
HY-W753201 5'-Methylthioadenosine-13C
5'-Methylthioadenosine-13C (5'-(Methylthio)-5'-deoxyadenosine-13C) is the 13C-labeled 5'-Methylthioadenosine (HY-16938). 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis.
Isotope-Labeled Compounds   Endogenous Metabolite   Parasite   Apoptosis  
/
HY-P992414 MS17-38
MS17-38 is a monoclonal antibody targeting PODXL-v2. MS17-38 binds to a specific conformational epitope of PODXL-v2 on gastric cancer cells, modulates target function, inhibits gastric cancer cell growth and migration, and blocks tumor growth and lung metastasis. MS17-38 can be used for the research of gastric cancer.

Species: Human

Others  
Gastric Cancer  
/
HY-P2564 Human PD-L1 inhibitor III
Human PD-L1 inhibitor III is a human PD-L1 inhibitor.
PD-1/PD-L1  
Cancer   Inflammation or Immune System Disease  
/
HY-159771 FAP6-19
FAP6-19 is a fibroblast activation protein (FAP) targeting radioligand with a Kd of 18.2 nM. FAP6-19 selectively delivers therapeutic radioactive nuclides (such as 177Lu) to the tumor site by targeting the overexpressed FAP protein in the tumor microenvironment, achieving precise killing of cancer cells while minimizing radiation damage to healthy tissues. FAP6-19 exhibits extremely high total cellular uptake and good intracellular retention ability in HT1080 cells. After being labeled with 111In, FAP6-19 produced extremely high tumor/kidney and tumor/liver dose ratios in the mouse model with 4T1 tumors. FAP6-19 can be used in the research of solid tumors expressing FAP.
FAP  
Cancer  
/
HY-NP002I SSA Protein
SSA Protein (Sheep Serum Albumin) is a plasma protein derived from sheep. Sheep serum albumin is a 583 amino acid residues long multidomain monomeric protein which is rich in cysteine and low in tryptophan content. SSA Protein can be used as a potential biomarker of age-related decline.
Biochemical Assay Reagents  
/
HY-151998S DMPG-d54
DMPG-d54 is the deuterium labeled DMPG (1,2-Dimyristoyl-sn-glycero-3-phosphatidylglycerol). DMPG is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Isotope-Labeled Compounds  
/
HY-Y1309S 1-Naphthol-d8
1-Naphthol-d8 is the deuterium labeled 1-Naphthol. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe.
Endogenous Metabolite  
/
HY-109541S4 Colfosceril miristate-d63
Colfosceril miristate-d63 (DMPC-d63) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery.
Isotope-Labeled Compounds  
Cancer  
/
HY-N20672 Scutellarein-7-O-gentiobioside
Scutellarein-7-O-gentiobioside (Compound 7) is a flavonoid glycoside that can be isolated from the seeds of Oroxylum indicum. Scutellarein-7-O-gentiobioside exerts antioxidant activity via electron transfer and hydrogen atom transfer. Scutellarein-7-O-gentiobioside can be used in antioxidant research.
Biochemical Assay Reagents  
Antioxidant Agent  
/
HY-P4120 MHV EPTM
MHV EPTM is a peptide used for in vitro giant unilamellar vesicle (GUV) deformation analysis. MHV-EPTM peptide with the GUV membranes made the GUVs smaller in size and more rugged in appearance.
Others  
/
HY-136490S1 Psychosine-d7
Psychosine-d7 is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell
PKC  
Cancer   Neurological, Eye or Ear Disease  
/
HY-143211 Murapalmitine
Murapalmitine is the component of liposomes for drug delivery.
Liposome  
/
HY-W251598J Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard
Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard is an inorganic salt. Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard is widely used in the fields of food, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort.
Bacterial   NO Synthase  
Cancer   Gastric Disease  
/
HY-D1641 5,5'-Dimethyl BAPTA tetrapotassium
5,5'-Dimethyl BAPTA tetrapotassium is a water-soluble, extracellular membrane metal chelator with relative selectivity for calcium ions.
Fluorescent Dye  
/
HY-D2286 HBT-Fl-BnB
HBT-Fl-BnB is a fluorescent probe for the ratiometric detection of ONOO- in vitro and in vivo. HBT-Fl-BnB consists of an HBT core with Fl groups at the ortho and para positions responding to the zwitterionic excited-state intramolecular proton-transfer (zwitterionic ESIPT) process and a boronic acid pinacol ester with dual roles that block the zwitterionic ESIPT and recognize ONOO-.
Fluorescent Dye  
/
HY-143202S DPhPC-d87
DPhPC-d87 is the deuterium labeled DPhPC (HY-143202). DPhPC is a phospholipid compound characterized by high mechanical and chemical stability, broad temperature phase stability, and high electrical resistance. DPhPC readily forms unilamellar vesicles and solid-supported bilayers. DPhPC is commonly used as a component of nanoliposomal drug carriers or as a model membrane material for studies on membrane proteins/ion channels.
Isotope-Labeled Compounds   Liposome   Biochemical Assay Reagents  
/
HY-W018772S6 D-Ribose-d
D-Ribose-d is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein gly
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
/
HY-N15990 4ME 16:0 Diether PE
4ME 16:0 Diether PE is a phospholipid that can be used to prepare lipid nanoparticles for drug delivery.

Source: Methanosarcina barkeri

Biochemical Assay Reagents  
/
HY-D2999 NIR-RED ATP Probe
NIR-RED ATP Probe is a NIR-II fluorescent probe. NIR-RED ATP Probe exhibits high affinity and selectivity for ATP and can non-invasively and with high contrast detect changes in ATP concentration at the cellular level, with minimal interference to the abundant biomolecules within the cells. NIR-RED ATP Probe can be used as a biomarker detection tool for drug-induced liver injury (DILI).
Fluorescent Dye  
/
HY-14667S Lomitapide-d8
Lomitapide-d8 is deuterium labeled Lomitapide. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
Isotope-Labeled Compounds  
Blood or Cardio-cerebrovascular Disease  
/
HY-P4080 MPG peptides, Pα
MPG peptides, Pα is an amphipathic carrier peptide that can be used for drug delivery.
Others  
/
HY-P11186 CALNN
CALNN is a pentapeptide that can be used as a ligand to stabilise and functionalise gold nanoparticles in drug delivery systems.
Others  
Cancer  
/
HY-W340113 15:0 PC
15:0 PC (1,2-Dipentadecanoyl-sn-glycero-3-phosphocholine) is a phosphatidylcholine that can be used for giant unilamellar lipid vesicles (GUVs) preparation.
Biochemical Assay Reagents  
/
HY-P991647 ALX-0651
ALX-0651 is a biparatopic humanized monoclonal antibody inhibitor targeting CXCR4. ALX-0651 inhibits hematopoietic stem cell trafficking, tumor progression and metastasis. ALX-0651 can be used for non-Hodgkin’s lymphoma and multiple myeloma research.

Species: Human

CXCR  
Cancer  
/
HY-P991403 BC011
BC011 is a human monoclonal antibody (mAb) targeting TNFRSF1B. BC011 promotes CD8+T cell proliferation and depletes Treg cells, thereby increasing the proportion of effector T cells in the tumor microenvironment. BC011 can be used in tumor Immunity research.

Species: Human

TNF Receptor  
Cancer  
/
HY-N12537 PD-1/PD-L1-IN-38
PD-1/ PD-L1-in-38 is a PD-1/PD-L1 inhibitor, which can inhibit the proliferation of tumor cells, promote the secretion of INF-γ by CD8+ T cells, and inhibit the ability of PD-1/PD-L1 signal transduction. PD-1/PD-L1-IN-38 has antitumor activity.
PD-1/PD-L1  
/
HY-P5423D Ahx-GALA-Cys
Ahx-GALA-Cys is a GALA peptide (HY-P5423) derivative with an N-terminal 6-aminohexanoic acid (Ahx) linker and a C-terminal cysteine residue. Ahx-GALA-Cys possesses strong covalent coupling capacity, which can be used to conjugate fluorophores and targeting ligands for investigating the surface functionalization of small extracellular vesicles (sEV) and lysosomal escape.
Exosomes  
/
HY-Y0607S 4-Nitrobenzoic acid-d4
4-Nitrobenzoic acid-d4 is the deuterium labeled 4-Nitrobenzoic acid (HY-Y0607). 4-Nitrobenzoic acid is an oxidoreduction mediator and an electron transfer promoter. 4-Nitrobenzoic acid accepts electrons from the reduced glucose oxidase and transfers them to the electrode to promote the glucose oxidation reaction, while minimizing the formation of protonated amine groups.
Isotope-Labeled Compounds   Drug Intermediate  
/
HY-W998694 6-CR, 6G
6-CR, 6G is an acceptor chromophore commonly used in energy transfer (ET) fluorescent primers.
Fluorescent Dye  
/
HY-D2734 Heparin-Cy3
Heparin-Cy3 is a fluorescent dye composed of Cy3 (HY-D0822) and Heparin. Heparin-Cy3 can be used for cell tracing and drug delivery.
Fluorescent Dye  
/
HY-P99658A Imaprelimab (powder)
Imaprelimab (powder) is a humanized IgG1κ anti-CD146 antibody. Imaprelimab (powder) exerts anti-angiogenic effects on brain metastasis of lung cancer in animal models. Imaprelimab (powder) can be used in studies related to brain metastasis of non-small cell lung cancer.

Species: Human

Transmembrane Glycoprotein  
Cerebrovascular Disease   Non-Small Cell Lung Cancer  
/
HY-P11907 Pac-525
Pac-525 is a tryptophan-rich cationic antibacterial peptide and membrane-disrupting agent. Pac-525 exhibits antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, anaerobic bacteria, *Candida albicans* and *Fusarium solani*. Pac-525 interacts strongly with negatively charged phospholipid vesicles, induces vesicle dye release and disrupts microbial membranes. Pac-525 shows cytotoxicity against macrophages. Pac-525 can be used in studies related to bacterial and fungal infections.
Bacterial   Fungal  
Escherichia Coli Infection  
/
HY-W012670 2-Deoxy-L-ribose
2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase.
Apoptosis  
/
HY-165394 Melafolone
Melafolone is a potent dual COX-2/EGFR inhibitor with IC50s of 13.2 μM (COX-2) and 17.4 μM (EGFR). Melafolone enhances the effect of anti-PD-1 through vascular normalization and PD-L1 downregulation via the PI3K/Akt pathway in Lewis lung carcinoma (LLC) and CMT167 models. Melafolone can be used for lung cancer research.
COX   EGFR   PD-1/PD-L1   PI3K   Akt  
/
HY-13238S1 Dolutegravir-d3
Dolutegravir-d3 is the deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM).
Isotope-Labeled Compounds   HIV Integrase   HIV  
Infection  
/
HY-P991680 Elipunercept
Elipunercept is a fusion protein that combines human TNFRSF1B extracellular domain fragment (1-235) fused at the C-terminus to a human IgG1 Fc fragment. Elipunercept is an immunomodulator.

Species: Human

TNF Receptor  
Inflammation or Immune System Disease  
/
HY-P10466A KZR-8445 TFA
KZR-8445 TFA, a cyclic depsipeptide, is a client-selective Sec61 inhibitor. KZR-8445 TFA binds to the fully opened Sec61 lateral gate, blocks lumenal plug domain access, stabilizes lateral gate helices, traps select signal peptides, and disrupts secretory and membrane protein biogenesis. KZR-8445 TFA inhibits pro-inflammatory cytokine secretion in primary immune cells. KZR-8445 TFA inhibits SARS-CoV-2 replication, virus-induced cytotoxicity, and spike protein biogenesis. KZR-8445 TFA blocks disease progression in a mouse model of rheumatoid arthritis. KZR-8445 TFA can be used for the researches of rheumatoid arthritis and SARS-CoV-2 infection.
Sec61   SARS-CoV   Interleukin Related   TNF Receptor   IFNAR  
Viral Infection   Rheumatoid Arthritis  
/
HY-P992465 SIWA318H
SIWA318H is an adbanvced glycation end product (AGE) specific antibody. SIWA318H selectively binds to advanced glycation end product biomarkers, human FcγRIIIa, and pancreatic cancer cells, and cancer-associated fibroblasts. SIWA318H suppresses tumor growth in mouse PSN1 xenografts. SIWA318H can be used for the research of pancreatic cancer.

Species: Human

Fc Receptor (FcR)  
Pancreatic Cancer  
/
HY-P10466 KZR-8445
KZR-8445, a cyclic depsipeptide, is a client-selective Sec61 inhibitor. KZR-8445 binds to the fully opened Sec61 lateral gate, blocks lumenal plug domain access, stabilizes lateral gate helices, traps select signal peptides, and disrupts secretory and membrane protein biogenesis. KZR-8445 inhibits pro-inflammatory cytokine secretion in primary immune cells. KZR-8445 inhibits SARS-CoV-2 replication, virus-induced cytotoxicity, and spike protein biogenesis. KZR-8445 blocks disease progression in a mouse model of rheumatoid arthritis. KZR-8445 can be used for the researches of rheumatoid arthritis and SARS-CoV-2 infection.
Sec61   SARS-CoV   Interleukin Related   TNF Receptor   IFNAR  
Infection   Rheumatoid Arthritis  
/
HY-174940A E. coli Extract Total
E. coli Extract Total is an extract of Escherichia coli (ATCC 11303) grown in culture at 37°C and at the 3/4 logarithmic growth phase, which can be used to prepare unilamellar vesicles.
Biochemical Assay Reagents  
/
HY-184830 Isosilychristin
Isosilychristin is a P-glycoprotein inhibitor with an IC50 of 25.9 μM. Isosilychristin downregulates the expression of transmembrane efflux pumps, exerts intracellular antioxidant effects, and inhibits NO production in macrophages. Isosilychristin regulates cell cycle progression, and exerts weak antiproliferative and colony formation inhibitory effects in prostate cancer cells. Isosilychristin reduces bacterial intercellular communication and reverses the drug resistance of Staphylococcus aureus. Isosilychristin can be used in studies related to prostate cancer, inflammation and bacterial infections.
P-glycoprotein   NO Synthase   Bacterial  
Inflammation or Immune System Disease   Prostate Cancer   Bacterial Infection  
/
HY-E70188 N-Acetylgalactosamine-6-Sulfatase
N-Acetylgalactosamine-6-Sulfatase (GALNS) is a potential general biomarker for multiple malignancies (such as lung cancer, breast cancer, head and neck cancer, etc.). N-Acetylgalactosamine-6-Sulfatase deficiency causes mucopolysaccharidosis type IVA (MPS IVA), also known as Morquio A syndrome. N-Acetylgalactosamine-6-Sulfatase can be used in MPS IVA as well as cancer research.
Biochemical Assay Reagents  
/
HY-P3140 α-Synuclein (61-75)
α-Synuclein (61-75) is the 61-75 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. α-Synuclein is a potential biomarker for Parkinson's disease (PD).
α-synuclein  
Neurological, Eye or Ear Disease  
/
HY-P992448 RC98
RC98 is a monoclonal antibody targeting programmed cell death ligand 1 (PD-L1) and acts as a selective PD-L1 inhibitor. RC98 binds specifically to human and cynomolgus monkey PD-L1. RC98 blocks the interaction between PD-L1 and its receptor PD-1 to reverse T-cell inactivation mediated by PD-1/PD-L1 signaling. RC98 enhances the cytotoxic T-lymphocyte-mediated anti-tumor immune response against PD-L1-expressing tumor cells. RC98 can be used for the research of tumor immunity and solid tumors.

Species: Human

PD-1/PD-L1  
Cancer  
/
HY-166974 Polysarcosine 150
Polysarcosine 150 (pSar 150) is a hydrophilic alternative to PEG that has good targeted drug delivery properties and can remain in the bloodstream longer. Polysarcosine 150 can be used in drug delivery research.
Biochemical Assay Reagents  
/
HY-B0094S Artemisinin-d3
Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects.
Akt   Parasite   HCV   Ferroptosis  
Infection   Neurological, Eye or Ear Disease  
/
HY-B1436S1 Nifuroxazide-13C6
Nifuroxazide-13C6 is the 13C6 labeled Nifuroxazide. Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity.
Isotope-Labeled Compounds   STAT   Bacterial   Antibiotic  
Cancer   Infection  
/
HY-P4654 H-Tyr-Lys-OH
H-Tyr-Lys-OH is a dipeptide that can be used as a biomarker for AJH-1. H-Tyr-Lys-OH has a good binding affinity to angiotensin converting enzyme (ACE).
Angiotensin-converting Enzyme (ACE)  
/
HY-B0448S1 Phenytoin-15N2,13C
Phenytoin-15N2,13C is the 13C and 15N labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.
Sodium Channel   Virus Protease  
Neurological, Eye or Ear Disease  
/
HY-14648S1 Dexamethasone-d5-1
Dexamethasone-d5-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
Exosomes   Isotope-Labeled Compounds   Glucocorticoid Receptor   SARS-CoV   Autophagy   Complement System   Mitophagy   Bacterial   Antibiotic  
Cancer   Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-100496 Nucleocidin
Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

Source: Streptomyces calvus

Bacterial  
Infection  
/
HY-N0565AG Doxycycline (hydrochloride) (GMP)
Doxycycline hydrochloride GMP is Doxycycline (hydrochloride) (HY-N0565A) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Doxycycline hydrochloride is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hydrochloride is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hydrochloride also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hydrochloride induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hydrochloride also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hydrochloride has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers.
Apoptosis   MMP   Akt   PI3K  
Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Breast Cancer   Prostate Cancer   Bladder Cancer  
/
HY-N8353 Stachybotramide
Stachybotramide is a natural fungal metabolite with the property of modulating the activity of cholesteryl ester transfer protein (CETP). Stachybotramide stimulates the transfer of cholesteryl esters (CE) from high-density lipoprotein (HDL) to very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), increasing the transfer efficiency by 1.3- to 1.5-fold. Stachybotramide slightly reduced the transfer of cholesteryl esters from LDL and VLDL to HDL at 0.5 mM. The effect of Stachybotramide on the transfer of triglycerides (TG) from HDL was not significant. By these results, Stachybotramide was shown to preferentially stimulate the CETP-mediated transfer of cholesteryl esters from HDL to VLDL and LDL.

Source: Stachybotrys cylindrospora

Others  
Metabolic or Endocrine Disease  
/
HY-D2630 Cy3 HA MA (MW 3000)
Cy3 HA MA (MW 3000) is a hyaluronic acid methacrylate labeled with CY3 (HY-D0822). Cy3 HA MA (MW 3000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 550/570 nm).
Fluorescent Dye  
/
HY-Y1309R 1-Naphthol (Standard)
1-Naphthol (Standard) is the analytical standard of 1-Naphthol. This product is intended for research and analytical applications. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe.
Reference Standards   Endogenous Metabolite  
/
HY-13238S2 Dolutegravir-d5
Dolutegravir-d5 is deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM).
Isotope-Labeled Compounds   HIV Integrase   HIV  
Infection  
/
HY-N1300 Shizukanolide F
Shizukanolide F is a dimeric sesquiterpene, which is derivated from Chloranthus japonicus Sieb. Shizukanolide F exhibits potent antifungal activities against various plant pathogenic fungi and anti-metastasis breast cancer.
Fungal  
Cancer   Infection  
/
HY-W738852 Hydroxylysylpyridinoline-d6
Hydroxylysylpyridinoline-d6 is deuterium labeled Pyridinoline. Pyridinoline, a fluorescent material, is a bone resorption biomarker. Pyridinoline also is a type crosslink of collagen.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-N3261 Methyllinderone
Methyllinderone is an inhibitor of AP-1/STAT/ERK. Methyllinderone has anti-inflammatory effect. Methyllinderone reduce the invasion and migration rate of TPA-stimulated MCF-7 cells. Methyllinderone can be used in study breast cancer metastasis.
AP-1   STAT   ERK  
Inflammation or Immune System Disease  
/
HY-P991309 ZM-008
ZM-008 is an anti-LLT1 monoclonal antibody. ZM-008 blocks the interaction between LLT1 and CD161 on the surface of NK cells and T cells. ZM-008 restores anti-tumor immune activity, shifts the tumor microenvironment to an immune-responsive state, and recovers NK cell-mediated cytotoxicity against tumor cells, thereby reversing immunosuppression in immune-resistant "cold" tumors. ZM-008 is applicable to the research of immune-resistant solid tumors.

Species: Human

C-type Lectin-like Receptors (CTLRs)  
Cancer  
/
HY-145782 Witepsol
Witepsol is a selective lipid-based vehicle for use in drug delivery systems.
Liposome  
Metabolic or Endocrine Disease  
/
HY-W704076 Glyceryl monostearate-d5
Glyceryl monostearate-d5 (GMS-d5) is deuterium labeled Glyceryl monostearate. Glyceryl monostearate (GMS) is a single-tailed lipidic monoglyceride that can be used to synthesize nanoliposomes for drug delivery.
Isotope-Labeled Compounds   Liposome  
Cancer  
/
HY-B0106S1 Levetiracetam-d3
Levetiracetam-d3 is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent.
DNA Methyltransferase  
Cancer   Neurological, Eye or Ear Disease  
/
HY-148851 Bacteriochlorophyll a, from Rhodopseudomonas sphaeroides (under argon)
Bacteriochlorophyll a, from Rhodopseudomonas sphaeroides (under argon) (BChl a, from Rhodopseudomonas sphaeroides (under argon)) is a chlorophyll analog found in some bacteria that participates in the light absorption and energy transfer processes of photosynthesis.

Source: Chlorobium tepidum

Bacterial  
/
HY-D2651 Cy5 HA MA (MW 50000)
Cy5 HA MA (MW 50000) is a hyaluronic acid methacrylate labeled with CY5 (HY-D0821). Cy5 HA MA (MW 50000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 633/670 nm).
Fluorescent Dye  
/
HY-D2649 Cy5 HA MA (MW 5000)
Cy5 HA MA (MW 5000) is a hyaluronic acid methacrylate labeled with CY5 (HY-D0821). Cy5 HA MA (MW 5000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 633/670 nm).
Fluorescent Dye  
/
HY-14667S1 Lomitapide-d4
Lomitapide-d4 (AEGR-733-d4) is deuterium labeled Lomitapide. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
Isotope-Labeled Compounds   Microsomal Triglyceride Transfer Protein (MTP)  
Blood or Cardio-cerebrovascular Disease  
/
HY-D2681 Cy7 HA MA (MW 3000)
Cy7 HA MA (MW 3000) is a hyaluronic acid methacrylate labeled with CY7 (HY-D0825). Cy7 HA MA (MW 3000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 740/770 nm).
Fluorescent Dye  
/
HY-P99694 Lepunafusp alfa
Lepunafusp alfa (JR-171) is a BBB-penetrable fusion protein consisting of J-Brain Cargo and IDUA (a lysosomal enzyme, α-L-iduronidase). Lepunafusp alfa can reduce concentration of heparan sulfate (HS) and dermatan sulfate (DS). Lepunafusp alfa can be used for research of mucopolysaccharidosis type I.
Transferrin Receptor  
Neurological, Eye or Ear Disease  
/
HY-116486 Aureusimine B
Aureusimine B (Phevalin) is a cyclic dipeptide. Aureusimine B can be produced by Staphylococcus aureus biofilms. Aureusimine B may be exploited as potential biomarker for chronic, S. aureus biofilm-based infections.

Source: Streptomyces coelicolor M1146

Others  
Staphylococcus Aureus Infection  
/
HY-N7131R Coumarin 6 (Standard)
Coumarin 6 (Standard) is the analytical standard of Coumarin 6 (HY-N7131). This product is intended for research and analytical applications. Coumarin 6, a fluorescent dye, is used as a fluorescent probe in a microparticle drug delivery system to conduct in vivo tracking, cell uptake, and transport mechanism studies of drug delivery systems (λexc=450 nm, λem=505 nm).
Fluorescent Dye   Reference Standards  
/
HY-P3448S Certepetide-13C6,15N2
Certepetide-13C6,15N2 (CEND-1-13C6,15N2) is the 13C- and 15N-labeled Certepetide (HY-P3448). Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors.
Isotope-Labeled Compounds   Integrin   Complement System  
/
HY-B0448S2 Phenytoin-d5
Phenytoin-d5 (5,5-Diphenylhydantoin-d5) is deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.
Isotope-Labeled Compounds   Sodium Channel   Virus Protease  
Cancer   Neurological, Eye or Ear Disease  
/
HY-D2632 Cy3 HA MA (MW 10000)
Cy3 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY3 (HY-D0822). Cy3 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 550/570 nm).
Fluorescent Dye  
/
HY-D2633 Cy3 HA MA (MW 50000)
Cy3 HA MA (MW 50000) is a hyaluronic acid methacrylate labeled with CY3 (HY-D0822). Cy3 HA MA (MW 50000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 550/570 nm).
Fluorescent Dye  
/
HY-N15825 C24:1 GB3 Ceramide (d18:1/24:1)
C24:1 GB3 Ceramide (d18:1/24:1) is a globoside that can be used to prepare lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
/
HY-W021040S Fludioxonil-13C3
Fludioxonil-13C3 (CGA-173506-13C3) is 13C labeled Fludioxonil. Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells.
Isotope-Labeled Compounds   Apoptosis   Fungal  
Cancer   Infection  
/
HY-D2443 AF594 DBCO
AF594 DBCO is an AlexaFluor 594-conjugated DBCO click chemistry probe for fluorescent labeling of azido-modified cholesterol probes. DBCO is a commonly used chemical biomarker group. AF594 DBCO (Excitation wavelength about 590 nm, emission wavelength about 617 nm) can be used to label proteins, cells and other biomolecules for fluorescence imaging and flow cytometry detection.
Fluorescent Dye  
Cancer  
/
HY-B0268S2 Enoxacin-d8 hydrate
Enoxacin-d8 (hydrate) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 μg/ml) and topoisomerase IV (IC50=26.5 μg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing.
Isotope-Labeled Compounds   DNA/RNA Synthesis   MicroRNA   Antibiotic   Bacterial  
Cancer   Infection  
/
HY-N15844 C24:1 GM3 Ceramide (d18:1/24:1)
C24:1 GM3 Ceramide (d18:1/24:1) is a globoside that can be used to prepare lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
/
HY-D2650 Cy5 HA MA (MW 10000)
Cy5 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY5 (HY-D0821). Cy5 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 633/670 nm).
Fluorescent Dye  
/
HY-B1180R Vinburnine (Standard)
Vinburnine ((-)-Eburnamonine; (-)-Vincamone) (Standard) is the analytical standard of Vinburnine (HY-B1180). This product is intended for research and analytical applications. Vinburnine ((-)-Eburnamonine; (-)-Vincamone) phosphate is an orally active, blood-brain barrier permeable immunomodulator and apoptosis inducer. Vinburnine drives the secretion of IL-24 by activating the P38/MAPK/ATF3 signaling axis. Vinburnine induces reactive oxygen species production and DNA damage in cancer cells, thereby inhibiting cancer cell proliferation, activating the apoptotic cascade, and enhancing CD8+ T cell function to remodel the tumor immune microenvironment. Vinburnine can be used in the research of diseases such as melanoma.
Reference Standards   Apoptosis   p38 MAPK  
Melanoma  
/
HY-D2634 Cy3 HA MA (MW 100000)
Cy3 HA MA (MW 100000) is a hyaluronic acid methacrylate labeled with CY3 (HY-D0822). Cy3 HA MA (MW 100000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 550/570 nm).
Fluorescent Dye  
/
HY-D2431 Galactose-PEG-Cy3
Galactose-PEG-Cy3 is a Cy3 (HY-D0822) labeled Galactose-PEG conjugate. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Galactose-PEG improves drug cellular uptake and reduces endosomal degradation, and can be used in drug delivery.
Fluorescent Dye  
/
HY-D2648 Cy5 HA MA (MW 3000)
Cy5 HA MA (MW 3000) is a hyaluronic acid methacrylate labeled with CY5 (HY-D0821). Cy5 HA MA (MW 3000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 633/670 nm).
Fluorescent Dye  
/
HY-108535R HEPES sodium (Standard)
HEPES sodium (Standard) is the analytical standard of HEPES (sodium) (HY-108535). This product is intended for research and analytical applications. HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis.
Biochemical Assay Reagents   Reference Standards  
/
HY-P3448S1 Certepetide-13C2,15N
Certepetide-13C2,15N (CEND-1-13C2,15N) is the 13C- and 15N-labeled Certepetide (HY-P3448). Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors.
Isotope-Labeled Compounds   Integrin   Complement System  
/
HY-132559S PD-166285-d4
PD-166285-d4 is the deuterium labeled PD-166285.
Isotope-Labeled Compounds  
/
HY-P990823 Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11)
Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) is rat-derived IgG2b κ type antibody inhibitor, targeting to PD-L1/B7-H1. Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) can block PD-L1/ B7-1 interactions and does not block PD-L1/PD-1 interactions. Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) can be used for the researches of cancer, infection, immunology and metabolic disease, such as MB49 tumor, heart graft and diabetes.

Species: Mouse

PD-1/PD-L1  
Cancer   Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-124151R Adenosine-2'-monophosphate (Standard)
Adenosine-2'-monophosphate (Standard) (2'-AMP (Standard)) is the analytical standard of Adenosine-2'-monophosphate (HY-124151). This product is intended for research and analytical applications. Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation.
Reference Standards   Adenosine Receptor   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-D2631 CY3 HA MA (MW 5000)
Cy3 HA MA (MW 5000) is a hyaluronic acid methacrylate labeled with CY3 (HY-D0822). Cy3 HA MA (MW 5000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 550/570 nm).
Fluorescent Dye  
/
HY-P2474 Human PD-L1 inhibitor I
Human PD-L1 inhibitor I is a hPD-1 peptide ligand, with a KD of 3.39 μM. Human PD-L1 inhibitor I may disturb the binding of hPD-L1 to hPD-1.
PD-1/PD-L1  
Cancer  
/
HY-P2478A Human PD-L1 inhibitor V TFA
Human PD-L1 inhibitor V TFA, a human PD-1 protein binding peptide with a Kd value of 3.32 μM. Human PD-L1 inhibitor V TFA inhibit the interaction of hPD-1/hPD-L1.
PD-1/PD-L1  
Inflammation or Immune System Disease  
/
HY-W010708S Cholesteryl palmitate-d9
Cholesteryl palmitate-d9 is the deuterium labeled Cholesteryl palmitate. Cholesteryl palmitate is a useful prognostic biomarker for chronic interstitial pneumonia (CIP).
Endogenous Metabolite  
Inflammation or Immune System Disease  
/
HY-172378 Poly(styrene)-block-poly(acrylic acid) (PS:PAA 30000:2000)
Poly(styrene)-block-poly(acrylic acid) (PS:PAA 30000:2000) is a diblock copolymer used to prepare polymer micelles or vesicles and other encapsulation applications.
Biochemical Assay Reagents  
/
HY-P10641 Heart-homing peptide
Heart-homing peptide is a heart-targeting peptide with the sequence CRPPR that mediates cardiac endothelial targeting and accumulates in cardiac tissues. Heart-homing peptide mediates the translocation of liposomal and exosomal cargos across cardiac endothelium into interstitial tissues, enhances the accumulation of exosomes in the heart, and inhibits the GP130-STAT3/ERK1/2/AKT pathway. Heart-homing peptide accumulates at sites of ischemia/reperfusion, myocardial infarction and hypertrophy in mice. Heart-homing peptide can be used for the research of cardiovascular diseases.
Exosomes   STAT   ERK   Akt  
Blood or Cardio-cerebrovascular Disease  
/
HY-D2401F1 Cy5-Polystyrene microsphere (20um)
Cy5-Polystyrene microsphere (20um) is a Cy5 (HY-D0821)-labeled microsphere that can be used for bioimaging and drug delivery.
Fluorescent Dye  
/
HY-W101255 Triethylmethylammonium chloride
Triethylmethylammonium chloride is a quaternary ammonium salt belonging to the class of alkylammonium salts. This compound is widely used as a phase transfer catalyst in organic synthesis to facilitate the transfer of reactants between immiscible phases. In addition, it can be used as an electrolyte in electrochemical devices, a surfactant in emulsion polymerization, and a corrosion inhibitor. Its unique chemical properties make it an important ingredient in a variety of industrial applications, including pharmaceuticals, agrochemicals, and materials science.
Biochemical Assay Reagents  
/
HY-W088100 Boc-N-gamma-trityl-D-asparagin
Boc-N-gamma-trityl-D-asparagin (N-Boc-N'-trityl-D-asparagine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize metastasis-inhibiting or tumor growth-inhibiting metastasis-inhibiting MS derivatives.
Amino Acid Derivatives  
/
HY-13662BS (R)-Lansoprazole-d4
(R)-Lansoprazole-d4 is deuterium labeled (R)-Lansoprazole. (R)-Lansoprazole is the R enantiomer of Lansoprazole, Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
Exosomes   Isotope-Labeled Compounds   Proton Pump  
Inflammation or Immune System Disease  
/
HY-138622S1 24:0 Lyso PC-d4
24:0 Lyso PC-d44 is the deuterium labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery.
Isotope-Labeled Compounds  
/
HY-N7486 Chamaejasmenin B
Chamaejasmenin B can be extracted from Stellera chamaejasme L. Chamaejasmenin B suppresses cancer cells migration and invasion. Chamaejasmenin B inhibits tumor metastasis. Chamaejasmenin B can be used in the research of cancers, such as breast cancers.
Others  
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HY-P2022 Pentetreotide
Pentetreotide is a diethylenetriaminopentaacetic (DTPA) conjugate of Octreotide (HY-P0036). Pentetreotide is a somatostatin analog that, when labeled with 111In, can be used for nuclear medicine imaging. Somatostatin receptor scintigraphy with Pentetreotide is effective in visualizing neuroendocrine tumors, and its metastasis.
Radionuclide-Drug Conjugates (RDCs)  
Cancer  
/
HY-W1120356 Bis-PEG12-NHS Ester
Bis-PEG12-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.
Biochemical Assay Reagents  
/
HY-P10068A LAH5 TFA
LAH5 TFA is an amphipathic cell-penetrating peptide. LAH5 THA forms nanocomplexes with both RNP and RNP/HDR cargo.
Others  
/
HY-P2145 Extracellular death factor
Extracellular death factor (EDF) is the only single signaling molecule involved in Escherichia coli quorum sensing, and can initiate MAZEF-mediated cell death. Extracellular death factor significantly amplifies the endoribonucleolytic activities of both MazF and ChpBK.
Bacterial  
Bacterial Infection  
/
HY-P4116A pH-Low Insertion Peptide TFA
pH-Low Insertion Peptide TFA (pHLIP TFA) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide TFA targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide TFA successfully modifys polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide TFA -based targeting of cancer presents an opportunity to monitor metabolic changes and to selectively deliver imaging and therapeutic agents to tumors.
Others  
Cancer   Metabolic or Endocrine Disease  
/
HY-P11800A GPLGVRGC
GPLGVRGC is a cysteine-tagged variant of GPLGVRG (HY-P11800). GPLGVRGC is hydrolyzable by MMP13. GPLGVRGC mediates the disassembly of micelle-exosome systems, enhances chondrocyte endocytosis, and promotes responsive system uptake. GPLGVRGC confers targeted delivery and responsive release properties to micelle-exosome systems. GPLGVRGC is applicable to the research of osteoarthritis.
Exosomes   MMP  
Inflammation or Immune System Disease   Osteoarthritis  
/
HY-136433S N,N'-Dinitrosopiperazine-d8
N,N'-Dinitrosopiperazine-d8 is the deuterium labeled N,N'-Dinitrosopiperazine. N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568.
Isotope-Labeled Compounds  
Cancer  
/
HY-P11797 EP9
EP9 is a peptide targeting CD63. EP9 binds specifically to the extracellular region of CD63, including a groove in the large extracellular loop (EC2) or the extracellular end of CD63’s central cavity, triggering endocytosis of decorated nanoemulsions/liposomes into cells. EP9 promotes cellular uptake of decorated nanoemulsions/liposomes into activated cardiac fibroblasts and epicardial stromal cells via caveolae and/or clathrin-coated pits. EP9 can be used for the research of myocardial infarction, cardiac fibrosis.
Transmembrane Glycoprotein  
Blood or Cardio-cerebrovascular Disease  
/
HY-P991689 Girancitug
Girancitug is a humanized IgG1κ monoclonal antibody inhibitor targeting VEGFR2/KDR/CD309. Girancitug effectively inhibits angiogenesis. Girancitug can be used for anti-angiogenic therapy in cancers like colorectal and ovarian cancer research.

Species: Human

VEGFR  
Cancer  
/
HY-B0268S1 Enoxacin-d8 hydrochloride
Enoxacin-d8 (hydrochloride) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 μg/ml) and topoisomerase IV (IC50=26.5 μg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing.
Isotope-Labeled Compounds   Bacterial   DNA/RNA Synthesis   MicroRNA   Antibiotic  
Cancer   Infection  
/
HY-P4117 Penetratin-Arg
Penetratin-Arg is an antimicrobial and is used for drug delivery vehicle.
Bacterial  
Inflammation or Immune System Disease  
/
HY-W250148 Solvent black 5
Solvent black 5 (Spirit nigrosine) is a synthetic dye belonging to the family of azo dyes. Also known as oil black or naphthol black, it is dark blue-black and has excellent solubility in organic solvents. Solvent black 5 is commonly used as a colorant in various industrial applications such as printing inks, coatings and plastics. It can also be used as an indicator dye to detect the presence of metals in solution. Furthermore, due to its high absorption and emission properties in the near-infrared region, it has been used in scientific research as a fluorescent biomarker for tissues and cells. However, Solvent black 5 has been reported to have potentially toxic effects on human health and the environment and its use is therefore regulated in some countries.
Biochemical Assay Reagents  
/
HY-P990720 Elritercept
Elritercept (KER-050) is a recombinant fusion protein comprising a modified activin receptor type IIA extracellular domain fused to a human IgG1 Fc. Elritercept inhibits activin A and other select TGF-β superfamily ligands.

Species: Human

TGF-beta/Smad  
Inflammation or Immune System Disease  
/
HY-109541S2 Colfosceril miristate-d9
Colfosceril miristate-d9 (DMPC-d9) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery.
Isotope-Labeled Compounds  
Cancer  
/
HY-P991660 ARGX-111
ARGX-111 is an anti-MET antibody. ARGX-111 blocks HGF-dependent and -independent signaling, downregulating MET expression on the tumor cell surface. ARGX-111 depletes MET-expressing circulating tumor cells through enhanced antibody-dependent cell-mediated cytotoxicity (ADCC), thereby inhibiting tumor metastasis. ARGX-111 depletes circulating tumor cells and inhibits bone and lung metastasis in an orthotopic mouse model of metastatic breast cancer. ARGX-111 is promising for research in breast cancer and other cancers.

Species: Human

c-Met/HGFR  
Breast Cancer  
/
HY-P1447 Exendin-3/4 (64-86)
Exendin-3/4 (64-86) is a polypeptide from patent CN 106029087 A. The incretin receptor ligands are derived from multiple skin toxicity Shan exosomes -3 skin of SDGTFTSDLSKQM Di EAVRLFIEWLKNGGPSSGAPPPS.
Others  
Metabolic or Endocrine Disease  
/
HY-P5304A RTQLLWTPAAPTAMA TFA
RTQLLWTPAAPTAMA TFA is a peptide antigen，used for drug delivery in immune response.
Others  
Inflammation or Immune System Disease  
/
HY-D2401F Cy5-Polystyrene microsphere (100nm)
Cy5-Polystyrene microsphere (100 nm) is a Cy5 (HY-D0821)-labeled microsphere that can be used for bioimaging and drug delivery.
Fluorescent Dye  
/
HY-138622S 24:0 Lyso PC-13C6
24:0 Lyso PC-13C6 is the 13C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery.
Isotope-Labeled Compounds  
/
HY-128736 L-2-Phosphoglyceric acid
L-2-Phosphoglyceric acid is an endogenous metabolite. L-2-Phosphoglyceric acid serves as a substrate for phosphatases and releases inorganic phosphate upon catalytic dephosphorylation. L-2-phosphoglyceric acid is upregulated in human oral fibroblasts treated with Porphyromonas gingivalis bacterial extracellular vesicles. L-2-Phosphoglyceric acid is useful for research related to prostate cancer and periodontitis.
Endogenous Metabolite  
Metabolic or Endocrine Disease   Digestive System Disease   Prostate Cancer   Periodontal Disease  
/
HY-A0108S Trimethyl phosphate-d9
Trimethyl phosphate-d9 is the deuterium labeled Trimethyl phosphate (HY-A0108A). Trimethyl phosphate is a methylating agent. Trimethyl phosphate transfers methyl groups to aliphatic alcohols, phenols, and amines.
Isotope-Labeled Compounds  
/
HY-W654139 5'-Deoxy-5'-(methylthio)adenosine-d3
5'-Deoxy-5'-(methylthio)adenosine-d3 is deuterium labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis.
Isotope-Labeled Compounds   Apoptosis   Parasite   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P10600 BIMAX2
BIMAX2 is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence.
Ras  
/
HY-P10217 PD-1/PD-L1-IN-42
PD-1/PD-L1-IN-42 (Compound B8.4) is an inhibitor of the interaction between PD-1 and PD-L1, with an EC50 of 0.1 μM. PD-1/PD-L1-IN-42 can be used for the research of cancer immunotherapy.
PD-1/PD-L1  
Lung Cancer   Breast Cancer   Colorectal Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer  
/
HY-W018772S1 D-Ribose-13C
D-Ribose-13C is the 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glycati
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
/
HY-P2478 Human PD-L1 inhibitor V
Human PD-L1 inhibitor V, a human PD-1 protein binding peptide with a Kd value of 3.32 μM. Human PD-L1 inhibitor V inhibit the interaction of hPD-1/hPD-L1.
PD-1/PD-L1  
Inflammation or Immune System Disease   Lung Cancer   Breast Cancer   Colorectal Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer  
/
HY-P2477 Human PD-L1 inhibitor IV
Human PD-L1 inhibitor IV, a polypeptide, is a competitive human PD-1 protein inhibitor with a Kd value of 1.38 μM. Human PD-L1 inhibitor IV inhibits the interaction of hPD-1/hPD-L1.
PD-1/PD-L1  
Inflammation or Immune System Disease  
/
HY-P11174 CP05
CP05 is a peptide that specifically recognizes an exosome surface marker (CD63). CP05 anchors exosomes to target tissues for in vivo delivery of exosomes.
Exosomes   Transmembrane Glycoprotein  
/
HY-P3987A Cotransin TFA
Cotransin TFA is a cyclic ester peptide and a Sec61 translocator binder with signal sequence-selective activity to inhibit co-translational protein translocation. Cotransin TFA inhibits the biogenesis of a subset of secretory and membrane proteins in a signal peptide-dependent manner. Cotransin TFA is applicable for cancer-related research.
Sec61  
Cancer  
/
HY-P2470 Human PD-L1 inhibitor II
Human PD-L1 inhibitor II is a potent PD-L1 inhibitor with anti-cancer activity.
PD-1/PD-L1  
Cancer  
/
HY-W012450 Trimethylphenylammonium bromide
Trimethylphenylammonium bromide is a quaternary ammonium salt consisting of a positively charged N,N,N-trimethylanilinium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a reagent in the synthesis of various organic compounds and in some applications as a surfactant or corrosion inhibitor.
Biochemical Assay Reagents  
/
HY-P990082 Suvemcitug
Suvemcitug (APX-003) is a selective humanized rabbit monoclonal IgG1 (κ) anti-VEGF antibody. Suvemcitug inhibits the binding of VEGF to purified VEGFR1 (IC50 = 21.0 ng/mL) and VEGFR2 (IC50 = 275.4 ng/mL). Suvemcitug suppresses tumor angiogenesis, tumor growth and metastasis. Suvemcitug is applicable to research related to epithelial ovarian cancer, fallopian tube cancer and primary peritoneal cancer.

Species: Human

VEGFR  
Blood or Cardio-cerebrovascular Disease   Epithelial Ovarian Cancer  
/
HY-D1438 RH 414
RH 414 is the styryl pyridinium dye. RH 414 can be used for optical monitoring of synaptic vesicle membrane trafficking.
Fluorescent Dye  
/
HY-N10535 Lewis y tetrasaccharide
Lewis Y tetrasaccharide (Lewis Y, LeY) is a tetrasaccharide derivative form of Lewis X trisaccharide (HY-N10534). Lewis Y tetrasaccharide is an antigen associated with malignant ovarian carcinomas metastasis and poor prognosis.
FAK  
Cancer  
/
HY-W110542H Poly(ethylene glycol) diacrylate (MW 10000)
Poly(ethylene glycol) diacrylate (PEGDA) (MW 10000) is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine. Poly(ethylene glycol) diacrylate (MW 10000) can be used to create a three-dimensional (3D) breast cancer cell culture model.
Biochemical Assay Reagents  
/
HY-P11578 CKGGRAKDC (linear)
CKGGRAKDC (linear) is an adipose tissue homing peptide. CKGGRAKDC (linear) binds to vasculature-enriched prohibitin in adipose tissue to enable selective tissue targeting. CKGGRAKDC (linear) can be used to selective delivery of cargos to adipose tissues.
Others  
Metabolic or Endocrine Disease  
/
HY-172378A Poly(styrene)-block-poly(acrylic acid) (PS:PAA 3,000:5,000,DDMAT terminated)
Poly(styrene)-block-poly(acrylic acid) (PS:PAA 3,000:5,000,DDMAT terminated) is a diblock copolymer used to prepare polymer micelles or vesicles and other encapsulation applications.
Biochemical Assay Reagents  
/
HY-14648S5 Dexamethasone-d3-1
Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Mitophagy   Exosomes   Autophagy   ADC Payloads   Bacterial   Antibiotic   SARS-CoV   Complement System  
Cancer  
/
HY-16938S 5'-Methylthioadenosine-13C6
5'-Methylthioadenosine-13C6 is the 13C-labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis.
Endogenous Metabolite   Apoptosis  
Metabolic or Endocrine Disease  
/
HY-P11578A CKGGRAKDC (linear) TFA
CKGGRAKDC (linear) TFA is an adipose tissue homing peptide. CKGGRAKDC (linear) TFA binds to vasculature-enriched prohibitin in adipose tissue to enable selective tissue targeting. CKGGRAKDC (linear) TFA can be used to selective delivery of cargos to adipose tissues.
Others  
Metabolic or Endocrine Disease  
/
HY-W011052 Tetrapentylammonium bromide
Tetrapentylammonium bromide is a quaternary ammonium salt consisting of a positively charged tetrapentylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic synthesis reactions to facilitate the transfer of reactants between immiscible phases. It is also used in the production of surfactants, detergents and the synthesis of pharmaceuticals.
Biochemical Assay Reagents  
/
HY-P5421 Caloxin 1B1
Caloxin 1B1 is a biological active peptide. (Caloxin 1b1 is obtained by screening for binding to extracellular domain 1 of PMCA4, which inhibited PMCA extracellularly, selectively, and had a higher affinity for PMCA4 than PMCA1. Because caloxin 1b1 had been selected to bind to an extracellular domain of PMCA, it could be added directly to cells and tissues to examine its effects on smooth muscle and endothelium.)
Proton Pump  
/
HY-N0822R Shikonin (Standard)
Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
Reference Standards   Exosomes   Chloride Channel   Pyruvate Kinase   NF-κB   TNF Receptor   HIV   AIM2  
Cancer  
/
HY-136490S Psychosine-d5
Psychosine-d5 is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell.
PKC  
Cancer   Neurological, Eye or Ear Disease  
/
HY-N0565S1 Doxycycline-d3 (hyclate) (major)
Doxycycline-d3 hyclate (major) is the deuterium labeled Doxycycline hyclate (HY-N0565B). Doxycycline hyclate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hyclate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hyclate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hyclate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hyclate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hyclate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers.
Isotope-Labeled Compounds   MMP   Parasite   Bacterial   Antibiotic   Apoptosis   Akt   PI3K  
Cancer   Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-D2433 Glucose-PEG2000-Cy3
Glucose-PEG2000-Cy3 is a Cy3 (HY-D0822) labeled Glucose-PEG conjugate. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Glucose-PEG improves drug cellular uptake and reduces endosomal degradation, and can be used in drug delivery.
Fluorescent Dye  
/
HY-N8389 Globulol
Globulol is a terpenoid metabolite and Antimicrobial agent. Globulol can be isolated from Alpinia oxyphylla Miq. Globulol binds to PAK4, reduces the expression level of PAK4 in cancer cells, decreases the phosphorylation of AKT, and downregulates the expressions of STAT3, phosphorylated STAT3, and PD-L1. Globulol promotes the secretion of CCL4 by cancer cells. Globulol reduces the viability and proliferation ability of cancer cells, induces G0/G1 cell cycle arrest and Apoptosis in cancer cells, and inhibits cancer cell migration and the integrity of 3D tumor spheres. Globulol enhances the relevant effects of anti-PD-1 agents in the cancer cell microenvironment. Globulol exhibits anticancer activity against liver cancer. Globulol inhibits the mycelial growth of phytopathogenic fungi and the growth of phytopathogenic bacteria. Globulol can be used in studies related to hepatocellular carcinoma.
Bacterial   Fungal   PAK   Akt   STAT   PD-1/PD-L1   Apoptosis   CCR  
Liver Cancer   Bacterial Infection   Fungal Infection  
/
HY-176785S MCB-294
MCB-294 is a dual-state pan-KRAS inhibitor that selectively inhibits KRAS over NRAS and HRAS. MCB-294 capable of binding both the active (GTP-bound) and inactive (GDP-bound) forms of KRAS with Kds of approximately 1 pM and 10 nM, respectively. MCB-294 broadly impairs the growth of hTERT-HPNE cells expressing G12D, G12C, G12V, G12S, G13D, and wild-type KRAS, with IC50s of approximately 700 nM. MCB-294 induces irreversible apoptosis in KRAS-mutated tumors. MCB-294 effectively suppress KRASG12C inhibitor-resistant cancer cells and remodel the tumor immune microenvironment. MCB-294 can be used for the study of pancreatic cancer, colorectal cancer and lung cancer.
Ras   Apoptosis   p38 MAPK   Caspase   TNF Receptor  
/
HY-14648S Dexamethasone-d5
Dexamethasone-d5 is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
Exosomes   Glucocorticoid Receptor   SARS-CoV   Autophagy   Complement System   Mitophagy   Bacterial   Antibiotic  
Cancer   Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-N7882 Ptaquiloside
Ptaquiloside (Braxin C; Aquilide A) is an illudane-type sesquiterpene glycoside natural toxin derived from ferns, with carcinogenic properties. Ptaquiloside can be converted to Pterosin B (HY-N1570). Ptaquiloside upregulates the expression of metallothioneins Mt1 and Mt2, and depletes intracellular free zinc ions. Ptaquiloside downregulates the expression of CD44 and CD107a in lesion-infiltrating CD8+ T cells, impairs T cell activation and degranulation capacity, and promotes immune evasion. Ptaquiloside can be used in cancer-related research.
Melatonin Receptor   CD44   Drug Intermediate  
Cancer  
/
HY-P10862A AH-D peptide TFA
AH-D peptide TFA is an antiviral peptide that selectively disrupts membrane structures within the size range of exosomes, inducing T-EXO depletion and enhancing cancer immunotherapy.
Exosomes   Virus Protease  
Cancer   Infection  
/
HY-P991736 Anti-IL11 Antibody (X203, Mouse IgG)
Anti-IL11 Antibody (X203, Mouse IgG) is an antibody targeting IL-11. Anti-IL11 Antibody (X203, Mouse IgG) inhibits IL-11-mediated activation of the ERK-mTORC1 axis, inactivation of LKB1-AMPK, and pro-senescence pathways. Anti-IL11 Antibody (X203, Mouse IgG) alleviates age-related metabolic decline, improves muscle function, reduces tissue fibrosis, decreases the expression of senescence markers, and maintains telomere length and mtDNA copy number. Anti-IL11 Antibody (X203, Mouse IgG) restores browning of white adipose tissue, upregulates thermogenic and mitochondrial biogenesis gene programs, reduces lipid droplet size, and decreases immune cell infiltration in visceral white adipose tissue. Anti-IL11 Antibody (X203, Mouse IgG) extends the median lifespan of mice and reduces the incidence of age-related tumors. Anti-IL11 Antibody (X203, Mouse IgG) can be used in the research of age-related metabolic decline, sarcopenia and age-related cancers.

Species: Human

Interleukin Related   ERK   mTOR   AMPK  
Cancer   Inflammation or Immune System Disease  
/
HY-N14001 Naamidine J
Naamidine J is an imidazole-type alkaloids discovered in a sponge. Naamidine J inhibits inflammation by binding to the protein CSE1L (KD = 5.41 μM). Namidine J significantly inhibits the expression of pro-inflammatory factors such as TNF-α, IL-1β, and IL-6, and upregulates anti-inflammatory factors such as CD206 and Arg-1. Namidine J inhibits PD-L1 and shows antitumor activity. Namidine J significantly reduces pulmonary tissue edema, inflammatory cell infiltration and cytokine storm in mice. Namidine J can be used for the research on the immune microenvironment of acute lung injury and tumors.

Source: Pericharax heteroraphis

TNF Receptor   Interleukin Related   Arginase   PD-1/PD-L1  
Cancer   Inflammation or Immune System Disease  
/
HY-P990704 Rilvegostomig
Rilvegostomig (AZD-2936) is a bispecific humanized IgG1 antibody targeting PD-1 and TIGIT. Rilvegostomig induces tumor growth inhibition and modulates the tumor immune microenvironment. Rilvegostomig exhibits anti-tumor activity in metastatic non-small cell lung cancer (without prior immune checkpoint inhibitor treatment). Rilvegostomig can be used in research related to metastatic non-small cell lung cancer and endometrial cancer.

Species: Human

PD-1/PD-L1   Transmembrane Glycoprotein  
Non-Small Cell Lung Cancer   Endometrial Cancer  
/
HY-P10862 AH-D peptide
AH-D peptide is a brain-penetrant antiviral agent disrupting highly curved lipid membranes. AH-D peptide exhibits broad-spectrum antiviral activity against ZIKV, Dengue virus, Chikungunya virus, yellow fever virus and Japanese encephalitis virus, with
IC50
values of 11.9, 12.5, 35.7, 206 and 136 nM, respectively. AH-D peptide reduces the viral load in the brain, suppresses inflammation, protects neurons, and does not damage the blood brain barrier. AH-D peptide restores antitumor immunity by decreasing circulating PD-L1+ exosomes, reducing intratumoral immunosuppressive cells (regulatory T cells, myeloid-derived suppressor cells), and enhancing T cell function. AH-D peptide inhibits membrane-enveloped viruses and cancer cell metastasis in vivo. AH-D peptide exhibits no immunogenicity and has negligible effects on normal tissues. AH-D peptide can be used for research in Zika virus and other mosquito-borne viruses, cancer immunotherapy and metastasis.
Exosomes   Virus Protease  
Cancer   Infection  
/
HY-101013 D-SNAP
D-SNAP (S-Nitroso-N-acetylpenicillamine) can Generate nitric oxide and form superoxides spontaneously under physiological conditions and is often used to probe the cell stress response and stimulate calcium-independent synaptic vesicle release.
Fluorescent Dye  
/
HY-W014075S 1-Hydroxypyrene-d9
1-Hydroxypyrene-d9 is the deuterium labeled 1-Hydroxypyrene (HY-W014075). 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis.
Isotope-Labeled Compounds   Aryl Hydrocarbon Receptor   Cytochrome P450   Collagen  
Inflammation or Immune System Disease  
/
HY-D2841 FITC-Heparin
FITC-Heparin is a fluorescent dye composed of FITC (HY-66019) and Heparin. FITC-Heparin can be used for cell tracing and drug delivery.
Fluorescent Dye  
/
HY-N3387 Licoricidin
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC50=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer. Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect. Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo. Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations.
Apoptosis   NF-κB   Akt   MMP  
Cancer   Inflammation or Immune System Disease  
/
HY-W134005 Mg(Ⅱ)-EDTA disodium tetrahydrate
Mg(Ⅱ)-EDTA (Ethylenediaminetetraacetic acid magnesium) disodium tetrahydrate is a divalent metal chelator and ferroptosis inducer. Mg (Ⅱ)-EDTA disodium tetrahydrate reduces E-cadherin expression by chelating Ca2+ on the surface of tumor cells, thereby triggering cell dissociation and inducing epithelial-mesenchymal transition (EMT). Mg (Ⅱ)-EDTA disodium tetrahydrate further chelates lysosomal iron to form EDTA-Fe, induces ferroptosis through the Fenton reaction, and synergistically enhances immune responses to inhibit tumor metastasis. Mg (Ⅱ)-EDTA (disodium tetrahydrate) can be used in tumor-related research.
Ferroptosis   Cadherin  
/
HY-P10153 gH625
gH625 is a cell-penetrating viral peptide which is a part of glycoprotein H of Herpes simplex virus type I. gH625 is able to cross the cell membrane and to transport many conjugated cargoes into the cytosol. gH625 is permeable to the blood-brain barrier (BBB) and can enter the rat brain in vivo without toxic effects. gH625 can be used for siRNA delivery research.
Others  
/
HY-P991646 ING-1
ING-1 (heMab) is a high-affinity humanized monoclonal antibody against epithelial cell adhesion molecule (Ep-CAM). ING-1 is a transmembrane glycoprotein mediating Ca2+. ING-1 binds to Ep-CAM on tumor cells and exhibits potent in vitro activity, targeting and inhibiting tumor growth and metastasis in mouse cancer models. ING-1 is useful in the research of breast, colorectal, and lung cancers, among other cancers.

Species: Human

Transmembrane Glycoprotein  
Cancer  
/
HY-103048A PD-1/PD-L1-IN 3 TFA
PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases.
PD-1/PD-L1  
/
HY-P10449 M2 Peptide
M2 Peptide is a peptide targeting M2-like tumor-associated macrophages (TAMs). M2 Peptide is used to carry drugs or small interfering RNA (siRNA) to promote the repolarization of M2-like macrophages to M1-like macrophages, thereby altering the immunosuppressive state in the tumor microenvironment and enhancing the anti-tumor immune response. M2 Peptide can be used to study the effect of macrophage polarization and how this polarization change affects tumor growth and metastasis.
Others  
Cancer   Inflammation or Immune System Disease  
/
HY-W010708S1 Cholesteryl palmitate-d7
Cholesteryl palmitate-d7 is deuterium labeled Cholesteryl palmitate. Cholesteryl palmitate is a useful prognostic biomarker for chronic interstitial pneumonia (CIP).
Isotope-Labeled Compounds   Endogenous Metabolite  
Inflammation or Immune System Disease  
/
HY-W190740 dPEG(R)4-SATA
dPEG(R)4-SATA is a PEG derivative that can be used for drug delivery research, etc.
Biochemical Assay Reagents  
/
HY-P3586 HKPao
HKPao (Hunter-killer peptide ao) is a biologically active peptide. HKPao (Hunter-killer peptide ao) has anti-obesity and anti-tumor pro-apoptotic activity to cause release of cytochrome c from vesicles.
Apoptosis  
Cancer  
/
HY-W110542O Poly(ethylene glycol) diacrylate (MW 575),MEHQ as inhibitor
Poly(ethylene glycol) diacrylate (PEGDA) (MW 575), MEHQ as inhibitor is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine. Poly(ethylene glycol) diacrylate (MW 575), MEHQ as inhibitor can be used for the synthesis of a class of biodegradable polymers.
Biochemical Assay Reagents  
/
HY-P4896 FITC-Ahx-Gly-Arg-Gly-Asp-Ser-Pro
FITC-Ahx Gly Arg Gly Asp Ser Pro is a GRGDSP (HY-P0290) coupled to FITC. GRGDSP is an integrin inhibitor that can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis.
Integrin  
Cancer  
/
HY-113247S trans-trans-Muconic acid-d4
trans-trans-Muconic acid-d4 is the deuterium labeled trans-trans-Muconic acid. trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-130189R S-Phenylmercapturic acid (Standard)
S-Phenylmercapturic acid (Standard) is the analytical standard of S-Phenylmercapturic acid. This product is intended for research and analytical applications. S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay.
Drug Metabolite   Reference Standards  
/
HY-W014408 Tetraethylammonium bromide
Tetraethylammonium bromide is a quaternary ammonium salt consisting of a positively charged tetraethylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a reagent for the synthesis of various organic compounds, an electrolyte in electrochemical experiments, and a source of tetraethylammonium ions in biochemical and pharmacological research.
Biochemical Assay Reagents  
/
HY-D0957 Ethyl Violet
Ethyl Violet is a triphenylmethane cationic dye with antibacterial activity. Ethyl Violet is applicable to research related to antibacterial therapy and histological staining.
Fluorescent Dye   Bacterial  
Staphylococcus Aureus Infection  
/
HY-N6717 Tentoxin
Tentoxin is a cyclic tetrapeptide isolated from Alternaria tenuis, acts as a herbicide, causes seedling chlorosis, inhibits cyclic photophosphorylation and functions as an energy transfer inhibitor.

Source: Alternaria tenuis

Herbicide  
Infection  
/
HY-P3436 WLSEAGPVVTVRALRGTGSW
WLSEAGPVVTVRALRGTGSW is a cardiomyocyte-targeting peptide that specifically recognizes tenascin X on the surface of cardiomyocytes. WLSEAGPVVTVRALRGTGSW can serve as a targeting ligand to conjugate with various therapeutic carriers (drugs, genes, exosomes, nanoparticles, etc.) for research on cardiovascular diseases (such as myocardial infarction, heart failure).
Exosomes  
Heart Disease  
/
HY-P990828 Anti-PD-L1/B7-H1 Antibody (29E.2A3)
Anti-PD-L1/B7-H1 Antibody (29E.2A3) is a kind of mouse IgG2b κ chimeric antibody inhibitor, targeting to human PD-L1/B7-H1. Anti-PD-L1/B7-H1 Antibody (29E.2A3) can block the binding of PD-1 to PD-L1. Anti-PD-L1/B7-H1 Antibody (29E.2A3) can be used for the research of infection, such as hepatitis C virus (HCV).

Species: Human

PD-1/PD-L1  
Infection  
/
HY-P10336 Serpinin
Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function. Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects.
Serpin  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P991222 AMG-529
AMG-529 is a humanized monoclonal antibody against ASGR1 that binds to ASGR1, blocks ligand binding, and causes a dose-dependent increase in ALP (a biomarker of ASGR1 inhibition). AMG-529 can be used for the research of cardiovascular diseases.

Species: Human

Phosphatase  
Blood or Cardio-cerebrovascular Disease  
/
HY-W110542D Poly(ethylene glycol) diacrylate (MW 1000)
Poly(ethylene glycol) diacrylate (PEGDA) (MW 1000) is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine.
Biochemical Assay Reagents  
/
HY-DY1102 BODIPY FL-C16 (solution)
BODIPY FL-C16 (solution) is a BODIPY-labeled analog of Palmitic acid (HY-N0830), which serves as a fluorescent lipid tracer. BODIPY FL-C16 (solution) also acts as a ligand for liver fatty acid-binding protein (L-FABP) and intestinal fatty acid-binding protein (I-FABP) , with Kd values of 270 nM and 330 nM, respectively. BODIPY FL-C16 (solution) is rapidly taken up by cells, and after metabolic conversion to phospholipids, it is incorporated into the membrane structures of intracellular organelles and extracellular vesicles.
Solvent and concentration: DMSO: 5 mM
Fluorescent Dye  
/
HY-143368S L-Phenylmercapturic acid-d5
L-Phenylmercapturic acid-d5 is the deuterium labeled L-Phenylmercapturic acid (HY-143368). L-Phenylmercapturic acid is often used as a biomarker for exposure to aniline compounds such as aniline and xylene.
Isotope-Labeled Compounds  
/
HY-P4511 Serylleucine
Serylleucine (H-Ser-Leu-OH) is a dipeptide. Serylleucine's core 1 o-glycosylated peptide (SLC1G) can be detected in urine as a metabolite and is a biomarker in TB studies.
Others  
Infection  
/
HY-P2500 (Arg)9, FAM-labeled
(Arg)9, FAM-labeled, a cell-penetrating peptide (CPP), is a nona-arginine (ARG) with FAM label. CPPs have emerged as powerful tools for delivering bioactive cargoes into the cytosol of intact cells.
Fluorescent Dye  
/
HY-166979 Stearic acid-mPEG2000
Stearic acid-mPEG2000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Stearic acid-mPEG2000 can be used in drug delivery research.
Biochemical Assay Reagents  
/
HY-W145519A Hydroxyethyl starch (Mw 110-150 kDa)
Hydroxyethyl starch (Mw 110-150 kDa) is a biochemical reagent used in drug delivery and other research.
Biochemical Assay Reagents  
/
HY-D2479 DMANI
DMANI is an intramolecular charge transfer (ICT)-based mitochondria-targeted ratiometric fluorescent probe. DMANI can monitor mitochondrial peroxynitrite (ONOO−) in living cells.
Fluorescent Dye  
Metabolic or Endocrine Disease  
/
HY-Y0080 Methyl trioctyl ammonium chloride
Methyl trioctyl ammonium chloride is a quaternary ammonium salt commonly used as a surfactant, stabilizer and phase transfer catalyst in various chemical reactions, especially in organic synthesis. Methyl trioctyl ammonium chloride has unique chemical properties that facilitate the transfer of ions or molecules from one phase to another, making it an important ingredient in a variety of industrial processes.
Environmental Pollutants   Biochemical Assay Reagents  
/
HY-D0830 Calcein (tetraethyl ester)
Calcein tetraethyl ester is a tetraethylated derivative of calcein, with its core function serving as a live cell-specific fluorescent tracer. Calcein tetraethyl ester can diffuse between human periodontal ligament cells via gap junctions, thus enabling the evaluation of gap junction intercellular communication function, and its diffusion is enhanced under hydrogen peroxide induction. Calcein tetraethyl ester can be applied in the fields of cell biology and fluorescent labeling.
Fluorescent Dye  
/
HY-B0448S Phenytoin-d10
Phenytoin-d10 is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.
Isotope-Labeled Compounds   Sodium Channel   Virus Protease  
Cancer   Neurological, Eye or Ear Disease  
/
HY-D1629 Calcium Orange AM
Calcium Orange AM is an intracellular calcium reporter. Specific fluorescence can be detected when free calcium binds to Calcium Orange AM (Ex/Em=549/576 nm). Calcium Orange AM does not enter the vacuoles and does not compartmentalize into acidic vesicles.
Fluorescent Dye  
/
HY-D0805 Eosin 5-isothiocyanate
Eosin 5-isothiocyanate is an orange-red fluorescent and phosphorescent probe that reacts with amino groups. Eosin 5-isothiocyanate also acts as a photocatalyst. Eosin 5-isothiocyanate can be used for protein labeling, investigation of molecular rotational diffusion, and serves as a fluorescence resonance energy transfer (FRET) acceptor.
Fluorescent Dye  
/
HY-W001069 RuCl(p-cymene)[(R,R)-Ts-DPEN]
RuCl (p-cymene)[(R,R)-Ts-DPEN] (RuCl[(R,R)-Tsdpen](p-cymene)) is a Noyori-type chiral ruthenium asymmetric transfer hydrogenation catalyst. RuCl (p-cymene)[(R,R)-Ts-DPEN] is widely used in the asymmetric transfer hydrogenation and enantioselective reduction of ketones, imines and quinolines to construct specific stereoisomers with high optical purity.
Biochemical Assay Reagents  
/
HY-N4168B Methyl chlorogenate
Methyl chlorogenate is an antioxidant, and has radical scavenging activity. Methyl chlorogenate is an anti-inflammatory agent. Methyl chlorogenate also inhibits hepatocellular carcinoma (HCC) cell proliferation and metastasis.
Others  
Liver Cancer  
/
HY-P990130 Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26)
Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat CD71/TfR1. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) targets the transferrin receptor and binds to an extracellular domain for the transferrin receptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain.

Species: Mouse/Rat

Transferrin Receptor  
Neurological, Eye or Ear Disease  
/
HY-P99169 Uliledlimab
Uliledlimab is a potent against CD73 humanizedized monoclonal antibody. Uliledlimab inhibits the conversion of extracellular adenosine monophosphate (AMP) to adenosine. Uliledlimab can be used in research of cancer.

Species: Human

CD73  
Triple-Negative Breast Cancer  
/
HY-14648S3 Dexamethasone-4,6α,21,21-d4
Dexamethasone-4,6α,21,21-d4 is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
Isotope-Labeled Compounds   Glucocorticoid Receptor   SARS-CoV   Autophagy   Complement System   Mitophagy   Bacterial   Antibiotic  
Metabolic or Endocrine Disease  
/
HY-W110542N Poly(ethylene glycol) diacrylate (MW 250),MEHQ as inhibitor
Poly(ethylene glycol) diacrylate (PEGDA) (MW 250), MEHQ as inhibitor is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine. Poly(ethylene glycol) diacrylate (MW 250), MEHQ as inhibitor can be used to construct optical cross-linked hydrogel implants.
Biochemical Assay Reagents  
/
HY-W110542J Poly(ethylene glycol) diacrylate (MW 700)
Poly(ethylene glycol) diacrylate (PEGDA) (MW 700) is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine. Poly(ethylene glycol) diacrylate (MW 700) mimics the extracellular matrix (ECM), providing support and growth space for cells.
Biochemical Assay Reagents  
/
HY-P10600A BIMAX2 acetate
BIMAX2 acetate is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 acetate can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 acetate can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence.
Ras  
/
HY-W923198 Fluorescein O-methacrylate
Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-responsive fluorescent monomeric dye. Fluorescein O-methacrylate exhibits pH-responsive fluorescence properties: its fluorescence is activated under alkaline conditions and quenched under neutral or acidic conditions; reversible switching of fluorescence is achievable by adjusting the pH of the solution. Fluorescein O-methacrylate can be used as a monomer for the synthesis of amphiphilic fluorescein polymers. These polymers can self-assemble into stable polymer nanoparticles with enhanced aqueous-phase fluorescence, and also enable the conjugation of nanoparticles with amine-containing biomolecules to support sensitive optical detection of biomarkers (Ex/Em = 490/520 nm).
Fluorescent Dye  
/
HY-W251598S Bicarbonate-13C sodium
Bicarbonate-13C sodium is the 13C-labeled Sodium bicarbonate (HY-Y0756). Sodium bicarbonate is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort.
Reference Standards   Bacterial   NO Synthase  
Cancer   Gastric Disease  
/
HY-P990651 PY314
PY314 is a humanized antibody targeting TREM2. PY314 binds TREM2 on tumor-associated macrophages, depletes TREM2-high tumor-associated macrophages, reduces pro-tumorigenic M2 macrophage infiltration, increases CD8+ T cell, NK cell, and M1 macrophage infiltration, creates a proinflammatory tumor microenvironment, and promotes antitumor immune responseS. PY314 can be used for the research of platinum-resistant ovarian cancer, advanced solid tumors, breast cancer, and advanced refractory solid tumors.

Species: Human

TREM receptor  
Ovarian Cancer   Lung Adenocarcinoma   Triple-Negative Breast Cancer  
/
HY-D0936 SPQ
SPQ is a fluorescent dye. SPQ can be used to measure chloride ion concentration transients and transport rates in vesicles, cells, and even intact epithelium.
Fluorescent Dye  
/
HY-W110542P Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor
Poly(ethylene glycol) diacrylate (PEGDA) (MW 4000), MEHQ as inhibitor is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine. Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor can be used to construct enzyme-responsive hydrogel drug delivery system.
Biochemical Assay Reagents  
/
HY-P99591 Sontuzumab
Sontuzumab (AS1402) is a humanizedised IgG1κ MUC1 specific monoclonal antibody. Sontuzumab binds the extracellular MUC1 peptide sequence PDTR with a Kd of ~1 nM. Sontuzumab can be used for the research of breast cancer.

Species: Human

Mucin  
Breast Cancer  
/
HY-P990042 Gotistobart
Gotistobart (ONC-392; BNT 316) is a humanized anti-CTLA-4 antibody with selective regulatory T cell depletion activity in the tumor microenvironment. Gotistobart can be used for the research of cancer, such as non-small cell lung cancer.

Species: Human

CTLA-4  
Inflammation or Immune System Disease   Non-Small Cell Lung Cancer  
/
HY-W018597 2-Chloro-N-methylethanamine hydrochloride
2-Chloro-N-methylethanamine hydrochloride is a nitro compound that can be used to synthesize PD-1 inhibitors.
Biochemical Assay Reagents  
/
HY-N0150R Monensin sodium (Standard)
Monensin (sodium) (Standard) is the analytical standard of Monensin (sodium). This product is intended for research and analytical applications. Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects.
Exosomes   Reference Standards   Bacterial   Antibiotic   Na+/H+ Exchanger (NHE)   Parasite   Apoptosis   Fungal   Wnt  
Cancer   Infection  
/
HY-W014106 Tetraethylammonium tetrafluoroborate
Tetraethylammonium tetrafluoroborate is a quaternary ammonium salt consisting of a positively charged tetraethylammonium cation and a negatively charged tetrafluoroborate anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a reagent for the synthesis of various organic compounds, an electrolyte in electrochemical experiments, and a source of tetraethylammonium ions in biochemical and pharmacological research.
Biochemical Assay Reagents  
/
HY-108398B 11(Z),14(Z),17(Z)-Eicosatrienoic acid
11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid is an unsaturated fatty acid that affects mitochondrial genome maintenance. 11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid fully incorporates into cell membrane phospholipids and supports the initial induction of cellular respiration, but fails to sustain the continuous replication and retention of mitochondrial genomes. 11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid is applicable to research related to fatty acid acyl chain structure-dependent mitochondrial genome maintenance and mitochondrial biogenesis.

Source: Saccharomyces cerevisiae

Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P99697 Leronlimab
Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer.

Species: Human

CCR   HIV  
Cancer   Infection  
/
HY-NP002E PSA Protein (Porcine)
PSA Protein (Porcine) (Porcine Serum Albumin) is a serum albumin protein that contains a flexible C-terminal region. PSA Protein (Porcine) can serve both as a pork allergen and as a biomarker for detecting pork.
Biochemical Assay Reagents  
/
HY-114988 PGE-M
PGE-M (tetranor-PGEM) is a metabolite of Prostaglandin E2 (HY-101952) and also an inflammatory biomarker. Urinary PGE-M is a potential biomarker for detecting advanced colorectal tumors. PGE-M can be used in studies related to colorectal cancer, obesity, aging and breast cancer.
Drug Metabolite  
Inflammation or Immune System Disease   Breast Cancer   Colorectal Cancer   Obesity  
/
HY-P10131 3BP-3940
3BP-3940 is a highly potent and selective peptide inhibitor of FAP that targets cancer-associated fibroblasts (CAFs) in the tumor microenvironment. 3BP-3940 can be labeled with radionuclides (such as Ga-68) for precise tumor imaging or Lu-177 for the development of targeted anticancer technologies. 3BP-3940 accumulates in tumor lesions and can be used to diagnose and inhibit various solid cancers and CAFs-related diseases.
Radionuclide-Drug Conjugates (RDCs)   FAP  
Cancer  
/
HY-P4116 pH-Low Insertion Peptide
pH-Low Insertion Peptide (pHLIP) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide successfully modify polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide-based targeting of cancer presents an opportunity to monitor metabolic changes, and to selectively deliver imaging and therapeutic agents to tumors.
Others  
Cancer   Metabolic or Endocrine Disease  
/
HY-P990049 Becotatug
Becotatug (JMT-101) is a humanized IgG1 monoclonal antibody targeting epidermal growth factor receptor (EGFR), and serves as the antibody component of the antibody-drug conjugate Becotatug vedotin (HY-171265). Becotatug specifically binds to the extracellular domain of EGFR, induces receptor internalization and degradation, blocks the EGFR signaling pathway, and mediates antibody-dependent cellular cytotoxicity. When conjugated to monomethyl auristatin E (MMAE) (HY-15162) via a valine-citrulline cleavable linker, Becotatug enables targeted delivery of cytotoxic drugs to EGFR-positive tumor cells. Becotatug can be used for research related to non-small cell lung cancer, nasopharyngeal carcinoma, and head and neck squamous cell carcinoma..

Species: Human

EGFR   ADC Antibodies  
Non-Small Cell Lung Cancer   Nasopharyngeal Cancer  
/
HY-P99781 Plozalizumab
Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

CCR  
Cancer   Inflammation or Immune System Disease  
/
HY-W251598B Sodium bicarbonate, for molecular biology
Sodium bicarbonate, for molecular biology (Sodium hydrogen carbonate for molecular biolog; Soda bicarbonate for molecular biolog) is an inorganic salt. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort.
Bacterial   NO Synthase  
Cancer   Gastric Disease  
/
HY-107202GL Polyinosinic-polycytidylic acid (GMP Like)
Polyinosinic-polycytidylic acid (Poly(I:C)) (GMP Like) is the GMP Like class Polyinosinic-polycytidylic acid (HY-107202), and can be used as pharmaceutical excipients. Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis.
Toll-like Receptor (TLR)   PKD   HSP   Bcl-2 Family   Interleukin Related   Apoptosis  
Infection   Inflammation or Immune System Disease  
/
HY-160971 Ribonucleic Acid, Transfer from Brewing yeast
Ribonucleic Acid, Transfer from Brewing yeast is tRNA, which is isolated from brewer yeast. Ribonucleic Acid, Transfer from Brewing yeast is arranged in a cloverleaf model in total sequence. Ribonucleic Acid, Transfer from Brewing yeast is utilized as a substrate in reactions with participant of tRNAs.
DNA/RNA Synthesis  
/
HY-124151 Adenosine-2'-monophosphate
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation.
Adenosine Receptor   Endogenous Metabolite  
Cancer   Pain  
/
HY-W011819 Tetradecanedioic acid
Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid is an endogenous biomarker for assessing the activity of organic anion transporting polypeptides (OATPs).
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W073080 Coproporphyrin I dihydrochloride
Coproporphyrin I dihydrochlorideIt is an organic compound belonging to the class of porphyrins. It is a derivative of heme, an iron-containing molecule found in hemoglobin and other proteins. Coproporphyrin I dihydrochlorideOften used as a biomarker in the assessment of certain liver and metabolic diseases, especially those related to bile synthesis and transport. It can also be used as a reference standard for analytical chemistry and pharmacological research.
MOFs  
/
HY-145746 Sulfo-Cy5 azide
Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. Sulfo-Cy5 azide enables fluorescence imaging, tissue and cellular visualization of PD-L1 in tumors, and site-specific modification of anti-PD-L1 antibodies. Sulfo-Cy5 azide has been employed for RNA labeling and imaging. Sulfo-Cy5 azide can be conjugated to targeting agents for fluorescence imaging in atherosclerosis and breast cancer models (Ex/Em = 645/670 nm).
Fluorescent Dye   PD-1/PD-L1  
Breast Cancer   Atherosclerosis and Inflammation  
/
HY-159069 Zymosan (ZM), 95%
Zymosan (ZM), 95% is a yeast cell wall-derived carbohydrate-rich preparation and immunomodulator. Zymosan (ZM), 95% binds to and activates TLR-2, TLR-4, and Dectin-1 receptor to trigger downstream signaling pathways. Zymosan (ZM), 95% upregulates TLR-2, TLR-4, and TNF-α mRNA expression, increases serum TNF-α levels, and stimulates splenocyte number and viability in mice. Zymosan (ZM), 95% attenuates melanoma growth progression, modulates macrophage marker gene expression, and mediates phagocytosis, ROS generation, and cytokine production. Zymosan (ZM), 95% reduces Connexin 43 protein and mRNA levels, inhibits gap junctional intercellular communication, and induces proinflammatory factor production in human corneal cells. Zymosan (ZM), 95% induces peritoneal inflammation in mice, functions as a drug carrier, and supports fibroblast cell attachment in hydrogel formulations. Zymosan (ZM), 95% can be used for the research of melanoma, tumors, fungal keratitis, ocular surface inflammatory disorders, and peritoneal inflammation.
C-type Lectin-like Receptors (CTLRs)   Toll-like Receptor (TLR)   TNF Receptor   Connexin  
Cancer   Fungal Infection  
/
HY-P10068 LAH5
LAH5 is an amphipathic cell-penetrating peptide. LAH5 forms nanocomplexes with both RNP and RNP/HDR cargo.
Others  
/
HY-113092 Propionylcarnitine
Propionylcarnitine is metabolized by carnitine acetyltransferase from propionyl-CoA. Increased propionylcarnitine is regarded as a biomarker of vitamin B12 deficiency.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-D1435 Oxonol VI
Oxonol VI is an optical indicator of membrane potential in lipid vesicles (excitation/emission wavelengths: 614/646 nm). Oxonol VI can be used to detect changes in membrane potential associated with (Na+ + K+)-ATPase activity in reconstituted vesicles.
Na+/K+ ATPase   Fluorescent Dye  
Metabolic or Endocrine Disease  
/
HY-P10739 WYRGRL
WYRGRL is a selective, high-affinity collagen type II-binding peptide with a IC50 of 140 nM. Collagen type II is the most abundant and specific structural protein in the extracellular matrix of articular cartilage. WYRGRL can precisely target small-molecule compounds such as Dexamethasone (HY-14648) and nanocarrier-engineered exosomes to cartilage, significantly enhancing their therapeutic effects on osteoarthritis.
Exosomes   Collagen  
Inflammation or Immune System Disease   Osteoarthritis  
/
HY-P99505 Ziltivekimab
Ziltivekimab (COR-001) is a fully human monoclonal antibody and also an IL-6 inhibitor. Ziltivekimab significantly reduces inflammatory biomarkers and Lipoprotein (a) in chronic kidney disease patients with systemic inflammation. Ziltivekimab does not increase pro-atherosclerotic lipid levels. Ziltivekimab is used in studies related to atherosclerotic thrombotic diseases and chronic kidney disease.

Species: Human

Interleukin Related   LDLR  
Renal Disease   Atherosclerosis and Inflammation  
/
HY-P99480 Bintrafusp alfa
Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer.
TGF-β Receptor  
Non-Small Cell Lung Cancer   HER-2 Positive Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
/
HY-P5423 GALA
GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. GALA significantly promotes the cytosolic release of cargos carried by exosomes, plasmids and liposomes, effectively enhances gene transfection efficiency, and drives gene knockdown of functional macromolecules (such as siRNA) in alveolar epithelial cells (with no significant cytotoxicity at effective concentrations). GALA serves as a critical tool for studies on lung cancer metastasis (e.g., melanoma lung metastasis) and lung-targeted drug delivery systems.
Exosomes   Liposome  
Metastatic Melanoma  
/
HY-128736C L-2-Phosphoglyceric acid sodium hydrate
L-2-Phosphoglyceric acid sodium hydrate is an endogenous metabolite. L-2-Phosphoglyceric acid sodium hydrate serves as a substrate for phosphatases and releases inorganic phosphate upon catalytic dephosphorylation. L-2-Phosphoglyceric acid sodium hydrate is upregulated in human oral fibroblasts treated with Porphyromonas gingivalis bacterial extracellular vesicles. L-2-Phosphoglyceric acid sodium hydrate is useful for research related to prostate cancer and periodontitis.
Endogenous Metabolite  
Metabolic or Endocrine Disease   Digestive System Disease   Prostate Cancer   Periodontal Disease  
/
HY-W110542G Poly(ethylene glycol) diacrylate (MW 6000)
Poly(ethylene glycol) diacrylate (PEGDA) (MW 6000) is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine. Poly(ethylene glycol) diacrylate (MW 6000) can be used as a building material for wound dressing hydrogels.
Biochemical Assay Reagents  
/
HY-171821 PF-08046054
PF-08046054 (SGN-PDL1V) is a PD-L1-directed Antibody-drug conjugate (ADC), which is comprised of an anti-PD-L1 antibody conjugated to VcMMAE (HY-15575). PF-08046054 is direct cytotoxicity to PD-L1-expressing tumor cells via the intracellular delivery of MMAE. PF-08046054 can be used for the study of solid tumors
Antibody-Drug Conjugates (ADCs)   PD-1/PD-L1  
Cancer  
/
HY-P6292A KS-133 TFA
KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2) with IC50 values for Ca influx measurement and cAMP measurement of 24.8 nM and 500 nM, respectively. KS-133 TFA reverses the tumor-promoting M2 phenotype of tumor-associated macrophages to the anti-tumor M1 phenotype, alters the tumor immune microenvironment, and inhibits tumor growth. KS-133 TFA can be used for research on schizophrenia and cancer immune regulation.
PACAP Receptor  
Cancer   Neurological, Eye or Ear Disease   Immunomodulation  
/
HY-P3160C Fibronectin, bovine plasma
Fibronectin, bovine plasma is a fibronectin derived from bovine plasma. Fibronectin is an extracellular matrix protein that is upregulated and essential in many developmental processes, and also exists in the pathological progression of tissues and wound healing. Fibronectin specifically binds to a large number of molecules, including other components of the extracellular matrix, signaling molecules and cell adhesion molecules. The interaction between cells and fibronectin leads to bidirectional crosstalk, which regulates cell functions and induces cell-dependent changes in the extracellular matrix. Fibronectin, bovine plasma inhibits the production of bovine leukemia virus (BLV) p24 core protein in naturally infected bovine peripheral blood mononuclear cells.
Biochemical Assay Reagents  
Viral Infection  
/
HY-D1736 BODIPY FL-C16
BODIPY FL-C16 is a BODIPY-labeled analog of Palmitic acid (HY-N0830), which serves as a fluorescent lipid tracer. BODIPY FL-C16 also acts as a ligand for liver fatty acid-binding protein (L-FABP) and intestinal fatty acid-binding protein (I-FABP) , with Kd values of 270 nM and 330 nM, respectively. BODIPY FL-C16 is rapidly taken up by cells, and after metabolic conversion to phospholipids, it is incorporated into the membrane structures of intracellular organelles and extracellular vesicles.
Fluorescent Dye  
/
HY-P99046 Selicrelumab
Selicrelumab is an agonist CD40 antibody, induces changes in the tumor microenvironment. Selicrelumab can be used for the research of pancreatic cance and neoadjuvant study.

Species: Human

TNF Receptor  
Colorectal Cancer   Metastatic Breast Cancer   Chronic Lymphocytic Leukemia   Non-Hodgkin Lymphoma   Pancreatic Ductal Adenocarcinoma  
/
HY-W007432 RuPhos
RuPhos is a Buchwald ligand. In aqueous Suzuki-Miyaura catalytic transfer polymerization, RuPhos forms inactive Pd (RuPhos)2 with palladium and inhibits diffusion to improve polymerization controllability. RuPhos additional addition in anhydrous Kumada polymerization exacerbates catalyst deactivation and chain transfer, significantly impairing polymerization control.
Biochemical Assay Reagents  
/
HY-W251598C Sodium bicarbonate, for cell culture
Sodium bicarbonate, for cell culture (Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture) is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate, for cell culture can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort.
Environmental Pollutants   Bacterial  
Gastric Disease   Triple-Negative Breast Cancer  
/
HY-131498 Mca-PLGL-Dpa-AR-NH2
MOCAc-PLGL (Dpa) AR (Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) is a synthetic fluorescent substrate mainly used for in vitro enzymatic activity assays of MMP-7 (detection at 393 nm after excitation at 328 nm). MOCAc-PLGL (Dpa) AR is specifically cleaved and hydrolyzed by MMP-7 at the Gly-Leu peptide bond, allowing enzymatic activity to be monitored via fluorometry or HPLC (DMSO is usually added to ensure sufficient dissolution when determining kinetic parameters). MOCAc-PLGL (Dpa) AR is used to accurately evaluate the catalytic activity and pH dependence of recombinant mature human MMP-7 in vitro. MOCAc-PLGL (Dpa) AR is suitable for research on the mechanisms of tumor metastasis and invasion, particularly in fields such as prostate cancer, colon cancer, lung cancer and breast cancer.\n
Fluorescent Dye   MMP  
Cancer   Digestive System Cancer   Urogenital Cancer  
/
HY-P7851 Cystatin F/CST7 Protein, Human (HEK293, His)
Cystatin F/CST7 is a protein that acts as an inhibitor of papain and cathepsin L, but with lower affinity than other cystatins. It plays a potential role in immunomodulation by targeting specific components within the hematopoietic system. Cystatin F/CST7 Protein, Human (HEK293, His) is the recombinant human-derived Cystatin F/CST7 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Protease Inhibitors Cystatin Family Cystatin F

/
HY-P73717 PD-L1 Protein, Canine (HEK293, Fc)
PD-L1 Protein, Canine (HEK293, Fc) is a trans-membrane protein that is considered to be a co-inhibitory factor of the immune response. The amino acid sequence of PD-L1 is encoded by 7 exons, which form a protein of ~40 kDa. PD-L1 is a type I transmembrane protein, is part of the immunoglobulin (Ig) superfamily and is composed of IgV-like and IgC-like extracellular domains, a hydrophobic transmembrane domain and a short cytoplasmic tail composed of 30 amino acids. PD-L1 can combine with PD-1 to reduce the proliferation of PD-1 positive cells, inhibit their cytokine secretion and induce apoptosis. PD-L1 also plays an important role in various malignancies where it can attenuate the host immune response to tumor cells. PD-L1 Protein, Canine (HEK293, Fc) is the recombinant canine-derived PD-L1 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Canine; Source: HEK293

Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins PD-L1

/
HY-P73364 PD-L1 Protein, Rat (HEK293, Fc)
PD-L1 (Programmed death-ligand 1) critically regulates T cell proliferation and migration, acting as a biomarker for periodontitis and pre-eclampsia. CD274 is its human ortholog. Biased expression in the thymus (RPKM 102.9), spleen (RPKM 58.3), and other tissues emphasizes PD-L1's centrality in immune regulation across diverse physiological and pathological conditions. PD-L1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived PD-L1 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Rat; Source: HEK293

Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins PD-L1

/
HY-P73365 PD-L1 Protein, Rat (HEK293, His)
PD-L1 (Programmed death-ligand 1) critically regulates T cell proliferation and migration, acting as a biomarker for periodontitis and pre-eclampsia. CD274 is its human ortholog. Biased expression in the thymus (RPKM 102.9), spleen (RPKM 58.3), and other tissues emphasizes PD-L1's centrality in immune regulation across diverse physiological and pathological conditions. PD-L1 Protein, Rat (HEK293, His) is the recombinant rat-derived PD-L1 protein, expressed by HEK293 , with C-10*His labeled tag.

Species: Rat; Source: HEK293

Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins PD-L1

/
HY-P70663 PD-L1 Protein, Human (HEK293, Flag)
The PD-L1 protein critically regulates immune tolerance by acting as a ligand for PDCD1/PD-1, regulating T cell activation threshold, and limiting effector responses. It may act as a costimulatory molecule for IL10-producing T cell subsets. PD-L1 Protein, Human (HEK293, Flag) is the recombinant human-derived PD-L1 protein, expressed by HEK293 , with C-Flag labeled tag.

Species: Human; Source: HEK293

Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins PD-L1

/
HY-P70564 PD-L1 Protein, Cynomolgus (HEK293, His)
CD274 molecule, also known as programmed death ligand 1 (PD-L1), binds to the checkpoint suppressor molecule PD-1 to inhibit TCR-mediated IL-2 production and T cell proliferation signaling. PD-L1 is involved in the PI3K/JAK/STAT signaling pathway to promote tumor occurrence. PD-L1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PD-L1 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Cynomolgus; Source: HEK293

Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins PD-L1

/
HY-P70657 PD-L1 Protein, Human (HEK293, mFc)
The PD-L1 protein critically regulates immune tolerance by acting as a ligand for PDCD1/PD-1, regulating T cell activation threshold, and limiting effector responses. It may act as a costimulatory molecule for IL10-producing T cell subsets. PD-L1 Protein, Human (HEK293, mFc) is the recombinant human-derived PD-L1 protein, expressed by HEK293 , with C-mFc labeled tag.

Species: Human; Source: HEK293

Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins PD-L1

/
HY-P78192 PD-L1 Protein, Human (Biotinylated, HEK293, His-Avi)
The PD-L1 protein critically regulates immune tolerance by acting as a ligand for PDCD1/PD-1, regulating T cell activation threshold, and limiting effector responses. It may act as a costimulatory molecule for IL10-producing T cell subsets. PD-L1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived PD-L1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

Species: Human; Source: HEK293

Immune Checkpoint Proteins CD Antigens Biotinylated Proteins Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins PD-L1

/
HY-P74625 PLTP Protein, Human (HEK293, His)
PLTP proteins are centrally involved in lipid metabolism, mediating the transfer of phospholipids and free cholesterol between lipoproteins and HDL. This includes the exchange of various molecules such as diacylglycerol, sphingomyelin, and phosphatidylcholine. PLTP Protein, Human (HEK293, His) is the recombinant human-derived PLTP protein, expressed by HEK293 , with C-10*His labeled tag.

Species: Human; Source: HEK293

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HY-P73716 PD-L1 Protein, Mouse (HEK293, His-Fc)
PD-L1 protein serves as a ligand for the inhibitory receptor PDCD1/PD-1 and is critical for maintaining immune tolerance. This interaction modulates T cell activation, limits effector responses and may stimulate IL10-producing T cell subsets. PD-L1 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived PD-L1 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

Species: Mouse; Source: HEK293

Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins PD-L1

/
HY-P77819 PD-L1 Protein, Mouse (Biotinylated, HEK293, His)
PD-L1 protein serves as a ligand for the inhibitory receptor PDCD1/PD-1 and is critical for maintaining immune tolerance. This interaction modulates T cell activation, limits effector responses and may stimulate IL10-producing T cell subsets. PD-L1 Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived PD-L1 protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

Immune Checkpoint Proteins CD Antigens Biotinylated Proteins Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins PD-L1

/
HY-P7853 Cystatin F/CST7 Protein, Mouse (HEK293, His)
Cystatin F/CST7 Protein inhibits papain and cathepsin L, showing lower affinities compared to other cystatins. Notably, its distinct feature is its potential role in immune regulation, inhibiting a unique target within the hematopoietic system. This specialization implies Cystatin F/CST7's involvement in modulating immune responses within the complex regulatory network of hematopoiesis. Cystatin F/CST7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Cystatin F/CST7 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Mouse; Source: HEK293

Enzymes & Regulators Protease Inhibitors Cystatin Family Cystatin F

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HY-P76121 VAMP3 Protein, Human (His)
VAMP3 protein is an important SNARE protein that promotes vesicle transport from late endosomes to the trans-Golgi network. Its interaction with BVES, mediated by its C-terminal cytoplasmic tail, is crucial in this process. VAMP3 Protein, Human (His) is the recombinant human-derived VAMP3 protein, expressed by E. coli , with N-His labeled tag.

Species: Human; Source: E. coli

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HY-P71044 VAPB Protein, Human (His)
VAPB protein interacts with STARD3 through a phosphorylation-dependent mechanism to form a contact site between the endoplasmic reticulum (ER) and late endosomes. VAPB Protein, Human (His) is the recombinant human-derived VAPB protein, expressed by E. coli , with C-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P76171 BLOC1S2 Protein, Human
BLOC1S2 is an essential component of the BLOC-1 complex and is critical for the biogenesis of lysosome-related organelles (LROs), including platelet dense granules and melanosomes. BLOC-1 cooperates with the AP-3 complex to direct membrane protein cargo into vesicles for delivery to neurites and nerve terminals, suggesting that it is involved in neurite extension. BLOC1S2 Protein, Human (GST) is the recombinant human-derived BLOC1S2 protein, expressed by E. coli , with no tagged.

Species: Human; Source: E. coli

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HY-P76171A BLOC1S2 Protein, Human (N-GST)
BLOC1S2 is an essential component of the BLOC-1 complex and is critical for the biogenesis of lysosome-related organelles (LROs), including platelet dense granules and melanosomes. BLOC-1 cooperates with the AP-3 complex to direct membrane protein cargo into vesicles for delivery to neurites and nerve terminals, suggesting that it is involved in neurite extension. BLOC1S2 Protein, Human (N-GST) is the recombinant human-derived BLOC1S2 protein, expressed by E. coli , with N-GST labeled tag.

Species: Human; Source: E. coli

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HY-P704102 VAT1L Protein, Human (His)
VAT1L Protein, Human (His) is the recombinant human-derived VAT1L protein, expressed by E. coli, with C-6*His tag.

Species: Human; Source: E. coli

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HY-P76483 LYPD3/C4.4A Protein, Mouse (HEK293, His)
The LYPD3/C4.4A protein is a multifunctional cell surface molecule that is critical for cell migration and has been implicated in potential tumor progression. It binds laminin 1 and laminin 5, emphasizing its role in extracellular matrix interactions. LYPD3/C4.4A Protein, Mouse (HEK293, His) is the recombinant mouse-derived LYPD3/C4.4A protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

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HY-P73024 Ephrin-A1/EFNA1 Protein, Mouse (HEK293, His)
The Ephrin-A1/EFNA1 protein is a GPI-binding ligand critical for migration, repulsion, and adhesion in developing neurons, blood vessels, and epithelia. It binds to nearby Eph receptors, initiating bidirectional signaling. Ephrin-A1/EFNA1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Ephrin-A1/EFNA1 protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Ephrin/Eph Family Ephrins Ephrin-A1

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HY-P70219 LYPD3/C4.4A Protein, Human (HEK293, His)
LYPD3/C4.4A protein facilitates cell migration and potentially influences urothelial cell-matrix interactions.It plays a role in tumor progression, binding to laminin-1 and laminin-5.Interactions with LGALS3, AGR2, and AGR3 emphasize its functional associations and impact in diverse biological processes.LYPD3/C4.4A Protein, Human (HEK293, His) is the recombinant human-derived LYPD3/C4.4A protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

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HY-P70911 Lacritin Protein, Human (His)
Lacritin protein plays a pivotal role in modulating lacrimal acinar cell secretion. Lacritin Protein, Human (His) is the recombinant human-derived Lacritin protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P71162 NIP7 Protein, Human (His)
NIP7 is essential for precise processing of 34S pre-rRNA and assembly of 60S ribosomal subunits. As a monomer, NIP7 interacts with preribosomal complexes, may bind to RNA, and binds to key protein partners, including NOL8, SBDS, and FTSJ3. NIP7 Protein, Human (His) is the recombinant human-derived NIP7 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P71207 PITPNA Protein, Human (His)
PITPNA Protein catalyzes phosphatidylinositol (PI) and phosphatidylcholine (PC) transfer between membranes, displaying a preference for shorter saturated or monosaturated acyl chains at sn-1 and sn-2 positions. For PC, the preference order is C16:1 > C16:0 > C18:1 > C18:0 > C20:4, and for PI, it is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3. PITPNA Protein, Human (His) is the recombinant human-derived PITPNA protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P76700 VTI1A Protein, Human (HEK293, His)
VTI1A protein is a V-SNARE that mediates vesicle trafficking and promotes lipid bilayer fusion by interacting with t-SNARE on target membranes. It plays a role in vesicle trafficking from late endosomes to the trans-Golgi network. VTI1A Protein, Human (HEK293, His) is the recombinant human-derived VTI1A protein, expressed by HEK293 , with N-His labeled tag.

Species: Human; Source: HEK293

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HY-P76701 VTI1A Protein, Human (HEK293, Fc)
VTI1A protein is a V-SNARE that mediates vesicle trafficking and promotes lipid bilayer fusion by interacting with t-SNARE on target membranes. It plays a role in vesicle trafficking from late endosomes to the trans-Golgi network. VTI1A Protein, Human (HEK293, Fc) is the recombinant human-derived VTI1A protein, expressed by HEK293 , with N-mFc labeled tag.

Species: Human; Source: HEK293

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HY-P76844 COL4A3BP Protein, Human (sf9, His-GST)
COL4A3BP, a lipid-binding molecule, crucially facilitates intracellular trafficking of ceramides and diacylglycerol lipids via its START domain using a non-vesicular mechanism. COL4A3BP Protein, Human (sf9, His-GST) is the recombinant human-derived COL4A3BP protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

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HY-P77133 PEX11A Protein, Human (HEK293, Fc)
The PEX11A protein may regulate peroxisome dynamics, affecting peroxisome proliferation and division by promoting the association of coating proteins with the peroxisomal membrane. PEX11A is associated with structural organization and promotes membrane protrusion and elongation at the peroxisomal surface. PEX11A Protein, Human (HEK293, Fc) is the recombinant human-derived PEX11A protein, expressed by HEK293 , with N-mFc labeled tag.

Species: Human; Source: HEK293

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HY-P77996 MEPE/OF45 Protein, Mouse (HEK293, His)
MEPE/OF45 Protein, pivotal in regulating renal phosphate and uric acid excretion, influences bone mineralization in osteoblasts and chondrocytes, with notable effects on craniofacial structures. Its role in dental pulp stem cell proliferation is significant. MEPE/OF45's interaction with PHEX, mediated by its ASARM motif, is zinc-dependent, adding complexity to its regulatory functions. MEPE/OF45 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MEPE/OF45 protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

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HY-P75930 MTSS1 Protein, Human (His)
MTSS1 Protein is a protein down-regulated in MTSS1 in metastatic bladder carcinoma cell lines. MTSS1 is widely expressed but most abundant in spleen, thymus, testis, prostate and peripheral blood, with low levels also detected in uterus and colon. MTSS1 is proposed to function as a metastatic suppressor protein in both bladder and prostate cancers. MTSS1 Protein, Human (His) is the recombinant human-derived MTSS1 protein, expressed by E. coli , with N-His labeled tag.

Species: Human; Source: E. coli

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HY-P700383 PEX19 Protein, Human (GST)
The PEX19 protein is critical in early peroxisome biogenesis, serving as a cytosolic chaperone and import receptor for peroxisomal membrane proteins (PMPs). It binds and stabilizes newly synthesized PMP in the cytoplasm, specifically its hydrophobic domain. PEX19 Protein, Human (GST) is the recombinant human-derived PEX19 protein, expressed by E. coli , with N-GST labeled tag.

Species: Human; Source: E. coli

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HY-P702934 MAPK15 Protein, Human (Active, sf9, His-GST)
MAPK15 Protein, Human (Active, sf9, His-GST) is the recombinant human-derived MAPK15, expressed by Sf9 insect cells , with N-6*His and N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CMGC MAPK Family MAPK ERK7/MAPK15

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HY-P704001 SCP2 Protein, Human (GST)
SCP2 Protein, Human (GST) is the recombinant human-derived SCP2 protein, expressed by E. coli, with N-GST tag.

Species: Human; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

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HY-P705752 CAMKV Protein, Human (sf9, His-GST)
Although the CAMKV protein is classified as a kinase, it does not exhibit detectable kinase activity. This feature distinguishes CAMKV from classical kinases, which typically phosphorylate substrates as an essential aspect of their enzymatic function. CAMKV, Human (sf9, His-GST) is the recombinant human-derived CAMKV protein, expressed by sf9 insect cells, with N-Avi labeled tag.

Species: Human; Source: sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) CAMK CAMK-Unique CAMKV/VACAMKL

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HY-P705969 LYPD3/C4.4A Protein, Cynomolgus (HEK293, His)

Species: Cynomolgus; Source: HEK293

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HY-P705975 LYPD3/C4.4A Protein, Rat (HEK293, His)

Species: Rat; Source: HEK293

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HY-P706347 SCP2 Protein, Human (His)
SCP2 Protein, Human (His) is the recombinant human-derived SCP2 protein, expressed by E. coli, with C-His tag.

Species: Human; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

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HY-P706348 SCP2 Protein, Human (122a.a, His)
SCP2 Protein, Human (122a.a, His) is the recombinant human-derived SCP2 protein, expressed by E. coli, with N-His tag.

Species: Human; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

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HY-P80273 PD-L1 Antibody (YA235)
PD-L1 Antibody (YA235) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PD-L1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87006 PD-L1 Antibody (YA6699)
PD-L1 Antibody (YA6699) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PD-L1.

Host: Rabbit; Reactivity: Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80354 Synaptophysin Antibody (YA043)
Synaptophysin Antibody (YA043) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Synaptophysin.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80907 Synaptophysin Antibody (YA664)
Synaptophysin Antibody (YA664) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Synaptophysin.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P81192 StAR Antibody (YA3542)
StAR Antibody (YA3542) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to StAR.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82675 Superoxide Dismutase 3 Antibody (YA2420)
Superoxide Dismutase 3 Antibody (YA2420) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Superoxide Dismutase 3.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87090 SV2A Antibody (YA6783)
SV2A Antibody (YA6783) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SV2A.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86684 PD-L1 Antibody (YA6376)
PD-L1 Antibody (YA6376) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PD-L1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87647 PEX11B Antibody (YA7331)
PEX11B Antibody (YA7331) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PEX11B.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P811225 Dysbindin 1 Antibody
Dysbindin 1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Dysbindin 1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P83042 Extracellular Matrix Protein 1 Antibody (YA2787)
Extracellular Matrix Protein 1 Antibody (YA2787) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Extracellular Matrix Protein 1.

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811806 Dysbindin 1 Antibody (YA10277)
Dysbindin 1 Antibody (YA10277) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to Dysbindin 1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811806A Dysbindin 1 Antibody (YA10277) (PBS only)
Dysbindin 1 Antibody (YA10277) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to Dysbindin 1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P81286 LYRIC Antibody (YA995)
LYRIC Antibody (YA995) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LYRIC.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P83599 MTA2 Antibody (YA3344)
MTA2 Antibody (YA3344) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MTA2.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P89655 MTA3 Antibody (YA8999)
MTA3 Antibody (YA8999) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MTA3.

Host: Mouse; Reactivity: human

Monoclonal Antibodies Primary Antibodies

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HY-P811901 LAS1L Antibody(YA10372)
LAS1L Antibody(YA10372) is a Mouse-derived and non-conjugated IgG multiclonal antibody, targeting to LAS1L.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811901A LAS1L Antibody(YA10372) (PBS only)
LAS1L Antibody(YA10372) is a Mouse-derived and non-conjugated IgG multiclonal antibody, targeting to LAS1L.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P81192A StAR Antibody (YA3542)(PBS only)
StAR Antibody (YA3542) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to StAR.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81286A LYRIC Antibody (YA996)
LYRIC Antibody (YA996) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LYRIC.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81286AA LYRIC Antibody (YA996)(PBS only)
LYRIC Antibody (YA996) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LYRIC.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83236 CETP Antibody (YA2981)
CETP Antibody (YA2981) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CETP.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P84536A MTA1 Antibody (YA4233)(PBS only)
MTA1 Antibody (YA4233) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to MTA1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P84842A PD-L1 Antibody (YA4539)(PBS only)
PD-L1 Antibody (YA4539) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PD-L1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P85286 LYRIC/AEG1 Antibody (YA4978)
LYRIC/AEG1 Antibody (YA4978) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to LYRIC/AEG1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86295 STARD4 Antibody (YA5987)
STARD4 Antibody (YA5987) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STARD4.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86751A PD-L1 Antibody (YA6443)(PBS only)
PD-L1 Antibody (YA6443) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to PD-L1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P86843 Cystatin F Antibody (YA6536)
Cystatin F Antibody (YA6536) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cystatin F.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87068 SEC14L2 Antibody (YA6761)
SEC14L2 Antibody (YA6761) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SEC14L2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87089 SV2A Antibody (YA6782)
SV2A Antibody (YA6782) is a Rat -derived and non-conjugated IgG monoclonal antibody, targeting to SV2A.

Host: Rat ; Reactivity: Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87146 VTI1B Antibody (YA6839)
VTI1B Antibody (YA6839) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VTI1B.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P87282 BRMS1 Antibody (YA6965)
BRMS1 Antibody (YA6965) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRMS1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87538 PLIN3 Antibody (YA7222)
PLIN3 Antibody (YA7222) is a Mouse-derived and non-conjugated IgG2a, monoclonal antibody, targeting to PLIN3.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P88381 VAMP5 Antibody (YA8065)
VAMP5 Antibody (YA8065) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to VAMP5.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P88381A VAMP5 Antibody (YA8065)(PBS only)
VAMP5 Antibody (YA8065) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to VAMP5.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P8F048A FITC-conjugated CD274 (PD-L1) Antibody (29E.2A3)
FITC-conjugated CD274 (PD-L1) Antibody (29E.2A3) is a Mouse-derived and FITC conjugated monoclonal antibody, targeting to CD274 (PD-L1).

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Conjugated Primary Antibodies Primary Antibodies

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HY-P8F048C PE-conjugated CD274 (PD-L1) Antibody (29E.2A3)
PE-conjugated CD274 (PD-L1) Antibody (29E.2A3) is a Mouse-derived and PE conjugated monoclonal antibody, targeting to CD274 (PD-L1).

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Conjugated Primary Antibodies Primary Antibodies

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HY-P810357 CETP Antibody (YA9679)
CETP Antibody (YA9679) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to CETP.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P811124 RRS1 Antibody
RRS1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to RRS1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P811195 DLC1 Antibody
DLC1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to DLC1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P811218 SEC22B Antibody
SEC22B Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to SEC22B.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P84842 PD-L1 Antibody (YA4539)
PD-L1 Antibody (YA4539) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PD-L1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P86751 PD-L1 Antibody (YA6443)
PD-L1 Antibody (YA6443) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to PD-L1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P87874 TIAM2 Antibody (YA7559)
TIAM2 Antibody (YA7559) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to TIAM2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-K0272 ConA Agarose

MCE ConA agarose is prepared by covalently coupling ConA to agarose and is widely used for the separation and purification of glycoproteins, membrane proteins, glycolipids, polysaccharides, membrane vesicles containing mannose or glucose residues, IgM, and lipoprotein hormones.

Protein Biology Protein Purification Agarose Beads

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HY-K1028 Transfer Buffer (Semi Dry) Powder (1 L of 1×)

MCE Transfer Buffer (Semi Dry) Powder (1 L of 1×) consists of Tris, Glycine and SDS, and is suitable for Western Blot semi-dry electrophoresis. The 20 pouches are defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Protein Biology Protein Electrophoresis & WB Transfer Buffer

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HY-K1063A Exosome Isolation and Purification Plus Kit (From Plasma and Serum)

MCE Exosome Isolation and Purification Plus Kit (From Plasma and Serum) provides a simple and effective method to isolate and purify intact exosomes from plasma and serum

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-K1064 Exosome Protein Detection Kit (CD63 & TSG101)

MCE Exosome Protein Detection Kit (CD63&TSG101) can specifically detect exosome proteins CD63 and TSG101. This product is suitable for the detection of human, rat and mouse exosomes.


Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-K1066 Exosome Purification Filter

MCE Exosome Purification Filter is designed for use with the corresponding exosome extraction/purification kit and is suitable for the further purification of crude exosome preparations. It helps remove residual impurities and facilitates the preparation of exosome samples with improved purity.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-K1068 Exosome Protein Detection Kit (CD81)

MCE Exosome Protein Detection Kit (CD81) can specifically detect the exosome marker protein CD81.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-K1098 Exosome Isolation and Purification Kit (From Milk)

MCE Exosome Isolation and Purification Kit (From Milk) provides a simple and effective method to isolate and purify intact exosomes from milk.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-K1200 Rapid Protein Transfer Buffer, No Ice Bath Required (10×)

MCE Rapid Protein Transfer Buffer, No Ice Bath Required (10×) is formulated with an optimized rapid protein transfer system for both wet transfer and semi-dry transfer applications. It enables the rapid and efficient transfer of proteins from PAGE gels onto PVDF or nitrocellulose (NC) membranes for Western blot analysis.

Protein Biology Protein Electrophoresis & WB Transfer Buffer

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HY-K3111 Exosome-Specific Culture Medium (Serum-Free, Phenol Red-Free)

MCE Exosome-Specific Culture Medium (Serum-Free, Phenol Red-Free) is specifically formulated for optimized exosome collection.

Cell Biology Cell Culture Cell Analysis Specialized Cell Culture Medium Exosome Isolation, Purification and Detection

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HY-K3113 Exosome-Specific 293 Cell Medium (Serum-Free)

MCE Exosome-Specific 293 Cell Medium (Serum-Free) is specifically optimized for exosome production from HEK293 cells.

Cell Biology Cell Culture Cell Analysis Specialized Cell Culture Medium Exosome Isolation, Purification and Detection

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HY-K3119 Exosome Preservation Solution (Chemically Defined)

MCE Exosome Preservation Solution (Chemically Defined) is a buffer specifically formulated for the storage of exosome samples, designed to maintain their morphological integrity and biological activity.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-K3120 Serum/Plasma Exosome Isolation and Purification Kit (Magnetic Beads)

MCE Serum/Plasma Exosome Isolation and Purification Kit (Magnetic Beads) utilizes a magnetic bead-based method for the isolation and purification of exosomes. The underlying principle is based on the charge-dependent interaction between exosomes and functional polymers on the surface of the magnetic beads under an optimized buffer system, enabling selective adsorption of exosomes. Subsequent adjustment of the ionic strength and pH of the buffer promotes the gentle dissociation of exosomes from the magnetic beads, thereby enabling efficient exosome isolation and purification while maintaining high vesicle integrity and low impurity carryover.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-K3121 Bacterial Membrane Vesicle Isolation and Purification Kit

MCE Bacterial Membrane Vesicle Isolation and Purification Kit has been optimized specifically for the isolation and purification of bacterial membrane vesicles. The optimized formulation and purification workflow enable the isolation and purification of bacterial membrane vesicles from bacterial culture supernatants. In combination with an exosome purification column, the kit enables rapid and efficient enrichment of bacterial membrane vesicles, yielding vesicle particles with high purity and preserved structural integrity.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-K3122 Dry Plant-Derived Extracellular Vesicle Isolation and Purification Kit

MCE Dry Plant-Derived Extracellular Vesicle Isolation and Purification Kit is specifically optimized for dried plant samples. It facilitates the efficient release of vesicles from plant tissues and employs an optimized extraction and purification system to remove non-vesicular components such as polysaccharides and phenolic compounds, thereby enabling the efficient extraction and purification of plant-derived vesicles. The isolated plant-derived vesicles can be used for downstream applications including transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blotting, qPCR, cell-based studies, and animal experiments.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-K3123 Succulent Plant-Derived Extracellular Vesicle Isolation and Purification Kit

MCE Succulent Plant -Derived Extracellular Vesicle Isolation and Purification Kit is specifically optimized for succulent plant samples. It facilitates the efficient release of vesicles from plant tissues and employs an optimized extraction and purification system to remove non-vesicular components such as polysaccharides and phenolic compounds, thereby enabling the efficient extraction and purification of plant-derived vesicles. The isolated plant-derived vesicles can be used for downstream applications including transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blotting, qPCR, cell-based studies, and animal experiments.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-K3124 Macrofungal-Derived Extracellular Vesicle Isolation and Purification Kit

MCE Macrofungal-Derived Extracellular Vesicle Isolation and Purification Kit is specifically optimized for fungal fruiting body samples. The optimized extraction system facilitates the release of EVs from fungal tissues, while the purification system effectively removes polysaccharides, proteins, phenolic compounds, terpenoids, and other non-vesicular components, enabling efficient isolation and purification of fungal EVs. The isolated macrofungal-derived vesicles can be used for downstream applications including transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blotting, qPCR, cell-based studies, and animal experiments.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-K3125 Extracellular Vesicle (EV) Ultrafiltration Concentrator (500 μL, 100 kDa)

MCE Extracellular Vesicle (EV) Ultrafiltration Concentrator (500 μL, 100 kDa) features a polyethersulfone (PES) ultrafiltration membrane with a molecular weight cutoff (MWCO) of 100 kDa. It provides rapid filtration, high concentration efficiency, and high exosome recovery. Its specialized anti-dry-spin design effectively minimizes sample loss caused by excessive centrifugation and membrane drying, thereby helping maintain high exosome recovery.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-K6003 Basement Membrane Matrix GFR (Phenol Red)

MCE Growth Factor Reduced Basement Membrane Matrix (with Phenol Red) is primarily composed of natural basement membrane matrix extracted from mouse tumors and contains abundant extracellular matrix components and a variety of naturally occurring growth factors. This product is primarily designed for 3D organoid culture and other research applications requiring high-quality basement membrane matrix.

Cell Biology 3D Cell Culture Basement Membrane Matrix

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References

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[7]. Han C, et al. Extracellular vesicles in cardiovascular disease: Biological functions and therapeutic implications. Pharmacol Ther. 2022;233:108025.  [Content Brief]

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Keywords

extracellular vesicles | exosomes | microvesicles | intercellular communication | EV biogenesis | cargo transfer | tumor microenvironment | metastasis | immune evasion | PD-L1 | drug delivery | biomarkers | regenerative medicine | extracellular vesicle therapy | pre-metastatic niche